Qingshan Chang

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. pmc JNK1 activation predicts the prognostic outcome of the human hepatocellular carcinoma
    Qingshan Chang
    Graduate Center for Toxicology, University of Kentucky, Lexington, KY40536, USA
    Mol Cancer 8:64. 2009
  2. pmc NADPH oxidase activation is required in reactive oxygen species generation and cell transformation induced by hexavalent chromium
    Xin Wang
    Graduate Center for Toxicology, 1095 V A Drive, 306 Health Sciences Research Building, Lexington, KY 40536, USA
    Toxicol Sci 123:399-410. 2011
  3. doi request reprint Sustained JNK1 activation is associated with altered histone H3 methylations in human liver cancer
    Qingshan Chang
    Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536, USA
    J Hepatol 50:323-33. 2009
  4. pmc Reduced reactive oxygen species-generating capacity contributes to the enhanced cell growth of arsenic-transformed epithelial cells
    Qingshan Chang
    Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky 40536, USA
    Cancer Res 70:5127-35. 2010
  5. pmc Nickel-induced down-regulation of ΔNp63 and its role in the proliferation of keratinocytes
    Zhuo Zhang
    Department of Preventive Medicine and Environmental Health, University of Kentucky, 121 Washington Avenue, Lexington, KY 40536, USA
    Toxicol Appl Pharmacol 253:235-43. 2011
  6. doi request reprint Cr(VI) induces mitochondrial-mediated and caspase-dependent apoptosis through reactive oxygen species-mediated p53 activation in JB6 Cl41 cells
    Young Ok Son
    Graduate Center for Toxicology, College of Medicine, University of Kentucky, Lexington, KY 40536 0305, USA
    Toxicol Appl Pharmacol 245:226-35. 2010
  7. pmc Arsenic inhibits neurite outgrowth by inhibiting the LKB1-AMPK signaling pathway
    Xin Wang
    Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky 40536, USA
    Environ Health Perspect 118:627-34. 2010

Collaborators

Detail Information

Publications7

  1. pmc JNK1 activation predicts the prognostic outcome of the human hepatocellular carcinoma
    Qingshan Chang
    Graduate Center for Toxicology, University of Kentucky, Lexington, KY40536, USA
    Mol Cancer 8:64. 2009
    ..Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide with an extremely poor prognosis. The classification of HCC based on the molecular signature is not well-established...
  2. pmc NADPH oxidase activation is required in reactive oxygen species generation and cell transformation induced by hexavalent chromium
    Xin Wang
    Graduate Center for Toxicology, 1095 V A Drive, 306 Health Sciences Research Building, Lexington, KY 40536, USA
    Toxicol Sci 123:399-410. 2011
    ..Our results suggest that NOX plays an important role in Cr(VI)-induced ROS generation and carcinogenesis...
  3. doi request reprint Sustained JNK1 activation is associated with altered histone H3 methylations in human liver cancer
    Qingshan Chang
    Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536, USA
    J Hepatol 50:323-33. 2009
    ..It remains unclear whether JNK activation plays an important role in human HCC and, if so, how JNK signaling contributes to the initiation or progression of HCC...
  4. pmc Reduced reactive oxygen species-generating capacity contributes to the enhanced cell growth of arsenic-transformed epithelial cells
    Qingshan Chang
    Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky 40536, USA
    Cancer Res 70:5127-35. 2010
    ....
  5. pmc Nickel-induced down-regulation of ΔNp63 and its role in the proliferation of keratinocytes
    Zhuo Zhang
    Department of Preventive Medicine and Environmental Health, University of Kentucky, 121 Washington Avenue, Lexington, KY 40536, USA
    Toxicol Appl Pharmacol 253:235-43. 2011
    ..Np63 plays an important role in nickel-induced cell proliferation...
  6. doi request reprint Cr(VI) induces mitochondrial-mediated and caspase-dependent apoptosis through reactive oxygen species-mediated p53 activation in JB6 Cl41 cells
    Young Ok Son
    Graduate Center for Toxicology, College of Medicine, University of Kentucky, Lexington, KY 40536 0305, USA
    Toxicol Appl Pharmacol 245:226-35. 2010
    ..These results suggest that Cr(VI) induced a mitochondrial-mediated and caspase-dependent apoptosis in skin epidermal cells through activation of p53, which are mainly mediated by reactive oxidants generated by the chemical...
  7. pmc Arsenic inhibits neurite outgrowth by inhibiting the LKB1-AMPK signaling pathway
    Xin Wang
    Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky 40536, USA
    Environ Health Perspect 118:627-34. 2010
    ..Arsenic (As) is an environmental pollutant that induces numerous pathological effects, including neurodevelopmental disorders...