Research Topics
Species | L ChangSummaryAffiliation: University of California Country: USA Publications
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Publications
Serum and colonic mucosal immune markers in irritable bowel syndromeLin Chang
Center for Neurobiology of Stress, University of California, Los Angeles, California 90095 7378, USA
Am J Gastroenterol 107:262-72. 2012....
Gender differences in irritable bowel syndromeLin Chang
UCLA CURE Neuroenteric Disease Program, Department of Medicine, and Brain Research Institute, UCLA School of Medicine, Los Angeles, California 90073, USA
Gastroenterology 123:1686-701. 2002..Although gender differences in the therapeutic benefit of serotonergic agents have been observed, less is known about potential differences in responsiveness to nondrug therapies for irritable bowel syndrome...- Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis in irritable bowel syndromeL Chang
Center for Neurobiology of Stress, David Geffen School of Medicine, University of California, Los Angeles, CA 90073, USA
Neurogastroenterol Motil 21:149-59. 2009..05). Although dysregulations in stress-responsive systems such as the HPA axis and mucosal immune function are demonstrated in IBS, they do not appear to have a primary role in modulating IBS severity and abdominal pain... - Effect of sex on perception of rectosigmoid stimuli in irritable bowel syndromeLin Chang
Center for Neurovisceral Sciences and Women s Health, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, and Veterans Affairs Greater Los Angeles Healthcare System, California 90073, USA
Am J Physiol Regul Integr Comp Physiol 291:R277-84. 2006..01), while men did not. Sex significantly influences perceptual sensitivity to rectosigmoid distension. Women show greater perceptual responses to this paradigm... 
The trials and tribulations of drug development for functional gastrointestinal disordersL Chang
Division of Digestive Diseases, Center for Neurobiology of Stress, David Geffen School of Medicine at UCLA, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
Neurogastroenterol Motil 20:130-8. 2008....- Brain responses to visceral and somatic stimuli in irritable bowel syndrome: a central nervous system disorder?Lin Chang
Center for Neurovisceral Sciences and Women s Health, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90024, USA
Gastroenterol Clin North Am 34:271-9. 2005.... - Perceptual responses in patients with inflammatory and functional bowel diseaseL Chang
UCLA CURE Neuroenteric Disease Program, Department of Medicine and Physiology, UCLA School of Medicine, Los Angeles, California 90073, USA
Gut 47:497-505. 2000.... - Assessment of potential risk factors associated with ischaemic colitisL Chang
David Geffen School of Medicine, University of California, Los Angeles, CA 90073, USA
Neurogastroenterol Motil 20:36-42. 2008..A significant interaction was observed between age and prior IBS on risk for IC. In conclusion, multiple risk factors for IC were identified and we confirmed that patients with IBS or constipation are at greater risk for IC... - Differences in somatic perception in female patients with irritable bowel syndrome with and without fibromyalgiaL Chang
UCLA CURE Neuroenteric Disease Program, Departments of Medicine and Physiology, UCLA School of Medicine, Los Angeles, CA 90024, USA
Pain 84:297-307. 2000..Because there is a significant overlap of IBS and FM, shared pathophysiological mechanisms have been suggested. Although visceral perception has been well studied in IBS, somatic perception has not... - Gender, age, society, culture, and the patient's perspective in the functional gastrointestinal disordersLin Chang
CNS WH Center for Neurovisceral Sciences and Women s Health Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90073, USA
Gastroenterology 130:1435-46. 2006..The prevalence of IBS appears to be lower in non-Western than Western countries. Although further studies are needed, the existing literature suggests that they are important to consider from both research and clinical perspectives... - Characterizing abdominal pain in IBS: guidance for study inclusion criteria, outcome measurement and clinical practiceB M R Spiegel
Department of Gastroenterology, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA
Aliment Pharmacol Ther 32:1192-202. 2010..Despite consensus that IBS trials should measure pain to define study entry and determine efficacy, the optimal method of measuring pain remains uncertain... - Measuring symptoms in the irritable bowel syndrome: development of a framework for clinical trialsB M R Spiegel
Department of Gastroenterology, VA Greater Los Angeles Healthcare System, CA, USA
Aliment Pharmacol Ther 32:1275-91. 2010..The Food and Drug Administration (FDA) emphasizes that PROs must be couched in a conceptual framework, yet existing IBS PROs were not based on such a framework... - Neural correlates of attention and working memory deficits in HIV patientsL Chang
Department of Neurology, UCLA School of Medicine, Harbor UCLA Medical Center, Torrance, CA, USA
Neurology 57:1001-7. 2001..To evaluate the neural correlates of attention and working memory deficits in patients with HIV-1... - Sex specific alterations in autonomic function among patients with irritable bowel syndromeK Tillisch
CNS WH Center for Neurovisceral Sciences and Women s Health, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA
Gut 54:1396-401. 2005..The few studies directly examining ANS measures have been suggestive of alterations in some IBS patients, but no studies to date have examined the potentially critical variables of sex differences or response to visceral stimulation... - Anti-hyperalgesic effect of octreotide in patients with irritable bowel syndromeI Schwetz
CNS/WH: Center for Neurovisceral Sciences and Women's Health, Los Angeles, CA 90073, USA
Aliment Pharmacol Ther 19:123-31. 2004..These findings suggest that octreotide exerts primarily an anti-hyperalgesic rather than analgesic effect on visceral perception... - Gender effects on persistent cerebral metabolite changes in the frontal lobes of abstinent cocaine usersL Chang
Department of Neurology, UCLA School of Medicine, Harbor UCLA Medical Center, Torrance 90509, USA
Am J Psychiatry 156:716-22. 1999..The aim of this study was to investigate persistent neurochemical changes in the frontal lobes of subjects with a history of crack cocaine dependence and to determine whether these changes are different in male and female users... - Cerebral (1)H MRS alterations in recreational 3, 4-methylenedioxymethamphetamine (MDMA, "ecstasy") usersL Chang
Department of Neurology, UCLA School of Medicine, Harbor UCLA Medical Center, Torrance, California 90502, USA
J Magn Reson Imaging 10:521-6. 1999..However, the usage-related increase in MI suggests that exposure to MDMA, even at recreational doses, may cause increased glial content. J. Magn. Reson. Imaging 1999;10:521-526... - Neural and psychological predictors of treatment response in irritable bowel syndrome patients with a 5-HT3 receptor antagonist: a pilot studyJ M Jarcho
UCLA Center for Neurovisceral Sciences and Women s Health, Los Angeles, CA 90073, USA
Aliment Pharmacol Ther 28:344-52. 2008..Factors predicting treatment responsiveness are not known, although we have demonstrated that symptom improvement with the 5-HT3R antagonist alosetron is correlated with reduced amygdala activity... - Antiretroviral treatment is associated with increased attentional load-dependent brain activation in HIV patientsL Chang
Department of Medicine, Division of Neurology, John A Burns School of Medicine, University of Hawaii at Manoa, The Queen s Medical Center University Tower, 1356 Lusitana Street, Honolulu, HI 96813, USA
J Neuroimmune Pharmacol 3:95-104. 2008.... - Gender-related differences in IBS symptomsO Y Lee
CURE Digestive Diseases Research Center/Neuroenteric Disease Program, Department of Medicine and Physiology, UCLA School of Medicine, Los Angeles, California, USA
Am J Gastroenterol 96:2184-93. 2001..The apparent differences in sensitivity to nonpainful visceral sensations, medications, and food may represent altered sensory processes, autonomic responses, and/or cognitive hypervigilance... - Lower diffusion in white matter of children with prenatal methamphetamine exposureC C Cloak
Department of Medicine, John A Burns School of Medicine, Queen s University Tower, Honolulu, HI 96813, USA
Neurology 72:2068-75. 2009..Whether microstructural brain changes associated with prenatal methamphetamine exposure can be detected with diffusion tensor imaging (DTI) is unknown... - Altered neurometabolites and motor integration in children exposed to methamphetamine in uteroL Chang
Division of Neurology, Department of Medicine, John A Burns School of Medicine, Queen s University Tower, 1356 Lusitana Street, Honolulu, HI 96813, USA
Neuroimage 48:391-7. 2009..These findings combined with their poorer performance on VMI also suggest accelerated but aberrant neuronal and glial development in these brain regions... - Approaches to the modulation of abdominal painE A Mayer
UCLA CURE Neuroenteric Disease Program, Department of Medicine, Physiology and Brain Research Institute, UCLA School of Medicine, Los Angeles, California 90073, USA
Can J Gastroenterol 13:65A-70A. 1999.... - Impact of apolipoprotein E ε4 and HIV on cognition and brain atrophy: antagonistic pleiotropy and premature brain agingL Chang
Department of Medicine, John A Burns School of Medicine, The Queen s Medical Center, Honolulu, Hawaii 96813, USA
Neuroimage 58:1017-27. 2011..Whether APOEε4 allele(s) and age may influence brain atrophy in HIV patients is unknown and was evaluated... - Combined and independent effects of chronic marijuana use and HIV on brain metabolitesL Chang
Department of Medicine, John A Burns School of Medicine, Queen s University Tower, 1356 Lusitana Street, Honolulu, HI 96813, USA
J Neuroimmune Pharmacol 1:65-76. 2006..These findings suggest chronic MJ use may lead to decreased neuronal and glial metabolites, but may normalize the decreased glutamate in HIV patients... - Functional GI disorders: from animal models to drug developmentE A Mayer
UCLA Center for Neurovisceral Sciences and Women s Health, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA
Gut 57:384-404. 2008.... - Basic pathophysiologic mechanisms in irritable bowel syndromeE A Mayer
UCLA CURE Neuroenteric Disease Program, Department of Medicine, Physiology and Biobehavioral Sciences, UCLA School of Medicine, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
Dig Dis 19:212-8. 2001..IBS patients show an enhanced responsiveness of this system manifesting in altered modulation of gastrointestinal motility, secretion, immune function and in alterations in the perceptual and emotional response to visceral events... - Meta-analysis: do irritable bowel syndrome symptoms vary between men and women?M A Adeyemo
Center for Neurobiology of Stress, Los Angeles, CA 90095, USA
Aliment Pharmacol Ther 32:738-55. 2010..Studies suggest that sex and gender-related differences exist in irritable bowel syndrome (IBS), but data is often conflicting... - Effect of ecstasy [3,4-methylenedioxymethamphetamine (MDMA)] on cerebral blood flow: a co-registered SPECT and MRI studyL Chang
Department of Neurology, UCLA School of Medicine, Harbor UCLA Medical Center, 1000 W Carson Street, B 4, Torrance, CA 90509, USA
Psychiatry Res 98:15-28. 2000.... - Measuring irritable bowel syndrome patient-reported outcomes with an abdominal pain numeric rating scaleB Spiegel
VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA
Aliment Pharmacol Ther 30:1159-70. 2009..Pain numeric rating scales (NRS) are widely used in the non-IBS pain literature. The Food and Drug Administration has proposed using the NRS in IBS... - Brain proton magnetic resonance spectroscopy in children exposed to methamphetamine in uteroL M Smith
Department of Pediatrics, Harbor UCLA Medical Center, University of California, Los Angeles School of Medicine, Torrance 90502, USA
Neurology 57:255-60. 2001..To examine the possible neurotoxic effects of prenatal methamphetamine exposure on the developing brain using 1H-MRS... - Brain responses to visceral and somatic stimuli in patients with irritable bowel syndrome with and without fibromyalgiaLin Chang
C.N.S. Center for Neurovisceral Sciences and Women's Health, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
Am J Gastroenterol 98:1354-61. 2003.... - The Visceral Sensitivity Index: development and validation of a gastrointestinal symptom-specific anxiety scaleJ S Labus
Center for Neurovisceral Sciences and Women's Health, VA GLA Healthcare System, Los Angeles, CA 90073, USA
Aliment Pharmacol Ther 20:89-97. 2004.... - Traditional Chinese medicine based subgrouping of irritable bowel syndrome patientsS Tan
Center for Neurovisceral Sciences and Women's Health, Department of Medicine David Geffen School of Medicine, University of California, Los Angeles, USA
Am J Chin Med 33:365-79. 2005..This pilot study provides preliminary support for a methodology to identify novel subgroups of IBS patients related to the TCM classification, which may differ in underlying pathophysiology and treatment responses... - Is there a difference between abdominal pain and discomfort in moderate to severe IBS patients?Joel Sach
C N S Center for Neurovisceral Sciences and Women s Health, Los Angeles, California, USA
Am J Gastroenterol 97:3131-8. 2002.... - Childhood trauma is associated with hypothalamic-pituitary-adrenal axis responsiveness in irritable bowel syndromeElizabeth J Videlock
Center for Neurobiology of Stress, David Geffen School of Medicine, University of California, Los Angeles, California 90095 7378, USA
Gastroenterology 137:1954-62. 2009..We sought to determine if EALs affect the HPA axis response to a visceral stressor in irritable bowel syndrome (IBS) patients and healthy controls, and to determine if this is affected by sex or related to symptoms or quality of life... - Biexponential modeling of multigradient-echo MRI data of the brainO Speck
Department of Neurology, Harbor UCLA Medical Center, UCLA School of Medicine, Torrance, California, USA
Magn Reson Med 45:1116-21. 2001..The activation-induced parameter changes are detected with a sensitivity equal to that of a monoexponential method. The resulting T2* and DeltaT2* values describe the experimental data more accurately... - HIV-2 infection with cerebral toxoplasmosis and lymphomatoid granulomatosisM Issakhanian
Department of Neurology, University of California, Los Angeles (UCLA) School of Medicine, Harbor-UCLA Medical Center, Torrance, CA, USA
J Neuroimaging 11:212-6. 2001..The lesion showed a biochemical and perfusion pattern that was intermediate for infectious and neoplastic processes. Further neuropathology confirmed a secondary diagnosis of lymphomatoid granulomatosis... - Marijuana use is associated with a reorganized visual-attention network and cerebellar hypoactivationL Chang
Department of Medicine, University of Hawaii, Honolulu, Hawaii 96813, USA
Brain 129:1096-112. 2006.... - V. Stress and irritable bowel syndromeE A Mayer
UCLA CURE Neuroenteric Disease Program, Departments of Medicine, Physiology, and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, California 90024, USA
Am J Physiol Gastrointest Liver Physiol 280:G519-24. 2001..Functional brain imaging techniques are beginning to identify brain circuits involved in the perceptual alterations. Animal models have recently been proposed that mimic key features of the human syndrome... - Cerebral activation in patients with irritable bowel syndrome and control subjects during rectosigmoid stimulationB D Naliboff
CURE Digestive Diseases Research Center Neuroenteric Disease Program, University of California School of Medicine, VA Greater Los Angeles Health Care System, 90073, USA
Psychosom Med 63:365-75. 2001..In the current study, brain responses to anticipated and delivered rectal balloon distension were assessed... - Review article: gender-related differences in functional gastrointestinal disordersE A Mayer
CURE Neuroenteric Disease Program, UCLA Division of Digestive Diseases, USA
Aliment Pharmacol Ther 13:65-9. 1999.... - Novel techniques to study visceral hypersensitivity in irritable bowel syndromeTrinh T Truong
Building 115, Room 215, Los Angeles, CA 90073, USA
Curr Gastroenterol Rep 10:369-78. 2008..There are few effective pharmacologic treatments that relieve IBS symptoms, and improved understanding of brain-gut interactions and factors relating to enhanced visceral perception may guide us in developing more efficacious treatments... - Longitudinal change in perceptual and brain activation response to visceral stimuli in irritable bowel syndrome patientsBruce D Naliboff
Center for Neurovisceral Sciences and Women s Health, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
Gastroenterology 131:352-65. 2006..Repeated stimulus exposure leads to decreased salience of threat and reduction of hypervigilance. We sought to evaluate hypervigilance in IBS visceral hypersensitivity and associated brain activity... - The central role of gastrointestinal-specific anxiety in irritable bowel syndrome: further validation of the visceral sensitivity indexJennifer S Labus
Department of Psychiatry and Biobehavioral Sciences, Center for Neurovisceral Sciences and Women s Health, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Psychosom Med 69:89-98. 2007.... - Developing valid and reliable health utilities in irritable bowel syndrome: results from the IBS PROOF CohortBrennan Spiegel
VA Greater Los Angeles Healthcare System UCLA, Digestive Diseaes, 11301 Wilshire Blvd, Building 11, Room 21E, Los Angeles, California 90073, USA
Am J Gastroenterol 104:1984-91. 2009..To inform future cost-utility analyses in IBS, we measured and validated the IBS utilities... - New treatments for irritable bowel syndrome in womenMopelola A Adeyemo
Center for Neurobiology of Stress, Division of Digestive Diseases, David Geffen School of Medicine at UCLA, 11301 Wilshire Blvd, Building 115, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
Womens Health (Lond Engl) 4:605-22; quiz 623. 2008..This article provides an overview of current and emerging therapies for IBS and also highlights sex and gender differences in clinical trials and treatment response... - Increased acoustic startle responses in IBS patients during abdominal and nonabdominal threatBruce D Naliboff
Center for Neurobiology of Stress, Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, UCLA, Los Angeles, California, USA
Psychosom Med 70:920-7. 2008..The eye-blink startle response represents a noninvasive measure of central defensive responding. Evidence for central hyperexcitability was studied in IBS patients by examining potentiation of the startle reflex to a nociceptive threat... - Predictors of patient-assessed illness severity in irritable bowel syndromeBrennan Spiegel
VA Greater Los Angeles Healthcare System, Center for Outcomes Research and Education, Los Angeles, California, USA
Am J Gastroenterol 103:2536-43. 2008..Since severity is a patient-centered outcome, it is essential that future instruments are based on patients' self-perceptions of severity. We measured patient-derived predictors of severity in a large cohort of IBS patients... - The effect of life stress on symptoms of heartburnBruce D Naliboff
Center for Neurovisceral Sciences and Women s Health, Department of Medicine, UCLA, Los Angeles, CA, USA
Psychosom Med 66:426-34. 2004..The present longitudinal study tests the general hypothesis that life stressors can exacerbate symptoms in patients with chronic heartburn... - Racial differences in the impact of irritable bowel syndrome on health-related quality of lifeIan M Gralnek
VA Greater Los Angeles Health Care System, Los Angeles, CA, USA
J Clin Gastroenterol 38:782-9. 2004..To compare the impact of irritable bowel syndrome (IBS) on health related quality of life (HRQOI) for non-white and white IBS patients... - Differences in brain responses to visceral pain between patients with irritable bowel syndrome and ulcerative colitisEmeran A Mayer
Center for Neurovisceral Sciences and Women s Health, David Geffen School of Medicine, University of California, Los Angeles, CA 90073, USA
Pain 115:398-409. 2005.... - Sex-based differences in gastrointestinal painEmeran A Mayer
Departments of Medicine, Psychiatry and Biobehavioral Sciences, CNS Center for Neurovisceral Sciences and Women s Health, UCLA Division of Digestive Diseases, UCLA and VA GLAHS, WLA VA Medical Center, Los Angeles, CA 90073, USA
Eur J Pain 8:451-63. 2004..Consistent with experimental findings in animals, current evidence is consistent with a pathophysiological model which emphasizes sex-related differences in autonomic and antinociceptive responses to certain visceral stimuli... - Condition-specific deactivation of brain regions by 5-HT3 receptor antagonist AlosetronSteven M Berman
CURE/Neuroenteric Disease Program, Department of Medicine, University of California School of Medicine, Los Angeles, California 90073, USA
Gastroenterology 123:969-77. 2002..CONCLUSIONS: Reduction in IBS symptoms correlated with a drug-induced reduction in the activity of central autonomic networks mediating emotional expression that was maximal in the absence of nociceptive input... - Clinical determinants of health-related quality of life in patients with irritable bowel syndromeBrennan M R Spiegel
Division of Gastroenterology, the VA Greater Los Angeles Healthcare System, CA 90073, USA
Arch Intern Med 164:1773-80. 2004..The identification of predictive factors could allow physicians to better assess HRQOL without using misleading clinical clues. We, therefore, sought to identify determinants of HRQOL in patients with IBS... - Irritable bowel syndrome patients show enhanced modulation of visceral perception by auditory stressBritta Dickhaus
University of California, Department of Medicine, Los Angeles (UCLA)/CNS: Center for Neurovisceral Sciences and Women's Health, VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
Am J Gastroenterol 98:135-43. 2003..CONCLUSION: These findings confirm the hypothesis of altered stress-induced modulation of visceral perception in IBS patients... - Sex-related differences in IBS patients: central processing of visceral stimuliBruce D Naliboff
Center for Neurovisceral Sciences and Women s Health, UCLA School of Medicine, CURE Building, 115 Room 223, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
Gastroenterology 124:1738-47. 2003..The aim of this study was to determine possible sex-related differences in brain responses to a visceral and a psychological stressor in IBS... - Review article: epidemiology and quality of life in functional gastrointestinal disordersL Chang
Center for Neurovisceral Sciences and Women s Health, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Aliment Pharmacol Ther 20:31-9. 2004..The presence of extra-intestinal symptoms appears to have a major if not greater impact on health care visits, excess health care costs and health-related quality of life in patients with functional gastrointestinal disorders... - The effect of the 5-HT3 receptor antagonist, alosetron, on brain responses to visceral stimulation in irritable bowel syndrome patientsE A Mayer
CURE Digestive Diseases Research Center Neuroenteric Disease Program, Department of Medicine, University of California School of Medicine, Los Angeles, CA 90073, USA
Aliment Pharmacol Ther 16:1357-66. 2002.... - Segmentation of progressive multifocal leukoencephalopathy lesions in fluid-attenuated inversion recovery magnetic resonance imagingL Itti
Department of Computer Science, University of Southern California, Hedco Neuroscience Building, Room 30A, 3641 Watt Way, Los Angeles, CA 90089 2520, USA
J Neuroimaging 11:412-7. 2001..The authors compared the reproducibility of a manual and a semiautomated technique for the quantitation of white-matter lesions in magnetic resonance imaging (MRI)... - A multicenter in vivo proton-MRS study of HIV-associated dementia and its relationship to ageL Chang
Department of Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA
Neuroimage 23:1336-47. 2004..Aging may further exacerbate brain metabolites associated with inflammation in HIV patient and thereby increase the risk for cognitive impairment... - Enhanced preattentive central nervous system reactivity in irritable bowel syndromeSteven M Berman
CURE Digestive Diseases Research Center, Department of Medicine, University of California, Los Angeles 90073, USA
Am J Gastroenterol 97:2791-7. 2002..A generalized preattentive increase in central nervous system reactivity may be a feature that IBS shares with several anxiety disorders that frequently co-occur in these patients... - Is a negative colonoscopy associated with reassurance or improved health-related quality of life in irritable bowel syndrome?Brennan M R Spiegel
Division of Gastroenterology, VA Greater Los Angeles Healthcare System, CA 90073, USA
Gastrointest Endosc 62:892-9. 2005..However, no previous data have measured these effects. We sought to measure the association of a normal colonoscopy with reassurance and HRQOL in patients with IBS aged <50 years... - Cerebral perfusion abnormalities in abstinent cocaine abusers: a perfusion MRI and SPECT studyT Ernst
Department of Neurology, UCLA School of Medicine, Harbor UCLA Medical Center, 100 West Carson Street, B 4, 90509, Torrance, CA, USA
Psychiatry Res 99:63-74. 2000..The hypoperfusion in the cortex and deep gray matter of the cocaine users is consistent with previous results. The increased rCBF in the white matter of cocaine users may be due to the presence of reactive glia... - Increased frontal white matter diffusion is associated with glial metabolites and psychomotor slowing in HIVC C Cloak
Department of Medicine, John A. Burns School of Medicine, University of Hawaii, Queen's University Tower, 7th Floor, 1356 Lusitana St, Honolulu, HI 96813, USA
J Neuroimmunol 157:147-52. 2004..43, p=0.05). These findings suggest increased brain water diffusion may reflect increased glial activation or inflammation, which in turn, may contribute to the cognitive deficits in HIV patients... - A dose-ranging, phase II study of the efficacy and safety of alosetron in men with diarrhea-predominant IBSLin Chang
Center for Neurovisceral Sciences and Women's Health, UCLA Division of Digestive Diseases, Los Angeles, California, USA
Am J Gastroenterol 100:115-23. 2005..CONCLUSIONS: Alosetron 1 mg twice daily provided adequate relief of IBS pain and discomfort, and improved stool consistency in men with diarrhea-predominant IBS... - Characterization of the alternating bowel habit subtype in patients with irritable bowel syndromeKirsten Tillisch
CNS/WH: Center for Neurovisceral Sciences and Women's Health, Department of Medicine, UCLA, and the VA Greater Los Angeles Healthcare System, Los Angeles, California, USA
Am J Gastroenterol 100:896-904. 2005..CONCLUSIONS: IBS-A patients have rapidly fluctuating symptoms and increased psychological comorbidity, which should be taken into account for clinical practice and clinical trials... - Management of Crohn's disease in adultsGary R Lichtenstein
Department of Medicine, Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Am J Gastroenterol 104:465-83; quiz 464, 484. 2009..The final recommendations are based on the data available at the time of the production of the document and may be updated with pertinent scientific developments at a later time... - Diagnosis and treatment of irritable bowel syndrome: state of the artKirsten Tillisch
VA Greater Los Angeles Healthcare System, CURE Building 115, Room 223, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
Curr Gastroenterol Rep 7:249-56. 2005..Although only two medications, tegaserod for constipation-predominant IBS and alosetron for diarrhea-predominant IBS, are specifically indicated, a wide variety of treatment options are available and are discussed in this review... - Irritable bowel syndrome: current approach to symptoms, evaluation, and treatmentElizabeth J Videlock
Center for Neurovisceral Sciences and Women s Health, Division of Digestive Diseases, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System, CURE Building 115, Room 223, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
Gastroenterol Clin North Am 36:665-85, x. 2007.... - Is irritable bowel syndrome a diagnosis of exclusion?: a survey of primary care providers, gastroenterologists, and IBS expertsBrennan M R Spiegel
Department of Gastroenterology, VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
Am J Gastroenterol 105:848-58. 2010..Yet many clinicians are concerned about overlooking alternative diagnoses. We measured beliefs about whether IBS is a diagnosis of exclusion, and measured testing proclivity between IBS experts and community providers... - Incidence of ischemic colitis and serious complications of constipation among patients using alosetron: systematic review of clinical trials and post-marketing surveillance dataLin Chang
Center for Neurovisceral Sciences and Women's Health, Department of Medicine, UCLA and VA Greater Los Angeles Healthcare Center, California, USA
Am J Gastroenterol 101:1069-79. 2006..66 per 1,000 patient-years of alosetron use. CONCLUSION: The incidence of ischemic colitis and serious complications of constipation is very low and is rarely associated with long-term sequelae or serious morbidity... - Ischemic colitis and complications of constipation associated with the use of alosetron under a risk management plan: clinical characteristics, outcomes, and incidencesLin Chang
Center for Neurobiology Stress, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
Am J Gastroenterol 105:866-75. 2010..The objectives of this study were to characterize IC and CoC clinical features, outcomes, and incidence rates in the new restricted patient population to evaluate the effectiveness of the RMP in the prevention of serious outcomes... - Bacterial overgrowth and irritable bowel syndrome: unifying hypothesis or a spurious consequence of proton pump inhibitors?Brennan M R Spiegel
VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
Am J Gastroenterol 103:2972-6. 2008..Our article explores these premises, lays out the argument supporting this "PPI hypothesis," discusses potential implications, and outlines next steps to further investigate this possibility... - Utility of the Rome I and Rome II criteria for irritable bowel syndrome in U.S. womenWilliam D Chey
University of Michigan, Ann Arbor, USA
Am J Gastroenterol 97:2803-11. 2002..These findings have important implications for clinical research in IBS patients and raise questions about whether the Rome II criteria are sensitive enough to be useful in clinical practice... - New insights into the pathophysiology of irritable bowel syndrome: implications for future treatmentsMichael D Crowell
Division of Gastroenterology and Hepatology, Mayo Clinic Scottsdale, 13400 E Shea Boulevard, Scottsdale, AZ 85259, USA
Curr Gastroenterol Rep 7:272-9. 2005..Increasingly novel mechanisms are being identified that should aid in better understanding of the complex pathophysiology of IBS and developing new therapies... - Impact of sex and gender on irritable bowel syndromeMargaret Heitkemper
Dept of Biobehavioral Nursing and Health Systems, Box 357266, University of Washington, Seattle, WA 98195, USA
Biol Res Nurs 5:56-65. 2003..This review examines sex and gender modulation of gastrointestinal motility and transit, visceral pain sensitivity, autonomic nervous system function, serotonin biochemistry, and differences in health care-seeking behavior for IBS... - Prevalence of irritable bowel syndrome among university students: the roles of worry, neuroticism, anxiety sensitivity and visceral anxietyHolly Hazlett-Stevens
Department of Psychology 298, University of Nevada, Reno, NV 89557, USA
J Psychosom Res 55:501-5. 2003..Relationships between presence of irritable bowel syndrome (IBS) and generalized anxiety disorder (GAD), chronic worry, neuroticism, anxiety sensitivity and anxiety about visceral sensations were examined among university students... - Impact of irritable bowel syndrome on patients' lives: development and psychometric documentation of a disease-specific measure for use in clinical trialsGeorge F Longstreth
Department of Gastroenterology, Kaiser Permanente Medical Center, San Diego, California, USA
Eur J Gastroenterol Hepatol 17:411-20. 2005..To develop a disease-specific questionnaire to capture the impact of irritable bowel syndrome (IBS) and its treatment on patients' lives, the Irritable Bowel Syndrome Impact Scale (IBS-IS)... - A comparison of visceral and somatic pain processing in the human brainstem using functional magnetic resonance imagingPaul Dunckley
Department of Human Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, United Kingdom
J Neurosci 25:7333-41. 2005..05, Pearson's r, two-tailed) but not somatic stimulation. We propose that the differences in NCF and right PAG activation observed may represent a greater nocifensive response and greater emotive salience of visceral over somatic pain... - Irritable bowel syndrome: new and emerging therapiesLucinda A Harris
Mayo Clinic College of Medicine, Scottsdale, Arizona, USA
Curr Opin Gastroenterol 22:128-35. 2006..Antidepressants are used to modulate pain and treat comorbid psychological distress. Newer agents target various receptor sites. Advances in psychological/behavioral treatments and alternative modalities hold promise for the future... - Efficacy and safety of hypertonic saline solutions in the treatment of severe head injurySheng-Jean Huang
Division of Neurosurgery, Department of Surgery, National Taiwan University Hospital, Taipei 100, Taiwan, ROC
Surg Neurol 65:539-46; discussion 546. 2006..Further evaluations of long-term consequences and complications and of maximal tolerance to this treatment are required... - Clinical experience of hydroxyethyl starch (10% HES 200/0.5) in cerebral perfusion pressure protocol for severe head injurySheng-Jean Huang
Division of Neurosurgery, Department of Surgery, National Taiwan University Hospital, Taipei 100, ROC Taiwan
Surg Neurol 66:S26-31. 2006..Besides, balanced fluid management can be achieved without causing serious pulmonary complications. However, a further randomized, prospective study is needed to define the actual benefit of HES in fluid management and clinical outcome... - Update on the management of adults with chronic idiopathic constipationBrooks D Cash
Uniformed Services University of the Health Sciences and Division of Gastroenterology, National Naval Medical Center, Bethesda, MD USA
J Fam Pract 56:S13-9; quiz S20. 2007 - Neuroendocrine and neuroimmune markers in IBS: pathophysiological role or epiphenomenon?Lin Chang
Gastroenterology 130:596-600. 2006
Research Grants
- NEUROENDOCRINE ALTERATIONS IN FIBROMYALGIA AND IBSLin Chang; Fiscal Year: 2009..abstract_text> ..
- NEUROENDOCRINE ALTERATIONS IN FIBROMYALGIA AND IBSLin Chang; Fiscal Year: 2007....
- NEUROENDOCRINE ALTERATIONS IN FIBROMYALGIA AND IBSLin Chang; Fiscal Year: 2003..The combination of experimental approaches should improve our understanding of the CNS mechanisms underlying functional pain syndromes. ..
- NEUROENDOCRINE ALTERATIONS IN FIBROMYALGIA AND IBSLin Chang; Fiscal Year: 2010..abstract_text> ..