L Chang

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Gender differences in irritable bowel syndrome
    Lin Chang
    UCLA CURE Neuroenteric Disease Program, Department of Medicine, and Brain Research Institute, UCLA School of Medicine, Los Angeles, California 90073, USA
    Gastroenterology 123:1686-701. 2002
  2. ncbi request reprint Effect of sex on perception of rectosigmoid stimuli in irritable bowel syndrome
    Lin Chang
    Center for Neurovisceral Sciences and Women s Health, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, and Veterans Affairs Greater Los Angeles Healthcare System, California 90073, USA
    Am J Physiol Regul Integr Comp Physiol 291:R277-84. 2006
  3. pmc Serum and colonic mucosal immune markers in irritable bowel syndrome
    Lin Chang
    Center for Neurobiology of Stress, University of California, Los Angeles, California 90095 7378, USA
    Am J Gastroenterol 107:262-72. 2012
  4. ncbi request reprint Brain responses to visceral and somatic stimuli in irritable bowel syndrome: a central nervous system disorder?
    Lin Chang
    Center for Neurovisceral Sciences and Women s Health, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90024, USA
    Gastroenterol Clin North Am 34:271-9. 2005
  5. pmc Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis in irritable bowel syndrome
    L Chang
    Center for Neurobiology of Stress, David Geffen School of Medicine, University of California, Los Angeles, CA 90073, USA
    Neurogastroenterol Motil 21:149-59. 2009
  6. doi request reprint The trials and tribulations of drug development for functional gastrointestinal disorders
    L Chang
    Division of Digestive Diseases, Center for Neurobiology of Stress, David Geffen School of Medicine at UCLA, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Neurogastroenterol Motil 20:130-8. 2008
  7. ncbi request reprint Assessment of potential risk factors associated with ischaemic colitis
    L Chang
    David Geffen School of Medicine, University of California, Los Angeles, CA 90073, USA
    Neurogastroenterol Motil 20:36-42. 2008
  8. ncbi request reprint Gender, age, society, culture, and the patient's perspective in the functional gastrointestinal disorders
    Lin Chang
    CNS WH Center for Neurovisceral Sciences and Women s Health Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90073, USA
    Gastroenterology 130:1435-46. 2006
  9. pmc Perceptual responses in patients with inflammatory and functional bowel disease
    L Chang
    UCLA CURE Neuroenteric Disease Program, Department of Medicine and Physiology, UCLA School of Medicine, Los Angeles, California 90073, USA
    Gut 47:497-505. 2000
  10. ncbi request reprint Differences in somatic perception in female patients with irritable bowel syndrome with and without fibromyalgia
    L Chang
    UCLA CURE Neuroenteric Disease Program, Departments of Medicine and Physiology, UCLA School of Medicine, Los Angeles, CA 90024, USA
    Pain 84:297-307. 2000

Detail Information

Publications88

  1. ncbi request reprint Gender differences in irritable bowel syndrome
    Lin Chang
    UCLA CURE Neuroenteric Disease Program, Department of Medicine, and Brain Research Institute, UCLA School of Medicine, Los Angeles, California 90073, USA
    Gastroenterology 123:1686-701. 2002
    ..Although gender differences in the therapeutic benefit of serotonergic agents have been observed, less is known about potential differences in responsiveness to nondrug therapies for irritable bowel syndrome...
  2. ncbi request reprint Effect of sex on perception of rectosigmoid stimuli in irritable bowel syndrome
    Lin Chang
    Center for Neurovisceral Sciences and Women s Health, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, and Veterans Affairs Greater Los Angeles Healthcare System, California 90073, USA
    Am J Physiol Regul Integr Comp Physiol 291:R277-84. 2006
    ..01), while men did not. Sex significantly influences perceptual sensitivity to rectosigmoid distension. Women show greater perceptual responses to this paradigm...
  3. pmc Serum and colonic mucosal immune markers in irritable bowel syndrome
    Lin Chang
    Center for Neurobiology of Stress, University of California, Los Angeles, California 90095 7378, USA
    Am J Gastroenterol 107:262-72. 2012
    ....
  4. ncbi request reprint Brain responses to visceral and somatic stimuli in irritable bowel syndrome: a central nervous system disorder?
    Lin Chang
    Center for Neurovisceral Sciences and Women s Health, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90024, USA
    Gastroenterol Clin North Am 34:271-9. 2005
    ....
  5. pmc Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis in irritable bowel syndrome
    L Chang
    Center for Neurobiology of Stress, David Geffen School of Medicine, University of California, Los Angeles, CA 90073, USA
    Neurogastroenterol Motil 21:149-59. 2009
    ..05). Although dysregulations in stress-responsive systems such as the HPA axis and mucosal immune function are demonstrated in IBS, they do not appear to have a primary role in modulating IBS severity and abdominal pain...
  6. doi request reprint The trials and tribulations of drug development for functional gastrointestinal disorders
    L Chang
    Division of Digestive Diseases, Center for Neurobiology of Stress, David Geffen School of Medicine at UCLA, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Neurogastroenterol Motil 20:130-8. 2008
    ....
  7. ncbi request reprint Assessment of potential risk factors associated with ischaemic colitis
    L Chang
    David Geffen School of Medicine, University of California, Los Angeles, CA 90073, USA
    Neurogastroenterol Motil 20:36-42. 2008
    ..A significant interaction was observed between age and prior IBS on risk for IC. In conclusion, multiple risk factors for IC were identified and we confirmed that patients with IBS or constipation are at greater risk for IC...
  8. ncbi request reprint Gender, age, society, culture, and the patient's perspective in the functional gastrointestinal disorders
    Lin Chang
    CNS WH Center for Neurovisceral Sciences and Women s Health Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90073, USA
    Gastroenterology 130:1435-46. 2006
    ..The prevalence of IBS appears to be lower in non-Western than Western countries. Although further studies are needed, the existing literature suggests that they are important to consider from both research and clinical perspectives...
  9. pmc Perceptual responses in patients with inflammatory and functional bowel disease
    L Chang
    UCLA CURE Neuroenteric Disease Program, Department of Medicine and Physiology, UCLA School of Medicine, Los Angeles, California 90073, USA
    Gut 47:497-505. 2000
    ....
  10. ncbi request reprint Differences in somatic perception in female patients with irritable bowel syndrome with and without fibromyalgia
    L Chang
    UCLA CURE Neuroenteric Disease Program, Departments of Medicine and Physiology, UCLA School of Medicine, Los Angeles, CA 90024, USA
    Pain 84:297-307. 2000
    ..Because there is a significant overlap of IBS and FM, shared pathophysiological mechanisms have been suggested. Although visceral perception has been well studied in IBS, somatic perception has not...
  11. doi request reprint Characterizing abdominal pain in IBS: guidance for study inclusion criteria, outcome measurement and clinical practice
    B M R Spiegel
    Department of Gastroenterology, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA
    Aliment Pharmacol Ther 32:1192-202. 2010
    ..Despite consensus that IBS trials should measure pain to define study entry and determine efficacy, the optimal method of measuring pain remains uncertain...
  12. doi request reprint Measuring symptoms in the irritable bowel syndrome: development of a framework for clinical trials
    B M R Spiegel
    Department of Gastroenterology, VA Greater Los Angeles Healthcare System, CA, USA
    Aliment Pharmacol Ther 32:1275-91. 2010
    ..The Food and Drug Administration (FDA) emphasizes that PROs must be couched in a conceptual framework, yet existing IBS PROs were not based on such a framework...
  13. ncbi request reprint Neural correlates of attention and working memory deficits in HIV patients
    L Chang
    Department of Neurology, UCLA School of Medicine, Harbor UCLA Medical Center, Torrance, CA, USA
    Neurology 57:1001-7. 2001
    ..To evaluate the neural correlates of attention and working memory deficits in patients with HIV-1...
  14. pmc Sex specific alterations in autonomic function among patients with irritable bowel syndrome
    K Tillisch
    CNS WH Center for Neurovisceral Sciences and Women s Health, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA
    Gut 54:1396-401. 2005
    ..The few studies directly examining ANS measures have been suggestive of alterations in some IBS patients, but no studies to date have examined the potentially critical variables of sex differences or response to visceral stimulation...
  15. ncbi request reprint Anti-hyperalgesic effect of octreotide in patients with irritable bowel syndrome
    I Schwetz
    CNS WH Center for Neurovisceral Sciences and Women s Health, Los Angeles, CA 90073, USA
    Aliment Pharmacol Ther 19:123-31. 2004
    ..Octreotide has been found to be beneficial in the treatment of chronic pain, although the mechanisms underlying its therapeutic effect are incompletely understood...
  16. ncbi request reprint Gender effects on persistent cerebral metabolite changes in the frontal lobes of abstinent cocaine users
    L Chang
    Department of Neurology, UCLA School of Medicine, Harbor UCLA Medical Center, Torrance 90509, USA
    Am J Psychiatry 156:716-22. 1999
    ..The aim of this study was to investigate persistent neurochemical changes in the frontal lobes of subjects with a history of crack cocaine dependence and to determine whether these changes are different in male and female users...
  17. ncbi request reprint Cerebral (1)H MRS alterations in recreational 3, 4-methylenedioxymethamphetamine (MDMA, "ecstasy") users
    L Chang
    Department of Neurology, UCLA School of Medicine, Harbor UCLA Medical Center, Torrance, California 90502, USA
    J Magn Reson Imaging 10:521-6. 1999
    ..However, the usage-related increase in MI suggests that exposure to MDMA, even at recreational doses, may cause increased glial content. J. Magn. Reson. Imaging 1999;10:521-526...
  18. pmc Antiretroviral treatment is associated with increased attentional load-dependent brain activation in HIV patients
    L Chang
    Department of Medicine, Division of Neurology, John A Burns School of Medicine, University of Hawaii at Manoa, The Queen s Medical Center University Tower, 1356 Lusitana Street, Honolulu, HI 96813, USA
    J Neuroimmune Pharmacol 3:95-104. 2008
    ....
  19. pmc Neural and psychological predictors of treatment response in irritable bowel syndrome patients with a 5-HT3 receptor antagonist: a pilot study
    J M Jarcho
    UCLA Center for Neurovisceral Sciences and Women s Health, Los Angeles, CA 90073, USA
    Aliment Pharmacol Ther 28:344-52. 2008
    ..Factors predicting treatment responsiveness are not known, although we have demonstrated that symptom improvement with the 5-HT3R antagonist alosetron is correlated with reduced amygdala activity...
  20. pmc Neuropsychological function and cerebral metabolites in HIV-infected youth
    R Nagarajan
    David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, CA, USA
    J Neuroimmune Pharmacol 7:981-90. 2012
    ..Scy and Glu ratios are also potential markers of brain health in chronic, lifelong HIV infection in perinatally infected youths receiving antiretroviral therapy...
  21. pmc Lower diffusion in white matter of children with prenatal methamphetamine exposure
    C C Cloak
    Department of Medicine, John A Burns School of Medicine, Queen s University Tower, Honolulu, HI 96813, USA
    Neurology 72:2068-75. 2009
    ..Whether microstructural brain changes associated with prenatal methamphetamine exposure can be detected with diffusion tensor imaging (DTI) is unknown...
  22. pmc Impact of apolipoprotein E ε4 and HIV on cognition and brain atrophy: antagonistic pleiotropy and premature brain aging
    L Chang
    Department of Medicine, John A Burns School of Medicine, The Queen s Medical Center, Honolulu, Hawaii 96813, USA
    Neuroimage 58:1017-27. 2011
    ..Whether APOEε4 allele(s) and age may influence brain atrophy in HIV patients is unknown and was evaluated...
  23. ncbi request reprint Gender-related differences in IBS symptoms
    O Y Lee
    CURE Digestive Diseases Research Center/Neuroenteric Disease Program, Department of Medicine and Physiology, UCLA School of Medicine, Los Angeles, California, USA
    Am J Gastroenterol 96:2184-93. 2001
    ..The apparent differences in sensitivity to nonpainful visceral sensations, medications, and food may represent altered sensory processes, autonomic responses, and/or cognitive hypervigilance...
  24. ncbi request reprint Approaches to the modulation of abdominal pain
    E A Mayer
    UCLA CURE Neuroenteric Disease Program, Department of Medicine, Physiology and Brain Research Institute, UCLA School of Medicine, Los Angeles, California 90073, USA
    Can J Gastroenterol 13:65A-70A. 1999
    ....
  25. pmc Altered neurometabolites and motor integration in children exposed to methamphetamine in utero
    L Chang
    Division of Neurology, Department of Medicine, John A Burns School of Medicine, Queen s University Tower, 1356 Lusitana Street, Honolulu, HI 96813, USA
    Neuroimage 48:391-7. 2009
    ..These findings combined with their poorer performance on VMI also suggest accelerated but aberrant neuronal and glial development in these brain regions...
  26. ncbi request reprint Combined and independent effects of chronic marijuana use and HIV on brain metabolites
    L Chang
    Department of Medicine, John A Burns School of Medicine, Queen s University Tower, 1356 Lusitana Street, Honolulu, HI 96813, USA
    J Neuroimmune Pharmacol 1:65-76. 2006
    ..These findings suggest chronic MJ use may lead to decreased neuronal and glial metabolites, but may normalize the decreased glutamate in HIV patients...
  27. ncbi request reprint Functional GI disorders: from animal models to drug development
    E A Mayer
    UCLA Center for Neurovisceral Sciences and Women s Health, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA
    Gut 57:384-404. 2008
    ....
  28. ncbi request reprint Basic pathophysiologic mechanisms in irritable bowel syndrome
    E A Mayer
    UCLA CURE Neuroenteric Disease Program, Department of Medicine, Physiology and Biobehavioral Sciences, UCLA School of Medicine, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Dig Dis 19:212-8. 2001
    ..IBS patients show an enhanced responsiveness of this system manifesting in altered modulation of gastrointestinal motility, secretion, immune function and in alterations in the perceptual and emotional response to visceral events...
  29. pmc Meta-analysis: do irritable bowel syndrome symptoms vary between men and women?
    M A Adeyemo
    Center for Neurobiology of Stress, Los Angeles, CA 90095, USA
    Aliment Pharmacol Ther 32:738-55. 2010
    ..Studies suggest that sex and gender-related differences exist in irritable bowel syndrome (IBS), but data is often conflicting...
  30. pmc Measuring irritable bowel syndrome patient-reported outcomes with an abdominal pain numeric rating scale
    B Spiegel
    VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA
    Aliment Pharmacol Ther 30:1159-70. 2009
    ..Pain numeric rating scales (NRS) are widely used in the non-IBS pain literature. The Food and Drug Administration has proposed using the NRS in IBS...
  31. ncbi request reprint Effect of ecstasy [3,4-methylenedioxymethamphetamine (MDMA)] on cerebral blood flow: a co-registered SPECT and MRI study
    L Chang
    Department of Neurology, UCLA School of Medicine, Harbor UCLA Medical Center, 1000 W Carson Street, B 4, Torrance, CA 90509, USA
    Psychiatry Res 98:15-28. 2000
    ....
  32. ncbi request reprint Brain proton magnetic resonance spectroscopy in children exposed to methamphetamine in utero
    L M Smith
    Department of Pediatrics, Harbor UCLA Medical Center, University of California, Los Angeles School of Medicine, Torrance 90502, USA
    Neurology 57:255-60. 2001
    ..To examine the possible neurotoxic effects of prenatal methamphetamine exposure on the developing brain using 1H-MRS...
  33. ncbi request reprint Brain responses to visceral and somatic stimuli in patients with irritable bowel syndrome with and without fibromyalgia
    Lin Chang
    C N S Center for Neurovisceral Sciences and Women s Health, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Am J Gastroenterol 98:1354-61. 2003
    ....
  34. pmc Autonomic response to a visceral stressor is dysregulated in irritable bowel syndrome and correlates with duration of disease
    P Cheng
    Gail and Gerald Oppenheimer Family Center for the Neurobiology of Stress, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Neurogastroenterol Motil 25:e650-9. 2013
    ..This study examined heart rate variability (HRV) and plasma catecholamines as an index of ANS responsiveness in IBS during flexible sigmoidoscopy (FS) and explored associations of HRV with clinical measures...
  35. ncbi request reprint Traditional Chinese medicine based subgrouping of irritable bowel syndrome patients
    S Tan
    Center for Neurovisceral Sciences and Women s Health, Department of Medicine David Geffen School of Medicine, University of California, Los Angeles, USA
    Am J Chin Med 33:365-79. 2005
    ..This pilot study provides preliminary support for a methodology to identify novel subgroups of IBS patients related to the TCM classification, which may differ in underlying pathophysiology and treatment responses...
  36. ncbi request reprint The Visceral Sensitivity Index: development and validation of a gastrointestinal symptom-specific anxiety scale
    J S Labus
    Center for Neurovisceral Sciences and Women s Health, VA GLA Healthcare System, Los Angeles, CA 90073, USA
    Aliment Pharmacol Ther 20:89-97. 2004
    ..Anxiety related to gastrointestinal sensations, symptoms or the contexts in which these may occur is thought to play a significant role in the pathophysiology as well as in the health outcomes of patients with irritable bowel syndrome...
  37. pmc Childhood trauma is associated with hypothalamic-pituitary-adrenal axis responsiveness in irritable bowel syndrome
    Elizabeth J Videlock
    Center for Neurobiology of Stress, David Geffen School of Medicine, University of California, Los Angeles, California 90095 7378, USA
    Gastroenterology 137:1954-62. 2009
    ..We sought to determine if EALs affect the HPA axis response to a visceral stressor in irritable bowel syndrome (IBS) patients and healthy controls, and to determine if this is affected by sex or related to symptoms or quality of life...
  38. ncbi request reprint Is there a difference between abdominal pain and discomfort in moderate to severe IBS patients?
    Joel Sach
    C N S Center for Neurovisceral Sciences and Women s Health, Los Angeles, California, USA
    Am J Gastroenterol 97:3131-8. 2002
    ....
  39. ncbi request reprint Biexponential modeling of multigradient-echo MRI data of the brain
    O Speck
    Department of Neurology, Harbor UCLA Medical Center, UCLA School of Medicine, Torrance, California, USA
    Magn Reson Med 45:1116-21. 2001
    ..The activation-induced parameter changes are detected with a sensitivity equal to that of a monoexponential method. The resulting T2* and DeltaT2* values describe the experimental data more accurately...
  40. ncbi request reprint V. Stress and irritable bowel syndrome
    E A Mayer
    UCLA CURE Neuroenteric Disease Program, Departments of Medicine, Physiology, and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, California 90024, USA
    Am J Physiol Gastrointest Liver Physiol 280:G519-24. 2001
    ..Functional brain imaging techniques are beginning to identify brain circuits involved in the perceptual alterations. Animal models have recently been proposed that mimic key features of the human syndrome...
  41. ncbi request reprint HIV-2 infection with cerebral toxoplasmosis and lymphomatoid granulomatosis
    M Issakhanian
    Department of Neurology, University of California, Los Angeles (UCLA) School of Medicine, Harbor-UCLA Medical Center, Torrance, CA, USA
    J Neuroimaging 11:212-6. 2001
    ..The lesion showed a biochemical and perfusion pattern that was intermediate for infectious and neoplastic processes. Further neuropathology confirmed a secondary diagnosis of lymphomatoid granulomatosis...
  42. ncbi request reprint Marijuana use is associated with a reorganized visual-attention network and cerebellar hypoactivation
    L Chang
    Department of Medicine, University of Hawaii, Honolulu, Hawaii 96813, USA
    Brain 129:1096-112. 2006
    ....
  43. ncbi request reprint Cerebral activation in patients with irritable bowel syndrome and control subjects during rectosigmoid stimulation
    B D Naliboff
    CURE Digestive Diseases Research Center Neuroenteric Disease Program, University of California School of Medicine, VA Greater Los Angeles Health Care System, 90073, USA
    Psychosom Med 63:365-75. 2001
    ..In the current study, brain responses to anticipated and delivered rectal balloon distension were assessed...
  44. ncbi request reprint Review article: gender-related differences in functional gastrointestinal disorders
    E A Mayer
    CURE Neuroenteric Disease Program, UCLA Division of Digestive Diseases, USA
    Aliment Pharmacol Ther 13:65-9. 1999
    ....
  45. ncbi request reprint The effect of life stress on symptoms of heartburn
    Bruce D Naliboff
    Center for Neurovisceral Sciences and Women s Health, Department of Medicine, UCLA, Los Angeles, CA, USA
    Psychosom Med 66:426-34. 2004
    ..The present longitudinal study tests the general hypothesis that life stressors can exacerbate symptoms in patients with chronic heartburn...
  46. ncbi request reprint Sex-related differences in IBS patients: central processing of visceral stimuli
    Bruce D Naliboff
    Center for Neurovisceral Sciences and Women s Health, UCLA School of Medicine, CURE Building, 115 Room 223, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Gastroenterology 124:1738-47. 2003
    ..The aim of this study was to determine possible sex-related differences in brain responses to a visceral and a psychological stressor in IBS...
  47. ncbi request reprint The central role of gastrointestinal-specific anxiety in irritable bowel syndrome: further validation of the visceral sensitivity index
    Jennifer S Labus
    Department of Psychiatry and Biobehavioral Sciences, Center for Neurovisceral Sciences and Women s Health, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Psychosom Med 69:89-98. 2007
    ....
  48. ncbi request reprint Irritable bowel syndrome patients show enhanced modulation of visceral perception by auditory stress
    Britta Dickhaus
    University of California, Department of Medicine, Los Angeles UCLA CNS Center for Neurovisceral Sciences and Women s Health, VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    Am J Gastroenterol 98:135-43. 2003
    ..The aim of this study was to test the primary hypothesis that IBS patients show altered perceptual responses to rectal balloon distention during experimentally induced psychological stress compared with healthy control subjects...
  49. ncbi request reprint Novel techniques to study visceral hypersensitivity in irritable bowel syndrome
    Trinh T Truong
    Building 115, Room 215, Los Angeles, CA 90073, USA
    Curr Gastroenterol Rep 10:369-78. 2008
    ..There are few effective pharmacologic treatments that relieve IBS symptoms, and improved understanding of brain-gut interactions and factors relating to enhanced visceral perception may guide us in developing more efficacious treatments...
  50. pmc New treatments for irritable bowel syndrome in women
    Mopelola A Adeyemo
    Center for Neurobiology of Stress, Division of Digestive Diseases, David Geffen School of Medicine at UCLA, 11301 Wilshire Blvd, Building 115, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Womens Health (Lond Engl) 4:605-22; quiz 623. 2008
    ..This article provides an overview of current and emerging therapies for IBS and also highlights sex and gender differences in clinical trials and treatment response...
  51. ncbi request reprint Condition-specific deactivation of brain regions by 5-HT3 receptor antagonist Alosetron
    Steven M Berman
    CURE Neuroenteric Disease Program, Department of Medicine, University of California School of Medicine, Los Angeles, California 90073, USA
    Gastroenterology 123:969-77. 2002
    ....
  52. pmc Developing valid and reliable health utilities in irritable bowel syndrome: results from the IBS PROOF Cohort
    Brennan Spiegel
    VA Greater Los Angeles Healthcare System UCLA, Digestive Diseaes, 11301 Wilshire Blvd, Building 11, Room 21E, Los Angeles, California 90073, USA
    Am J Gastroenterol 104:1984-91. 2009
    ..To inform future cost-utility analyses in IBS, we measured and validated the IBS utilities...
  53. ncbi request reprint Longitudinal change in perceptual and brain activation response to visceral stimuli in irritable bowel syndrome patients
    Bruce D Naliboff
    Center for Neurovisceral Sciences and Women s Health, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Gastroenterology 131:352-65. 2006
    ..Repeated stimulus exposure leads to decreased salience of threat and reduction of hypervigilance. We sought to evaluate hypervigilance in IBS visceral hypersensitivity and associated brain activity...
  54. ncbi request reprint Increased acoustic startle responses in IBS patients during abdominal and nonabdominal threat
    Bruce D Naliboff
    Center for Neurobiology of Stress, Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, UCLA, Los Angeles, California, USA
    Psychosom Med 70:920-7. 2008
    ..The eye-blink startle response represents a noninvasive measure of central defensive responding. Evidence for central hyperexcitability was studied in IBS patients by examining potentiation of the startle reflex to a nociceptive threat...
  55. pmc Predictors of patient-assessed illness severity in irritable bowel syndrome
    Brennan Spiegel
    VA Greater Los Angeles Healthcare System, Center for Outcomes Research and Education, Los Angeles, California, USA
    Am J Gastroenterol 103:2536-43. 2008
    ..Since severity is a patient-centered outcome, it is essential that future instruments are based on patients' self-perceptions of severity. We measured patient-derived predictors of severity in a large cohort of IBS patients...
  56. ncbi request reprint Sex-based differences in gastrointestinal pain
    Emeran A Mayer
    Departments of Medicine, Psychiatry and Biobehavioral Sciences, CNS Center for Neurovisceral Sciences and Women s Health, UCLA Division of Digestive Diseases, UCLA and VA GLAHS, WLA VA Medical Center, Los Angeles, CA 90073, USA
    Eur J Pain 8:451-63. 2004
    ..Consistent with experimental findings in animals, current evidence is consistent with a pathophysiological model which emphasizes sex-related differences in autonomic and antinociceptive responses to certain visceral stimuli...
  57. ncbi request reprint Clinical determinants of health-related quality of life in patients with irritable bowel syndrome
    Brennan M R Spiegel
    Division of Gastroenterology, the VA Greater Los Angeles Healthcare System, CA 90073, USA
    Arch Intern Med 164:1773-80. 2004
    ..The identification of predictive factors could allow physicians to better assess HRQOL without using misleading clinical clues. We, therefore, sought to identify determinants of HRQOL in patients with IBS...
  58. ncbi request reprint Differences in brain responses to visceral pain between patients with irritable bowel syndrome and ulcerative colitis
    Emeran A Mayer
    Center for Neurovisceral Sciences and Women s Health, David Geffen School of Medicine, University of California, Los Angeles, CA 90073, USA
    Pain 115:398-409. 2005
    ....
  59. ncbi request reprint Racial differences in the impact of irritable bowel syndrome on health-related quality of life
    Ian M Gralnek
    VA Greater Los Angeles Health Care System, Los Angeles, CA, USA
    J Clin Gastroenterol 38:782-9. 2004
    ..To compare the impact of irritable bowel syndrome (IBS) on health related quality of life (HRQOI) for non-white and white IBS patients...
  60. ncbi request reprint The effect of the 5-HT3 receptor antagonist, alosetron, on brain responses to visceral stimulation in irritable bowel syndrome patients
    E A Mayer
    CURE Digestive Diseases Research Center Neuroenteric Disease Program, Department of Medicine, University of California School of Medicine, Los Angeles, CA 90073, USA
    Aliment Pharmacol Ther 16:1357-66. 2002
    ....
  61. ncbi request reprint Review article: epidemiology and quality of life in functional gastrointestinal disorders
    L Chang
    Center for Neurovisceral Sciences and Women s Health, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Aliment Pharmacol Ther 20:31-9. 2004
    ..The presence of extra-intestinal symptoms appears to have a major if not greater impact on health care visits, excess health care costs and health-related quality of life in patients with functional gastrointestinal disorders...
  62. ncbi request reprint Segmentation of progressive multifocal leukoencephalopathy lesions in fluid-attenuated inversion recovery magnetic resonance imaging
    L Itti
    Department of Computer Science, University of Southern California, Hedco Neuroscience Building, Room 30A, 3641 Watt Way, Los Angeles, CA 90089 2520, USA
    J Neuroimaging 11:412-7. 2001
    ..The authors compared the reproducibility of a manual and a semiautomated technique for the quantitation of white-matter lesions in magnetic resonance imaging (MRI)...
  63. ncbi request reprint A multicenter in vivo proton-MRS study of HIV-associated dementia and its relationship to age
    L Chang
    Department of Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA
    Neuroimage 23:1336-47. 2004
    ..Therefore, a multicenter MRS consortium was formed to evaluate the neurometabolites in HIV patients with or without cognitive impairment...
  64. ncbi request reprint Is a negative colonoscopy associated with reassurance or improved health-related quality of life in irritable bowel syndrome?
    Brennan M R Spiegel
    Division of Gastroenterology, VA Greater Los Angeles Healthcare System, CA 90073, USA
    Gastrointest Endosc 62:892-9. 2005
    ..However, no previous data have measured these effects. We sought to measure the association of a normal colonoscopy with reassurance and HRQOL in patients with IBS aged <50 years...
  65. ncbi request reprint Enhanced preattentive central nervous system reactivity in irritable bowel syndrome
    Steven M Berman
    CURE Digestive Diseases Research Center, Department of Medicine, University of California, Los Angeles 90073, USA
    Am J Gastroenterol 97:2791-7. 2002
    ..We hypothesize that the increased responsiveness of IBS patients is a generalized phenomenon applying to stimuli other than visceral and attempt to demonstrate increased responsiveness to sounds as measured by the P1 scalp potential...
  66. ncbi request reprint Increased frontal white matter diffusion is associated with glial metabolites and psychomotor slowing in HIV
    C C Cloak
    Department of Medicine, John A Burns School of Medicine, University of Hawaii, Queen s University Tower, 7th Floor, 1356 Lusitana St, Honolulu, HI 96813, USA
    J Neuroimmunol 157:147-52. 2004
    ..43, p=0.05). These findings suggest increased brain water diffusion may reflect increased glial activation or inflammation, which in turn, may contribute to the cognitive deficits in HIV patients...
  67. ncbi request reprint Cerebral perfusion abnormalities in abstinent cocaine abusers: a perfusion MRI and SPECT study
    T Ernst
    Department of Neurology, UCLA School of Medicine, Harbor UCLA Medical Center, 100 West Carson Street, B 4, 90509, Torrance, CA, USA
    Psychiatry Res 99:63-74. 2000
    ..The hypoperfusion in the cortex and deep gray matter of the cocaine users is consistent with previous results. The increased rCBF in the white matter of cocaine users may be due to the presence of reactive glia...
  68. ncbi request reprint Characterization of the alternating bowel habit subtype in patients with irritable bowel syndrome
    Kirsten Tillisch
    CNS WH Center for Neurovisceral Sciences and Women s Health, Department of Medicine, UCLA, and the VA Greater Los Angeles Healthcare System, Los Angeles, California, USA
    Am J Gastroenterol 100:896-904. 2005
    ..Due to a wide range of symptom patterns, patients with irritable bowel syndrome (IBS) are often subgrouped by bowel habit. However, the IBS subgroup with alternating bowel habits (IBS-A) has been poorly characterized...
  69. ncbi request reprint A dose-ranging, phase II study of the efficacy and safety of alosetron in men with diarrhea-predominant IBS
    Lin Chang
    Center for Neurovisceral Sciences and Women s Health, UCLA Division of Digestive Diseases, Los Angeles, California, USA
    Am J Gastroenterol 100:115-23. 2005
    ..A randomized, double blind, placebo-controlled dose-ranging study was conducted to assess the efficacy of alosetron in men with diarrhea-predominant irritable bowel syndrome (IBS)...
  70. pmc Overlap between functional GI disorders and other functional syndromes: what are the underlying mechanisms?
    S E Kim
    Oppenheimer Family Center of Neurobiology of Stress, Los Angeles, CA, USA
    Neurogastroenterol Motil 24:895-913. 2012
    ..They commonly coexist within the same individual. The pathophysiologic mechanisms of these disorders are not well understood, but it has been hypothesized that they share a common pathogenesis...
  71. ncbi request reprint Irritable bowel syndrome: current approach to symptoms, evaluation, and treatment
    Elizabeth J Videlock
    Center for Neurovisceral Sciences and Women s Health, Division of Digestive Diseases, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System, CURE Building 115, Room 223, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Gastroenterol Clin North Am 36:665-85, x. 2007
    ....
  72. doi request reprint Management of Crohn's disease in adults
    Gary R Lichtenstein
    Department of Medicine, Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Am J Gastroenterol 104:465-83; quiz 464, 484. 2009
    ..The final recommendations are based on the data available at the time of the production of the document and may be updated with pertinent scientific developments at a later time...
  73. ncbi request reprint Incidence of ischemic colitis and serious complications of constipation among patients using alosetron: systematic review of clinical trials and post-marketing surveillance data
    Lin Chang
    Center for Neurovisceral Sciences and Women s Health, Department of Medicine, UCLA and VA Greater Los Angeles Healthcare Center, California, USA
    Am J Gastroenterol 101:1069-79. 2006
    ..This systematic review calculated the incidence of these adverse events in alosetron-using patients in clinical trials and post-marketing surveillance...
  74. pmc Is irritable bowel syndrome a diagnosis of exclusion?: a survey of primary care providers, gastroenterologists, and IBS experts
    Brennan M R Spiegel
    Department of Gastroenterology, VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    Am J Gastroenterol 105:848-58. 2010
    ..Yet many clinicians are concerned about overlooking alternative diagnoses. We measured beliefs about whether IBS is a diagnosis of exclusion, and measured testing proclivity between IBS experts and community providers...
  75. ncbi request reprint Diagnosis and treatment of irritable bowel syndrome: state of the art
    Kirsten Tillisch
    VA Greater Los Angeles Healthcare System, CURE Building 115, Room 223, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Curr Gastroenterol Rep 7:249-56. 2005
    ..Although only two medications, tegaserod for constipation-predominant IBS and alosetron for diarrhea-predominant IBS, are specifically indicated, a wide variety of treatment options are available and are discussed in this review...
  76. doi request reprint Ischemic colitis and complications of constipation associated with the use of alosetron under a risk management plan: clinical characteristics, outcomes, and incidences
    Lin Chang
    Center for Neurobiology Stress, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Am J Gastroenterol 105:866-75. 2010
    ..The objectives of this study were to characterize IC and CoC clinical features, outcomes, and incidence rates in the new restricted patient population to evaluate the effectiveness of the RMP in the prevention of serious outcomes...
  77. pmc Bacterial overgrowth and irritable bowel syndrome: unifying hypothesis or a spurious consequence of proton pump inhibitors?
    Brennan M R Spiegel
    VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    Am J Gastroenterol 103:2972-6. 2008
    ..Our article explores these premises, lays out the argument supporting this "PPI hypothesis," discusses potential implications, and outlines next steps to further investigate this possibility...
  78. ncbi request reprint New insights into the pathophysiology of irritable bowel syndrome: implications for future treatments
    Michael D Crowell
    Division of Gastroenterology and Hepatology, Mayo Clinic Scottsdale, 13400 E Shea Boulevard, Scottsdale, AZ 85259, USA
    Curr Gastroenterol Rep 7:272-9. 2005
    ..Increasingly novel mechanisms are being identified that should aid in better understanding of the complex pathophysiology of IBS and developing new therapies...
  79. ncbi request reprint Utility of the Rome I and Rome II criteria for irritable bowel syndrome in U.S. women
    William D Chey
    University of Michigan, Ann Arbor, USA
    Am J Gastroenterol 97:2803-11. 2002
    ....
  80. ncbi request reprint Prevalence of irritable bowel syndrome among university students: the roles of worry, neuroticism, anxiety sensitivity and visceral anxiety
    Holly Hazlett-Stevens
    Department of Psychology 298, University of Nevada, Reno, NV 89557, USA
    J Psychosom Res 55:501-5. 2003
    ..Relationships between presence of irritable bowel syndrome (IBS) and generalized anxiety disorder (GAD), chronic worry, neuroticism, anxiety sensitivity and anxiety about visceral sensations were examined among university students...
  81. ncbi request reprint A comparison of visceral and somatic pain processing in the human brainstem using functional magnetic resonance imaging
    Paul Dunckley
    Department of Human Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, United Kingdom
    J Neurosci 25:7333-41. 2005
    ..05, Pearson's r, two-tailed) but not somatic stimulation. We propose that the differences in NCF and right PAG activation observed may represent a greater nocifensive response and greater emotive salience of visceral over somatic pain...
  82. ncbi request reprint Impact of sex and gender on irritable bowel syndrome
    Margaret Heitkemper
    Dept of Biobehavioral Nursing and Health Systems, Box 357266, University of Washington, Seattle, WA 98195, USA
    Biol Res Nurs 5:56-65. 2003
    ..This review examines sex and gender modulation of gastrointestinal motility and transit, visceral pain sensitivity, autonomic nervous system function, serotonin biochemistry, and differences in health care-seeking behavior for IBS...
  83. ncbi request reprint Impact of irritable bowel syndrome on patients' lives: development and psychometric documentation of a disease-specific measure for use in clinical trials
    George F Longstreth
    Department of Gastroenterology, Kaiser Permanente Medical Center, San Diego, California, USA
    Eur J Gastroenterol Hepatol 17:411-20. 2005
    ..To develop a disease-specific questionnaire to capture the impact of irritable bowel syndrome (IBS) and its treatment on patients' lives, the Irritable Bowel Syndrome Impact Scale (IBS-IS)...
  84. ncbi request reprint Neuroendocrine and neuroimmune markers in IBS: pathophysiological role or epiphenomenon?
    Lin Chang
    Gastroenterology 130:596-600. 2006
  85. ncbi request reprint Irritable bowel syndrome: new and emerging therapies
    Lucinda A Harris
    Mayo Clinic College of Medicine, Scottsdale, Arizona, USA
    Curr Opin Gastroenterol 22:128-35. 2006
    ..Many central and peripheral factors are involved. This article will review important pathophysiologic mechanisms with a focus on new and emerging therapies...
  86. ncbi request reprint Update on the management of adults with chronic idiopathic constipation
    Brooks D Cash
    Uniformed Services University of the Health Sciences and Division of Gastroenterology, National Naval Medical Center, Bethesda, MD USA
    J Fam Pract 56:S13-9; quiz S20. 2007
  87. ncbi request reprint Clinical experience of hydroxyethyl starch (10% HES 200/0.5) in cerebral perfusion pressure protocol for severe head injury
    Sheng Jean Huang
    Division of Neurosurgery, Department of Surgery, National Taiwan University Hospital, Taipei 100, ROC Taiwan
    Surg Neurol 66:S26-31. 2006
    ..The present study was undertaken to evaluate 10% hydroxyethyl starch (HES 200/0.5) with regard to its clinical outcome and safety in the treatment of severe head injury...
  88. ncbi request reprint Efficacy and safety of hypertonic saline solutions in the treatment of severe head injury
    Sheng Jean Huang
    Division of Neurosurgery, Department of Surgery, National Taiwan University Hospital, Taipei 100, Taiwan, ROC
    Surg Neurol 65:539-46; discussion 546. 2006
    ..The present study was undertaken to evaluate the efficacy and safety of hypertonic saline (HS) in the treatment of intracranial hypertension after severe head injury...

Research Grants10

  1. NEUROENDOCRINE ALTERATIONS IN FIBROMYALGIA AND IBS
    Lin Chang; Fiscal Year: 1999
    ..The combination of experimental approaches should improve our understanding of the CNS mechanisms underlying functional pain syndromes. ..
  2. NEUROENDOCRINE ALTERATIONS IN FIBROMYALGIA AND IBS
    Lin Chang; Fiscal Year: 2009
    ..abstract_text> ..
  3. NEUROENDOCRINE ALTERATIONS IN FIBROMYALGIA AND IBS
    Lin Chang; Fiscal Year: 2007
    ....
  4. NEUROENDOCRINE ALTERATIONS IN FIBROMYALGIA AND IBS
    Lin Chang; Fiscal Year: 2006
    ....
  5. NEUROENDOCRINE ALTERATIONS IN FIBROMYALGIA AND IBS
    Lin Chang; Fiscal Year: 2003
    ..The combination of experimental approaches should improve our understanding of the CNS mechanisms underlying functional pain syndromes. ..
  6. NEUROENDOCRINE ALTERATIONS IN FIBROMYALGIA AND IBS
    Lin Chang; Fiscal Year: 2002
    ..The combination of experimental approaches should improve our understanding of the CNS mechanisms underlying functional pain syndromes. ..
  7. NEUROENDOCRINE ALTERATIONS IN FIBROMYALGIA AND IBS
    Lin Chang; Fiscal Year: 2001
    ..The combination of experimental approaches should improve our understanding of the CNS mechanisms underlying functional pain syndromes. ..
  8. NEUROENDOCRINE ALTERATIONS IN FIBROMYALGIA AND IBS
    Lin Chang; Fiscal Year: 2000
    ..The combination of experimental approaches should improve our understanding of the CNS mechanisms underlying functional pain syndromes. ..
  9. NEUROENDOCRINE ALTERATIONS IN FIBROMYALGIA AND IBS
    Lin Chang; Fiscal Year: 2010
    ..abstract_text> ..