L Chang

Summary

Affiliation: University of Hawaii
Country: USA

Publications

  1. ncbi request reprint Structural and metabolic brain changes in the striatum associated with methamphetamine abuse
    Linda Chang
    Department of Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA
    Addiction 102:16-32. 2007
  2. ncbi request reprint Effects of APOE ε4, age, and HIV on glial metabolites and cognitive deficits
    Linda Chang
    From the Department of Medicine, Division of Neurology, John A Burns School of Medicine L C, C J, E C, S B, V D, T E, and Pacific Biosciences Research Center M A, University of Hawai i at Manoa, and the Queen s Medical Center, Honolulu, HI
    Neurology 82:2213-22. 2014
  3. pmc Development of protein biomarkers in cerebrospinal fluid for secondary progressive multiple sclerosis using selected reaction monitoring mass spectrometry (SRM-MS)
    Yan Jia
    Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD, 21205, USA
    Clin Proteomics 9:9. 2012
  4. pmc Magnetic resonance spectroscopy to assess neuroinflammation and neuropathic pain
    Linda Chang
    Department of Medicine, John A Burns School of Medicine, University of Hawai i at Manoa, Neuroscience and Magnetic Resonance Research Program, The Queen s Medical Center, 1356 Lusitana Street, UH Tower 7th Floor, Honolulu, HI 96813, USA
    J Neuroimmune Pharmacol 8:576-93. 2013
  5. pmc Imaging biomarkers and the role of neuroinflammation in neuropathic pain
    Linda Chang
    University of Hawaii, Honolulu, HI, USA
    J Neuroimmune Pharmacol 8:448-51. 2013
  6. pmc Lower cognitive reserve in the aging human immunodeficiency virus-infected brain
    Linda Chang
    Department of Medicine, Division of Neurology, John A Burns School of Medicine, University of Hawai i at Manoa, and the Queen s Medical Center, Honolulu, HI 96813, USA
    Neurobiol Aging 34:1240-53. 2013
  7. pmc Lower glial metabolite levels in brains of young children with prenatal nicotine exposure
    Linda Chang
    Division of Neurology, Department of Medicine, John A Burns School of Medicine, University of Hawai i at Manoa, 7th floor University Tower, Honolulu, HI 96813, USA
    J Neuroimmune Pharmacol 7:243-52. 2012
  8. pmc Correlations between Diffusion Tensor Imaging (DTI) and Magnetic Resonance Spectroscopy (1H MRS) in schizophrenic patients and normal controls
    Cheuk Y Tang
    Department of Radiology, Mount Sinai School of Medicine NY, NY 10029, USA
    BMC Psychiatry 7:25. 2007
  9. ncbi request reprint Antiretroviral treatment alters relationship between MCP-1 and neurometabolites in HIV patients
    Linda Chang
    Department of Medicine, John A Burns School of Medicine, University of Hawai, Honolulu, HI, USA
    Antivir Ther 9:431-40. 2004
  10. ncbi request reprint Adaptation of the attention network in human immunodeficiency virus brain injury
    Linda Chang
    Medical Department, Brookhaven National Laboratory, Upton, NY, USA
    Ann Neurol 56:259-72. 2004

Detail Information

Publications76

  1. ncbi request reprint Structural and metabolic brain changes in the striatum associated with methamphetamine abuse
    Linda Chang
    Department of Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA
    Addiction 102:16-32. 2007
    ..To review structural, chemical and metabolic brain changes, particularly those in the basal ganglia, in individuals who used methamphetamine, as well as in children with prenatal methamphetamine exposure...
  2. ncbi request reprint Effects of APOE ε4, age, and HIV on glial metabolites and cognitive deficits
    Linda Chang
    From the Department of Medicine, Division of Neurology, John A Burns School of Medicine L C, C J, E C, S B, V D, T E, and Pacific Biosciences Research Center M A, University of Hawai i at Manoa, and the Queen s Medical Center, Honolulu, HI
    Neurology 82:2213-22. 2014
    ..We aimed to evaluate the combined effects of HIV and APOE ε4 allele(s) on glial metabolite levels, and on known cognitive deficits associated with either condition, across the ages...
  3. pmc Development of protein biomarkers in cerebrospinal fluid for secondary progressive multiple sclerosis using selected reaction monitoring mass spectrometry (SRM-MS)
    Yan Jia
    Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD, 21205, USA
    Clin Proteomics 9:9. 2012
    ..abstract:..
  4. pmc Magnetic resonance spectroscopy to assess neuroinflammation and neuropathic pain
    Linda Chang
    Department of Medicine, John A Burns School of Medicine, University of Hawai i at Manoa, Neuroscience and Magnetic Resonance Research Program, The Queen s Medical Center, 1356 Lusitana Street, UH Tower 7th Floor, Honolulu, HI 96813, USA
    J Neuroimmune Pharmacol 8:576-93. 2013
    ....
  5. pmc Imaging biomarkers and the role of neuroinflammation in neuropathic pain
    Linda Chang
    University of Hawaii, Honolulu, HI, USA
    J Neuroimmune Pharmacol 8:448-51. 2013
    ..Furthermore, the use of telemedicine to disseminate knowledge and improve the diagnosis and treatment of pain syndromes is also discussed...
  6. pmc Lower cognitive reserve in the aging human immunodeficiency virus-infected brain
    Linda Chang
    Department of Medicine, Division of Neurology, John A Burns School of Medicine, University of Hawai i at Manoa, and the Queen s Medical Center, Honolulu, HI 96813, USA
    Neurobiol Aging 34:1240-53. 2013
    ..While the SN and HIV+NC subjects compensated for their declining attention with age by using reserve and "top-down" attentional networks, older HAND subjects were unable to compensate which resulted in cognitive decline...
  7. pmc Lower glial metabolite levels in brains of young children with prenatal nicotine exposure
    Linda Chang
    Division of Neurology, Department of Medicine, John A Burns School of Medicine, University of Hawai i at Manoa, 7th floor University Tower, Honolulu, HI 96813, USA
    J Neuroimmune Pharmacol 7:243-52. 2012
    ..These alterations were not influenced by the amount of nicotine exposure prenatally. However, the effects of PNE on energy metabolism may be sex specific, with greater alterations in girls...
  8. pmc Correlations between Diffusion Tensor Imaging (DTI) and Magnetic Resonance Spectroscopy (1H MRS) in schizophrenic patients and normal controls
    Cheuk Y Tang
    Department of Radiology, Mount Sinai School of Medicine NY, NY 10029, USA
    BMC Psychiatry 7:25. 2007
    ..DTI is thus sensitive to demyelination and other structural abnormalities. DTI has also shown abnormalities in these regions...
  9. ncbi request reprint Antiretroviral treatment alters relationship between MCP-1 and neurometabolites in HIV patients
    Linda Chang
    Department of Medicine, John A Burns School of Medicine, University of Hawai, Honolulu, HI, USA
    Antivir Ther 9:431-40. 2004
    ..The relationships between neurometabolites and macrophage chemoattractant protein (MCP-1) in serum and cerebrospinal fluid (CSF) were evaluated in HIV patients before and after antiretroviral treatment...
  10. ncbi request reprint Adaptation of the attention network in human immunodeficiency virus brain injury
    Linda Chang
    Medical Department, Brookhaven National Laboratory, Upton, NY, USA
    Ann Neurol 56:259-72. 2004
    ..Exceeding the brain reserve capacity may lead to attention deficits and cognitive impairment in HIV patients...
  11. pmc Impact of apolipoprotein E ε4 and HIV on cognition and brain atrophy: antagonistic pleiotropy and premature brain aging
    L Chang
    Department of Medicine, John A Burns School of Medicine, The Queen s Medical Center, Honolulu, Hawaii 96813, USA
    Neuroimage 58:1017-27. 2011
    ..Whether APOEε4 allele(s) and age may influence brain atrophy in HIV patients is unknown and was evaluated...
  12. pmc Brain metabolite abnormalities in the white matter of elderly schizophrenic subjects: implication for glial dysfunction
    Linda Chang
    Department of Medicine, John A Burns School of Medicine, Honolulu, Hawaii 96813, USA
    Biol Psychiatry 62:1396-404. 2007
    ....
  13. ncbi request reprint Insights from recent positron emission tomographic studies of drug abuse and dependence
    Linda Chang
    Department of Medicine, Division of Neurology, John A Burns School of Medicine, University of Hawaii, Queen s University Tower, 7th Floor, 1356 Lusitana St, Honolulu, HI 96813, USA
    Curr Opin Psychiatry 19:246-52. 2006
    ..Recent positron emission tomographic studies demonstrate a variety of abnormalities in the brains of addicted individuals. This review aims to discuss and highlight these findings...
  14. ncbi request reprint Smaller subcortical volumes and cognitive deficits in children with prenatal methamphetamine exposure
    Linda Chang
    Department of Medicine, John A Burns School of Medicine, University of Hawai i, HI 96813, USA
    Psychiatry Res 132:95-106. 2004
    ..These preliminary findings suggest prenatal Meth exposure may be neurotoxic to the developing brain...
  15. ncbi request reprint Marijuana use is associated with a reorganized visual-attention network and cerebellar hypoactivation
    L Chang
    Department of Medicine, University of Hawaii, Honolulu, Hawaii 96813, USA
    Brain 129:1096-112. 2006
    ....
  16. ncbi request reprint Enlarged striatum in abstinent methamphetamine abusers: a possible compensatory response
    Linda Chang
    Department of Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu 96813, USA
    Biol Psychiatry 57:967-74. 2005
    ....
  17. ncbi request reprint Additive effects of HIV and chronic methamphetamine use on brain metabolite abnormalities
    Linda Chang
    Department of Medicine, John A Burns School of Medicine, University of Hawaii, 1356 Lusitana St, 7th Floor, Honolulu, HI 96813, USA
    Am J Psychiatry 162:361-9. 2005
    ..The authors sought to determine whether HIV and a history of chronic methamphetamine use might have additive or interactive effects on brain metabolite abnormalities...
  18. pmc Altered neurometabolites and motor integration in children exposed to methamphetamine in utero
    L Chang
    Division of Neurology, Department of Medicine, John A Burns School of Medicine, Queen s University Tower, 1356 Lusitana Street, Honolulu, HI 96813, USA
    Neuroimage 48:391-7. 2009
    ..These findings combined with their poorer performance on VMI also suggest accelerated but aberrant neuronal and glial development in these brain regions...
  19. pmc Greater than age-related changes in brain diffusion of HIV patients after 1 year
    Linda Chang
    Department of Medicine, Division of Neurology, John A Burns School of Medicine, University of Hawaii at Manoa, and the Queen s Medical Center, University Tower, 1356 Lusitana Street, Honolulu, HI 96813, USA
    J Neuroimmune Pharmacol 3:265-74. 2008
    ..Measurements of MD in the genu may be useful for monitoring disease progression in HIV brain infection...
  20. pmc Effects of age and sex on brain glutamate and other metabolites
    Linda Chang
    Department of Medicine, John A Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96813, USA
    Magn Reson Imaging 27:142-5. 2009
    ..These findings indicate that brain glutamate concentrations decline markedly with age, and may be especially useful as a marker for brain diseases that are affected by aging...
  21. pmc Antiretroviral treatment is associated with increased attentional load-dependent brain activation in HIV patients
    L Chang
    Department of Medicine, Division of Neurology, John A Burns School of Medicine, University of Hawaii at Manoa, The Queen s Medical Center University Tower, 1356 Lusitana Street, Honolulu, HI 96813, USA
    J Neuroimmune Pharmacol 3:95-104. 2008
    ....
  22. ncbi request reprint Combined and independent effects of chronic marijuana use and HIV on brain metabolites
    L Chang
    Department of Medicine, John A Burns School of Medicine, Queen s University Tower, 1356 Lusitana Street, Honolulu, HI 96813, USA
    J Neuroimmune Pharmacol 1:65-76. 2006
    ..These findings suggest chronic MJ use may lead to decreased neuronal and glial metabolites, but may normalize the decreased glutamate in HIV patients...
  23. pmc Decreased brain dopamine transporters are related to cognitive deficits in HIV patients with or without cocaine abuse
    Linda Chang
    Department of Medicine, University of Hawai i, John A Burns School of Medicine, The Queen s Medical Center, Honolulu, HI 96813, USA
    Neuroimage 42:869-78. 2008
    ....
  24. ncbi request reprint A multicenter in vivo proton-MRS study of HIV-associated dementia and its relationship to age
    L Chang
    Department of Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA
    Neuroimage 23:1336-47. 2004
    ..Therefore, a multicenter MRS consortium was formed to evaluate the neurometabolites in HIV patients with or without cognitive impairment...
  25. ncbi request reprint Increased glial metabolites predict increased working memory network activation in HIV brain injury
    T Ernst
    Medical Department, Brookhaven National Laboratory, Building 490, P O Box 5000, Upton, NY 11973 5000, USA
    Neuroimage 19:1686-93. 2003
    ..The same mechanism may also contribute to cognitive dysfunction in other brain diseases that involve inflammation...
  26. ncbi request reprint Low level of brain dopamine D2 receptors in methamphetamine abusers: association with metabolism in the orbitofrontal cortex
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Am J Psychiatry 158:2015-21. 2001
    ..Because the orbitofrontal cortex is associated with compulsive behaviors, its disruption may contribute to compulsive drug intake in addicted subjects. This study explored whether a similar association occurs in methamphetamine abusers...
  27. pmc Different activation patterns for working memory load and visual attention load
    D Tomasi
    Medical Department, Bldg 490, Brookhaven National Laboratory, 30 Bell Ave, Upton, NY 11973, USA
    Brain Res 1132:158-65. 2007
    ..Conversely, VA tasks activated more strongly an occipito-parietal network comprising the postcentral (PostCG) and the superior occipital (SOG) gyri, suggesting complex visual processing in this network...
  28. pmc Sex differences in sensory gating of the thalamus during auditory interference of visual attention tasks
    D Tomasi
    Medical Department, Building 490, Brookhaven National Laboratory, 30 Bell Avenue, Upton, NY 11973, USA
    Neuroscience 151:1006-15. 2008
    ..Together, these sex-specific differences in brain activation during the VA task, at different cognitive and acoustic levels suggest differences in auditory gating of the thalamus for men and women...
  29. pmc fMRI-acoustic noise alters brain activation during working memory tasks
    D Tomasi
    Medical Department, Bldg 490, Brookhaven National Laboratory, 30 Bell Avenue, Upton, NY 11973, USA
    Neuroimage 27:377-86. 2005
    ....
  30. pmc Lower diffusion in white matter of children with prenatal methamphetamine exposure
    C C Cloak
    Department of Medicine, John A Burns School of Medicine, Queen s University Tower, Honolulu, HI 96813, USA
    Neurology 72:2068-75. 2009
    ..Whether microstructural brain changes associated with prenatal methamphetamine exposure can be detected with diffusion tensor imaging (DTI) is unknown...
  31. ncbi request reprint Relationships among brain metabolites, cognitive function, and viral loads in antiretroviral-naïve HIV patients
    Linda Chang
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973 5000, USA
    Neuroimage 17:1638-48. 2002
    ..Metabolite concentrations, rather than metabolite ratios, should be measured since [CR], a commonly used reference for metabolite ratios, varies with disease severity in both frontal lobe and basal ganglia...
  32. ncbi request reprint Increased frontal white matter diffusion is associated with glial metabolites and psychomotor slowing in HIV
    C C Cloak
    Department of Medicine, John A Burns School of Medicine, University of Hawaii, Queen s University Tower, 7th Floor, 1356 Lusitana St, Honolulu, HI 96813, USA
    J Neuroimmunol 157:147-52. 2004
    ..43, p=0.05). These findings suggest increased brain water diffusion may reflect increased glial activation or inflammation, which in turn, may contribute to the cognitive deficits in HIV patients...
  33. ncbi request reprint Practice-induced changes of brain function during visual attention: a parametric fMRI study at 4 Tesla
    D Tomasi
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neuroimage 23:1414-21. 2004
    ..Since short-term practice-effects in the prefrontal cortex may be similar to attentional load-effects, studies of attentional load need to take practice effects into account...
  34. ncbi request reprint Effect of aging on brain metabolism in antiretroviral-naive HIV patients
    Thomas Ernst
    Medical Department, Brookhaven National Laboratory, Upton, NY, USA
    AIDS 18:S61-7. 2004
    ..The goal of this pilot study was to evaluate the interaction between aging and HIV infection in the brain using proton magnetic resonance spectroscopy (H-MRS)...
  35. ncbi request reprint Methamphetamine and AIDS: 1HMRS studies in a feline model of human disease
    C C Cloak
    Medical Department, Brookhaven National Laboratory, Buliding 490, Upton, NY, USA
    J Neuroimmunol 147:16-20. 2004
    ..The decreased glutamate in FIV cats normalized with MA exposure. FIV and MA both affect brain metabolites individually and combined. 1HMRS is useful for evaluating the effects of FIV and drug abuse in the brain...
  36. ncbi request reprint Functional GI disorders: from animal models to drug development
    E A Mayer
    UCLA Center for Neurovisceral Sciences and Women s Health, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA
    Gut 57:384-404. 2008
    ....
  37. ncbi request reprint Loss of dopamine transporters in methamphetamine abusers recovers with protracted abstinence
    N D Volkow
    Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Neurosci 21:9414-8. 2001
    ..These findings have treatment implications because they suggest that protracted abstinence may reverse some of methamphetamine-induced alterations in brain DA terminals...
  38. ncbi request reprint Basic pathophysiologic mechanisms in irritable bowel syndrome
    E A Mayer
    UCLA CURE Neuroenteric Disease Program, Department of Medicine, Physiology and Biobehavioral Sciences, UCLA School of Medicine, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Dig Dis 19:212-8. 2001
    ..IBS patients show an enhanced responsiveness of this system manifesting in altered modulation of gastrointestinal motility, secretion, immune function and in alterations in the perceptual and emotional response to visceral events...
  39. ncbi request reprint Approaches to the modulation of abdominal pain
    E A Mayer
    UCLA CURE Neuroenteric Disease Program, Department of Medicine, Physiology and Brain Research Institute, UCLA School of Medicine, Los Angeles, California 90073, USA
    Can J Gastroenterol 13:65A-70A. 1999
    ....
  40. ncbi request reprint Abnormal brain activation on functional MRI in cognitively asymptomatic HIV patients
    T Ernst
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neurology 59:1343-9. 2002
    ..The current study aims to determine whether patients who are HIV-1 positive and have normal cognitive function also show increased brain activation on fMRI...
  41. ncbi request reprint Persistent brain abnormalities in antiretroviral-naive HIV patients 3 months after HAART
    Linda Chang
    Medical Department, Brookhaven National Laboratory, Upton, NY, USA
    Antivir Ther 8:17-26. 2003
    ..We aimed to evaluate whether brain abnormalities will improve 3 months after HAART...
  42. ncbi request reprint Partial recovery of brain metabolism in methamphetamine abusers after protracted abstinence
    Gene Jack Wang
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Am J Psychiatry 161:242-8. 2004
    ..In this study, the authors assessed whether metabolism recovers with protracted abstinence...
  43. pmc Common deactivation patterns during working memory and visual attention tasks: an intra-subject fMRI study at 4 Tesla
    Dardo Tomasi
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Hum Brain Mapp 27:694-705. 2006
    ..The task-dependent balance of activation and deactivation might allow maximization of resources for the activated network...
  44. pmc The human immunodeficiency virus reduces network capacity: acoustic noise effect
    Dardo Tomasi
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Ann Neurol 59:419-23. 2006
    ..Increased acoustic noise (AN) during working memory leads to increased brain activation in healthy individuals and may have greater impact in human immunodeficiency virus (HIV) patients...
  45. pmc Adaptation of brain glutamate plus glutamine during abstinence from chronic methamphetamine use
    Thomas Ernst
    Department of Medicine, John A Burns School of Medicine, The University of Hawaii at Manoa, 1356 Lusitana Street, 7th Floor, Honolulu, HI 96813, USA
    J Neuroimmune Pharmacol 3:165-72. 2008
    ..Since craving may contribute to relapse, medications that normalize GLX may minimize craving in METH users...
  46. ncbi request reprint Functional imaging studies in cannabis users
    Linda Chang
    Department of Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96813
    Neuroscientist 13:422-32. 2007
    ..Considerable further work, employing longitudinal designs, is also required to determine whether cannabis use causes permanent functional alterations in the brains of adults...
  47. ncbi request reprint Perfusion MRI and computerized cognitive test abnormalities in abstinent methamphetamine users
    Linda Chang
    Medical Department, Brookhaven National Laboratory, Building 490, Upton, NY, 11973 5000, USA
    Psychiatry Res 114:65-79. 2002
    ..These findings suggest that METH abuse is associated with persistent physiologic changes in the brain, and these changes are accompanied by slower reaction times on computerized measures of cognitive function...
  48. pmc Association between psychiatric symptoms and craving in methamphetamine users
    Helenna Nakama
    Department of Psychiatry, John A Burns School of Medicine, The Queen s Medical Center, University of Hawaii at Manoa, Honolulu, Hawaii 96813, USA
    Am J Addict 17:441-6. 2008
    ..Therefore, methamphetamine users, regardless of their usage patterns, may benefit from treatment of their psychiatric symptoms in order to minimize craving and subsequent relapse to drug use...
  49. pmc Building infrastructure for HIV/AIDS and mental health research at institutions serving minorities
    Richard Yanagihara
    Department of Pediatrics, John A Burns School of Medicine, University of Hawaii at Manoa, 651 Ilalo St, BSB320L, Honolulu, HI 96813, USA
    Am J Public Health 99:S82-6. 2009
    ..Although our analysis is drawn from lessons learned at an institution serving a largely Asian and Pacific Islander population, analogous situations may be found for other institutions serving minorities...
  50. pmc Declined neural efficiency in cognitively stable human immunodeficiency virus patients
    Thomas Ernst
    Department of Medicine, University of Hawaii at Manoa, and the Queen s Medical Center, Honolulu, HI 96813, USA
    Ann Neurol 65:316-25. 2009
    ..To determine whether brain activation changes in clinically and neurocognitively normal human immunodeficiency virus (HIV)-infected and in HIV-seronegative control (SN) participants over a 1-year period...
  51. pmc Psychiatric symptoms and HPA axis function in adolescent methamphetamine users
    George King
    Department of Medicine, John A Burns School of Medicine, Honolulu, HI 96812, USA
    J Neuroimmune Pharmacol 5:582-91. 2010
    ..The results further suggest that treatment approaches should focus on stress-coping strategies to decrease the probability of relapse...
  52. pmc Higher diffusion in striatum and lower fractional anisotropy in white matter of methamphetamine users
    Daniel Alicata
    Department of Psychiatry, John A Burns School of Medicine, Honolulu, HI 96813, USA
    Psychiatry Res 174:1-8. 2009
    ..The higher ADC in the basal ganglia suggests greater inflammation or less myelination in these brain regions of those with younger age of first METH use and greater METH usage...
  53. pmc Neuropsychological deficits in adolescent methamphetamine abusers
    George King
    Department of Psychiatry, John A Burns School of Medicine, 1356 Lusitana St 4th Floor, Honolulu, HI 96813, USA
    Psychopharmacology (Berl) 212:243-9. 2010
    ..Methamphetamine (METH) is a widely abused psychostimulant that is associated with neurotoxicity and neurocognitive impairments in adults. However, the effects of METH use on neurocognitive performance of adolescents are unclear...
  54. pmc Lower brain glutamate is associated with cognitive deficits in HIV patients: a new mechanism for HIV-associated neurocognitive disorder
    Thomas Ernst
    Department of Medicine, John A Burns School of Medicine, University of Hawai i, and Queen s Medical Center, Honolulu, Hawai i 96813, USA
    J Magn Reson Imaging 32:1045-53. 2010
    ..To determine whether subjects with human immunodeficiency virus (HIV)-associated neurocognitive disorder (HAND) show altered concentrations of brain glutamate (GLU), and whether lower GLU levels correlate with cognitive deficits...
  55. pmc Regional variations and the effects of age and gender on glutamate concentrations in the human brain
    Napapon Sailasuta
    Department of Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA
    Magn Reson Imaging 26:667-75. 2008
    ..Our results also highlight the importance of brain region, age and gender matching in clinical studies...
  56. pmc Is decreased prefrontal cortical sensitivity to monetary reward associated with impaired motivation and self-control in cocaine addiction?
    Rita Z Goldstein
    State University of New York at Stony Brook, Brookhaven National Laboratory, P O Box 5000, Upton, NY 11973 5000, USA
    Am J Psychiatry 164:43-51. 2007
    ..This study attempted to examine the brain's sensitivity to monetary rewards of different magnitudes in cocaine abusers and to study its association with motivation and self-control...
  57. ncbi request reprint Magnetic resonance spectroscopy studies of GABA in neuropsychiatric disorders
    Linda Chang
    Brookhaven National Laboratory, Upton, NY 11973, USA
    J Clin Psychiatry 64:7-14. 2003
    ..Examples of such a rational therapeutic approach include anticonvulsants that elevate brain GABA levels and are effective for the treatment of epilepsy and anxiety disorder...
  58. ncbi request reprint Decreased brain dopaminergic transporters in HIV-associated dementia patients
    Gene Jack Wang
    Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, NY, USA
    Brain 127:2452-8. 2004
    ..The inverse relationship between viral burden and DAT availability further supports HIV-mediated neurotoxicity to dopaminergic terminals...
  59. pmc Imaging the addicted human brain
    Joanna S Fowler
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Sci Pract Perspect 3:4-16. 2007
    ..The authors give examples of key findings illustrating how each technique has extended and deepened our knowledge of the neurobiological bases of drug abuse and addiction, and they address potential clinical and therapeutic applications...
  60. pmc Asian women have greater abdominal and visceral adiposity than Caucasian women with similar body mass index
    U Lim
    Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA
    Nutr Diabetes 1:e6. 2011
    ..This may contribute to their elevated metabolic risk for obesity-related diseases...
  61. ncbi request reprint Review article: epidemiology and quality of life in functional gastrointestinal disorders
    L Chang
    Center for Neurovisceral Sciences and Women s Health, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Aliment Pharmacol Ther 20:31-9. 2004
    ..The presence of extra-intestinal symptoms appears to have a major if not greater impact on health care visits, excess health care costs and health-related quality of life in patients with functional gastrointestinal disorders...
  62. ncbi request reprint The effect of the 5-HT3 receptor antagonist, alosetron, on brain responses to visceral stimulation in irritable bowel syndrome patients
    E A Mayer
    CURE Digestive Diseases Research Center Neuroenteric Disease Program, Department of Medicine, University of California School of Medicine, Los Angeles, CA 90073, USA
    Aliment Pharmacol Ther 16:1357-66. 2002
    ....
  63. ncbi request reprint The effects of tamoxifen and estrogen on brain metabolism in elderly women
    Thomas Ernst
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    J Natl Cancer Inst 94:592-7. 2002
    ..Consequently, we assessed the effects of tamoxifen and estrogen on the brain chemistry of elderly women...
  64. ncbi request reprint k-Space based summary motion detection for functional magnetic resonance imaging
    Elisabeth C Caparelli
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neuroimage 20:1411-8. 2003
    ..This method makes it possible to evaluate brain motion within seconds after a scan and to decide whether a study needs to be repeated...
  65. pmc The orbitofrontal cortex in methamphetamine addiction: involvement in fear
    Rita Z Goldstein
    Department of Human Development, Laboratory of Neurobiology of Personality and Emotion, Cornell University, Ithaca, NY 14853, USA
    Neuroreport 13:2253-7. 2002
    ..051). These results suggest that the role of the orbitofrontal cortex in inhibitory control can be manifested in stable personality predispositions and further implicate this region in the core characteristics of drug addiction...
  66. ncbi request reprint Relationships between white matter metabolite abnormalities, cognitive and social functioning in elderly schizophrenic subjects
    Joseph I Friedman
    Schizophr Res 100:356-8. 2008
  67. ncbi request reprint Neuropsychological effects of 3,4-methylenedioxymethamphetamine (MDMA or ecstasy) in recreational users
    Carla Back-Madruga
    Department of Psychiatry, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Clin Neuropsychol 17:446-59. 2003
    ..Our results suggest that a subgroup of MDMA patients, specifically heavy MDMA users, evidence declines in nonverbal (visual) memory, however, other cognitive areas appear to be spared...
  68. ncbi request reprint Regional patterns of brain metabolites in AIDS dementia complex
    Constantin T Yiannoutsos
    Division of Biostatistics, Indiana University School of Medicine, 1050 Wishard Boulevard, RG 4101, Indianapolis, IN 46202, USA
    Neuroimage 23:928-35. 2004
    ..We conclude that by using factor analysis, we are able to combine multiple metabolites across brain regions in a biologically plausible manner and construct a predictive model of ADC adjusting for relevant factors such as age...
  69. ncbi request reprint The effects of repeated endotoxin exposure on rat brain metabolites as measured by ex vivo 1HMRS
    Sulie L Chang
    Department of Biology, Seton Hall University, 400 South Orange Avenue, South Orange, NJ 07079, USA
    J Neuroimmunol 166:39-46. 2005
    ..These findings suggest that chronic inflammation induced by LPS could lead to cell loss/dysfunction, and hence, desensitization of the HPA axis, particularly in the hypothalamus...
  70. ncbi request reprint Unified structural equation modeling approach for the analysis of multisubject, multivariate functional MRI data
    Jieun Kim
    Department of Applied Mathematics and Statistics, State University of New York at Stony Brook, Stony Brook, New York, USA
    Hum Brain Mapp 28:85-93. 2007
    ....
  71. ncbi request reprint A multicenter study of two magnetic resonance spectroscopy techniques in individuals with HIV dementia
    Ned Sacktor
    Department of Neurology, Johns Hopkins Bayview Medical Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    J Magn Reson Imaging 21:325-33. 2005
    ..To evaluate single-voxel proton magnetic resonance spectroscopy (SV-MRS) and magnetic resonance spectroscopic imaging (MRSI) metabolite results in individuals with HIV dementia...
  72. ncbi request reprint Memantine and HIV-associated cognitive impairment: a neuropsychological and proton magnetic resonance spectroscopy study
    Giovanni Schifitto
    University of Rochester, Rochester, New York 14620, USA
    AIDS 21:1877-86. 2007
    ..To assess the safety and efficacy of memantine, an uncompetitive antagonist of the N-methyl-D-aspartate receptor as treatment of HIV-associated cognitive impairment...
  73. ncbi request reprint Proton MRS and neuropsychological correlates in AIDS dementia complex: evidence of subcortical specificity
    Robert H Paul
    Department of Behavioral Neuroscience, University of Missouri, St Louis, St Louis, MO 63121, USA
    J Neuropsychiatry Clin Neurosci 19:283-92. 2007
    ..Prospective studies are needed to elucidate the evolution of these changes in the setting of antiretroviral therapy...
  74. ncbi request reprint A multi-center 1H MRS study of the AIDS dementia complex: validation and preliminary analysis
    Patricia Lani Lee
    NMR Center, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02111, USA
    J Magn Reson Imaging 17:625-33. 2003
    ....
  75. pmc Response: images and interventions
    Linda Chang
    Sci Pract Perspect 3:17-9. 2007
  76. ncbi request reprint NeuroAIDS, drug abuse, and inflammation: building collaborative research activities
    Joan W Berman
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Neuroimmune Pharmacol 1:351-99. 2006
    ..Research priorities were identified. Additional information about this meeting is available through links from the NIDA AIDS Research Program website ( http://www.nida.nih.gov/about/organization/arp/arp-websites.htm )...

Research Grants17

  1. MONITORING METHAMPHETAMINE ABUSE TREATMENT WITH 1H MRS
    Linda Chang; Fiscal Year: 2000
    ..This comprehensive approach will allow us to determine the relationship between changes in cognitive function and metabolite changes in brain tissue associated with chronic methamphetamine abuse and treatment. ..
  2. Early brain development after prenatal "Ice" exposure: A Longitudinal MR study
    Linda Chang; Fiscal Year: 2007
    ..Detailed maternal drug use, psychosocial and mood evaluations will be performed and correlated with biological brain changes in these children. ..
  3. Brain Activation in Patients with Early HIV Dementia
    Linda Chang; Fiscal Year: 2007
    ..The knowledge gained from this study will provide a better understanding of how HIV affects the aging brain (even at middle age), and may lead to future preventive measures (e.g. neuroprotective or anti-inflammatory treatments). ..
  4. Imaging Studies in Neurotoxicity and Neurodevelopment
    Linda Chang; Fiscal Year: 2007
    ..g. glaucoma, HIV, cancer), it is a matter of utmost concern to public health to determine the consequences of frequent cannabis use for the brain. We thus envisage that this project will inform issues of public policy. ..
  5. Neuroimaging and Mentoring in Drug Abuse Research
    Linda Chang; Fiscal Year: 2007
    ..With the strong publication record, experienced collaborators, and novel approaches, the ongoing projects should be successfully renewed or extended, and lead to new directions in HIV and drug abuse research. ..
  6. Early brain development after prenatal "Ice" exposure: A Longitudinal MR study
    Linda Chang; Fiscal Year: 2006
    ..Detailed maternal drug use, psychosocial and mood evaluations will be performed and correlated with biological brain changes in these children. ..
  7. Brain Activation in Patients with Early HIV Dementia
    Linda Chang; Fiscal Year: 2006
    ..The knowledge gained from this study will provide a better understanding of how HIV affects the aging brain (even at middle age), and may lead to future preventive measures (e.g. neuroprotective or anti-inflammatory treatments). ..
  8. Early brain development after prenatal "Ice" exposure: A Longitudinal MR study
    Linda Chang; Fiscal Year: 2005
    ..Detailed maternal drug use, psychosocial and mood evaluations will be performed and correlated with biological brain changes in these children. ..
  9. Brain Activation in Patients with Early HIV Dementia
    Linda Chang; Fiscal Year: 2005
    ..The knowledge gained from this study will provide a better understanding of how HIV affects the aging brain (even at middle age), and may lead to future preventive measures (e.g. neuroprotective or anti-inflammatory treatments). ..
  10. MONITORING METHAMPHETAMINE ABUSE TREATMENT WITH 1H MRS
    Linda Chang; Fiscal Year: 2001
    ..This comprehensive approach will allow us to determine the relationship between changes in cognitive function and metabolite changes in brain tissue associated with chronic methamphetamine abuse and treatment. ..
  11. Brain Activation in Patients with Early HIV Dementia
    Linda Chang; Fiscal Year: 2004
    ..The knowledge gained from this study will provide a better understanding of how HIV affects the aging brain (even at middle age), and may lead to future preventive measures (e.g. neuroprotective or anti-inflammatory treatments). ..
  12. MONITORING METHAMPHETAMINE ABUSE TREATMENT WITH 1H MRS
    Linda Chang; Fiscal Year: 2001
    ..This comprehensive approach will allow us to determine the relationship between changes in cognitive function and metabolite changes in brain tissue associated with chronic methamphetamine abuse and treatment. ..
  13. Early brain development after prenatal "Ice" exposure: A Longitudinal MR study
    Linda Chang; Fiscal Year: 2009
    ..Detailed maternal drug use, psychosocial and mood evaluations will be performed and correlated with biological brain changes in these children. ..