Lee J, Geng J, Lee J, Wang A, Chang K. Activity-Induced Synaptic Structural Modifications by an Activator of Integrin Signaling at the Drosophila Neuromuscular Junction. J Neurosci. 2017;37:3246-3263 pubmed publisher
..This work identifies Shv as a key modulator of activity-induced structural remodeling and suggests that neurons use distinct molecular cues to differentially modulate synaptic growth and remodeling to meet synaptic demand. ..
Shaw J, Zhang S, Chang K. Bidirectional Regulation of Amyloid Precursor Protein-Induced Memory Defects by Nebula/DSCR1: A Protein Upregulated in Alzheimer's Disease and Down Syndrome. J Neurosci. 2015;35:11374-83 pubmed publisher
..These results suggest that chronic Nebula/DSCR1 upregulation may contribute to age-dependent memory loss in DS and AD and points to correcting calcineurin signaling as a means to improve memory during aging. ..
Geng J, Wang L, Lee J, Chen C, Chang K. Phosphorylation of Synaptojanin Differentially Regulates Endocytosis of Functionally Distinct Synaptic Vesicle Pools. J Neurosci. 2016;36:8882-94 pubmed publisher