John T Chang

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Geometrically controlled asymmetric division of CD4+ T cells studied by immunological synapse arrays
    Hong Ryul Jung
    School of Interdisciplinary Bioscience and Bioengineering I Bio, Pohang University of Science and Technology POSTECH, Pohang, Korea
    PLoS ONE 9:e91926. 2014
  2. pmc Polarity and lymphocyte fate determination
    John T Chang
    Department of Medicine, University of California San Diego, La Jolla, CA, USA
    Curr Opin Cell Biol 24:526-33. 2012
  3. pmc Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division
    John T Chang
    Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Immunity 34:492-504. 2011
  4. pmc Early specification of CD8+ T lymphocyte fates during adaptive immunity revealed by single-cell gene-expression analyses
    Janilyn Arsenio
    1 Department of Medicine, University of California San Diego, La Jolla, California, USA 2
    Nat Immunol 15:365-72. 2014
  5. pmc Regulation of asymmetric division and CD8+ T lymphocyte fate specification by protein kinase Cζ and protein kinase Cλ/ι
    Patrick J Metz
    Department of Medicine, University of California San Diego, La Jolla, CA 92093
    J Immunol 194:2249-59. 2015
  6. ncbi Asymmetric T lymphocyte division in the initiation of adaptive immune responses
    John T Chang
    Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 315:1687-91. 2007
  7. pmc Cutting edge: Asymmetric memory T cell division in response to rechallenge
    Maria L Ciocca
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 188:4145-8. 2012
  8. doi Specifying helper T cell fates during immunity
    John T Chang
    University of Pennsylvania, Philadelphia, PA, USA
    J Pediatr Gastroenterol Nutr 46:E19-20. 2008
  9. ncbi Protection one cell thick
    John T Chang
    Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Immunity 27:832-4. 2007
  10. pmc Inducible MHC class II expression by mast cells supports effector and regulatory T cell activation
    Taku Kambayashi
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104 6160, USA
    J Immunol 182:4686-95. 2009

Collaborators

Detail Information

Publications11

  1. pmc Geometrically controlled asymmetric division of CD4+ T cells studied by immunological synapse arrays
    Hong Ryul Jung
    School of Interdisciplinary Bioscience and Bioengineering I Bio, Pohang University of Science and Technology POSTECH, Pohang, Korea
    PLoS ONE 9:e91926. 2014
    ....
  2. pmc Polarity and lymphocyte fate determination
    John T Chang
    Department of Medicine, University of California San Diego, La Jolla, CA, USA
    Curr Opin Cell Biol 24:526-33. 2012
    ..In this review, recent findings in polarity and asymmetric division in lymphocytes are discussed...
  3. pmc Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division
    John T Chang
    Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Immunity 34:492-504. 2011
    ..These results suggest a mechanism by which a cell may unequally localize cellular activities during division, thereby imparting disparity in the abundance of cell fate regulators in the daughter cells...
  4. pmc Early specification of CD8+ T lymphocyte fates during adaptive immunity revealed by single-cell gene-expression analyses
    Janilyn Arsenio
    1 Department of Medicine, University of California San Diego, La Jolla, California, USA 2
    Nat Immunol 15:365-72. 2014
    ..Our findings emphasize the importance of single-cell analyses in understanding fate determination and provide new insights into the specification of divergent lymphocyte fates early during an immune response to microbial infection. ..
  5. pmc Regulation of asymmetric division and CD8+ T lymphocyte fate specification by protein kinase Cζ and protein kinase Cλ/ι
    Patrick J Metz
    Department of Medicine, University of California San Diego, La Jolla, CA 92093
    J Immunol 194:2249-59. 2015
    ..Together, these results demonstrate a role for atypical PKC in regulating asymmetric division and the specification of divergent CD8(+) T lymphocyte fates early during an immune response. ..
  6. ncbi Asymmetric T lymphocyte division in the initiation of adaptive immune responses
    John T Chang
    Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 315:1687-91. 2007
    ..These results suggest a mechanism by which a single lymphocyte can apportion diverse cell fates necessary for adaptive immunity...
  7. pmc Cutting edge: Asymmetric memory T cell division in response to rechallenge
    Maria L Ciocca
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 188:4145-8. 2012
    ..Memory T cells may thus use asymmetric cell division to generate cellular heterogeneity when faced with pathogen rechallenge...
  8. doi Specifying helper T cell fates during immunity
    John T Chang
    University of Pennsylvania, Philadelphia, PA, USA
    J Pediatr Gastroenterol Nutr 46:E19-20. 2008
  9. ncbi Protection one cell thick
    John T Chang
    Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Immunity 27:832-4. 2007
    ..In this issue of Immunity, Stemberger et al. (2007) now take this concept to its logical extreme by offering evidence that expenditure of a single lymphocyte yields its own replenishment...
  10. pmc Inducible MHC class II expression by mast cells supports effector and regulatory T cell activation
    Taku Kambayashi
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104 6160, USA
    J Immunol 182:4686-95. 2009
    ..These data support the notion that, in the appropriate setting, MCs may regulate T cell responses through the direct presentation of Ag...
  11. pmc Loss of T cell CD98 H chain specifically ablates T cell clonal expansion and protects from autoimmunity
    Joseph Cantor
    Department of Medicine, University of California San Diego, La Jolla, CA 92093 0726, USA
    J Immunol 187:851-60. 2011
    ..Thus, the integrin-binding domain of CD98 is required for Ag-driven T cell clonal expansion in the pathogenesis of an autoimmune disease and may represent a useful therapeutic target...