John T Chang

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Geometrically controlled asymmetric division of CD4+ T cells studied by immunological synapse arrays
    Hong Ryul Jung
    School of Interdisciplinary Bioscience and Bioengineering I Bio, Pohang University of Science and Technology POSTECH, Pohang, Korea
    PLoS ONE 9:e91926. 2014
  2. pmc Polarity and lymphocyte fate determination
    John T Chang
    Department of Medicine, University of California San Diego, La Jolla, CA, USA
    Curr Opin Cell Biol 24:526-33. 2012
  3. pmc Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division
    John T Chang
    Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Immunity 34:492-504. 2011
  4. pmc Early specification of CD8+ T lymphocyte fates during adaptive immunity revealed by single-cell gene-expression analyses
    Janilyn Arsenio
    1 Department of Medicine, University of California San Diego, La Jolla, California, USA 2
    Nat Immunol 15:365-72. 2014
  5. ncbi Asymmetric T lymphocyte division in the initiation of adaptive immune responses
    John T Chang
    Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 315:1687-91. 2007
  6. pmc Cutting edge: Asymmetric memory T cell division in response to rechallenge
    Maria L Ciocca
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 188:4145-8. 2012
  7. doi Specifying helper T cell fates during immunity
    John T Chang
    University of Pennsylvania, Philadelphia, PA, USA
    J Pediatr Gastroenterol Nutr 46:E19-20. 2008
  8. ncbi Protection one cell thick
    John T Chang
    Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Immunity 27:832-4. 2007
  9. pmc Inducible MHC class II expression by mast cells supports effector and regulatory T cell activation
    Taku Kambayashi
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104 6160, USA
    J Immunol 182:4686-95. 2009
  10. pmc Loss of T cell CD98 H chain specifically ablates T cell clonal expansion and protects from autoimmunity
    Joseph Cantor
    Department of Medicine, University of California San Diego, La Jolla, CA 92093 0726, USA
    J Immunol 187:851-60. 2011

Collaborators

Detail Information

Publications10

  1. pmc Geometrically controlled asymmetric division of CD4+ T cells studied by immunological synapse arrays
    Hong Ryul Jung
    School of Interdisciplinary Bioscience and Bioengineering I Bio, Pohang University of Science and Technology POSTECH, Pohang, Korea
    PLoS ONE 9:e91926. 2014
    ....
  2. pmc Polarity and lymphocyte fate determination
    John T Chang
    Department of Medicine, University of California San Diego, La Jolla, CA, USA
    Curr Opin Cell Biol 24:526-33. 2012
    ..In this review, recent findings in polarity and asymmetric division in lymphocytes are discussed...
  3. pmc Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division
    John T Chang
    Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Immunity 34:492-504. 2011
    ..These results suggest a mechanism by which a cell may unequally localize cellular activities during division, thereby imparting disparity in the abundance of cell fate regulators in the daughter cells...
  4. pmc Early specification of CD8+ T lymphocyte fates during adaptive immunity revealed by single-cell gene-expression analyses
    Janilyn Arsenio
    1 Department of Medicine, University of California San Diego, La Jolla, California, USA 2
    Nat Immunol 15:365-72. 2014
    ..Our findings emphasize the importance of single-cell analyses in understanding fate determination and provide new insights into the specification of divergent lymphocyte fates early during an immune response to microbial infection. ..
  5. ncbi Asymmetric T lymphocyte division in the initiation of adaptive immune responses
    John T Chang
    Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 315:1687-91. 2007
    ..These results suggest a mechanism by which a single lymphocyte can apportion diverse cell fates necessary for adaptive immunity...
  6. pmc Cutting edge: Asymmetric memory T cell division in response to rechallenge
    Maria L Ciocca
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 188:4145-8. 2012
    ..Memory T cells may thus use asymmetric cell division to generate cellular heterogeneity when faced with pathogen rechallenge...
  7. doi Specifying helper T cell fates during immunity
    John T Chang
    University of Pennsylvania, Philadelphia, PA, USA
    J Pediatr Gastroenterol Nutr 46:E19-20. 2008
  8. ncbi Protection one cell thick
    John T Chang
    Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Immunity 27:832-4. 2007
    ..In this issue of Immunity, Stemberger et al. (2007) now take this concept to its logical extreme by offering evidence that expenditure of a single lymphocyte yields its own replenishment...
  9. pmc Inducible MHC class II expression by mast cells supports effector and regulatory T cell activation
    Taku Kambayashi
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104 6160, USA
    J Immunol 182:4686-95. 2009
    ..These data support the notion that, in the appropriate setting, MCs may regulate T cell responses through the direct presentation of Ag...
  10. pmc Loss of T cell CD98 H chain specifically ablates T cell clonal expansion and protects from autoimmunity
    Joseph Cantor
    Department of Medicine, University of California San Diego, La Jolla, CA 92093 0726, USA
    J Immunol 187:851-60. 2011
    ..Thus, the integrin-binding domain of CD98 is required for Ag-driven T cell clonal expansion in the pathogenesis of an autoimmune disease and may represent a useful therapeutic target...