John T Chang

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division
    John T Chang
    Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Immunity 34:492-504. 2011
  2. pmc Polarity and lymphocyte fate determination
    John T Chang
    Department of Medicine, University of California San Diego, La Jolla, CA, USA
    Curr Opin Cell Biol 24:526-33. 2012
  3. ncbi Asymmetric T lymphocyte division in the initiation of adaptive immune responses
    John T Chang
    Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 315:1687-91. 2007
  4. doi Specifying helper T cell fates during immunity
    John T Chang
    University of Pennsylvania, Philadelphia, PA, USA
    J Pediatr Gastroenterol Nutr 46:E19-20. 2008
  5. pmc Cutting edge: Asymmetric memory T cell division in response to rechallenge
    Maria L Ciocca
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 188:4145-8. 2012
  6. ncbi Protection one cell thick
    John T Chang
    Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Immunity 27:832-4. 2007
  7. pmc Inducible MHC class II expression by mast cells supports effector and regulatory T cell activation
    Taku Kambayashi
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104 6160, USA
    J Immunol 182:4686-95. 2009
  8. pmc Loss of T cell CD98 H chain specifically ablates T cell clonal expansion and protects from autoimmunity
    Joseph Cantor
    Department of Medicine, University of California San Diego, La Jolla, CA 92093 0726, USA
    J Immunol 187:851-60. 2011

Collaborators

Detail Information

Publications8

  1. pmc Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division
    John T Chang
    Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Immunity 34:492-504. 2011
    ..These results suggest a mechanism by which a cell may unequally localize cellular activities during division, thereby imparting disparity in the abundance of cell fate regulators in the daughter cells...
  2. pmc Polarity and lymphocyte fate determination
    John T Chang
    Department of Medicine, University of California San Diego, La Jolla, CA, USA
    Curr Opin Cell Biol 24:526-33. 2012
    ..In this review, recent findings in polarity and asymmetric division in lymphocytes are discussed...
  3. ncbi Asymmetric T lymphocyte division in the initiation of adaptive immune responses
    John T Chang
    Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 315:1687-91. 2007
    ..These results suggest a mechanism by which a single lymphocyte can apportion diverse cell fates necessary for adaptive immunity...
  4. doi Specifying helper T cell fates during immunity
    John T Chang
    University of Pennsylvania, Philadelphia, PA, USA
    J Pediatr Gastroenterol Nutr 46:E19-20. 2008
  5. pmc Cutting edge: Asymmetric memory T cell division in response to rechallenge
    Maria L Ciocca
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 188:4145-8. 2012
    ..Memory T cells may thus use asymmetric cell division to generate cellular heterogeneity when faced with pathogen rechallenge...
  6. ncbi Protection one cell thick
    John T Chang
    Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Immunity 27:832-4. 2007
    ..In this issue of Immunity, Stemberger et al. (2007) now take this concept to its logical extreme by offering evidence that expenditure of a single lymphocyte yields its own replenishment...
  7. pmc Inducible MHC class II expression by mast cells supports effector and regulatory T cell activation
    Taku Kambayashi
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104 6160, USA
    J Immunol 182:4686-95. 2009
    ..These data support the notion that, in the appropriate setting, MCs may regulate T cell responses through the direct presentation of Ag...
  8. pmc Loss of T cell CD98 H chain specifically ablates T cell clonal expansion and protects from autoimmunity
    Joseph Cantor
    Department of Medicine, University of California San Diego, La Jolla, CA 92093 0726, USA
    J Immunol 187:851-60. 2011
    ..Thus, the integrin-binding domain of CD98 is required for Ag-driven T cell clonal expansion in the pathogenesis of an autoimmune disease and may represent a useful therapeutic target...