Chawnshang Chang

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi request reprint TR4 nuclear receptor functions as a tumor suppressor for prostate tumorigenesis via modulation of DNA damage/repair system
    Shin Jen Lin
    Carcinogenesis 35:1399-406. 2014
  2. pmc Neuronal androgen receptor regulates insulin sensitivity via suppression of hypothalamic NF-κB-mediated PTP1B expression
    I Chen Yu
    George Whipple Laboratory for Cancer Research, Department of Pathology, and The Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York, USA
    Diabetes 62:411-23. 2013
  3. pmc Neutropenia with impaired host defense against microbial infection in mice lacking androgen receptor
    Kuang Hsiang Chuang
    George Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Exp Med 206:1181-99. 2009
  4. ncbi request reprint New therapy via targeting androgen receptor in monocytes/macrophages to battle atherosclerosis
    Chiung Kuei Huang
    George Whipple Lab for Cancer Research, Departments of Pathology, Urology, Radiation Oncology, Wilmot Cancer Center, University of Rochester Medical Center, 601 Elmwood Ave, Box 626, Rochester, NY 14642 or Lin Wang, Chawnshang Chang Sex Hormone Research Center, The Kidney and Blood Purification Center, Tianjin Institute of Urology, Tianjin Medical University, 23 Pingjiang Road, Hexi District, Tianjin, China 300211 E mail
    Hypertension 63:1345-53. 2014
  5. pmc Metformin inhibits nuclear receptor TR4-mediated hepatic stearoyl-CoA desaturase 1 gene expression with altered insulin sensitivity
    Eungseok Kim
    Department of Pathology and the Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York, USA
    Diabetes 60:1493-503. 2011
  6. pmc Abnormal mammary gland development and growth retardation in female mice and MCF7 breast cancer cells lacking androgen receptor
    Shuyuan Yeh
    Department of Pathology, University of Rochester, Rochester, NY 14642, USA
    J Exp Med 198:1899-908. 2003
  7. pmc Anti-androgen receptor ASC-J9 versus anti-androgens MDV3100 (Enzalutamide) or Casodex (Bicalutamide) leads to opposite effects on prostate cancer metastasis via differential modulation of macrophage infiltration and STAT3-CCL2 signaling
    T H Lin
    George Whipple Lab for Cancer Research, University of Rochester Medical Center, Rochester, NY 14642, USA
    Cell Death Dis 4:e764. 2013
  8. pmc Loss of stromal androgen receptor leads to suppressed prostate tumourigenesis via modulation of pro-inflammatory cytokines/chemokines
    Kuo Pao Lai
    Departments of Pathology, Urology, and Radiation Oncology, University of Rochester Medical Center, Rochester, NY, USA
    EMBO Mol Med 4:791-807. 2012
  9. doi request reprint Androgen receptor (AR) pathophysiological roles in androgen-related diseases in skin, bone/muscle, metabolic syndrome and neuron/immune systems: lessons learned from mice lacking AR in specific cells
    Chawnshang Chang
    George Whipple Lab for Cancer Research, Departments of Pathology, Urology, Radiation Oncology, and The Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York, USA CC, SY, Sol, T MC and Sex Hormone Research Center, China Medical University Hospital, Taichung, Taiwan CC
    Nucl Recept Signal 11:e001. 2013
  10. pmc Targeting stromal androgen receptor suppresses prolactin-driven benign prostatic hyperplasia (BPH)
    Kuo Pao Lai
    George Whipple Distinguished University of Rochester Medical Center, 601 Elmwood Avenue, Box 626, Rochester, New York 14642
    Mol Endocrinol 27:1617-31. 2013

Research Grants

  1. Loss of Androgen Receptor Promotes Metastatic Prostate Cancer
    Shuyuan Yeh; Fiscal Year: 2010
  2. Androgen Receptor in B Cell Development and Functions
    Chawnshang Chang; Fiscal Year: 2010
  3. Androgen Receptor Roles in Liver Cancer Incidence and Progression
    Chawnshang Chang; Fiscal Year: 2007
  4. Androgen Receptor in B Cell Development and Functions
    Chawnshang Chang; Fiscal Year: 2007
  5. Suppression of Androgen Receptor by PTEN
    Chawnshang Chang; Fiscal Year: 2006
  6. Single and Double Knockout of TR2 and TR4 Receptors
    Chawnshang Chang; Fiscal Year: 2006
  7. Androgen Receptor in Prostate Cancer and Bone
    Chawnshang Chang; Fiscal Year: 2005
  8. Suppression of Androgen Receptor by PTEN
    Chawnshang Chang; Fiscal Year: 2005
  9. Androgen Receptor in Prostate Cancer and Bone
    Chawnshang Chang; Fiscal Year: 2004
  10. Loss of Androgen Receptor Promotes Metastatic Prostate Cancer
    Chawnshang Chang; Fiscal Year: 2007

Collaborators

Detail Information

Publications117 found, 100 shown here

  1. ncbi request reprint TR4 nuclear receptor functions as a tumor suppressor for prostate tumorigenesis via modulation of DNA damage/repair system
    Shin Jen Lin
    Carcinogenesis 35:1399-406. 2014
    ..Together, these results suggest TR4 may function as a tumor suppressor to prevent or delay prostate tumorigenesis via regulating ATM expression at the transcriptional level. ..
  2. pmc Neuronal androgen receptor regulates insulin sensitivity via suppression of hypothalamic NF-κB-mediated PTP1B expression
    I Chen Yu
    George Whipple Laboratory for Cancer Research, Department of Pathology, and The Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York, USA
    Diabetes 62:411-23. 2013
    ..Pharmacotherapies targeting neuronal AR and NF-κB may be developed to combat the metabolic syndrome in men receiving ADT and in elderly men with age-associated hypogonadism...
  3. pmc Neutropenia with impaired host defense against microbial infection in mice lacking androgen receptor
    Kuang Hsiang Chuang
    George Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Exp Med 206:1181-99. 2009
    ..Collectively, our findings demonstrate an essential role for AR in granulopoiesis and host defense against microbial infection...
  4. ncbi request reprint New therapy via targeting androgen receptor in monocytes/macrophages to battle atherosclerosis
    Chiung Kuei Huang
    George Whipple Lab for Cancer Research, Departments of Pathology, Urology, Radiation Oncology, Wilmot Cancer Center, University of Rochester Medical Center, 601 Elmwood Ave, Box 626, Rochester, NY 14642 or Lin Wang, Chawnshang Chang Sex Hormone Research Center, The Kidney and Blood Purification Center, Tianjin Institute of Urology, Tianjin Medical University, 23 Pingjiang Road, Hexi District, Tianjin, China 300211 E mail
    Hypertension 63:1345-53. 2014
    ..In conclusion, the AR in monocytes/macrophages plays key roles in atherosclerosis and targeting AR with ASC-J9 may represent a new potential therapeutic approach to battle atherosclerosis. ..
  5. pmc Metformin inhibits nuclear receptor TR4-mediated hepatic stearoyl-CoA desaturase 1 gene expression with altered insulin sensitivity
    Eungseok Kim
    Department of Pathology and the Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York, USA
    Diabetes 60:1493-503. 2011
    ..TR4 is a nuclear receptor without clear pathophysiological roles. We investigated the roles of hepatic TR4 in the regulation of lipogenesis and insulin sensitivity in vivo and in vitro...
  6. pmc Abnormal mammary gland development and growth retardation in female mice and MCF7 breast cancer cells lacking androgen receptor
    Shuyuan Yeh
    Department of Pathology, University of Rochester, Rochester, NY 14642, USA
    J Exp Med 198:1899-908. 2003
    ..Together, our data provide the first in vivo evidence showing that AR-mediated MAPK and ER activation may play important roles for mammary gland development and MCF7 breast cancer cell proliferation...
  7. pmc Anti-androgen receptor ASC-J9 versus anti-androgens MDV3100 (Enzalutamide) or Casodex (Bicalutamide) leads to opposite effects on prostate cancer metastasis via differential modulation of macrophage infiltration and STAT3-CCL2 signaling
    T H Lin
    George Whipple Lab for Cancer Research, University of Rochester Medical Center, Rochester, NY 14642, USA
    Cell Death Dis 4:e764. 2013
    ....
  8. pmc Loss of stromal androgen receptor leads to suppressed prostate tumourigenesis via modulation of pro-inflammatory cytokines/chemokines
    Kuo Pao Lai
    Departments of Pathology, Urology, and Radiation Oncology, University of Rochester Medical Center, Rochester, NY, USA
    EMBO Mol Med 4:791-807. 2012
    ..Finally, targeting stromal fibromuscular AR with the AR degradation enhancer, ASC-J9®, resulted in the reduction of PIN development/progression, which might provide a new approach to suppress PIN development...
  9. doi request reprint Androgen receptor (AR) pathophysiological roles in androgen-related diseases in skin, bone/muscle, metabolic syndrome and neuron/immune systems: lessons learned from mice lacking AR in specific cells
    Chawnshang Chang
    George Whipple Lab for Cancer Research, Departments of Pathology, Urology, Radiation Oncology, and The Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York, USA CC, SY, Sol, T MC and Sex Hormone Research Center, China Medical University Hospital, Taichung, Taiwan CC
    Nucl Recept Signal 11:e001. 2013
    ....
  10. pmc Targeting stromal androgen receptor suppresses prolactin-driven benign prostatic hyperplasia (BPH)
    Kuo Pao Lai
    George Whipple Distinguished University of Rochester Medical Center, 601 Elmwood Avenue, Box 626, Rochester, New York 14642
    Mol Endocrinol 27:1617-31. 2013
    ..Targeting stromal fibromuscular AR with the AR degradation enhancer, ASC-J9(®), led to the reduction of prostate size, which could be used in future therapy. ..
  11. doi request reprint Androgen receptor (AR) physiological roles in male and female reproductive systems: lessons learned from AR-knockout mice lacking AR in selective cells
    Chawnshang Chang
    George Whipple Lab for Cancer Research, Departments of Pathology, Urology, and Radiation Oncology, University of Rochester Medical Center, Rochester, NY, USA
    Biol Reprod 89:21. 2013
    ....
  12. pmc Endothelial cells enhance prostate cancer metastasis via IL-6→androgen receptor→TGF-β→MMP-9 signals
    Xiaohai Wang
    George Whipple Lab for Cancer Research, Department of Pathology, and The Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY 14642, USA
    Mol Cancer Ther 12:1026-37. 2013
    ....
  13. pmc Targeting androgen receptor to suppress macrophage-induced EMT and benign prostatic hyperplasia (BPH) development
    Tianjing Lu
    George Whipple Laboratory for Cancer Research, Departments of Pathology, Urology, and Radiation Oncology, and The Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York 14642, USA
    Mol Endocrinol 26:1707-15. 2012
    ..These results may provide new insights for a new therapeutic approach to battle BPH via targeting AR and AR-mediated inflammatory signaling pathways...
  14. pmc Reduced osteoblast activity in the mice lacking TR4 nuclear receptor leads to osteoporosis
    Shin Jen Lin
    George Whipple Lab for Cancer Research, Department of Pathology, The Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY 14642, USA
    Reprod Biol Endocrinol 10:43. 2012
    ..Early studies suggested that TR4 nuclear receptor might play important roles in the skeletal development, yet its detailed mechanism remains unclear...
  15. pmc Androgen and retinoic acid interaction in LNCaP cells, effects on cell proliferation and expression of retinoic acid receptors and epidermal growth factor receptor
    Ming Tang Li
    Department of Surgery, Division of Urology, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey 07103, USA
    BMC Cancer 2:16. 2002
    ..Modulation of the expression of retinoic acid receptors (RAR) alpha and gamma in adult rat prostate by testosterone (T) suggests that RAR signaling events might mediate some of the androgen effects on prostate cells...
  16. pmc Suppressed prostate epithelial development with impaired branching morphogenesis in mice lacking stromal fibromuscular androgen receptor
    Kuo Pao Lai
    George H Whipple Laboratory for Cancer Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    Mol Endocrinol 26:52-66. 2012
    ..Together, our data concluded that stromal fibromuscular AR could modulate epithelium growth and maintain cellular homeostasis through identified growth factors...
  17. pmc Premature aging with impaired oxidative stress defense in mice lacking TR4
    Yi Fen Lee
    George Whipple Laboratory for Cancer Research, Departments of Pathology, Urology, and Orthopaedics, University of Rochester Medical Center, Rochester, New York 14620, USA
    Am J Physiol Endocrinol Metab 301:E91-8. 2011
    ..Together, our finding identifies a novel role of TR4 in mediating the interplay between oxidative stress defense and aging...
  18. pmc Infertility with defective spermatogenesis and hypotestosteronemia in male mice lacking the androgen receptor in Sertoli cells
    Chawnshang Chang
    George Whipple Laboratory for Cancer Research, Departments of Pathology and Urology, and the Cancer Center, University of Rochester, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 101:6876-81. 2004
    ..Together, our Sertoli cell-specific AR knockout mice provide in vivo evidence of the need for functional AR in Sertoli cells to maintain normal spermatogenesis and testosterone production, and ensure normal male fertility...
  19. ncbi request reprint Androgen receptor (AR) NH2- and COOH-terminal interactions result in the differential influences on the AR-mediated transactivation and cell growth
    Cheng Lung Hsu
    The George H Whipple Laboratory for Cancer Research, Department of Pathology, and the Cancer Center, University of Rochester Medical Center, Rochester, New York 14642, USA
    Mol Endocrinol 19:350-61. 2005
    ..Therefore, drugs designed by targeting AR N-C interaction as a therapeutic intervention for prostate cancer treatment may face unpredictable in vivo effects...
  20. pmc Oxidative stress stimulates testicular orphan receptor 4 through forkhead transcription factor forkhead box O3a
    Gonghui Li
    George H Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Endocrinology 149:3490-9. 2008
    ..These results suggest that this new identified oxidative stress-FOXO3a-TR4 pathway is a fundamentally important mechanism regulating stress resistance and cell survival...
  21. doi request reprint A new prostate cancer therapeutic approach: combination of androgen ablation with COX-2 inhibitor
    Yi Cai
    George H Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Int J Cancer 123:195-201. 2008
    ..Together, these findings provide a possible explanation how CAB with antiandrogen HF therapy might fail and provide a potential new therapeutic approach to battle prostate cancer via combination of CAB therapy with COX-2 inhibitor(s)...
  22. ncbi request reprint Functional domain and motif analyses of androgen receptor coregulator ARA70 and its differential expression in prostate cancer
    Yueh Chiang Hu
    George Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 279:33438-46. 2004
    ....
  23. doi request reprint Increased hepatic steatosis and insulin resistance in mice lacking hepatic androgen receptor
    Hung Yun Lin
    George Whipple Lab for Cancer Research, Department of Pathology, and Cancer Center, University of Rochester Medical Center, Rochester, NY, USA
    Hepatology 47:1924-35. 2008
    ....
  24. pmc Differential androgen deprivation therapies with anti-androgens casodex/bicalutamide or MDV3100/Enzalutamide versus anti-androgen receptor ASC-J9(R) Lead to promotion versus suppression of prostate cancer metastasis
    Tzu Hua Lin
    George Whipple Laboratory for Cancer Research, Department of Pathology, Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 288:19359-69. 2013
    ..These findings suggest the potential risks of using anti-androgens and provide a potential new therapy using ASC-J9® to battle PCa metastasis at the castration-resistant stage. ..
  25. pmc Oligozoospermia with normal fertility in male mice lacking the androgen receptor in testis peritubular myoid cells
    Caixia Zhang
    George Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 103:17718-23. 2006
    ....
  26. ncbi request reprint Identification of a novel testicular orphan receptor-4 (TR4)-associated protein as repressor for the selective suppression of TR4-mediated transactivation
    Yue Yang
    George Whipple Laboratory for Cancer Research Department of Pathology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 278:7709-17. 2003
    ..These unique suppression mechanisms suggest that TRA16 may function as a novel repressor to selectively suppress the TR4-mediated transactivation...
  27. ncbi request reprint Infertility with defective spermatogenesis and steroidogenesis in male mice lacking androgen receptor in Leydig cells
    Qingquan Xu
    Department of Pathology, The Cancer Center, University of Rochester, 601 Elmwood Ave, Box 626, Rochester, NY 14642, USA
    Endocrine 32:96-106. 2007
    ..Together, L-AR(-/y) mice provide in vivo evidence that functional AR in Leydig cells is essential to maintain normal spermatogenesis, testosterone production, and required for normal male fertility...
  28. ncbi request reprint Loss of TR4 orphan nuclear receptor reduces phosphoenolpyruvate carboxykinase-mediated gluconeogenesis
    Ning Chun Liu
    Department of Pathology, Cancer Center, University of Rochester, Rochester, NY 14642, USA
    Diabetes 56:2901-9. 2007
    ..Regulation of phosphoenolpyruvate carboxykinase (PEPCK), the key gene in gluconeogenesis, is critical for glucose homeostasis in response to quick nutritional depletion and/or hormonal alteration...
  29. ncbi request reprint Transgelin functions as a suppressor via inhibition of ARA54-enhanced androgen receptor transactivation and prostate cancer cell growth
    Zhiming Yang
    George Whipple Laboratory for Cancer Research, University of Rochester Medical Center, 601 Elmwood Avenue, Box 626, Rochester, New York 14642, USA
    Mol Endocrinol 21:343-58. 2007
    ..The finding that a protein can modulate AR function without direct interaction with AR might provide a new therapeutic approach, with fewer side effects, to battle prostate cancer by targeting AR indirectly...
  30. ncbi request reprint Androgen receptor in sertoli cell is essential for germ cell nursery and junctional complex formation in mouse testes
    Ruey Sheng Wang
    George H Whipple Lab for Cancer Research, Department of Urology, University of Rochester, Rochester, New York 14642, USA, and Department of Obstetrics and Gynecology, China Medical University Hospital, Taichung, Taiwan
    Endocrinology 147:5624-33. 2006
    ..5, which contributed to functional defects in production and/or secretion of specific proteases, transport proteins, and paracrine factors of SC, leading to impairment of its germ cells' nursery functions...
  31. ncbi request reprint TR3 orphan nuclear receptor mediates apoptosis through up-regulating E2F1 in human prostate cancer LNCaP cells
    Xiaomin Mu
    George Whipple Laboratory for Cancer Research, Departments of Pathology and Urology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 278:42840-5. 2003
    ..Further studies of how to modulate this pathway may allow us to better understand how to control the prostate cancer growth...
  32. pmc Differential effects of spermatogenesis and fertility in mice lacking androgen receptor in individual testis cells
    Meng Yin Tsai
    George H Whipple Laboratory for Cancer Research, Departments of Urology and Pathology, University of Rochester, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 103:18975-80. 2006
    ..These contrasting data with G-AR(-/y) mice suggest AR might have different roles in the various cells within testis to contribute to normal spermatogenesis and male fertility in mice...
  33. pmc Androgen receptor is a new potential therapeutic target for the treatment of hepatocellular carcinoma
    Wen Lung Ma
    Department of Pathology, George Whipple Laboratory for Cancer Research, Cancer Center, University of Rochester Medical Center, Rochester, New York 14642, USA
    Gastroenterology 135:947-55, 955.e1-5. 2008
    ..Here we examine androgen receptor (AR) roles in hepatocarcinogenesis using mice lacking AR in hepatocytes...
  34. ncbi request reprint Disruption of TR4 orphan nuclear receptor reduces the expression of liver apolipoprotein E/C-I/C-II gene cluster
    Eungseok Kim
    George Whipple Laboratory for Cancer Research, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Biol Chem 278:46919-26. 2003
    ..Together our data show that loss of TR4 down-regulates expression of the apoE/C-I/C-II gene cluster in liver cells, demonstrating important roles of TR4 in the modulation of lipoprotein metabolism...
  35. ncbi request reprint Suppression of androgen receptor transactivation and prostate cancer cell growth by heterogeneous nuclear ribonucleoprotein A1 via interaction with androgen receptor coregulator ARA54
    Zhiming Yang
    George Whipple Lab for Cancer Research, and University of Rochester Medical Center, Rochester, NY 14642, USA
    Endocrinology 148:1340-9. 2007
    ..The novel finding that a protein can modulate AR function without direct interaction with AR might provide a new therapeutic approach to battle prostate cancer by targeting AR indirectly with fewer side effects...
  36. doi request reprint Defects of prostate development and reproductive system in the estrogen receptor-alpha null male mice
    Ming Chen
    Department of Urology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 656, Rochester, New York 14642, USA
    Endocrinology 150:251-9. 2009
    ....
  37. pmc New therapeutic approach to suppress castration-resistant prostate cancer using ASC-J9 via targeting androgen receptor in selective prostate cells
    Kuo Pao Lai
    Department of Pathology, Urology, and Radiation Oncology, the George Whipple Laboratory for Cancer Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    Am J Pathol 182:460-73. 2013
    ..These results demonstrate that ASC-J9 could serve as an AR degradation enhancer that effectively suppresses PCa development/progression in the androgen-sensitive and castration-resistant stages...
  38. ncbi request reprint Interleukin-6 differentially regulates androgen receptor transactivation via PI3K-Akt, STAT3, and MAPK, three distinct signal pathways in prostate cancer cells
    Lin Yang
    George Whipple Lab for Cancer Research, Department of Pathology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Biochem Biophys Res Commun 305:462-9. 2003
    ..Together, our results indicate that the balance of these various pathways may then determine the overall effect of IL-6 on AR transactivation...
  39. pmc Targeting the stromal androgen receptor in primary prostate tumors at earlier stages
    Yuanjie Niu
    George Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester Medical Center, Rochester, NY 14620, USA
    Proc Natl Acad Sci U S A 105:12188-93. 2008
    ....
  40. pmc Increased prostate cell proliferation and loss of cell differentiation in mice lacking prostate epithelial androgen receptor
    Chun Te Wu
    George Whipple Laboratory for Cancer Research, Departments of Pathology and Urology, University of Rochester, Rochester, NY 14620, USA
    Proc Natl Acad Sci U S A 104:12679-84. 2007
    ..These data support the hypothesis that epithelial AR controls prostate growth by suppressing epithelial proliferation in the mature gland...
  41. ncbi request reprint Suppression of androgen receptor-mediated transactivation and cell growth by the glycogen synthase kinase 3 beta in prostate cells
    Liang Wang
    George Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester Medical Center, New York 14642, USA
    J Biol Chem 279:32444-52. 2004
    ..Together, our data demonstrated that GSK3 beta may function as a repressor to suppress AR-mediated transactivation and cell growth, which may provide a new strategy to modulate the AR-mediated prostate cancer growth...
  42. pmc Subfertility with defective folliculogenesis in female mice lacking testicular orphan nuclear receptor 4
    Lu Min Chen
    George Whipple Laboratory for Cancer Research, University of Rochester Medical Center, Rochester, New York 14620, USA
    Mol Endocrinol 22:858-67. 2008
    ..Modulation of TR4 expression and/or activation via its upstream signals or unidentified ligand(s) might allow us to develop small molecule(s) to control folliculogenesis...
  43. pmc Human checkpoint protein hRad9 functions as a negative coregulator to repress androgen receptor transactivation in prostate cancer cells
    Liang Wang
    George H Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester Medical Center, Rochester, New York 14642, USA
    Mol Cell Biol 24:2202-13. 2004
    ..Together, our data provide the first linkage between androgen-AR signals and radiation-induced responses. Further studies of the influence of hRad9 on prostate cancer growth may provide potential new therapeutic approaches...
  44. ncbi request reprint Mutations in the helix 3 region of the androgen receptor abrogate ARA70 promotion of 17beta-estradiol-induced androgen receptor transactivation
    Tin Htwe Thin
    George Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 277:36499-508. 2002
    ..Therefore, the presence of ARA70 in the testosterone and E2-producing Leydig cells may enhance the overall activity of AR during critical stages of male sex organ development...
  45. ncbi request reprint 9-cis-retinoic acid inhibits androgen receptor activity through activation of retinoid X receptor
    Kuang Hsiang Chuang
    George Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Mol Endocrinol 19:1200-12. 2005
    ....
  46. pmc Androgen receptor is a tumor suppressor and proliferator in prostate cancer
    Yuanjie Niu
    George Whipple Lab for Cancer Research, Department of Pathology, University of Rochester Medical Center, Rochester, NY 14620, USA
    Proc Natl Acad Sci U S A 105:12182-7. 2008
    ..Collectively, our understanding of these opposing roles of prostatic AR may revolutionize the way we combat prostate cancer, and allow the development of new and better therapies by targeting only the proliferative role of AR...
  47. pmc Infiltrating macrophages promote prostate tumorigenesis via modulating androgen receptor-mediated CCL4-STAT3 signaling
    Lei Ya Fang
    Authors Affiliations George Whipple Lab for Cancer Research, Departments of Pathology, Urology, and Radiation Oncology, The Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York Immunology Research Center, National Health Research Institutes, Zhunan, Miaoli County, and Sex Hormone Research Center, China Medical University and Hospital, Taichung, Taiwan
    Cancer Res 73:5633-46. 2013
    ..Together, our results identify the AR-CCL4-STAT3 axis as key regulators during prostate tumor initiation and highlight the important roles of infiltrating macrophages and inflammatory cytokines for the prostate tumorigenesis...
  48. ncbi request reprint Androgen receptor regulates expression of skeletal muscle-specific proteins and muscle cell types
    Saleh Altuwaijri
    George Whipple Lab for Cancer Research, Department of Pathology, The Cancer Center, University of Rochester Medical Center, Rochester, New York 14642, USA
    Endocrine 25:27-32. 2004
    ....
  49. ncbi request reprint Interruption of nuclear factor kappaB signaling by the androgen receptor facilitates 12-O-tetradecanoylphorbolacetate-induced apoptosis in androgen-sensitive prostate cancer LNCaP cells
    Saleh Altuwaijri
    George Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Cancer Res 63:7106-12. 2003
    ..These data describe a signaling pathway that could potentially be useful in proposed therapeutic treatment strategies exploiting combinations of different agents that control apoptosis in prostate tumors...
  50. pmc Growth retardation and abnormal maternal behavior in mice lacking testicular orphan nuclear receptor 4
    Loretta L Collins
    George Whipple Laboratory for Cancer Research, Departments of Pathology, Urology, and Radiation Oncology, and Cancer Center, University of Rochester Medical Center, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 101:15058-63. 2004
    ..These results provide in vivo evidence that TR4 plays important roles in growth, embryonic and early postnatal pup survival, female reproductive function, and maternal behavior...
  51. ncbi request reprint Isolation and characterization of androgen receptor mutant, AR(M749L), with hypersensitivity to 17-beta estradiol treatment
    Tin Htwe Thin
    George Whipple Laboratory for Cancer Research Department of Pathology, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 278:7699-708. 2003
    ..Therefore, amino acid 749 may represent an important site within the AR-LBD that is involved in interaction with E(2) that, when mutated, allows E(2) induction of AR transactivation...
  52. pmc Targeted inactivation of testicular nuclear orphan receptor 4 delays and disrupts late meiotic prophase and subsequent meiotic divisions of spermatogenesis
    Xiaomin Mu
    Department of Pathology, Cancer Center, University of Rochester Medical Center, Rochester, NY 14642, USA
    Mol Cell Biol 24:5887-99. 2004
    ..Taken together, results from TR4(+/+) and TR4(-/-) mice indicate that TR4 is essential for normal spermatogenesis in mice...
  53. pmc TR4 nuclear receptor functions as a fatty acid sensor to modulate CD36 expression and foam cell formation
    Shaozhen Xie
    George Whipple Lab for Cancer Research, Department of Pathology, and Cardiovascular Research Institute, University of Rochester Medical Center, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 106:13353-8. 2009
    ....
  54. ncbi request reprint Regulation of interleukin-6-mediated PI3K activation and neuroendocrine differentiation by androgen signaling in prostate cancer LNCaP cells
    Shaozhen Xie
    George H Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester, Rochester, New York 14642, USA
    Prostate 60:61-7. 2004
    ..In this study, we investigate how androgen plays a role in IL-6-mediated NE differentiation in LNCaP cell line...
  55. ncbi request reprint Suppression of hepatitis B virus core promoter by the nuclear orphan receptor TR4
    Wen Jye Lin
    George Whipple Lab for Cancer Research, Department of Pathology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 278:9353-60. 2003
    ..Together, these results demonstrate that TR4 can serve as a negative modulator in the transcriptional regulation of HBV core gene expression...
  56. pmc New therapy targeting differential androgen receptor signaling in prostate cancer stem/progenitor vs. non-stem/progenitor cells
    Soo Ok Lee
    George Whipple Lab for Cancer Research, Department of Pathology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Mol Cell Biol 5:14-26. 2013
    ....
  57. ncbi request reprint Reducing the agonist activity of antiandrogens by a dominant-negative androgen receptor coregulator ARA70 in prostate cancer cells
    Mujib M Rahman
    George Whipple Laboratory for Cancer Research, Department of Biochemistry, University of Rochester Medical Center, New York 14642, USA
    J Biol Chem 278:19619-26. 2003
    ..ARA70 may, thus, be a critical target for developing therapeutic agents against AR-mediated progression of prostate cancer...
  58. pmc Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissues
    Shuyuan Yeh
    Departments of Urology and Pathology, George H Whipple Lab for Cancer Research, University of Rochester, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 99:13498-503. 2002
    ..The cre-lox ARKO mouse provides a much-needed in vivo animal model to study androgen functions in the selective androgen target tissues in female or male mice...
  59. pmc Inactivation of androgen receptor coregulator ARA55 inhibits androgen receptor activity and agonist effect of antiandrogens in prostate cancer cells
    Mujib M Rahman
    George Whipple Laboratory for Cancer Research, Department of Biochemistry, and the Cancer Center, University of Rochester Medical Center, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 100:5124-9. 2003
    ....
  60. pmc Hyperleptinemia without obesity in male mice lacking androgen receptor in adipose tissue
    I Chen Yu
    Department of Pathology, George Whipple Laboratory for Cancer Research, and the Cancer Center, University of Rochester Medical Center, Rochester, New York 14642, USA
    Endocrinology 149:2361-8. 2008
    ..The present study in A-AR(-/y) mice suggests a differential tissue-specific role of AR in energy balance control in males...
  61. pmc Tissue prostate-specific antigen facilitates refractory prostate tumor progression via enhancing ARA70-regulated androgen receptor transactivation
    Yuanjie Niu
    George Whipple Lab for Cancer Research, Department of Pathology, University of Rochester Medical Center, Rochester, New York 14642, USA
    Cancer Res 68:7110-9. 2008
    ..PSA small interfering RNA or smaller molecules that can degrade PSA protein may be developed as alternative approaches to treat the prostate cancer...
  62. pmc Targeting thymic epithelia AR enhances T-cell reconstitution and bone marrow transplant grafting efficacy
    Kuo Pao Lai
    George H Whipple Laboratory for Cancer Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    Mol Endocrinol 27:25-37. 2013
    ....
  63. doi request reprint Altered prostate epithelial development in mice lacking the androgen receptor in stromal fibroblasts
    Shengqiang Yu
    George Whipple Lab for Cancer Research, Departments of Pathology and Urology, The Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York 14642, USA
    Prostate 72:437-49. 2012
    ..We have recently knocked out AR gene in smooth muscle cells and found the reduced luminal infolding and IGF-1 production in the mouse prostate. However, AR roles of stromal fibroblasts in prostate development remain unclear...
  64. pmc Deficiency in TR4 nuclear receptor abrogates Gadd45a expression and increases cytotoxicity induced by ionizing radiation
    Shian Jang Yan
    George Whipple Lab for Cancer Research, Department of Pathology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Cell Mol Biol Lett 17:309-22. 2012
    ..As GADD45A is directly involved in the DNA repair pathway, this suggests that TR4 senses genotoxic stress and up-regulates GADD45A expression to protect cells from IR-induced genotoxicity...
  65. ncbi request reprint Regulation of androgen receptor signaling by PTEN (phosphatase and tensin homolog deleted on chromosome 10) tumor suppressor through distinct mechanisms in prostate cancer cells
    Hui Kuan Lin
    George Whipple Laboratory for Cancer Research, Department of Urology, The Cancer Center, University of Rochester, Rochester, New York 14642, USA
    Mol Endocrinol 18:2409-23. 2004
    ..Together, these contrasting PTEN effects on AR activity in the same prostate cancer cell line with different passage numbers suggest that PTEN, via distinct mechanisms, differentially regulates AR in various stages of prostate cancers...
  66. ncbi request reprint Androgen suppresses PML protein expression in prostate cancer CWR22R cells
    Lin Yang
    George Whipple Lab for Cancer Research, Department of Pathology, The Cancer Center, University of Rochester Medical Center, Rochester, NY 14642, USA
    Biochem Biophys Res Commun 314:69-75. 2004
    ..Together our results suggest that PML may suppress prostate cancer cell growth by inhibiting AR transactivation and/or enhancing p53 activity...
  67. ncbi request reprint Induction of androgen receptor expression by phosphatidylinositol 3-kinase/Akt downstream substrate, FOXO3a, and their roles in apoptosis of LNCaP prostate cancer cells
    Lin Yang
    George Whipple Laboratory for Cancer Research, Department of Pathology, The Cancer Center, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 280:33558-65. 2005
    ..Together, our data provide the first model to explain how PI3K/Akt and AR can cooperate to control LNCaP cell growth and death under normal conditions...
  68. doi request reprint Activation of TR4 orphan nuclear receptor gene promoter by cAMP/PKA and C/EBP signaling
    Ning Chun Liu
    George Whipple Laboratory for Cancer Research, Department of Pathology and Urology, University of Rochester Medical Center, Rochester, NY, 14642, USA
    Endocrine 36:211-7. 2009
    ..The identification of activator(s)/inhibitor(s) or ligand(s) of TR4 may provide us an alternative way to control gluconeogenesis...
  69. ncbi request reprint The use of phage display technique for the isolation of androgen receptor interacting peptides with (F/W)XXL(F/W) and FXXLY new signature motifs
    Cheng Lung Hsu
    Department of Pathology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 278:23691-8. 2003
    ..Together, our data suggest that AR interacting peptides and/or AR coregulators may utilize the (F/W)XXL(F/W) and FXXLY motifs to mediate their interaction with AR and exert their influences on the AR transactivation...
  70. doi request reprint Roles of testicular orphan nuclear receptors 2 and 4 in early embryonic development and embryonic stem cells
    Chih Rong Shyr
    Department of Pathology, The Cancer Center, George Whipple Lab for Cancer Research, University of Rochester, Rochester, New York 14642, USA
    Endocrinology 150:2454-62. 2009
    ..Together, our findings highlight possible roles for TR2 and TR4 in early embryonic development by regulating key genes involved in stem cell self-renewal, commitment, and differentiation...
  71. pmc TR4 orphan nuclear receptor functions as an apoptosis modulator via regulation of Bcl-2 gene expression
    Eungseok Kim
    George Whipple Lab for Cancer Research, Department of Pathology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Biochem Biophys Res Commun 361:323-8. 2007
    ..Together, our results demonstrate that TR4 might function as an apoptosis modulator through induction of Bcl-2 gene expression...
  72. ncbi request reprint Loss of testicular orphan receptor 4 impairs normal myelination in mouse forebrain
    Yanqing Zhang
    George Whipple Laboratory for Cancer Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    Mol Endocrinol 21:908-20. 2007
    ..The altered Jagged1-Notch signaling in TR4(-/-) forebrain underlies a potential mechanism that contributes to the reduced myelination in the forebrain...
  73. pmc Increased infiltrated macrophages in benign prostatic hyperplasia (BPH): role of stromal androgen receptor in macrophage-induced prostate stromal cell proliferation
    Xiaohai Wang
    Department of Pathology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 287:18376-85. 2012
    ....
  74. pmc Abnormal cerebellar cytoarchitecture and impaired inhibitory signaling in adult mice lacking TR4 orphan nuclear receptor
    Yei Tsung Chen
    Department of Pathology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Brain Res 1168:72-82. 2007
    ....
  75. ncbi request reprint Identification of steroid derivatives that function as potent antiandrogens
    Hiroshi Miyamoto
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Int J Cancer 117:866-72. 2005
    ..These results strengthen our hypothesis and suggest that selective steroid derivatives could be potent antiandrogenic drugs with less unfavorable effects for the treatment of prostate cancer...
  76. pmc Subfertility and defective folliculogenesis in female mice lacking androgen receptor
    Yueh Chiang Hu
    George Whipple Laboratory for Cancer Research, Departments of Pathology and Urology, University of Rochester, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 101:11209-14. 2004
    ..Taken together, these data provide in vivo evidence showing that AR plays an important role in female reproduction...
  77. ncbi request reprint Induction and repression of peroxisome proliferator-activated receptor alpha transcription by coregulator ARA70
    Cynthia A Heinlein
    George Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Endocrine 21:139-46. 2003
    ..However, in the adrenal cell line Y1, ARA70 behaved as a repressor of PPARalpha while still able to coactivate PPARgamma...
  78. pmc Susceptibility to autoimmunity and B cell resistance to apoptosis in mice lacking androgen receptor in B cells
    Saleh Altuwaijri
    Department of Pathology, University of Rochester Medical Center, Rochester, New York 14642, USA
    Mol Endocrinol 23:444-53. 2009
    ..Together, these data indicate that androgen/AR play a crucial role in B cell homeostasis and tolerance. Therapies targeting AR might provide an alternative strategy with which to battle autoimmune diseases...
  79. ncbi request reprint Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor
    Yueh Chiang Hu
    George Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Biol Chem 277:33571-9. 2002
    ..Taken together in addition to the potential roles in spermatogenesis and neurogenesis, our data provide a novel biological function of TR2 that may exert an important repressor in regulating ER activity in mammary glands...
  80. pmc Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase
    Hui Kuan Lin
    George H Whipple Laboratory for Cancer Research, Department of Pathology and The Cancer Center, University of Rochester, Rochester, NY 14642, USA
    EMBO J 21:4037-48. 2002
    ..These results suggest that phosphorylation-dependent AR ubiquitylation and degradation by Akt require the involvement of Mdm2 E3 ligase activity, a novel mechanism that provides insight into how AR is targeted for degradation...
  81. ncbi request reprint ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor
    Zhiming Yang
    George Whipple Lab for Cancer Research, Departments of Pathology, Urology, and Radiation Oncology, and the Cancer Center, University of Rochester Medical Center, Rochester, New York 14642, USA
    Nat Med 13:348-53. 2007
    ..Collectively, our results point to a better therapeutic and preventative approach to treating SBMA, by disrupting the interaction between AR and AR coregulators...
  82. ncbi request reprint Proteasome activity is required for androgen receptor transcriptional activity via regulation of androgen receptor nuclear translocation and interaction with coregulators in prostate cancer cells
    Hui Kuan Lin
    George Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 277:36570-6. 2002
    ....
  83. pmc The roles of testicular nuclear receptor 4 (TR4) in male fertility-priapism and sexual behavior defects in TR4 knockout mice
    Loretta L Collins
    George Whipple Lab for Cancer Research, Department of Pathology, The Cancer Center, University of Rochester Medical Center, Rochester, NY 14642, USA
    Reprod Biol Endocrinol 9:138. 2011
    ..TR4 nuclear receptor is known to be involved in male fertility via controlling spermatogenesis, yet its roles in regulating other biological events related to reproduction have not been completely revealed...
  84. pmc Testicular nuclear receptor 4 (TR4) regulates UV light-induced responses via Cockayne syndrome B protein-mediated transcription-coupled DNA repair
    Su Liu
    George Whipple Lab for Cancer Research, Departments of Pathology and Urology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 286:38103-8. 2011
    ..These results may lead to the development of new treatments for UV light-sensitive syndromes, skin cancer, and aging...
  85. pmc 3 beta-acetoxyandrost-1,5-diene-17-ethylene ketal functions as a potent antiandrogen with marginal agonist activity
    Hiroshi Miyamoto
    George Whipple Laboratory for Cancer Research, Department of Pathology, and the Cancer Center, University of Rochester, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 100:4440-4. 2003
    ..Further in vivo studies might facilitate the development of a better antiandrogen for the treatment of prostate cancer...
  86. ncbi request reprint Induction of apolipoprotein E expression by TR4 orphan nuclear receptor via 5' proximal promoter region
    Eungseok Kim
    George Whipple Lab for Cancer Research, Department of Pathology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Biochem Biophys Res Commun 328:85-90. 2005
    ..Together, our data demonstrate that TR4 can enhance apoE gene expression via binding to TR4RE-DR0 in apoE 5' promoter and this TR4 binding is essential for synergistic interaction with another transcription factor, Sp1...
  87. ncbi request reprint Suppression versus induction of androgen receptor functions by the phosphatidylinositol 3-kinase/Akt pathway in prostate cancer LNCaP cells with different passage numbers
    Hui Kuan Lin
    George Whipple Laboratory for Cancer Research, Department of Pathology, and the Cancer Center, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 278:50902-7. 2003
    ....
  88. pmc Androgen receptor roles in spermatogenesis and fertility: lessons from testicular cell-specific androgen receptor knockout mice
    Ruey Sheng Wang
    Department of Pathology and Urology, George Whipple Laboratory for Cancer Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    Endocr Rev 30:119-32. 2009
    ....
  89. ncbi request reprint Androgen receptor in prostate cancer
    Cynthia A Heinlein
    George Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester, Rochester, NY 14642, USA
    Endocr Rev 25:276-308. 2004
    ..The inhibition of AR activity through mechanisms in addition to androgen ablation, such as modulation of signal transduction pathways, may delay prostate cancer progression...
  90. pmc Mice lacking TR4 nuclear receptor develop mitochondrial myopathy with deficiency in complex I
    Su Liu
    Department of Pathology, University of Rochester, Medical Center, Rochester, New York 14646, USA
    Mol Endocrinol 25:1301-10. 2011
    ....
  91. doi request reprint Tissue-specific knockout of androgen receptor in mice
    Tzu Hua Lin
    George H Whipple Lab, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642 8626, USA
    Methods Mol Biol 776:275-93. 2011
    ..In brief, our floxed AR mouse model provides a powerful tool to study in vivo AR functions in selective tissues and cell types and has made possible several research breakthroughs in the field of endocrinology...
  92. ncbi request reprint Modulation of the retinoic acid-induced cell apoptosis and differentiation by the human TR4 orphan nuclear receptor
    Yi Fen Lee
    Department of Urology, University of Rochester, Rochester, NY 14642, USA
    Biochem Biophys Res Commun 323:876-83. 2004
    ..Together, these findings provide the first in vivo evidence that an orphan nuclear receptor, such as TR4, may play major roles in the RA-mediated apoptosis or differentiation in P19 cells...
  93. ncbi request reprint Androgen receptor corepressors: an overview
    Liang Wang
    George H Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester Medical Center, Rochester, New York, USA
    Prostate 63:117-30. 2005
    ..The potential impact and future directions of AR corepressors are also discussed...
  94. pmc Spermatogenesis and testis development are normal in mice lacking testicular orphan nuclear receptor 2
    Chih Rong Shyr
    George Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester Medical Center, Rochester, New York 14642, USA
    Mol Cell Biol 22:4661-6. 2002
    ..Further studies with double knockouts of both orphan nuclear receptors, TR2 and TR4, may reveal their real physiological roles...
  95. pmc Monocyte/macrophage androgen receptor suppresses cutaneous wound healing in mice by enhancing local TNF-alpha expression
    Jiann jyh Lai
    George Whipple Lab for Cancer Research, Department of Pathology, Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York, USA
    J Clin Invest 119:3739-51. 2009
    ..Finally, targeting AR by topical application of a compound (ASC-J9) that degrades AR protein resulted in accelerated healing, suggesting a potential new therapeutic approach that may lead to better treatment of wound healing...
  96. ncbi request reprint Cytochrome P450 genes are differentially expressed in female and male hepatocyte retinoid X receptor alpha-deficient mice
    Yan Cai
    Department of Pathology, University of Rochester, Rochester, New York 14642, USA
    Endocrinology 144:2311-8. 2003
    ..These data suggest that testosterone has a negative impact on retinoid signaling when the level of RXRalpha is low, which may in turn reduce the expression of the CYP450 genes...
  97. pmc Deficits in motor coordination with aberrant cerebellar development in mice lacking testicular orphan nuclear receptor 4
    Yei Tsung Chen
    University of Rochester Medical Center, Department of Pathology, Box 626, 601 Elmwood Ave, Rochester, NY 14642, USA
    Mol Cell Biol 25:2722-32. 2005
    ..Together, our findings suggest that TR4 is required for normal cerebellar development...
  98. ncbi request reprint Androgen receptor (AR) coregulators: an overview
    Cynthia A Heinlein
    George Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester, New York 14642, USA
    Endocr Rev 23:175-200. 2002
    ....
  99. ncbi request reprint Modulation of estrogen receptor-mediated transactivation by orphan receptor TR4 in MCF-7 cells
    Chih Rong Shyr
    George Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 277:14622-8. 2002
    ....
  100. ncbi request reprint Recent advances in the TR2 and TR4 orphan receptors of the nuclear receptor superfamily
    Yi Fen Lee
    George Whipple Laboratory for Cancer Research, Department of Urology, University of Rochester, NY 14642, USA
    J Steroid Biochem Mol Biol 81:291-308. 2002
    ..The essential and difficult tasks of identifying orphan receptor ligands, agonist/antagonist assignment, their physiological functions, and mechanisms of action will continue to challenge nuclear receptor researchers in the future...

Research Grants47

  1. Loss of Androgen Receptor Promotes Metastatic Prostate Cancer
    Shuyuan Yeh; Fiscal Year: 2010
    ....
  2. Androgen Receptor in B Cell Development and Functions
    Chawnshang Chang; Fiscal Year: 2010
    ..abstract_text> ..
  3. Androgen Receptor Roles in Liver Cancer Incidence and Progression
    Chawnshang Chang; Fiscal Year: 2007
    ....
  4. Androgen Receptor in B Cell Development and Functions
    Chawnshang Chang; Fiscal Year: 2007
    ....
  5. Suppression of Androgen Receptor by PTEN
    Chawnshang Chang; Fiscal Year: 2006
    ..abstract_text> ..
  6. Single and Double Knockout of TR2 and TR4 Receptors
    Chawnshang Chang; Fiscal Year: 2006
    ..In summary, this proposal provides us the first opportunity to study the potential in vivo physiological roles of the TR2 and TR4 orphan nuclear receptors. ..
  7. Androgen Receptor in Prostate Cancer and Bone
    Chawnshang Chang; Fiscal Year: 2005
    ..The success of this proposal will allow a better understanding of the role of androgen in the metastatic spread of prostate cancer to bone and the molecular mechanism of bone remodeling by prostate cancer cells. ..
  8. Suppression of Androgen Receptor by PTEN
    Chawnshang Chang; Fiscal Year: 2005
    ..abstract_text> ..
  9. Androgen Receptor in Prostate Cancer and Bone
    Chawnshang Chang; Fiscal Year: 2004
    ..The success of this proposal will allow a better understanding of the role of androgen in the metastatic spread of prostate cancer to bone and the molecular mechanism of bone remodeling by prostate cancer cells. ..
  10. Loss of Androgen Receptor Promotes Metastatic Prostate Cancer
    Chawnshang Chang; Fiscal Year: 2007
    ....
  11. Androgen Receptor Roles in Liver Cancer Incidence and Progression
    Chawnshang Chang; Fiscal Year: 2010
    ....
  12. Androgen Receptor in B Cell Development and Functions
    Chawnshang Chang; Fiscal Year: 2010
    ..abstract_text> ..
  13. New Mice Models for Studies of Androgen Receptor in Prostate Cancer
    Shuyuan Yeh; Fiscal Year: 2010
    ..In addition, these mice models may be useful for testing new drugs and treatments for prostate cancer therapy, which might eventually be used in humans. ..
  14. Loss of Androgen Receptor Promotes Metastatic Prostate Cancer
    Chawnshang Chang; Fiscal Year: 2009
    ....
  15. Androgen Receptor Roles in Liver Cancer Incidence and Progression
    Chawnshang Chang; Fiscal Year: 2009
    ....
  16. Androgen Receptor in B Cell Development and Functions
    Chawnshang Chang; Fiscal Year: 2009
    ..abstract_text> ..
  17. New Mice Models for Studies of Androgen Receptor in Prostate Cancer
    Chawnshang Chang; Fiscal Year: 2009
    ..In addition, these mice models may be useful for testing new drugs and treatments for prostate cancer therapy, which might eventually be used in humans. ..
  18. Induction of AR Transactivation by DHT and E2
    Chawnshang Chang; Fiscal Year: 2004
    ....
  19. Suppression of Androgen Receptor by PTEN
    Chawnshang Chang; Fiscal Year: 2004
    ..abstract_text> ..
  20. AR-ASSOCIATED PROTEINS IN PROSTATE CARCINOGENESIS
    Chawnshang Chang; Fiscal Year: 2001
    ..As a result, ultimately, we might find a potential protocol to manage the progression of CaP in the clinic. ..
  21. TR4 ORPHAN RECEPTOR IN TESTIS
    Chawnshang Chang; Fiscal Year: 2001
    ..Aim 5) Study cross talk between p53 and TR4 in testes. The successful completion of this proposal may help us to better understand the molecular mechanism of the TR4 and its potential biochemical functions. ..
  22. TR2 AND TR3 ORPHAN RECEPTORS IN PROSTATE CANCER
    Chawnshang Chang; Fiscal Year: 2000
    ..abstract_text> ..
  23. AR-ASSOCIATED PROTEINS IN PROSTATE CARCINOGENESIS
    Chawnshang Chang; Fiscal Year: 2000
    ..As a result, ultimately, we might find a potential protocol to manage the progression of CaP in the clinic. ..
  24. TR2 AND TR3 ORPHAN RECEPTORS IN PROSTATE CANCER
    Chawnshang Chang; Fiscal Year: 1999
    ..abstract_text> ..
  25. AR-ASSOCIATED PROTEINS IN PROSTATE CARCINOGENESIS
    Chawnshang Chang; Fiscal Year: 1999
    ..As a result, ultimately, we might find a potential protocol to manage the progression of CaP in the clinic. ..
  26. TR2 AND TR3 ORPHAN RECEPTORS IN PROSTATE CANCER
    Chawnshang Chang; Fiscal Year: 2001
    ..abstract_text> ..
  27. Induction of AR Transactivation by DHT and E2
    Chawnshang Chang; Fiscal Year: 2001
    ....
  28. TR4 ORPHAN RECEPTOR IN TESTIS
    Chawnshang Chang; Fiscal Year: 2002
    ..Aim 5) Study cross talk between p53 and TR4 in testes. The successful completion of this proposal may help us to better understand the molecular mechanism of the TR4 and its potential biochemical functions. ..
  29. TR4 ORPHAN RECEPTOR IN TESTIS
    Chawnshang Chang; Fiscal Year: 2004
    ..Aim 5) Study cross talk between p53 and TR4 in testes. The successful completion of this proposal may help us to better understand the molecular mechanism of the TR4 and its potential biochemical functions. ..
  30. Androgen Receptor in Prostate Cancer and Bone
    Chawnshang Chang; Fiscal Year: 2003
    ..The success of this proposal will allow a better understanding of the role of androgen in the metastatic spread of prostate cancer to bone and the molecular mechanism of bone remodeling by prostate cancer cells. ..
  31. Induction of AR Transactivation by DHT and E2
    Chawnshang Chang; Fiscal Year: 2003
    ....
  32. Suppression of Androgen Receptor by PTEN
    Chawnshang Chang; Fiscal Year: 2003
    ..abstract_text> ..
  33. TR4 ORPHAN RECEPTOR IN TESTIS
    Chawnshang Chang; Fiscal Year: 2003
    ..Aim 5) Study cross talk between p53 and TR4 in testes. The successful completion of this proposal may help us to better understand the molecular mechanism of the TR4 and its potential biochemical functions. ..
  34. Single and Double Knockout of TR2 and TR4 Receptors
    Chawnshang Chang; Fiscal Year: 2003
    ..In summary, this proposal provides us the first opportunity to study the potential in vivo physiological roles of the TR2 and TR4 orphan nuclear receptors. ..
  35. Suppression of Androgen Receptor by PTEN
    Chawnshang Chang; Fiscal Year: 2002
    ..abstract_text> ..
  36. Induction of AR Transactivation by DHT and E2
    Chawnshang Chang; Fiscal Year: 2002
    ....
  37. TR2 AND TR3 ORPHAN RECEPTORS IN PROSTATE CANCER
    Chawnshang Chang; Fiscal Year: 2002
    ..abstract_text> ..