Annette M Chang

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi request reprint Aging and insulin secretion
    Annette M Chang
    Divisions of Endocrinology and Geriatric Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor 48109, USA
    Am J Physiol Endocrinol Metab 284:E7-12. 2003
  2. ncbi request reprint Limitation of the homeostasis model assessment to predict insulin resistance and beta-cell dysfunction in older people
    Annette M Chang
    University of Michigan, 5570 MSRB II, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0678, USA
    J Clin Endocrinol Metab 91:629-34. 2006
  3. ncbi request reprint Impaired beta-cell function in human aging: response to nicotinic acid-induced insulin resistance
    Annette M Chang
    5570 MSRB II, 1150 West Medical Center Drive, Ann Arbor, Michigan 48109 0678, USA
    J Clin Endocrinol Metab 91:3303-9. 2006
  4. ncbi request reprint Effect of lowering postprandial hyperglycemia on insulin secretion in older people with impaired glucose tolerance
    Annette M Chang
    Department of Internal Medicine, University of Michigan, 1111 CCGC Bldg, 1500 E Medical Center Dr, Ann Arbor, MI 48109 0926, USA
    Am J Physiol Endocrinol Metab 287:E906-11. 2004
  5. ncbi request reprint The GLP-1 derivative NN2211 restores beta-cell sensitivity to glucose in type 2 diabetic patients after a single dose
    Annette M Chang
    Department of Internal Medicine, University of Michigan, Ann Arbor 48109 0926, USA
    Diabetes 52:1786-91. 2003
  6. pmc Short-term exercise improves beta-cell function and insulin resistance in older people with impaired glucose tolerance
    Cathie J Bloem
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 49109, USA
    J Clin Endocrinol Metab 93:387-92. 2008

Research Grants

  1. Postprandial hyperglycemia and insulin secretion
    ANNETTE CHANG; Fiscal Year: 2003

Collaborators

Detail Information

Publications6

  1. ncbi request reprint Aging and insulin secretion
    Annette M Chang
    Divisions of Endocrinology and Geriatric Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor 48109, USA
    Am J Physiol Endocrinol Metab 284:E7-12. 2003
    ..An improved understanding of the metabolic alterations associated with aging is essential for the development of preventive and therapeutic interventions in this population at high risk for glucose intolerance...
  2. ncbi request reprint Limitation of the homeostasis model assessment to predict insulin resistance and beta-cell dysfunction in older people
    Annette M Chang
    University of Michigan, 5570 MSRB II, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0678, USA
    J Clin Endocrinol Metab 91:629-34. 2006
    ..Studies in older people have shown inconsistent agreement between homeostasis model assessment of insulin resistance (HOMA-IR) and dynamic measures of insulin action and have not evaluated HOMA beta-cell...
  3. ncbi request reprint Impaired beta-cell function in human aging: response to nicotinic acid-induced insulin resistance
    Annette M Chang
    5570 MSRB II, 1150 West Medical Center Drive, Ann Arbor, Michigan 48109 0678, USA
    J Clin Endocrinol Metab 91:3303-9. 2006
    ..Glucose tolerance declines with age and may involve impaired beta-cell sensitivity to glucose and beta-cell compensation for insulin resistance...
  4. ncbi request reprint Effect of lowering postprandial hyperglycemia on insulin secretion in older people with impaired glucose tolerance
    Annette M Chang
    Department of Internal Medicine, University of Michigan, 1111 CCGC Bldg, 1500 E Medical Center Dr, Ann Arbor, MI 48109 0926, USA
    Am J Physiol Endocrinol Metab 287:E906-11. 2004
    ..301 +/- 54 pM, P = 0.4) remained unchanged and impaired. Thus short-term improvement of chronic hyperglycemia does not reverse beta-cell dysfunction in older people with IGT...
  5. ncbi request reprint The GLP-1 derivative NN2211 restores beta-cell sensitivity to glucose in type 2 diabetic patients after a single dose
    Annette M Chang
    Department of Internal Medicine, University of Michigan, Ann Arbor 48109 0926, USA
    Diabetes 52:1786-91. 2003
    ..44 +/- 0.18). The long-acting GLP-1 derivative, NN2211, restored beta-cell responsiveness to physiological hyperglycemia in type 2 diabetic subjects...
  6. pmc Short-term exercise improves beta-cell function and insulin resistance in older people with impaired glucose tolerance
    Cathie J Bloem
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 49109, USA
    J Clin Endocrinol Metab 93:387-92. 2008
    ..Short-term exercise has been found to increase insulin sensitivity, but little is known about acute exercise effects on beta-cell function in older people with IGT...

Research Grants1

  1. Postprandial hyperglycemia and insulin secretion
    ANNETTE CHANG; Fiscal Year: 2003
    ..Oral glucose tolerance testing and 72-hour continuous glucose monitoring will be performed at baseline and at completion of the dosing period to assess the degree of normalization of postprandial hyperglycemia. ..