Guillaume F Chanfreau

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Quality control of MATa1 splicing and exon skipping by nuclear RNA degradation
    Defne E Egecioglu
    Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California, Los Angeles, CA 90095 1569, USA
    Nucleic Acids Res 40:1787-96. 2012
  2. pmc Cryptic transcription mediates repression of subtelomeric metal homeostasis genes
    Isabelle Toesca
    Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS Genet 7:e1002163. 2011
  3. pmc Recognition of a conserved class of RNA tetraloops by Saccharomyces cerevisiae RNase III
    G Chanfreau
    Unité de Génétique des Interactions Macromoléculaires, URA1300 Centre National de la Recherche Scientifique, Departement des Biotechnologies, Institut Pasteur, Paris, France
    Proc Natl Acad Sci U S A 97:3142-7. 2000
  4. ncbi request reprint InvIGOrating mRNAs during Quiescence
    Guillaume Chanfreau
    Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California, Los Angeles, Box 951569, Los Angeles, CA 90095 1569, USA
    Mol Cell 38:317-8. 2010
  5. ncbi request reprint CUTting genetic noise by polyadenylation-induced RNA degradation
    Guillaume F Chanfreau
    Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA 90095 1569, USA
    Trends Cell Biol 15:635-7. 2005
  6. pmc Conservation of RNase III processing pathways and specificity in hemiascomycetes
    Guillaume Chanfreau
    Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California Los Angeles, Los Angeles, California 90095 1569, USA
    Eukaryot Cell 2:901-9. 2003
  7. pmc Widespread impact of nonsense-mediated mRNA decay on the yeast intronome
    Shakir Sayani
    Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095 1569, USA
    Mol Cell 31:360-70. 2008
  8. pmc Contributions of Trf4p- and Trf5p-dependent polyadenylation to the processing and degradative functions of the yeast nuclear exosome
    Defne E Egecioglu
    Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California Los Angeles, Box 951569, Los Angeles, CA 90095 1569, USA
    RNA 12:26-32. 2006
  9. pmc Sequential RNA degradation pathways provide a fail-safe mechanism to limit the accumulation of unspliced transcripts in Saccharomyces cerevisiae
    Shakir Sayani
    Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095, USA
    RNA 18:1563-72. 2012
  10. pmc Nonsense-mediated mRNA decay mutes the splicing defects of spliceosome component mutations
    Tadashi Kawashima
    Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California at Los Angeles, Los Angeles, California 90095 1569, USA
    RNA 15:2236-47. 2009

Research Grants

  1. The Control of Gene Expression by Eukaryotic Ribonucleases
    Guillaume F Chanfreau; Fiscal Year: 2010
  2. THE CONTROL OF GENE EXPRESSION BY EUKARYOTIC RNASE III
    Guillaume Chanfreau; Fiscal Year: 2006
  3. THE CONTROL OF GENE EXPRESSION BY EUKARYOTIC RNASE III
    Guillaume Chanfreau; Fiscal Year: 2007
  4. THE CONTROL OF GENE EXPRESSION BY EUKARYOTIC RNASE III
    Guillaume Chanfreau; Fiscal Year: 2007
  5. THE CONTROL OF GENE EXPRESSION BY EUKARYOTIC RNASE III
    Guillaume Chanfreau; Fiscal Year: 2009
  6. THE CONTROL OF GENE EXPRESSION BY EUKARYOTIC RNASE III
    Guillaume Chanfreau; Fiscal Year: 2004
  7. THE CONTROL OF GENE EXPRESSION BY EUKARYOTIC RNASE III
    Guillaume Chanfreau; Fiscal Year: 2003
  8. THE CONTROL OF GENE EXPRESSION BY EUKARYOTIC RNASE III
    Guillaume Chanfreau; Fiscal Year: 2003
  9. THE CONTROL OF GENE EXPRESSION BY EUKARYOTIC RNASE III
    Guillaume Chanfreau; Fiscal Year: 2002
  10. THE CONTROL OF GENE EXPRESSION BY EUKARYOTIC RNASE III
    Guillaume Chanfreau; Fiscal Year: 2001

Collaborators

Detail Information

Publications25

  1. pmc Quality control of MATa1 splicing and exon skipping by nuclear RNA degradation
    Defne E Egecioglu
    Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California, Los Angeles, CA 90095 1569, USA
    Nucleic Acids Res 40:1787-96. 2012
    ....
  2. pmc Cryptic transcription mediates repression of subtelomeric metal homeostasis genes
    Isabelle Toesca
    Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS Genet 7:e1002163. 2011
    ....
  3. pmc Recognition of a conserved class of RNA tetraloops by Saccharomyces cerevisiae RNase III
    G Chanfreau
    Unité de Génétique des Interactions Macromoléculaires, URA1300 Centre National de la Recherche Scientifique, Departement des Biotechnologies, Institut Pasteur, Paris, France
    Proc Natl Acad Sci U S A 97:3142-7. 2000
    ..These results also indicate that proteins belonging to the same class of RNA endonucleases require different structural elements for RNA cleavage...
  4. ncbi request reprint InvIGOrating mRNAs during Quiescence
    Guillaume Chanfreau
    Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California, Los Angeles, Box 951569, Los Angeles, CA 90095 1569, USA
    Mol Cell 38:317-8. 2010
    ..In this issue of Molecular Cell, De Virgilio and colleagues (Talarek et al., 2010) identify the Igo1/2 proteins as factors that protect mRNAs from degradation during quiescence...
  5. ncbi request reprint CUTting genetic noise by polyadenylation-induced RNA degradation
    Guillaume F Chanfreau
    Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA 90095 1569, USA
    Trends Cell Biol 15:635-7. 2005
    ..These cryptic transcripts are polyadenylated at their 3'-end by a poly(A) polymerase complex distinct from that used by the mRNA factory, which serves to tag these aberrant transcripts for nuclear degradation...
  6. pmc Conservation of RNase III processing pathways and specificity in hemiascomycetes
    Guillaume Chanfreau
    Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California Los Angeles, Los Angeles, California 90095 1569, USA
    Eukaryot Cell 2:901-9. 2003
    ..This analysis shows that RNase III processing signals and RNase III cleavage specificity are conserved in most Hemiascomycetes species but probably not in the evolutionarily more distant species Y. lipolytica...
  7. pmc Widespread impact of nonsense-mediated mRNA decay on the yeast intronome
    Shakir Sayani
    Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095 1569, USA
    Mol Cell 31:360-70. 2008
    ..These results show that NMD has a wider impact than previously thought on the degradation of yeast-unspliced transcripts and plays an important role in discarding precursors of regulated or suboptimally spliced transcripts...
  8. pmc Contributions of Trf4p- and Trf5p-dependent polyadenylation to the processing and degradative functions of the yeast nuclear exosome
    Defne E Egecioglu
    Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California Los Angeles, Box 951569, Los Angeles, CA 90095 1569, USA
    RNA 12:26-32. 2006
    ..These results suggest that polyadenylation of RNA processing intermediates plays a functional role in RNA processing pathways and is not limited to RNA surveillance functions...
  9. pmc Sequential RNA degradation pathways provide a fail-safe mechanism to limit the accumulation of unspliced transcripts in Saccharomyces cerevisiae
    Shakir Sayani
    Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095, USA
    RNA 18:1563-72. 2012
    ..The presence of these two sequential degradation pathways for unspliced pre-mRNAs underscores the importance of limiting their accumulation and might serve as a fail-safe mechanism to prevent the expression of these nonfunctional RNAs...
  10. pmc Nonsense-mediated mRNA decay mutes the splicing defects of spliceosome component mutations
    Tadashi Kawashima
    Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California at Los Angeles, Los Angeles, California 90095 1569, USA
    RNA 15:2236-47. 2009
    ....
  11. pmc Biochemical and genomic analysis of substrate recognition by the double-stranded RNA binding domain of yeast RNase III
    Anthony K Henras
    Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095 1569, USA
    RNA 11:1225-37. 2005
    ..This study underscores the importance of a few amino acid contacts for positioning of a dsRBD onto its RNA target, and implicates the specific orientation of helix 1 on the RNA for proper positioning of the catalytic domain...
  12. ncbi request reprint A conserved major groove antideterminant for Saccharomyces cerevisiae RNase III recognition
    Mui Sam
    Department of Chemistry and Biochemistry and Molecular Biology Institute, Box 951569, University of California, Los Angeles, California 90095 1569, USA
    Biochemistry 44:4181-7. 2005
    ..cerevisiae RNase III activity, and suggest a rationale for their apparent counter selection in RNA processing sites...
  13. pmc Structural basis for recognition of the AGNN tetraloop RNA fold by the double-stranded RNA-binding domain of Rnt1p RNase III
    Haihong Wu
    Department of Chemistry and Biochemistry and Molecular Biology Institute, University of California, Los Angeles, CA 90095 1569, USA
    Proc Natl Acad Sci U S A 101:8307-12. 2004
    ..These results show how a single dsRBD can convey specificity for particular RNA targets, by structure specific recognition of a conserved tetraloop fold...
  14. pmc RNA polymerase I stability couples cellular growth to metal availability
    Yueh Jung Lee
    Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California, Los Angeles, CA 90095 1569, USA
    Mol Cell 51:105-15. 2013
    ....
  15. pmc Sphingolipid signaling mediates iron toxicity
    Yueh Jung Lee
    Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095 1569, USA
    Cell Metab 16:90-6. 2012
    ..These results demonstrate an unexpected connection between sphingolipid flux and iron toxicity and show that activation of a signal transduction cascade contributes to iron-mediated cellular toxicity...
  16. pmc Widespread use of non-productive alternative splice sites in Saccharomyces cerevisiae
    Tadashi Kawashima
    Department of Chemistry and Biochemistry and the Molecular Biology Institute, UCLA, Los Angeles, California, United States of America
    PLoS Genet 10:e1004249. 2014
    ..cerevisiae but masked by RNA degradation and that the use of alternative splice sites in this organism is mostly aimed at controlling transcript levels rather than increasing proteome diversity. ..
  17. pmc A cotranscriptional model for 3'-end processing of the Saccharomyces cerevisiae pre-ribosomal RNA precursor
    Anthony K Henras
    Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California Los Angeles, Box 951569, Los Angeles, CA 90095 1569, USA
    RNA 10:1572-85. 2004
    ..These results show that a large fraction of Rnt1p is localized at the site of transcription of the rDNA, suggesting that the cleavage of the primary pre-rRNA transcript to generate the 35S pre-rRNA is a cotranscriptional event...
  18. ncbi request reprint The Shq1p.Naf1p complex is required for box H/ACA small nucleolar ribonucleoprotein particle biogenesis
    Pok Kwan Yang
    Department of Chemistry and Biochemistry and the Molecular Biology Institute, UCLA, Los Angeles, California 90095 1569, USA
    J Biol Chem 277:45235-42. 2002
    ..Shq1p and Naf1p form a complex, but they are not strongly associated with box H/ACA snoRNPs. We propose that Shq1p and Naf1p are involved in the early biogenesis steps of box H/ACA snoRNP assembly...
  19. ncbi request reprint RNAse III-mediated degradation of unspliced pre-mRNAs and lariat introns
    Michal Danin-Kreiselman
    Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California, Los Angeles, Box 951569, Los Angeles, CA 90095, USA
    Mol Cell 11:1279-89. 2003
    ..These results identify an alternative discard pathway for precursors and products of the splicing machinery and a physiological function for dsRNA in eukaryotic RNA catabolism...
  20. ncbi request reprint Regulation and surveillance of normal and 3'-extended forms of the yeast aci-reductone dioxygenase mRNA by RNase III cleavage and exonucleolytic degradation
    Cindy Zer
    Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
    J Biol Chem 280:28997-9003. 2005
    ....
  21. pmc Structure and functional studies of the CS domain of the essential H/ACA ribonucleoparticle assembly protein SHQ1
    Mahavir Singh
    Department of Chemistry and Biochemistry, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 284:1906-16. 2009
    ..These results show that the CS domain is essential for Shq1p function in H/ACA snoRNP biogenesis in vivo, possibly in an Hsp90-independent manner...
  22. pmc The roles of endonucleolytic cleavage and exonucleolytic digestion in the 5'-end processing of S. cerevisiae box C/D snoRNAs
    Chrissie Young Lee
    Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California Los Angeles, Los Angeles, California 90095 1569, USA
    RNA 9:1362-70. 2003
    ....
  23. pmc Cotranscriptional recruitment of the pseudouridylsynthetase Cbf5p and of the RNA binding protein Naf1p during H/ACA snoRNP assembly
    Pok Kwan Yang
    Department of Chemistry and Biochemistry and Molecular Biology Institute, UCLA, Box 951569, Los Angeles, CA 90095 1569, USA
    Mol Cell Biol 25:3295-304. 2005
    ....
  24. ncbi request reprint Multiple RNA surveillance pathways limit aberrant expression of iron uptake mRNAs and prevent iron toxicity in S. cerevisiae
    Albert Lee
    Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California, Los Angeles, Box 951569, Los Angeles, California 90095, USA
    Mol Cell 19:39-51. 2005
    ....
  25. pmc The Chlamydomonas genome reveals the evolution of key animal and plant functions
    Sabeeha S Merchant
    Department of Chemistry and Biochemistry, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Science 318:245-50. 2007
    ....

Research Grants14

  1. The Control of Gene Expression by Eukaryotic Ribonucleases
    Guillaume F Chanfreau; Fiscal Year: 2010
    ..Our studies of the turnover of unspliced and mis-spliced RNAs will shed light on the mechanisms by which RNA degradation controls the expression of genes mutated in the context of a large number of genetic diseases. ..
  2. THE CONTROL OF GENE EXPRESSION BY EUKARYOTIC RNASE III
    Guillaume Chanfreau; Fiscal Year: 2006
    ..These studies will contribute to our understanding of the roles of RNase III in the control of gene expression and of the mechanisms of adaptation of eukaryotic cell metabolism to iron deficiency. ..
  3. THE CONTROL OF GENE EXPRESSION BY EUKARYOTIC RNASE III
    Guillaume Chanfreau; Fiscal Year: 2007
    ..These studies will contribute to our understanding of the roles of RNase III in the control of gene expression and of the mechanisms of adaptation of eukaryotic cell metabolism to iron deficiency. ..
  4. THE CONTROL OF GENE EXPRESSION BY EUKARYOTIC RNASE III
    Guillaume Chanfreau; Fiscal Year: 2007
    ..These studies will contribute to our understanding of the roles of RNase III in the control of gene expression and of the mechanisms of adaptation of eukaryotic cell metabolism to iron deficiency. ..
  5. THE CONTROL OF GENE EXPRESSION BY EUKARYOTIC RNASE III
    Guillaume Chanfreau; Fiscal Year: 2009
    ..These studies will contribute to our understanding of the roles of RNase III in the control of gene expression and of the mechanisms of adaptation of eukaryotic cell metabolism to iron deficiency. ..
  6. THE CONTROL OF GENE EXPRESSION BY EUKARYOTIC RNASE III
    Guillaume Chanfreau; Fiscal Year: 2004
    ..In particular, provocative hypotheses suggesting that Rnt1p activity is modulated by N- terminal acetylation and that Rnt1p is involved in the sexual process will be tested. ..
  7. THE CONTROL OF GENE EXPRESSION BY EUKARYOTIC RNASE III
    Guillaume Chanfreau; Fiscal Year: 2003
    ..In particular, provocative hypotheses suggesting that Rnt1p activity is modulated by N- terminal acetylation and that Rnt1p is involved in the sexual process will be tested. ..
  8. THE CONTROL OF GENE EXPRESSION BY EUKARYOTIC RNASE III
    Guillaume Chanfreau; Fiscal Year: 2003
    ..In particular, provocative hypotheses suggesting that Rnt1p activity is modulated by N- terminal acetylation and that Rnt1p is involved in the sexual process will be tested. ..
  9. THE CONTROL OF GENE EXPRESSION BY EUKARYOTIC RNASE III
    Guillaume Chanfreau; Fiscal Year: 2002
    ..In particular, provocative hypotheses suggesting that Rnt1p activity is modulated by N- terminal acetylation and that Rnt1p is involved in the sexual process will be tested. ..
  10. THE CONTROL OF GENE EXPRESSION BY EUKARYOTIC RNASE III
    Guillaume Chanfreau; Fiscal Year: 2001
    ..In particular, provocative hypotheses suggesting that Rnt1p activity is modulated by N- terminal acetylation and that Rnt1p is involved in the sexual process will be tested. ..
  11. THE CONTROL OF GENE EXPRESSION BY EUKARYOTIC RNASE III
    Guillaume Chanfreau; Fiscal Year: 2006
    ..These studies will contribute to our understanding of the roles of RNase III in the control of gene expression and of the mechanisms of adaptation of eukaryotic cell metabolism to iron deficiency. ..
  12. THE CONTROL OF GENE EXPRESSION BY EUKARYOTIC RNASE III
    Guillaume Chanfreau; Fiscal Year: 2005
    ..These studies will contribute to our understanding of the roles of RNase III in the control of gene expression and of the mechanisms of adaptation of eukaryotic cell metabolism to iron deficiency. ..
  13. THE CONTROL OF GENE EXPRESSION BY EUKARYOTIC RNASE III
    Guillaume Chanfreau; Fiscal Year: 2001
    ..In particular, provocative hypotheses suggesting that Rnt1p activity is modulated by N- terminal acetylation and that Rnt1p is involved in the sexual process will be tested. ..