Research Topics
| Parakrama ChandrasomaSummaryAffiliation: University of Southern California Country: USA Publications
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Detail Information
Publications
The dilated distal esophagus: a new entity that is the pathologic basis of early gastroesophageal reflux diseaseParakrama Chandrasoma
Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Am J Surg Pathol 35:1873-81. 2011..Its recognition allows for accurate and evidence-based interpretation of biopsies from this region and removes the present confusion and permits the development of a reproducible pathologic diagnostic method...
Histologic classification of patients based on mapping biopsies of the gastroesophageal junctionParakrama T Chandrasoma
Department of Surgical Pathology, Keck School of Medicine at the University of Southern California, Los Angeles, CA 90033, USA
Am J Surg Pathol 27:929-36. 2003..4% in the 1- to 2-cm group, 89.5% in the 3- to 4-cm group, and 100% with in the >or=5 cm group. We propose a histologic grading system of biopsies based on these findings...- Controversies of the cardiac mucosa and Barrett's oesophagusP Chandrasoma
Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Histopathology 46:361-73. 2005..Histopathological precision cannot be matched by any other modality and can convert the confusion that exists regarding diagnosis of Barrett's oesophagus to complete lucidity in a manner that is simple, accurate, and reproducible... - Adenocarcinomas of the distal esophagus and "gastric cardia" are predominantly esophageal carcinomasParakrama Chandrasoma
Department of Surgical Pathology, Keck School of Medicine and University of Southern California, Los Angeles, CA 90033, USA
Am J Surg Pathol 31:569-75. 2007..We have recently suggested that the true gastro-esophageal junction is best defined by the proximal limit of gastric oxyntic mucosa... - The histologic squamo-oxyntic gap: an accurate and reproducible diagnostic marker of gastroesophageal reflux diseaseParakrama Chandrasoma
Department of Pathology, Keck School of Medicine at University of Southern California, Los Angeles, CA 90033, USA
Am J Surg Pathol 34:1574-81. 2010..The presence of intestinal metaplasia within the squamo-oxyntic gap is the most accurate risk indicator for esophageal adenocarcinoma and defines Barrett esophagus... - Is intestinal metaplasia a necessary precursor lesion for adenocarcinomas of the distal esophagus, gastroesophageal junction and gastric cardia?P Chandrasoma
The Departments of Surgical Pathology and Foregut Surgery, Keck School of Medicine and University of Southern California, Los Angeles, California, USA
Dis Esophagus 20:36-41. 2007..The absence of residual intestinal metaplasia in larger tumors is the result of tumor overgrowing the intestinal metaplasia from which it arose... - Columnar-lined esophagus without intestinal metaplasia has no proven risk of adenocarcinomaParakrama Chandrasoma
Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Am J Surg Pathol 36:1-7. 2012..Inadequate sampling is a powerful reason why the near absolute association between intestinal metaplasia and adenocarcinoma is not seen in some studies... - A proposal for a new validated histological definition of the gastroesophageal junctionParakrama Chandrasoma
Department of Surgical Pathology and Foregut Surgery, TDM, Keck School of Medicine, University of Southern California, Los Angeles, 90033, USA
Hum Pathol 37:40-7. 2006..05 cm of distal reflux-damaged dilated esophagus can be mistaken as proximal stomach when presently accepted definitions for the GEJ are used. The true GEJ is the proximal limit of gastric oxyntic mucosa defined by histology... - Pathological basis of gastroesophageal reflux diseaseParakrama Chandrasoma
Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
World J Surg 27:986-93. 2003..An attempt is made here to develop a rational grading system for reflux based on these highly objective histologic criteria... - Esophageal intraepithelial eosinophils in dysphagic patients with gastroesophageal reflux diseaseShahin Ayazi
Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Dig Dis Sci 55:967-72. 2010..Patients with gastroesophageal reflux disease (GERD) often complain of dysphagia and are frequently found to have intraepithelial eosinophils on esophageal biopsy... - Esophageal pH exposure and epithelial cell differentiationPhilip Wy Chiu
Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Dis Esophagus 22:596-9. 2009..This suggests that the exposure of stem cells to a luminal pH between 2 and 5 may trigger the differentiation of CE into intestinalized CE... - Progressive mucosal injury in patients with gastroesophageal reflux disease and increasing peripheral blood eosinophil countsFarzaneh Banki
University of Southern California, Los Angeles, USA
Arch Surg 145:363-6. 2010..Peripheral blood eosinophil count increases with the degree of mucosal injury associated with gastroesophageal reflux disease (GERD)... - Validation of a rodent model of Barrett's esophagus using quantitative gene expression profilingDaniel S Oh
Department of Surgery, University of Southern California, Los Angeles, CA, USA
Surg Endosc 23:1346-52. 2009..The aim of this study was to evaluate the esophageal intestinal-type mucosa in these animals by measuring expression of trefoil factor genes (TFF-1, -2, -3) and comparing it with adjacent jejunum in order to determine its etiology... - High intraepithelial eosinophil counts in esophageal squamous epithelium are not specific for eosinophilic esophagitis in adultsSonali Rodrigo
Department of Surgical Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Am J Gastroenterol 103:435-42. 2008..This is based on data that the number of intraepithelial eosinophils in gastroesophageal reflux disease (GERD) is less than 20/hpf. This study tests this belief... - Reduction of interleukin 8 gene expression in reflux esophagitis and Barrett's esophagus with antireflux surgeryDaniel S Oh
Department of Cardiothoracic Surgery, University of Southern California, 1510 San Pablo Street, Los Angeles, CA 90033, USA
Arch Surg 142:554-9; discussion 559-60. 2007..Chronic inflammation of esophageal mucosa secondary to refluxed gastric juice increases gene expression of interleukin 8 (IL-8). Antireflux surgery can reduce this overexpression... - Retinoic acid receptor-alpha messenger RNA expression is increased and retinoic acid receptor-gamma expression is decreased in Barrett's intestinal metaplasia, dysplasia, adenocarcinoma sequenceR V Lord
Department of Surgery, University of Southern California Keck School of Medicine and USC/Norris Cancer Center, Los Angeles, Calif, USA
Surgery 129:267-76. 2001..These results also suggest that a cancer field is present in the esophagus in patients with cancer and that genetic alterations can precede histopathologic alterations in this disease... - Genetic variations in angiogenesis pathway genes predict tumor recurrence in localized adenocarcinoma of the esophagusGeorg Lurje
Division of Medical Oncology, University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles, CA 90033, USA
Ann Surg 251:857-64. 2010..The aim of this study was to determine whether the risk of systemic disease after esophagectomy could be predicted by angiogenesis-related gene polymorphisms... - Loss of function of Trp53, but not Apc, leads to the development of esophageal adenocarcinoma in mice with jejunoesophageal refluxM Fein
Department of Surgery, University of Southern California, Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, Los Angeles, California 90033 4612, USA
J Surg Res 83:48-55. 1999..To determine the functional role of these genes in the development of EAC, we have created reflux in mice gene-targeted for either Trp53 or Apc... - Biology of gastroesophageal reflux disease: pathophysiology relating to medical and surgical treatmentT R Demeester
Department of Surgery, University of Southern California School of Medicine, Los Angeles 90033 4612, USA
Annu Rev Med 50:469-506. 1999..Practical concepts regarding the treatment of gastroesophageal reflux disease are developed, based on a review of studies on the natural history of the disease and the long-term outcome of therapy... - Ki67 expression in different epithelial types in columnar lined oesophagus indicates varying levels of expanded and aberrant proliferative patternsM Olvera
Department of Pathology, Los Angeles County University of Southern California Medical Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Histopathology 47:132-40. 2005.... - Gland ducts and multilayered epithelium in mucosal biopsies from gastroesophageal-junction region are useful in characterizing esophageal locationL Shi
Department of Surgical Pathology, Keck School of Medicine and University of Southern California, Los Angeles 90033, USA
Dis Esophagus 18:87-92. 2005..The presence of gland ducts and multilayered epithelium can be used by pathologists to objectively ascribe an esophageal or gastric location to a biopsy from the gastroesophageal junction... - Phlegmonous gastritis in a patient with myeloid sarcoma: a case reportJuan Guo
Department of Pathology, Keck School of Medicine, LAC USC Medical Center, University of Southern California, Los Angeles, CA 90030, USA
Appl Immunohistochem Mol Morphol 17:458-62. 2009..The limited autopsy confirmed the diagnosis of phlegmonous gastritis. Immunohistochemical studies further revealed the occurrence of myeloid sarcoma that involved the gastrointestinal tract... - Carditis: a manifestation of gastroesophageal reflux diseaseR Der
Department of Surgical Pathology, Foregut Surgery, Keck School of Medicine at the University of Southern California, Los Angeles, USA
Am J Surg Pathol 25:245-52. 2001..pylori gastritis develops, the infection frequently spreads to involve CM, resulting in acute inflammation with neutrophils that is superimposed on the chronic inflammation already present... 
Curative resection for esophageal adenocarcinoma: analysis of 100 en bloc esophagectomiesJ A Hagen
Department of Surgery, Keck School of Medicine, University of Southern California, 1510 San Pablo St, Los Angeles, CA 90033, USA
Ann Surg 234:520-30; discussion 530-1. 2001..Local control is excellent after en bloc resection. The extent of disease associated with tumors confined to the mucosa and submucosa provides justification for more limited and less morbid resections...- Laparoscopic ultrasonic epithelial ablation of the lower esophagus after nissen fundoplication in a porcine model: assessment of tissue damage and healing processP I Tsai
Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, USA
Am Surg 67:1178-80. 2001..No stricture formation was seen. We conclude that the CUSA technique can completely ablate Barrett's mucosa in the setting of a prior antireflux procedure. Healing with squamous mucosal regeneration is rapid and complete... - Prediction of patients with acute cholecystitis requiring emergent cholecystectomy: a simple scoreWael N Yacoub
Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
Gastroenterol Res Pract 2010:901739. 2010..5 points). A cutoff score of 2 identified 31 (69%) patients with no acute inflammation (PPV 90%). This scoring system can prioritize patients for emergent cholecystectomy based on their expected pathology... - Cytokeratin and DAS-1 immunostaining reveal similarities among cardiac mucosa, CIM, and Barrett's esophagusSteven R Demeester
Department of Cardiothoracic Surgery, The University of Southern California, Keck School of Medicine, Los Angeles, USA
Am J Gastroenterol 97:2514-23. 2002..This suggests that cardiac mucosa, like Barrett's, may be acquired. Likewise, immunostaining similarities between CIM and Barrett's biopsies point to the possibility of a reflux etiology for CIM in some patients... - Molecular determinants in targeted therapy for esophageal adenocarcinomaDaniel Vallbohmer
Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, USA
Arch Surg 141:476-81; discussion 481-2. 2006..Cyclooxygenase 2 (COX-2), vascular endothelial growth factor (VEGF), and epidermal growth factor receptor (EGFR) are useful biological determinants in targeted therapy for esophageal adenocarcinoma... - Barrett's esophagus can and does regress after antireflux surgery: a study of prevalence and predictive featuresRichard R Gurski
Department of Surgery, Division of Thoracic and Foregut Surgery, University of Southern California, Los Angeles, CA 90033, USA
J Am Coll Surg 196:706-12; discussion 712-3. 2003..Regression is dependent on the length of the columnar-lined esophagus and time of followup after antireflux surgery... - Histopathology of the endoscopic esophagogastric junction in patients with gastroesophageal reflux diseaseClaudia Ringhofer
University Clinic of Surgery, Medical University Vienna, Austria
Wien Klin Wochenschr 120:350-9. 2008..We compared endoscopy and histopathology of the esophagogastric junction in patients with gastroesophageal reflux disease... - Quantitative, tissue-specific analysis of cyclooxygenase gene expression in the pathogenesis of Barrett's adenocarcinomaHidekazu Kuramochi
From the Department of Biochemistry and Molecular Biology, USC/Norris Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
J Gastrointest Surg 8:1007-16; discussion 1016-7. 2004..These results confirm the important role of Cox-2 amplification in the pathogenesis of esophageal adenocarcinoma, but the unexpected down-regulation of Cox-1 raises questions about its role in carcinogenesis... - Clinical biology and surgical therapy of intramucosal adenocarcinoma of the esophagusDaniel S Oh
Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
J Am Coll Surg 203:152-61. 2006..A vagal-sparing technique had less morbidity than other forms of resection and no mortality. Survival after all types of resection was similar. Outcomes of endoscopic techniques should be compared with this benchmark... - Body mass index is associated with Barrett esophagus and cardiac mucosal metaplasiaXiangdong Bu
Department of Surgical Pathology, University of Southern California, Keck School of Medicine and LAC+USC Medical Center, Room 16-905, 1200 N. State Street, Los Angeles, California 90033, USA
Dig Dis Sci 51:1589-94. 2006..04). In conclusion, BMI is associated with BE and CM and appears to act early in the sequence of events leading from gastroesophageal reflux disease to metaplasia (CM and BE) to dysplasia and finally to adenocarcinoma... - Antireflux surgery normalizes cyclooxygenase-2 expression in squamous epithelium of the distal esophagusDaniel Vallbohmer
Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
Am J Gastroenterol 101:1458-66. 2006..Further, we hypothesized that Cox-2 expression in the squamous mucosa would be reduced following the elimination of reflux with an antireflux operation... - Survivin, a potential biomarker in the development of Barrett's adenocarcinomaDaniel Vallbohmer
Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, USA
Surgery 138:701-6; discussion 706-7. 2005..The aim of this study was to measure survivin gene expression in normal squamous/columnar epithelium and in the various stages of development of Barrett's adenocarcinoma... - Towards the molecular characterization of disease: comparison of molecular and histological analysis of esophageal epitheliaDaniel Vallbohmer
Department of Surgery, University of Southern California, Los Angeles, CA, USA
J Gastrointest Surg 11:1095-104. 2007..When differences occur, it is unclear whether this effect is due to intraobserver variability in pathological diagnosis or to a genuine difference between gene expression and histopathology... - Lack of reversal of carditis by PPI therapy only means that acid in refluxate is not responsible for carditisParakrama T Chandrasoma
Dig Dis Sci 53:1426-7. 2008 - Detection of Barrett's epithelium by acoustic microscopyKumari S Wickramasinghe
Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Ultrasound Med Biol 28:203-7. 2002.... - Increasing cyclooxygenase-2 (cox-2) gene expression in the progression of Barrett's esophagus to adenocarcinoma correlates with that of Bcl-2Daisuke Shimizu
Department of Biochemistry and Molecular Biology, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90033, USA
Int J Cancer 119:765-70. 2006..0053, p = 0.0220) and adenocarcinoma (p < 0.0001, p < 0.0001) compared to squamous epithelium or reflux-esophagitis. Furthermore, there is a significant correlation between these two genes, especially in carcinoma (p < 0.0001)... - Microcalcification in the breast and the pathologistParakrama T Chandrasoma
Am J Surg Pathol 26:135-6. 2002