Parakrama Chandrasoma

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. doi request reprint Histologic definition of gastro-esophageal reflux disease
    Parakrama T Chandrasoma
    Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Curr Opin Gastroenterol 29:460-7. 2013
  2. doi request reprint The dilated distal esophagus: a new entity that is the pathologic basis of early gastroesophageal reflux disease
    Parakrama Chandrasoma
    Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Am J Surg Pathol 35:1873-81. 2011
  3. ncbi request reprint Histologic classification of patients based on mapping biopsies of the gastroesophageal junction
    Parakrama T Chandrasoma
    Department of Surgical Pathology, Keck School of Medicine at the University of Southern California, Los Angeles, CA 90033, USA
    Am J Surg Pathol 27:929-36. 2003
  4. doi request reprint The histologic squamo-oxyntic gap: an accurate and reproducible diagnostic marker of gastroesophageal reflux disease
    Parakrama Chandrasoma
    Department of Pathology, Keck School of Medicine at University of Southern California, Los Angeles, CA 90033, USA
    Am J Surg Pathol 34:1574-81. 2010
  5. doi request reprint Columnar-lined esophagus without intestinal metaplasia has no proven risk of adenocarcinoma
    Parakrama Chandrasoma
    Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Am J Surg Pathol 36:1-7. 2012
  6. ncbi request reprint Controversies of the cardiac mucosa and Barrett's oesophagus
    P Chandrasoma
    Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Histopathology 46:361-73. 2005
  7. ncbi request reprint A proposal for a new validated histological definition of the gastroesophageal junction
    Parakrama Chandrasoma
    Department of Surgical Pathology and Foregut Surgery, TDM, Keck School of Medicine, University of Southern California, Los Angeles, 90033, USA
    Hum Pathol 37:40-7. 2006
  8. ncbi request reprint Adenocarcinomas of the distal esophagus and "gastric cardia" are predominantly esophageal carcinomas
    Parakrama Chandrasoma
    Department of Surgical Pathology, Keck School of Medicine and University of Southern California, Los Angeles, CA 90033, USA
    Am J Surg Pathol 31:569-75. 2007
  9. ncbi request reprint Is intestinal metaplasia a necessary precursor lesion for adenocarcinomas of the distal esophagus, gastroesophageal junction and gastric cardia?
    P Chandrasoma
    The Departments of Surgical Pathology and Foregut Surgery, Keck School of Medicine and University of Southern California, Los Angeles, California, USA
    Dis Esophagus 20:36-41. 2007
  10. ncbi request reprint Pathological basis of gastroesophageal reflux disease
    Parakrama Chandrasoma
    Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    World J Surg 27:986-93. 2003

Collaborators

Detail Information

Publications42

  1. doi request reprint Histologic definition of gastro-esophageal reflux disease
    Parakrama T Chandrasoma
    Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Curr Opin Gastroenterol 29:460-7. 2013
    ..To review recent data supporting the development of new histology-based definitions of gastro-esophageal reflux disease (GERD)...
  2. doi request reprint The dilated distal esophagus: a new entity that is the pathologic basis of early gastroesophageal reflux disease
    Parakrama Chandrasoma
    Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Am J Surg Pathol 35:1873-81. 2011
    ..Its recognition allows for accurate and evidence-based interpretation of biopsies from this region and removes the present confusion and permits the development of a reproducible pathologic diagnostic method...
  3. ncbi request reprint Histologic classification of patients based on mapping biopsies of the gastroesophageal junction
    Parakrama T Chandrasoma
    Department of Surgical Pathology, Keck School of Medicine at the University of Southern California, Los Angeles, CA 90033, USA
    Am J Surg Pathol 27:929-36. 2003
    ..4% in the 1- to 2-cm group, 89.5% in the 3- to 4-cm group, and 100% with in the >or=5 cm group. We propose a histologic grading system of biopsies based on these findings...
  4. doi request reprint The histologic squamo-oxyntic gap: an accurate and reproducible diagnostic marker of gastroesophageal reflux disease
    Parakrama Chandrasoma
    Department of Pathology, Keck School of Medicine at University of Southern California, Los Angeles, CA 90033, USA
    Am J Surg Pathol 34:1574-81. 2010
    ..The presence of intestinal metaplasia within the squamo-oxyntic gap is the most accurate risk indicator for esophageal adenocarcinoma and defines Barrett esophagus...
  5. doi request reprint Columnar-lined esophagus without intestinal metaplasia has no proven risk of adenocarcinoma
    Parakrama Chandrasoma
    Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Am J Surg Pathol 36:1-7. 2012
    ..Inadequate sampling is a powerful reason why the near absolute association between intestinal metaplasia and adenocarcinoma is not seen in some studies...
  6. ncbi request reprint Controversies of the cardiac mucosa and Barrett's oesophagus
    P Chandrasoma
    Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Histopathology 46:361-73. 2005
    ..Histopathological precision cannot be matched by any other modality and can convert the confusion that exists regarding diagnosis of Barrett's oesophagus to complete lucidity in a manner that is simple, accurate, and reproducible...
  7. ncbi request reprint A proposal for a new validated histological definition of the gastroesophageal junction
    Parakrama Chandrasoma
    Department of Surgical Pathology and Foregut Surgery, TDM, Keck School of Medicine, University of Southern California, Los Angeles, 90033, USA
    Hum Pathol 37:40-7. 2006
    ..05 cm of distal reflux-damaged dilated esophagus can be mistaken as proximal stomach when presently accepted definitions for the GEJ are used. The true GEJ is the proximal limit of gastric oxyntic mucosa defined by histology...
  8. ncbi request reprint Adenocarcinomas of the distal esophagus and "gastric cardia" are predominantly esophageal carcinomas
    Parakrama Chandrasoma
    Department of Surgical Pathology, Keck School of Medicine and University of Southern California, Los Angeles, CA 90033, USA
    Am J Surg Pathol 31:569-75. 2007
    ..We have recently suggested that the true gastro-esophageal junction is best defined by the proximal limit of gastric oxyntic mucosa...
  9. ncbi request reprint Is intestinal metaplasia a necessary precursor lesion for adenocarcinomas of the distal esophagus, gastroesophageal junction and gastric cardia?
    P Chandrasoma
    The Departments of Surgical Pathology and Foregut Surgery, Keck School of Medicine and University of Southern California, Los Angeles, California, USA
    Dis Esophagus 20:36-41. 2007
    ..The absence of residual intestinal metaplasia in larger tumors is the result of tumor overgrowing the intestinal metaplasia from which it arose...
  10. ncbi request reprint Pathological basis of gastroesophageal reflux disease
    Parakrama Chandrasoma
    Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    World J Surg 27:986-93. 2003
    ..An attempt is made here to develop a rational grading system for reflux based on these highly objective histologic criteria...
  11. doi request reprint Esophageal intraepithelial eosinophils in dysphagic patients with gastroesophageal reflux disease
    Shahin Ayazi
    Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Dig Dis Sci 55:967-72. 2010
    ..Patients with gastroesophageal reflux disease (GERD) often complain of dysphagia and are frequently found to have intraepithelial eosinophils on esophageal biopsy...
  12. doi request reprint Progressive mucosal injury in patients with gastroesophageal reflux disease and increasing peripheral blood eosinophil counts
    Farzaneh Banki
    University of Southern California, Los Angeles, USA
    Arch Surg 145:363-6. 2010
    ..Peripheral blood eosinophil count increases with the degree of mucosal injury associated with gastroesophageal reflux disease (GERD)...
  13. doi request reprint Esophageal pH exposure and epithelial cell differentiation
    Philip Wy Chiu
    Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Dis Esophagus 22:596-9. 2009
    ..This suggests that the exposure of stem cells to a luminal pH between 2 and 5 may trigger the differentiation of CE into intestinalized CE...
  14. doi request reprint Effect of Barrett's esophagus surveillance on esophageal preservation, tumor stage, and survival with esophageal adenocarcinoma
    Kimberly S Grant
    Department of Surgery, University of Southern California Keck School of Medicine, Los Angeles, Calif 90033, USA
    J Thorac Cardiovasc Surg 146:31-7. 2013
    ....
  15. doi request reprint Validation of a rodent model of Barrett's esophagus using quantitative gene expression profiling
    Daniel S Oh
    Department of Surgery, University of Southern California, Los Angeles, CA, USA
    Surg Endosc 23:1346-52. 2009
    ..The aim of this study was to evaluate the esophageal intestinal-type mucosa in these animals by measuring expression of trefoil factor genes (TFF-1, -2, -3) and comparing it with adjacent jejunum in order to determine its etiology...
  16. doi request reprint High intraepithelial eosinophil counts in esophageal squamous epithelium are not specific for eosinophilic esophagitis in adults
    Sonali Rodrigo
    Department of Surgical Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Am J Gastroenterol 103:435-42. 2008
    ..This is based on data that the number of intraepithelial eosinophils in gastroesophageal reflux disease (GERD) is less than 20/hpf. This study tests this belief...
  17. ncbi request reprint Reduction of interleukin 8 gene expression in reflux esophagitis and Barrett's esophagus with antireflux surgery
    Daniel S Oh
    Department of Cardiothoracic Surgery, University of Southern California, 1510 San Pablo Street, Los Angeles, CA 90033, USA
    Arch Surg 142:554-9; discussion 559-60. 2007
    ..Chronic inflammation of esophageal mucosa secondary to refluxed gastric juice increases gene expression of interleukin 8 (IL-8). Antireflux surgery can reduce this overexpression...
  18. ncbi request reprint Retinoic acid receptor-alpha messenger RNA expression is increased and retinoic acid receptor-gamma expression is decreased in Barrett's intestinal metaplasia, dysplasia, adenocarcinoma sequence
    R V Lord
    Department of Surgery, University of Southern California Keck School of Medicine and USC/Norris Cancer Center, Los Angeles, Calif, USA
    Surgery 129:267-76. 2001
    ..These results also suggest that a cancer field is present in the esophagus in patients with cancer and that genetic alterations can precede histopathologic alterations in this disease...
  19. doi request reprint Genetic variations in angiogenesis pathway genes predict tumor recurrence in localized adenocarcinoma of the esophagus
    Georg Lurje
    Division of Medical Oncology, University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles, CA 90033, USA
    Ann Surg 251:857-64. 2010
    ..The aim of this study was to determine whether the risk of systemic disease after esophagectomy could be predicted by angiogenesis-related gene polymorphisms...
  20. ncbi request reprint Loss of function of Trp53, but not Apc, leads to the development of esophageal adenocarcinoma in mice with jejunoesophageal reflux
    M Fein
    Department of Surgery, University of Southern California, Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, Los Angeles, California 90033 4612, USA
    J Surg Res 83:48-55. 1999
    ..To determine the functional role of these genes in the development of EAC, we have created reflux in mice gene-targeted for either Trp53 or Apc...
  21. ncbi request reprint Biology of gastroesophageal reflux disease: pathophysiology relating to medical and surgical treatment
    T R Demeester
    Department of Surgery, University of Southern California School of Medicine, Los Angeles 90033 4612, USA
    Annu Rev Med 50:469-506. 1999
    ..Practical concepts regarding the treatment of gastroesophageal reflux disease are developed, based on a review of studies on the natural history of the disease and the long-term outcome of therapy...
  22. ncbi request reprint Ki67 expression in different epithelial types in columnar lined oesophagus indicates varying levels of expanded and aberrant proliferative patterns
    M Olvera
    Department of Pathology, Los Angeles County University of Southern California Medical Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Histopathology 47:132-40. 2005
    ....
  23. ncbi request reprint Gland ducts and multilayered epithelium in mucosal biopsies from gastroesophageal-junction region are useful in characterizing esophageal location
    L Shi
    Department of Surgical Pathology, Keck School of Medicine and University of Southern California, Los Angeles 90033, USA
    Dis Esophagus 18:87-92. 2005
    ..The presence of gland ducts and multilayered epithelium can be used by pathologists to objectively ascribe an esophageal or gastric location to a biopsy from the gastroesophageal junction...
  24. doi request reprint Phlegmonous gastritis in a patient with myeloid sarcoma: a case report
    Juan Guo
    Department of Pathology, Keck School of Medicine, LAC USC Medical Center, University of Southern California, Los Angeles, CA 90030, USA
    Appl Immunohistochem Mol Morphol 17:458-62. 2009
    ..The limited autopsy confirmed the diagnosis of phlegmonous gastritis. Immunohistochemical studies further revealed the occurrence of myeloid sarcoma that involved the gastrointestinal tract...
  25. ncbi request reprint Carditis: a manifestation of gastroesophageal reflux disease
    R Der
    Department of Surgical Pathology, Foregut Surgery, Keck School of Medicine at the University of Southern California, Los Angeles, USA
    Am J Surg Pathol 25:245-52. 2001
    ..pylori gastritis develops, the infection frequently spreads to involve CM, resulting in acute inflammation with neutrophils that is superimposed on the chronic inflammation already present...
  26. pmc Curative resection for esophageal adenocarcinoma: analysis of 100 en bloc esophagectomies
    J A Hagen
    Department of Surgery, Keck School of Medicine, University of Southern California, 1510 San Pablo St, Los Angeles, CA 90033, USA
    Ann Surg 234:520-30; discussion 530-1. 2001
    ..Local control is excellent after en bloc resection. The extent of disease associated with tumors confined to the mucosa and submucosa provides justification for more limited and less morbid resections...
  27. ncbi request reprint Laparoscopic ultrasonic epithelial ablation of the lower esophagus after nissen fundoplication in a porcine model: assessment of tissue damage and healing process
    P I Tsai
    Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, USA
    Am Surg 67:1178-80. 2001
    ..No stricture formation was seen. We conclude that the CUSA technique can completely ablate Barrett's mucosa in the setting of a prior antireflux procedure. Healing with squamous mucosal regeneration is rapid and complete...
  28. pmc Prediction of patients with acute cholecystitis requiring emergent cholecystectomy: a simple score
    Wael N Yacoub
    Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
    Gastroenterol Res Pract 2010:901739. 2010
    ..5 points). A cutoff score of 2 identified 31 (69%) patients with no acute inflammation (PPV 90%). This scoring system can prioritize patients for emergent cholecystectomy based on their expected pathology...
  29. ncbi request reprint Barrett's esophagus can and does regress after antireflux surgery: a study of prevalence and predictive features
    Richard R Gurski
    Department of Surgery, Division of Thoracic and Foregut Surgery, University of Southern California, Los Angeles, CA 90033, USA
    J Am Coll Surg 196:706-12; discussion 712-3. 2003
    ..To investigate the factors leading to histologic regression of metaplastic and dysplastic Barrett's esophagus (BE)...
  30. ncbi request reprint Clinical biology and surgical therapy of intramucosal adenocarcinoma of the esophagus
    Daniel S Oh
    Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    J Am Coll Surg 203:152-61. 2006
    ..Acceptance of these alternative therapies requires an understanding of the clinical biology of IMC and the results of surgical resection modified for treatment of early disease...
  31. ncbi request reprint Cytokeratin and DAS-1 immunostaining reveal similarities among cardiac mucosa, CIM, and Barrett's esophagus
    Steven R Demeester
    Department of Cardiothoracic Surgery, The University of Southern California, Keck School of Medicine, Los Angeles, USA
    Am J Gastroenterol 97:2514-23. 2002
    ..We hypothesized that the immunostaining patterns of these foregut tissues would provide insight into the nature and etiology of cardiac mucosa and CIM...
  32. ncbi request reprint Quantitative, tissue-specific analysis of cyclooxygenase gene expression in the pathogenesis of Barrett's adenocarcinoma
    Hidekazu Kuramochi
    From the Department of Biochemistry and Molecular Biology, USC Norris Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    J Gastrointest Surg 8:1007-16; discussion 1016-7. 2004
    ..These results confirm the important role of Cox-2 amplification in the pathogenesis of esophageal adenocarcinoma, but the unexpected down-regulation of Cox-1 raises questions about its role in carcinogenesis...
  33. doi request reprint Histopathology of the endoscopic esophagogastric junction in patients with gastroesophageal reflux disease
    Claudia Ringhofer
    University Clinic of Surgery, Medical University Vienna, Austria
    Wien Klin Wochenschr 120:350-9. 2008
    ..We compared endoscopy and histopathology of the esophagogastric junction in patients with gastroesophageal reflux disease...
  34. ncbi request reprint Body mass index is associated with Barrett esophagus and cardiac mucosal metaplasia
    Xiangdong Bu
    Department of Surgical Pathology, University of Southern California, Keck School of Medicine and LAC USC Medical Center, Room 16 905, 1200 N State Street, Los Angeles, California 90033, USA
    Dig Dis Sci 51:1589-94. 2006
    ..04). In conclusion, BMI is associated with BE and CM and appears to act early in the sequence of events leading from gastroesophageal reflux disease to metaplasia (CM and BE) to dysplasia and finally to adenocarcinoma...
  35. ncbi request reprint Molecular determinants in targeted therapy for esophageal adenocarcinoma
    Daniel Vallbohmer
    Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, USA
    Arch Surg 141:476-81; discussion 481-2. 2006
    ..Cyclooxygenase 2 (COX-2), vascular endothelial growth factor (VEGF), and epidermal growth factor receptor (EGFR) are useful biological determinants in targeted therapy for esophageal adenocarcinoma...
  36. ncbi request reprint Antireflux surgery normalizes cyclooxygenase-2 expression in squamous epithelium of the distal esophagus
    Daniel Vallbohmer
    Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Am J Gastroenterol 101:1458-66. 2006
    ..Further, we hypothesized that Cox-2 expression in the squamous mucosa would be reduced following the elimination of reflux with an antireflux operation...
  37. ncbi request reprint Survivin, a potential biomarker in the development of Barrett's adenocarcinoma
    Daniel Vallbohmer
    Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, USA
    Surgery 138:701-6; discussion 706-7. 2005
    ..The aim of this study was to measure survivin gene expression in normal squamous/columnar epithelium and in the various stages of development of Barrett's adenocarcinoma...
  38. ncbi request reprint Towards the molecular characterization of disease: comparison of molecular and histological analysis of esophageal epithelia
    Daniel Vallbohmer
    Department of Surgery, University of Southern California, Los Angeles, CA, USA
    J Gastrointest Surg 11:1095-104. 2007
    ..When differences occur, it is unclear whether this effect is due to intraobserver variability in pathological diagnosis or to a genuine difference between gene expression and histopathology...
  39. doi request reprint Lack of reversal of carditis by PPI therapy only means that acid in refluxate is not responsible for carditis
    Parakrama T Chandrasoma
    Dig Dis Sci 53:1426-7. 2008
  40. ncbi request reprint Increasing cyclooxygenase-2 (cox-2) gene expression in the progression of Barrett's esophagus to adenocarcinoma correlates with that of Bcl-2
    Daisuke Shimizu
    Department of Biochemistry and Molecular Biology, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90033, USA
    Int J Cancer 119:765-70. 2006
    ..0053, p = 0.0220) and adenocarcinoma (p < 0.0001, p < 0.0001) compared to squamous epithelium or reflux-esophagitis. Furthermore, there is a significant correlation between these two genes, especially in carcinoma (p < 0.0001)...
  41. ncbi request reprint Microcalcification in the breast and the pathologist
    Parakrama T Chandrasoma
    Am J Surg Pathol 26:135-6. 2002
  42. ncbi request reprint Detection of Barrett's epithelium by acoustic microscopy
    Kumari S Wickramasinghe
    Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Ultrasound Med Biol 28:203-7. 2002
    ....