Bysani Chandrasekar

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. ncbi Calorie restriction attenuates inflammatory responses to myocardial ischemia-reperfusion injury
    B Chandrasekar
    Division of Cardiology, University of Texas Health Science Center, San Antonio, 78229 3900, Texas, USA
    Am J Physiol Heart Circ Physiol 280:H2094-102. 2001
  2. ncbi Activation of intrinsic and extrinsic proapoptotic signaling pathways in interleukin-18-mediated human cardiac endothelial cell death
    Bysani Chandrasekar
    Department of Medicine, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    J Biol Chem 279:20221-33. 2004
  3. ncbi Beta-adrenergic stimulation induces interleukin-18 expression via beta2-AR, PI3K, Akt, IKK, and NF-kappaB
    Bysani Chandrasekar
    Division of Cardiology, The University of Texas Health Science Center, San Antonio, TX, USA
    Biochem Biophys Res Commun 319:304-11. 2004
  4. pmc Fractalkine (CX3CL1) stimulated by nuclear factor kappaB (NF-kappaB)-dependent inflammatory signals induces aortic smooth muscle cell proliferation through an autocrine pathway
    Bysani Chandrasekar
    Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Biochem J 373:547-58. 2003
  5. ncbi TNF-alpha and H2O2 induce IL-18 and IL-18R beta expression in cardiomyocytes via NF-kappa B activation
    Bysani Chandrasekar
    Department of Medicine Cardiology, University of Texas Health Science Center, San Antonio 78229, USA
    Biochem Biophys Res Commun 303:1152-8. 2003
  6. ncbi The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88, interleukin-1 receptor-associated kinase, tumor necrosis factor receptor-associated factor 6, c-Src, phosphatidylinositol 3-kinase, Akt, c-J
    Bysani Chandrasekar
    Department of Medicine, Medicine Cardiology, The University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Biol Chem 280:26263-77. 2005
  7. ncbi Interleukin-18 induces human cardiac endothelial cell death via a novel signaling pathway involving NF-kappaB-dependent PTEN activation
    Bysani Chandrasekar
    Department of Medicine Cardiology, The University of Texas Health Science Center, San Antonio, TX 78229, USA
    Biochem Biophys Res Commun 339:956-63. 2006
  8. ncbi Chemokine-cytokine cross-talk. The ELR+ CXC chemokine LIX (CXCL5) amplifies a proinflammatory cytokine response via a phosphatidylinositol 3-kinase-NF-kappa B pathway
    Bysani Chandrasekar
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Biol Chem 278:4675-86. 2003
  9. ncbi CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation
    Bysani Chandrasekar
    Department of Medicine, The University of Texas Health Science Center, San Antonio, Texas 78229 390, USA
    J Biol Chem 279:3188-96. 2004
  10. ncbi Interleukin-18 suppresses adiponectin expression in 3T3-L1 adipocytes via a novel signal transduction pathway involving ERK1/2-dependent NFATc4 phosphorylation
    Bysani Chandrasekar
    Department of Veterans Affairs South Texas Veterans Health Care System, San Antonio, Texas 78229 4404, USA
    J Biol Chem 283:4200-9. 2008

Research Grants

Collaborators

Detail Information

Publications58

  1. ncbi Calorie restriction attenuates inflammatory responses to myocardial ischemia-reperfusion injury
    B Chandrasekar
    Division of Cardiology, University of Texas Health Science Center, San Antonio, 78229 3900, Texas, USA
    Am J Physiol Heart Circ Physiol 280:H2094-102. 2001
    ..Collectively these data indicate that CR significantly attenuates myocardial oxidative stress and the postischemic inflammatory response...
  2. ncbi Activation of intrinsic and extrinsic proapoptotic signaling pathways in interleukin-18-mediated human cardiac endothelial cell death
    Bysani Chandrasekar
    Department of Medicine, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    J Biol Chem 279:20221-33. 2004
    ..Taken together, our results indicate that IL-18 activates both intrinsic and extrinsic proapoptotic signaling pathways, induces endothelial cell death, and thereby may play a role in myocardial inflammation and injury...
  3. ncbi Beta-adrenergic stimulation induces interleukin-18 expression via beta2-AR, PI3K, Akt, IKK, and NF-kappaB
    Bysani Chandrasekar
    Division of Cardiology, The University of Texas Health Science Center, San Antonio, TX, USA
    Biochem Biophys Res Commun 319:304-11. 2004
    ..Similar events may occur in heart failure, a disease state characterized by sustained beta-AR activation...
  4. pmc Fractalkine (CX3CL1) stimulated by nuclear factor kappaB (NF-kappaB)-dependent inflammatory signals induces aortic smooth muscle cell proliferation through an autocrine pathway
    Bysani Chandrasekar
    Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Biochem J 373:547-58. 2003
    ..More importantly, fractalkine increased cell-cell adhesion and aortic SMC proliferation, indicating a role in initiation and progression of atherosclerotic vascular disease...
  5. ncbi TNF-alpha and H2O2 induce IL-18 and IL-18R beta expression in cardiomyocytes via NF-kappa B activation
    Bysani Chandrasekar
    Department of Medicine Cardiology, University of Texas Health Science Center, San Antonio 78229, USA
    Biochem Biophys Res Commun 303:1152-8. 2003
    ..Presence of both ligand and receptors suggests IL-18 impacts myocardial biology through an autocrine pathway...
  6. ncbi The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88, interleukin-1 receptor-associated kinase, tumor necrosis factor receptor-associated factor 6, c-Src, phosphatidylinositol 3-kinase, Akt, c-J
    Bysani Chandrasekar
    Department of Medicine, Medicine Cardiology, The University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Biol Chem 280:26263-77. 2005
    ..These data provide for the first time a mechanism of IL-18-mediated CXCL16 gene transcription and CXCL16-dependent ASMC proliferation and suggest a role for IL-18-CXCL16 cross-talk in atherogenesis and restenosis following angioplasty...
  7. ncbi Interleukin-18 induces human cardiac endothelial cell death via a novel signaling pathway involving NF-kappaB-dependent PTEN activation
    Bysani Chandrasekar
    Department of Medicine Cardiology, The University of Texas Health Science Center, San Antonio, TX 78229, USA
    Biochem Biophys Res Commun 339:956-63. 2006
    ....
  8. ncbi Chemokine-cytokine cross-talk. The ELR+ CXC chemokine LIX (CXCL5) amplifies a proinflammatory cytokine response via a phosphatidylinositol 3-kinase-NF-kappa B pathway
    Bysani Chandrasekar
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Biol Chem 278:4675-86. 2003
    ..Thus, in addition to attracting and activating neutrophils, the ELR(+) CXC chemokines amplify the inflammatory cascade, stimulating local production of cytokines that have negative inotropic and proapoptotic effects...
  9. ncbi CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation
    Bysani Chandrasekar
    Department of Medicine, The University of Texas Health Science Center, San Antonio, Texas 78229 390, USA
    J Biol Chem 279:3188-96. 2004
    ..Most importantly, CXCL16 increased cell-cell adhesion and induced kappa B-dependent ASMC proliferation, indicating that CXCL16 may play an important role in the development and progression of atherosclerotic vascular disease...
  10. ncbi Interleukin-18 suppresses adiponectin expression in 3T3-L1 adipocytes via a novel signal transduction pathway involving ERK1/2-dependent NFATc4 phosphorylation
    Bysani Chandrasekar
    Department of Veterans Affairs South Texas Veterans Health Care System, San Antonio, Texas 78229 4404, USA
    J Biol Chem 283:4200-9. 2008
    ..Thus, targeting IL-18 expression may enhance adiponectin expression and mitigate disease progression...
  11. ncbi Ischemia-reperfusion of rat myocardium activates nuclear factor-KappaB and induces neutrophil infiltration via lipopolysaccharide-induced CXC chemokine
    B Chandrasekar
    Department of Medicine, University of Texas Health Science Center at San Antonio, South Texas Veterans Healthcare System, Audie Murphy Division, San Antonio, Texas, USA
    Circulation 103:2296-302. 2001
    ..The goals of the present study were to evaluate the roles of these chemokines in a rat model of ischemia/reperfusion and to examine the mechanisms of chemokine induction by oxidative stress and cytokines in cultured cardiomyocytes...
  12. ncbi Interleukin-18-induced human coronary artery smooth muscle cell migration is dependent on NF-kappaB- and AP-1-mediated matrix metalloproteinase-9 expression and is inhibited by atorvastatin
    Bysani Chandrasekar
    Department of Veterans Affairs South Texas Veterans Health Care System, San Antonio, Texas 78229 4404, USA
    J Biol Chem 281:15099-109. 2006
    ..Atorvastatin inhibits IL-18-mediated aortic SMC migration and has therapeutic potential for attenuating the progression of atherosclerosis and restenosis...
  13. pmc Adiponectin blocks interleukin-18-mediated endothelial cell death via APPL1-dependent AMP-activated protein kinase (AMPK) activation and IKK/NF-kappaB/PTEN suppression
    Bysani Chandrasekar
    Department of Veterans Affairs South Texas Veterans Health Care System, San Antonio, Texas 78229, USA
    J Biol Chem 283:24889-98. 2008
    ....
  14. ncbi IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK- and ERK1/2-dependent C/EBP-beta , NF-kappaB, and AP-1 activation
    Dolores M Cortez
    Department of Veterans Affairs South Texas Veterans Health Care System, The University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Am J Physiol Heart Circ Physiol 293:H3356-65. 2007
    ..Our data indicate that IL-17 induces MMP-1 in human cardiac fibroblasts directly via p38 MAPK- and ERK-dependent AP-1, NF-kappaB, and C/EBP-beta activation and suggest that IL-17 may play a critical role in myocardial remodeling...
  15. ncbi Interleukin-18 is a pro-hypertrophic cytokine that acts through a phosphatidylinositol 3-kinase-phosphoinositide-dependent kinase-1-Akt-GATA4 signaling pathway in cardiomyocytes
    Bysani Chandrasekar
    Department of Medicine, The University of Texas Health Science Center, San Antonio, Texas 78229, USA
    J Biol Chem 280:4553-67. 2005
    ....
  16. pmc Neutralization of interleukin-18 ameliorates ischemia/reperfusion-induced myocardial injury
    Kaliyamurthi Venkatachalam
    Department of Veterans Affairs South Texas Veterans Health Care System and the Departments of Medicine and Surgery, University of Texas Health Science Center, San Antonio, Texas 78229, USA
    J Biol Chem 284:7853-65. 2009
    ..These results indicate that IL-18 plays a critical role in I/R injury and thus represents a promising therapeutic target...
  17. doi Resveratrol inhibits high glucose-induced PI3K/Akt/ERK-dependent interleukin-17 expression in primary mouse cardiac fibroblasts
    Kaliyamurthi Venkatachalam
    Department of Veterans Affairs, South Texas Veterans Health Care System Audie L Murphy Division, San Antonio, TX 78229 3900, USA
    Am J Physiol Heart Circ Physiol 294:H2078-87. 2008
    ..Thus, in hyperglycemic conditions, IL-17 may potentiate myocardial inflammation, injury, and remodeling through autocrine and paracrine mechanisms, and resveratrol has therapeutic potential in ameliorating this effect...
  18. pmc WISP1, a pro-mitogenic, pro-survival factor, mediates tumor necrosis factor-alpha (TNF-alpha)-stimulated cardiac fibroblast proliferation but inhibits TNF-alpha-induced cardiomyocyte death
    Kaliyamurthi Venkatachalam
    Department of Veterans Affairs, South Texas Veterans Health Care System, TX 78229, USA
    J Biol Chem 284:14414-27. 2009
    ..Our results suggest that a TNF-alpha/WISP1 signaling pathway may contribute to post-infarct cardiac remodeling, a condition characterized by fibrosis and progressive cardiomyocyte loss...
  19. ncbi Interleukin-18 stimulates fibronectin expression in primary human cardiac fibroblasts via PI3K-Akt-dependent NF-kappaB activation
    Venkatapuram Seenu Reddy
    Department of Surgery, University of Texas Health Science Center, San Antonio, Texas, USA
    J Cell Physiol 215:697-707. 2008
    ....
  20. pmc Interleukin-18 induces EMMPRIN expression in primary cardiomyocytes via JNK/Sp1 signaling and MMP-9 in part via EMMPRIN and through AP-1 and NF-kappaB activation
    Venkatapuram Seenu Reddy
    Cardiothoracic Surgery, University of Texas Health Science Center, San Antonio, Texas, USA
    Am J Physiol Heart Circ Physiol 299:H1242-54. 2010
    ..Therefore, targeting IL-18 or its signaling pathways may be of potential therapeutic benefit in adverse remodeling...
  21. pmc Angiotensin II enhances AT1-Nox1 binding and stimulates arterial smooth muscle cell migration and proliferation through AT1, Nox1, and interleukin-18
    Anthony J Valente
    Medicine, University of Texas Health Science Center, San Antonio, USA
    Am J Physiol Heart Circ Physiol 303:H282-96. 2012
    ..The ANG II/Nox1/IL-18 pathway may be critical in hyperplastic vascular diseases, including atherosclerosis and restenosis...
  22. pmc Interleukin-18/WNT1-inducible signaling pathway protein-1 signaling mediates human saphenous vein smooth muscle cell proliferation
    Venkatapuram Seenu Reddy
    Cardiothoracic Surgery, University of Texas Health Science Center, San Antonio, Texas
    J Cell Physiol 226:3303-15. 2011
    ....
  23. ncbi Phosphatidylinositol 3-kinase regulates bone morphogenetic protein-2 (BMP-2)-induced myocyte enhancer factor 2A-dependent transcription of BMP-2 gene in cardiomyocyte precursor cells
    Nandini Ghosh-Choudhury
    Department of Pathology, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    J Biol Chem 278:21998-2005. 2003
    ..Together these data provide the first evidence that BMP-2-induced PI 3-kinase signaling regulates MEF-2A expression and define a mechanism of MEF-2A-dependent BMP-2 transcription...
  24. pmc Advanced oxidation protein products induce cardiomyocyte death via Nox2/Rac1/superoxide-dependent TRAF3IP2/JNK signaling
    Anthony J Valente
    Medicine, University of Texas Health Science Center and South Texas Veterans Health Care System, San Antonio, TX 78229, USA
    Free Radic Biol Med 60:125-35. 2013
    ..Thus TRAF3IP2 may represent a potential therapeutic target in ischemic heart disease...
  25. pmc Interleukin-17A stimulates cardiac fibroblast proliferation and migration via negative regulation of the dual-specificity phosphatase MKP-1/DUSP-1
    Anthony J Valente
    Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229, United States
    Cell Signal 24:560-8. 2012
    ..These studies support a potential role for IL-17 in cardiac fibrosis and adverse myocardial remodeling...
  26. pmc Carbon monoxide donors or heme oxygenase-1 (HO-1) overexpression blocks interleukin-18-mediated NF-kappaB-PTEN-dependent human cardiac endothelial cell death
    Miguel Zabalgoitia
    Department of Veterans Affairs South Texas Veterans Health Care System, San Antonio, TX 78229, USA
    Free Radic Biol Med 44:284-98. 2008
    ..Thus, HO-1 inducers and CO donors may have the therapeutic potential to effectively block IL-18 signaling and reduce IL-18-dependent vascular injury and inflammation...
  27. pmc Interleukin-17 stimulates C-reactive protein expression in hepatocytes and smooth muscle cells via p38 MAPK and ERK1/2-dependent NF-kappaB and C/EBPbeta activation
    Devang N Patel
    Department of Veterans Affairs, South Texas Veterans Health Care System, San Antonio, TX 78229 4404, USA
    J Biol Chem 282:27229-38. 2007
    ....
  28. pmc Interleukin-18 enhances IL-18R/Nox1 binding, and mediates TRAF3IP2-dependent smooth muscle cell migration. Inhibition by simvastatin
    Anthony J Valente
    Medicine, University of Texas Health Science Center and South Texas Veterans Health Care System, San Antonio, TX 78229, United States
    Cell Signal 25:1447-56. 2013
    ..Further, Simvastatin inhibits inducible, but not ectopically-xpressed TRAF3IP2. Targeting TRAF3IP2 may blunt progression of hyperplastic vascular diseases in vivo...
  29. pmc Chronic oral exposure to the aldehyde pollutant acrolein induces dilated cardiomyopathy
    Mohamed Ameen Ismahil
    Department of Medicine, Institute of Molecular Cardiology, University of Louisville, Louisville, KY 40202, USA
    Am J Physiol Heart Circ Physiol 301:H2050-60. 2011
    ..Human exposure to acrolein may have analogous effects and raise consideration of an environmental, aldehyde-mediated basis for heart failure...
  30. pmc Resveratrol blocks interleukin-18-EMMPRIN cross-regulation and smooth muscle cell migration
    Balachandar Venkatesan
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Am J Physiol Heart Circ Physiol 297:H874-86. 2009
    ..Resveratrol, via its antioxidant and anti-inflammatory properties, has the potential to inhibit the progression of atherosclerosis by blocking IL-18 and EMMPRIN cross-regulation and SMC migration...
  31. ncbi BMP-2 regulates cardiomyocyte contractility in a phosphatidylinositol 3 kinase-dependent manner
    Nandini Ghosh-Choudhury
    Department of Pathology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, 78229, USA
    FEBS Lett 544:181-4. 2003
    ..Also we provide the first evidence that BMP-2-induced PI 3 kinase activity regulates this cardiomyocyte function...
  32. pmc Interleukin-18 knockout mice display maladaptive cardiac hypertrophy in response to pressure overload
    James T Colston
    South Texas Veterans Health Care System, San Antonio, TX, USA
    Biochem Biophys Res Commun 354:552-8. 2007
    ....
  33. ncbi beta-adrenergic blockade in developing heart failure: effects on myocardial inflammatory cytokines, nitric oxide, and remodeling
    S D Prabhu
    Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Circulation 101:2103-9. 2000
    ..Whether beta-adrenergic blockade modulates myocardial expression of inflammatory cytokines and nitric oxide (NO) in heart failure is unclear...
  34. pmc CIKS (Act1 or TRAF3IP2) mediates Angiotensin-II-induced Interleukin-18 expression, and Nox2-dependent cardiomyocyte hypertrophy
    Anthony J Valente
    Medicine, University of Texas Health Science Center and South Texas Veterans Health Care System, San Antonio, TX 78229, USA
    J Mol Cell Cardiol 53:113-24. 2012
    ..CIKS is a potential therapeutic target in cardiac hypertrophy, fibrosis, and congestive heart failure...
  35. doi Interaction of endothelial cells with self-assembled monolayers for potential use in drug-eluting coronary stents
    Gopinath Mani
    Department of Biomedical Engineering, College of Engineering, The University of Texas at San Antonio, San Antonio, Texas 78249 0619, USA
    J Biomed Mater Res B Appl Biomater 90:789-801. 2009
    ..Thus, this study demonstrated that SAMs and TSAMs do not elicit an adverse response from endothelial cells in in vitro conditions...
  36. ncbi Inhibition of inflammatory response in transgenic fat-1 mice on a calorie-restricted diet
    Arunabh Bhattacharya
    Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Biochem Biophys Res Commun 349:925-30. 2006
    ..These results suggest that n-3 lipids with moderate CR may confer protection in autoimmune and inflammatory diseases...
  37. ncbi Reduced nitric oxide synthase 2 (NOS2) promoter activity in the Syrian hamster renders the animal functionally deficient in NOS2 activity and unable to control an intracellular pathogen
    Luis E Perez
    Research Service, Department of Veterans Affairs Medical Center, South Texas Veterans Health Care System, 7400 Merton Minter Drive, San Antonio, TX 78229, USA
    J Immunol 176:5519-28. 2006
    ....
  38. ncbi Decreased pro-inflammatory cytokines and increased antioxidant enzyme gene expression by omega-3 lipids in murine lupus nephritis
    B Chandrasekar
    Department of Medicine, University of Texas Health Science Center, San Antonio 78284 7874
    Biochem Biophys Res Commun 200:893-8. 1994
    ....
  39. pmc TRAF3IP2 mediates interleukin-18-induced cardiac fibroblast migration and differentiation
    Anthony J Valente
    Medicine, University of Texas Health Science Center and South Texas Veterans Health Care System, San Antonio, TX 78229, USA
    Cell Signal 25:2176-84. 2013
    ..These results indicate that TRAF3IP2 is a critical intermediate in IL-18-induced CF migration and differentiation in vitro. TRAF3IP2 could serve as a potential therapeutic target in cardiac fibrosis and adverse remodeling in vivo. ..
  40. ncbi A novel peroxide-induced calcium transient regulates interleukin-6 expression in cardiac-derived fibroblasts
    James T Colston
    Division of Cardiology, University of Texas Health Science Center, South Texas Veterans Health Care System, Audie L Murphy Division, San Antonio, Texas 78284 7872, USA
    J Biol Chem 277:23477-83. 2002
    ..Furthermore, brief H(2)O(2) exposure led to calcium-dependent IL-6 expression...
  41. pmc Malnutrition alters the innate immune response and increases early visceralization following Leishmania donovani infection
    G M Anstead
    Medical Service, Department of Veterans Affairs Medical Center, South Texas Veterans Health Care System, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900, USA
    Infect Immun 69:4709-18. 2001
    ..Thus, malnutrition causes a failure of lymph node barrier function after L. donovani infection, which may be related to excessive production of PGE(2) and decreased levels of IL-10 and nitric oxide...
  42. ncbi Lipid peroxidation-derived aldehydes and oxidative stress in the failing heart: role of aldose reductase
    Sanjay Srivastava
    Department of Medicine Cardiology, University of Louisville Health Sciences Center, Kentucky 40202, USA
    Am J Physiol Heart Circ Physiol 283:H2612-9. 2002
    ..Reduced AR-mediated LP-DA metabolism contributes importantly to LP-DA accumulation in the failing heart and thus may augment chronic oxidative injury...
  43. ncbi TLR4-NOX4-AP-1 signaling mediates lipopolysaccharide-induced CXCR6 expression in human aortic smooth muscle cells
    Devang N Patel
    Department of Veterans Affairs South Texas Veterans Health Care System, San Antonio, TX, USA
    Biochem Biophys Res Commun 347:1113-20. 2006
    ..These results demonstrate that LPS-TLR4-NOX4-AP-1 signaling can induce CXCR6 expression in ASMC, and suggest that the CXCL16-CXCR6 axis may be an important proinflammatory pathway in the pathogenesis of atherosclerosis...
  44. ncbi Ultrasound-targeted antisense oligonucleotide attenuates ischemia/reperfusion-induced myocardial tumor necrosis factor-alpha
    John M Erikson
    Department of Medicine, Division of Cardiology, M C 7872, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    J Mol Cell Cardiol 35:119-30. 2003
    ..Thus, ultrasound-targeted antisense oligonucleotides can effectively attenuate post-ischemic cytokine expression when delivered in a clinically relevant time frame, obviating the need for pretreatment...
  45. pmc Docosahexaenoic acid-enriched fish oil attenuates kidney disease and prolongs median and maximal life span of autoimmune lupus-prone mice
    Ganesh V Halade
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    J Immunol 184:5280-6. 2010
    ....
  46. doi Periodontal disease in association with systemic levels of interleukin-18 and CXC ligand 16 in patients undergoing cardiac catheterization
    Rachel A Schallhorn
    Department of Periodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    J Periodontol 81:1180-6. 2010
    ..This research study correlates periodontal parameters with systemic levels of IL-18 and CXCL16...
  47. ncbi Multinutrient undernutrition dysregulates the resident macrophage proinflammatory cytokine network, nuclear factor-kappaB activation, and nitric oxide production
    Gregory M Anstead
    Medical Service, Department of Veterans Affairs Medical Center, South Texas Veterans Health Care System, San Antonio, TX, USA
    J Leukoc Biol 74:982-91. 2003
    ..The late activation of NF-kappaB in the macrophages from malnourished mice is due to absence of negative feedback from NO...
  48. pmc Cloning of Syrian hamster (Mesocricetus auratus) cytokine cDNAs and analysis of cytokine mRNA expression in experimental visceral leishmaniasis
    P C Melby
    Department of Veterans Affairs Medical Center, and Department of Medicine, The University of Texas Health Science Center, San Antonio 78284 7881, USA
    Infect Immun 66:2135-42. 1998
    ....
  49. ncbi Wnt-induced secreted protein-1 is a prohypertrophic and profibrotic growth factor
    J T Colston
    Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Am J Physiol Heart Circ Physiol 293:H1839-46. 2007
    ..WISP-1 stimulates cardiomyocyte hypertrophy, fibroblast proliferation, and ECM expression in vitro. These results suggest that WISP-1 may play a critical role in post-myocardial infarction remodeling...
  50. ncbi Chronic beta-adrenergic stimulation induces myocardial proinflammatory cytokine expression
    D R Murray
    Department of Medicine Cardiology, University of Texas Health Science Center at San Antonio, South Texas Veterans Healthcare System Audie Murphy Division, San Antonio, Texas, USA
    Circulation 101:2338-41. 2000
    ....
  51. ncbi The hamster as a model of human visceral leishmaniasis: progressive disease and impaired generation of nitric oxide in the face of a prominent Th1-like cytokine response
    P C Melby
    Medical Service, Department of Veterans Affairs Medical Center, South Texas Veterans Health Care System, San Antonio, TX 78284, USA
    J Immunol 166:1912-20. 2001
    ..Thus, although a Th1-like cytokine response was prominent, the major antileishmanial effector mechanism that is responsible for control of infection in mice was absent throughout the course of progressive VL in the hamster...
  52. ncbi NF-kappa B inhibition markedly enhances sensitivity of resistant breast cancer tumor cells to tamoxifen
    L A DeGraffenried
    Department of Medicine, UT Health Science Center at San Antonio, TX 78229, USA
    Ann Oncol 15:885-90. 2004
    ....
  53. ncbi Beta-adrenergic receptor blockade modulates Bcl-X(S) expression and reduces apoptosis in failing myocardium
    Sumanth D Prabhu
    Department of Medicine, University of Louisville Health Sciences Center, Louisville, KY, USA
    J Mol Cell Cardiol 35:483-93. 2003
    ..beta-AR blockade in HF reduces myocardial apoptosis; attenuation of Bcl-X(S) expression may be one mechanism underlying this effect...
  54. ncbi Calorie restriction modulates lymphocyte subset phenotype and increases apoptosis in MRL/lpr mice
    X Luan
    Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78284, USA
    Immunol Lett 47:181-6. 1995
    ....
  55. ncbi Genotype effects on the antioxidant enzymes activity and mRNA expression in liver and kidney tissues of autoimmune-prone MRL/MpJ-lpr/lpr mice
    J T Venkatraman
    Department of Medicine, University of Texas Health Science Center, San Antonio 78284 7874
    Biochim Biophys Acta 1213:167-75. 1994
    ..abstract truncated at 250 words)..
  56. ncbi Downregulation of CuZn-superoxide dismutase contributes to beta-adrenergic receptor-mediated oxidative stress in the heart
    Sanjay Srivastava
    Louisville VAMC and Institute of Molecular Cardiology, Department of Medicine, University of Louisville, Louisville, KY 40202, United States
    Cardiovasc Res 74:445-55. 2007
    ..Sustained beta-adrenergic receptor (beta-AR) activation augments oxidative stress in the heart; whether alterations in antioxidant enzymes contribute to this effect is unknown...
  57. ncbi The site of cutaneous infection influences the immunological response and clinical outcome of hamsters infected with Leishmania panamensis
    Yaneth Osorio
    Centro Internacional de Entrenamiento e Investigaciones Medicas CIDEIM, AA5390, Cali, Colombia
    Parasite Immunol 25:139-48. 2003
    ....
  58. pmc Gender is a major determinant of the clinical evolution and immune response in hamsters infected with Leishmania spp
    Bruno L Travi
    Centro Internacional de Entrenamiento e Investigaciones Medicas CIDEIM, Cali, Colombia
    Infect Immun 70:2288-96. 2002
    ..873; P < 0.001). These findings demonstrate an inherent risk of increased disease severity in male animals, which is associated with a more permissive immune response...

Research Grants5

  1. Chemokines, nitric oxide, and myocardial depression
    Bysani Chandrasekar; Fiscal Year: 2005
    ..The results from these studies will further our knowledge of chemokine biology and lead to new therapeutic strategies to prevent or treat myocardial dysfunction in ischemia-reperfusion injury. ..
  2. The role of interleukin-18 in myocardial hypertrophy and failure
    Bysani Chandrasekar; Fiscal Year: 2009
    ..The primary goal of this proposal is to better understand the role of inflammatory cytokines, interleukin-18 in particular, in myocardial hypertrophy and its transition to failure. ..