Bysani Chandrasekar

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. Chandrasekar B, Bysani S, Mummidi S. CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation. J Biol Chem. 2004;279:3188-96 pubmed
    ..Most importantly, CXCL16 increased cell-cell adhesion and induced kappa B-dependent ASMC proliferation, indicating that CXCL16 may play an important role in the development and progression of atherosclerotic vascular disease. ..
  2. Chandrasekar B, Valente A, Freeman G, Mahimainathan L, Mummidi S. Interleukin-18 induces human cardiac endothelial cell death via a novel signaling pathway involving NF-kappaB-dependent PTEN activation. Biochem Biophys Res Commun. 2006;339:956-63 pubmed
    ....
  3. Chandrasekar B, Patel D, Mummidi S, Kim J, Clark R, Valente A. Interleukin-18 suppresses adiponectin expression in 3T3-L1 adipocytes via a novel signal transduction pathway involving ERK1/2-dependent NFATc4 phosphorylation. J Biol Chem. 2008;283:4200-9 pubmed
    ..Thus, targeting IL-18 expression may enhance adiponectin expression and mitigate disease progression. ..
  4. Chandrasekar B, Boylston W, Venkatachalam K, Webster N, Prabhu S, Valente A. Adiponectin blocks interleukin-18-mediated endothelial cell death via APPL1-dependent AMP-activated protein kinase (AMPK) activation and IKK/NF-kappaB/PTEN suppression. J Biol Chem. 2008;283:24889-98 pubmed publisher
    ....
  5. Chandrasekar B, Nelson J, Colston J, Freeman G. Calorie restriction attenuates inflammatory responses to myocardial ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2001;280:H2094-102 pubmed
    ..Collectively these data indicate that CR significantly attenuates myocardial oxidative stress and the postischemic inflammatory response...
  6. Chandrasekar B, Smith J, Freeman G. Ischemia-reperfusion of rat myocardium activates nuclear factor-KappaB and induces neutrophil infiltration via lipopolysaccharide-induced CXC chemokine. Circulation. 2001;103:2296-302 pubmed
    ..Although KC and MIP-2 are expressed by inflammatory cells infiltrating the myocardium during reperfusion after ischemia, neutrophil recruitment to reperfused rat myocardium is mainly due to cardiomyocyte expression of LIX. ..
  7. Chandrasekar B, Melby P, Sarau H, Raveendran M, Perla R, Marelli Berg F, et al. Chemokine-cytokine cross-talk. The ELR+ CXC chemokine LIX (CXCL5) amplifies a proinflammatory cytokine response via a phosphatidylinositol 3-kinase-NF-kappa B pathway. J Biol Chem. 2003;278:4675-86 pubmed
    ..Thus, in addition to attracting and activating neutrophils, the ELR(+) CXC chemokines amplify the inflammatory cascade, stimulating local production of cytokines that have negative inotropic and proapoptotic effects. ..
  8. Chandrasekar B, Colston J, de la Rosa S, Rao P, Freeman G. TNF-alpha and H2O2 induce IL-18 and IL-18R beta expression in cardiomyocytes via NF-kappa B activation. Biochem Biophys Res Commun. 2003;303:1152-8 pubmed
    ..Presence of both ligand and receptors suggests IL-18 impacts myocardial biology through an autocrine pathway. ..
  9. Chandrasekar B, Marelli Berg F, Tone M, Bysani S, Prabhu S, Murray D. Beta-adrenergic stimulation induces interleukin-18 expression via beta2-AR, PI3K, Akt, IKK, and NF-kappaB. Biochem Biophys Res Commun. 2004;319:304-11 pubmed
    ..Similar events may occur in heart failure, a disease state characterized by sustained beta-AR activation. ..
  10. Chandrasekar B, Mummidi S, Valente A, Patel D, Bailey S, Freeman G, et al. The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88, interleukin-1 receptor-associated kinase, tumor necrosis factor receptor-associated factor 6, c-Src, phosphatidylinositol 3-kinase, Akt. J Biol Chem. 2005;280:26263-77 pubmed
    ..These data provide for the first time a mechanism of IL-18-mediated CXCL16 gene transcription and CXCL16-dependent ASMC proliferation and suggest a role for IL-18-CXCL16 cross-talk in atherogenesis and restenosis following angioplasty. ..

Detail Information

Publications10

  1. Chandrasekar B, Bysani S, Mummidi S. CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation. J Biol Chem. 2004;279:3188-96 pubmed
    ..Most importantly, CXCL16 increased cell-cell adhesion and induced kappa B-dependent ASMC proliferation, indicating that CXCL16 may play an important role in the development and progression of atherosclerotic vascular disease. ..
  2. Chandrasekar B, Valente A, Freeman G, Mahimainathan L, Mummidi S. Interleukin-18 induces human cardiac endothelial cell death via a novel signaling pathway involving NF-kappaB-dependent PTEN activation. Biochem Biophys Res Commun. 2006;339:956-63 pubmed
    ....
  3. Chandrasekar B, Patel D, Mummidi S, Kim J, Clark R, Valente A. Interleukin-18 suppresses adiponectin expression in 3T3-L1 adipocytes via a novel signal transduction pathway involving ERK1/2-dependent NFATc4 phosphorylation. J Biol Chem. 2008;283:4200-9 pubmed
    ..Thus, targeting IL-18 expression may enhance adiponectin expression and mitigate disease progression. ..
  4. Chandrasekar B, Boylston W, Venkatachalam K, Webster N, Prabhu S, Valente A. Adiponectin blocks interleukin-18-mediated endothelial cell death via APPL1-dependent AMP-activated protein kinase (AMPK) activation and IKK/NF-kappaB/PTEN suppression. J Biol Chem. 2008;283:24889-98 pubmed publisher
    ....
  5. Chandrasekar B, Nelson J, Colston J, Freeman G. Calorie restriction attenuates inflammatory responses to myocardial ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2001;280:H2094-102 pubmed
    ..Collectively these data indicate that CR significantly attenuates myocardial oxidative stress and the postischemic inflammatory response...
  6. Chandrasekar B, Smith J, Freeman G. Ischemia-reperfusion of rat myocardium activates nuclear factor-KappaB and induces neutrophil infiltration via lipopolysaccharide-induced CXC chemokine. Circulation. 2001;103:2296-302 pubmed
    ..Although KC and MIP-2 are expressed by inflammatory cells infiltrating the myocardium during reperfusion after ischemia, neutrophil recruitment to reperfused rat myocardium is mainly due to cardiomyocyte expression of LIX. ..
  7. Chandrasekar B, Melby P, Sarau H, Raveendran M, Perla R, Marelli Berg F, et al. Chemokine-cytokine cross-talk. The ELR+ CXC chemokine LIX (CXCL5) amplifies a proinflammatory cytokine response via a phosphatidylinositol 3-kinase-NF-kappa B pathway. J Biol Chem. 2003;278:4675-86 pubmed
    ..Thus, in addition to attracting and activating neutrophils, the ELR(+) CXC chemokines amplify the inflammatory cascade, stimulating local production of cytokines that have negative inotropic and proapoptotic effects. ..
  8. Chandrasekar B, Colston J, de la Rosa S, Rao P, Freeman G. TNF-alpha and H2O2 induce IL-18 and IL-18R beta expression in cardiomyocytes via NF-kappa B activation. Biochem Biophys Res Commun. 2003;303:1152-8 pubmed
    ..Presence of both ligand and receptors suggests IL-18 impacts myocardial biology through an autocrine pathway. ..
  9. Chandrasekar B, Marelli Berg F, Tone M, Bysani S, Prabhu S, Murray D. Beta-adrenergic stimulation induces interleukin-18 expression via beta2-AR, PI3K, Akt, IKK, and NF-kappaB. Biochem Biophys Res Commun. 2004;319:304-11 pubmed
    ..Similar events may occur in heart failure, a disease state characterized by sustained beta-AR activation. ..
  10. Chandrasekar B, Mummidi S, Valente A, Patel D, Bailey S, Freeman G, et al. The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88, interleukin-1 receptor-associated kinase, tumor necrosis factor receptor-associated factor 6, c-Src, phosphatidylinositol 3-kinase, Akt. J Biol Chem. 2005;280:26263-77 pubmed
    ..These data provide for the first time a mechanism of IL-18-mediated CXCL16 gene transcription and CXCL16-dependent ASMC proliferation and suggest a role for IL-18-CXCL16 cross-talk in atherogenesis and restenosis following angioplasty. ..