W L Chandler

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Effects of surgical trauma and cardiopulmonary bypass on active thrombin concentrations and the rate of thrombin inhibition in vivo
    Tomas Velan
    Department of Laboratory Medicine, University of Washington, Seattle, Wash 98195 7110, USA
    Pathophysiol Haemost Thromb 33:144-56. 2003
  2. pmc A community study of the effect of particulate matter on blood measures of inflammation and thrombosis in an elderly population
    Jeffrey H Sullivan
    University of Washington, Department of Environmental and Occupational Health Sciences, Seattle, WA, USA
    Environ Health 6:3. 2007
  3. ncbi request reprint Plasmin generation and D-dimer formation during cardiopulmonary bypass
    Wayne L Chandler
    Department of Laboratory Medicine, University of Washington, Seattle, Washington 98104, USA
    Blood Coagul Fibrinolysis 15:583-91. 2004
  4. ncbi request reprint Elevated hemostatic factor levels as potential risk factors for thrombosis
    Wayne L Chandler
    Department of Laboratory Medicine, University of Washington, Seattle 98195, USA
    Arch Pathol Lab Med 126:1405-14. 2002
  5. ncbi request reprint Factor XIIIA and clot strength after cardiopulmonary bypass
    W L Chandler
    Department of Laboratory Medicine, University of Washington, Seattle 98195, USA
    Blood Coagul Fibrinolysis 12:101-8. 2001
  6. ncbi request reprint Effects of hemodilution, blood loss, and consumption on hemostatic factor levels during cardiopulmonary bypass
    Wayne L Chandler
    Department of Laboratory Medicine, University of Washington, Harborview Medical Center, 325 9th Avenue, Seattle, WA 98104, USA
    J Cardiothorac Vasc Anesth 19:459-67. 2005
  7. ncbi request reprint Formation, inhibition and clearance of plasmin in vivo
    W L Chandler
    Department of Laboratory Medicine, University of Washington, Seattle, Wash, USA
    Haemostasis 30:204-18. 2000
  8. ncbi request reprint Measurement of different forms of tissue plasminogen activator in plasma
    W L Chandler
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA
    Clin Chem 46:38-46. 2000
  9. doi request reprint Development of a rapid emergency hemorrhage panel
    Wayne L Chandler
    Department of Laboratory Medicine, University of Washington, Seattle, Washington 98195, USA
    Transfusion 50:2547-52. 2010
  10. ncbi request reprint Estimating the rate of thrombin and fibrin generation in vivo during cardiopulmonary bypass
    Wayne L Chandler
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98195 7110, USA
    Blood 101:4355-62. 2003

Collaborators

Detail Information

Publications54

  1. ncbi request reprint Effects of surgical trauma and cardiopulmonary bypass on active thrombin concentrations and the rate of thrombin inhibition in vivo
    Tomas Velan
    Department of Laboratory Medicine, University of Washington, Seattle, Wash 98195 7110, USA
    Pathophysiol Haemost Thromb 33:144-56. 2003
    ..Both factors had returned to normal 2 h after surgery. We conclude that CPB with heparinization results in a rapid increase in thrombin inhibition leading to decreased active thrombin levels in vivo...
  2. pmc A community study of the effect of particulate matter on blood measures of inflammation and thrombosis in an elderly population
    Jeffrey H Sullivan
    University of Washington, Department of Environmental and Occupational Health Sciences, Seattle, WA, USA
    Environ Health 6:3. 2007
    ..We also hypothesized that elevated PM would increase levels of cytokines in individuals with heart disease...
  3. ncbi request reprint Plasmin generation and D-dimer formation during cardiopulmonary bypass
    Wayne L Chandler
    Department of Laboratory Medicine, University of Washington, Seattle, Washington 98104, USA
    Blood Coagul Fibrinolysis 15:583-91. 2004
    ....
  4. ncbi request reprint Elevated hemostatic factor levels as potential risk factors for thrombosis
    Wayne L Chandler
    Department of Laboratory Medicine, University of Washington, Seattle 98195, USA
    Arch Pathol Lab Med 126:1405-14. 2002
    ....
  5. ncbi request reprint Factor XIIIA and clot strength after cardiopulmonary bypass
    W L Chandler
    Department of Laboratory Medicine, University of Washington, Seattle 98195, USA
    Blood Coagul Fibrinolysis 12:101-8. 2001
    ..Maintenance of adequate platelet counts and factor XIIIA levels at the end of CPB may play a role in maintaining clot strength and reducing blood loss...
  6. ncbi request reprint Effects of hemodilution, blood loss, and consumption on hemostatic factor levels during cardiopulmonary bypass
    Wayne L Chandler
    Department of Laboratory Medicine, University of Washington, Harborview Medical Center, 325 9th Avenue, Seattle, WA 98104, USA
    J Cardiothorac Vasc Anesth 19:459-67. 2005
    ..The purpose of this study was to determine quantitatively the effects of consumption, hemodilution, and blood loss on coagulation and fibrinolytic factor levels during cardiopulmonary bypass...
  7. ncbi request reprint Formation, inhibition and clearance of plasmin in vivo
    W L Chandler
    Department of Laboratory Medicine, University of Washington, Seattle, Wash, USA
    Haemostasis 30:204-18. 2000
    ..The half-life of PAP was 4.5 +/- 1.6 h. In healthy subjects, the PAP level in plasma represents the average rate of plasminogen activation over the last 2-8 h...
  8. ncbi request reprint Measurement of different forms of tissue plasminogen activator in plasma
    W L Chandler
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA
    Clin Chem 46:38-46. 2000
    ..We evaluated assays to measure both total tissue plasminogen activator (tPA) and the three principle forms of tPA in plasma: active tPA, tPA complexed with plasminogen activator inhibitor type 1 (PAI-1), and tPA complexed with C1-inhibitor...
  9. doi request reprint Development of a rapid emergency hemorrhage panel
    Wayne L Chandler
    Department of Laboratory Medicine, University of Washington, Seattle, Washington 98195, USA
    Transfusion 50:2547-52. 2010
    ..Evaluation of hemostasis in bleeding patients requires both accuracy and speed...
  10. ncbi request reprint Estimating the rate of thrombin and fibrin generation in vivo during cardiopulmonary bypass
    Wayne L Chandler
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98195 7110, USA
    Blood 101:4355-62. 2003
    ....
  11. ncbi request reprint Reducing hemostatic activation during cardiopulmonary bypass: a combined approach
    Michael J Eisses
    Department of Anesthesiology, University of Washington School of Medicine, Seattle, 98105, USA
    Anesth Analg 98:1208-16, table of contents. 2004
    ..005). Overall, the combined strategy was associated with a reduction in CPB-induced increases in markers of thrombin generation, fibrin formation, tPA release, and fibrin degradation and better preservation of PAI-1...
  12. ncbi request reprint The kinetics of plasmin inhibition by aprotinin in vivo
    Hyoung Min Kang
    Department of Laboratory Medicine, Box 357110, University of Washington, Seattle, WA 98195 7110, USA
    Thromb Res 115:327-40. 2005
    ....
  13. ncbi request reprint Strategies to reduce hemostatic activation during cardiopulmonary bypass
    Michael J Eisses
    Department of Anesthesiology, Children s Hospital and Regional Medical Center, University of Washington, Seattle, USA
    Thromb Res 117:689-703. 2006
    ..We evaluated whether a modified protocol for cardiopulmonary bypass (CPB) could reduced the systemic hemostatic activation associated with this procedure...
  14. doi request reprint Cardiopulmonary bypass parameters and hemostatic response to cardiopulmonary bypass in infants versus children
    Michael J Eisses
    Department of Anesthesiology and Pain Medicine, University of Washington School of Medicine, Seattle, WA, USA
    J Cardiothorac Vasc Anesth 22:53-9. 2008
    ....
  15. ncbi request reprint Clearance of tissue plasminogen activator (TPA) and TPA/plasminogen activator inhibitor type 1 (PAI-1) complex: relationship to elevated TPA antigen in patients with high PAI-1 activity levels
    W L Chandler
    Department of Laboratory Medicine, University of Washington, Seattle 98195 7110, USA
    Circulation 96:761-8. 1997
    ....
  16. ncbi request reprint Does the type of surgery effect systemic response following cardiopulmonary bypass?
    Hiroo Takayama
    Department of Surgery, Division of Cardiothoracic Surgery, University of Washington School of Medicine, Seattle, Washington 98195, USA
    J Card Surg 22:307-13. 2007
    ..We hypothesized that valve surgery induces more prominent systemic reaction compared to isolated on-pump CABG...
  17. ncbi request reprint Prothrombotic coagulation abnormalities preceding the hemolytic-uremic syndrome
    Wayne L Chandler
    Department of Laboratory Medicine, University of Washington School of Medicine, Seattle 98105, USA
    N Engl J Med 346:23-32. 2002
    ..The hemolytic-uremic syndrome is a thrombotic complication of Escherichia coli O157:H7 infection. It is not known whether the coagulation abnormalities precede, and potentially cause, this disorder...
  18. ncbi request reprint Effect of polymer coating (poly 2-methoxyethylacrylate) of the oxygenator on hemostatic markers during cardiopulmonary bypass in children
    Michael J Eisses
    Department of Anesthesiology and Pain Medicine, University of Washington School of Medicine, Seattle, WA 98105, USA
    J Cardiothorac Vasc Anesth 21:28-34. 2007
    ....
  19. ncbi request reprint Thrombogenic alleles, Escherichia coli O157:H7 infections, and hemolytic uremic syndrome
    J T Sprouse
    Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, Washington, USA
    Blood Coagul Fibrinolysis 12:283-8. 2001
    ..Serum PAI-1 levels did not correlate with the PAI-1 genotype. We conclude that the alleles studied are not major risk factors for the acquisition of E. coli O157:H7 infection, or of E. coli O157:H7-related HUS...
  20. ncbi request reprint Activation, aggregation and adhesion of platelets exposed to high-intensity focused ultrasound
    S L Poliachik
    Center for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, 1013 NE 430th Street, Seattle, WA 98105, USA
    Ultrasound Med Biol 27:1567-76. 2001
    ..Regression analysis shows a weak correlation (r(2) = 0.11) between aggregation and ultrasound intensity, but a substantial correlation (r(2) = 0.76) between aggregation and cavitation occurrence...
  21. ncbi request reprint Coagulation factor VII gene haplotypes, obesity-related traits, and cardiovascular risk in young women
    A P Reiner
    Department of Epidemiology, University of Washington, Seattle, WA, USA
    J Thromb Haemost 5:42-9. 2007
    ..Associations between common F7 haplotypes, plasma factor VII (FVII) levels, and cardiovascular risk have recently been reported in population studies involving predominantly European men...
  22. ncbi request reprint Heritability of C-reactive protein and association with apolipoprotein E genotypes in Japanese Americans
    M A Austin
    Department of Epidemiology, School of Public Health and Community Medicine, Box 357236, University of Washington, Seattle, WA 98195 7236, USA
    Ann Hum Genet 68:179-88. 2004
    ..07). These results demonstrate the presence of both genetic and environmental effects on CRP levels among Asian Americans, and additional studies are needed to determine if the APOE gene contributes to these genetic influences...
  23. ncbi request reprint The relation between cavitation and platelet aggregation during exposure to high-intensity focused ultrasound
    Sandra L Poliachik
    Center for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle, USA
    Ultrasound Med Biol 30:261-9. 2004
    ..Our results show that increased cavitation activity lowers the intensity threshold to produce platelet aggregation and decreased cavitation activity in the overpressure system raises the intensity threshold for platelet aggregation...
  24. ncbi request reprint Heritability of multivariate factors of the metabolic syndrome in nondiabetic Japanese americans
    Melissa A Austin
    Department of Epidemiology and Institute for Public Health Genetics, School of Public Health and Community Medicine, University of Washington, Seattle, 98195 7236, USA
    Diabetes 53:1166-9. 2004
    ..25, P = 0.026). This analysis shows that independent, multivariate factors of the metabolic syndrome are heritable, demonstrating genetic influences on the underlying pathophysiological mechanisms of the syndrome...
  25. ncbi request reprint Effect of valproate on hemostatic function in patients with traumatic brain injury
    Gail D Anderson
    Department of Pharmacy, University of Washington, Box 357630, Seattle, WA 98195, USA
    Epilepsy Res 57:111-9. 2003
    ..To evaluate whether valproate (VPA) resulted in laboratory or clinical evidence of a change in bleeding-related measures associated with VPA therapy in patients sustaining a traumatic brain injury...
  26. ncbi request reprint Secretion of tissue plasminogen activator and plasminogen activator inhibitor 1 during cardiopulmonary bypass
    Wayne L Chandler
    Department of Laboratory Medicine, University of Washington, Box 357110, Seattle, WA 98195 7110, USA
    Thromb Res 112:185-92. 2003
    ..The goal of this study was to estimate the rate of t-PA and PAI-1 secretion in vivo, before, during and after CPB...
  27. ncbi request reprint Venous thromboembolism in trauma: a local manifestation of systemic hypercoagulability?
    Mark H Meissner
    Department of Surgery, Harborview Medical Center, University of Washington School of Medicine, Seattle, 98195, USA
    J Trauma 54:224-31. 2003
    ..The purpose of this study was to evaluate the relative importance of systemic hypercoagulability, preexisting and acquired risk factors, and specific injury patterns in the development of venous thromboembolism (VTE) after injury...
  28. ncbi request reprint Limitation of thrombin generation, platelet activation, and inflammation by elimination of cardiotomy suction in patients undergoing coronary artery bypass grafting treated with heparin-bonded circuits
    Gabriel S Aldea
    Division of Cardiothoracic Surgery, Department of Surgery, University of Washington School of Medicine, Seattle, WA 98195 3166, USA
    J Thorac Cardiovasc Surg 123:742-55. 2002
    ..A prospective, randomized study was undertaken to evaluate the specific effects of cardiotomy suction...
  29. ncbi request reprint Coagulation, fibrinolysis, and recanalization after acute deep venous thrombosis
    Mark H Meissner
    Department of Surgery, University of Washington School of Medicine, Seattle, USA
    J Vasc Surg 35:278-85. 2002
    ..The purpose of this study was to examine the relationship between recanalization and plasma markers of coagulation and fibrinolysis...
  30. doi request reprint Thrombin generation in trauma patients
    Nancy M Dunbar
    Department of Laboratory Medicine, University of Washington, Seattle, Washington 98195, USA
    Transfusion 49:2652-60. 2009
    ..ACT is incompletely understood, but is similar to disseminated intravascular coagulation (DIC) and is associated with poor outcome...
  31. ncbi request reprint Lack of depression effect on platelet activation in patients with heart failure
    Jagoda Pasic
    Department of Psychiatry and Behavioral Sciences, University of Washington, Harborview Medical Center, 325 Ninth Avenue, Box 350896, Seattle, WA 98104 2499, USA
    Psychiatry Res 129:289-92. 2004
    ..Our data show no group differences in P-selectin values, which suggests that comorbid depression has no additive effect on platelet activation in CHF patient...
  32. ncbi request reprint Comparison of the lipoprotein, carbohydrate, and hemostatic effects of phasic oral contraceptives containing desogestrel or levonorgestrel
    R H Knopp
    Northwest Lipid Research Clinic in the Department of Medicine, University of Washington, Seattle, USA
    Contraception 63:1-11. 2001
    ..The lipoprotein, SHBG, and protein S and factor V differences are likely due to the lesser androgenicity of DSG allowing for a greater expression of the dose of estrogen...
  33. ncbi request reprint The circulatory regulation of TPA and UPA secretion, clearance, and inhibition during exercise and during the infusion of isoproterenol and phenylephrine
    W L Chandler
    Department of Laboratory Medicine, University of Washington, Seattle 98195, USA
    Circulation 92:2984-94. 1995
    ..Exercise to exhaustion and infusions of isoproterenol and phenylephrine were used to study interactions between plasminogen activator regulation and the control of regional blood flow in 10 healthy males...
  34. ncbi request reprint Failure of peripheral arterial thrombolysis due to elevated plasminogen activator inhibitor type 1
    Stephen C Nicholls
    Division of Vascular Surgery, Department of Surgery, Harborview Medical Center, University of Washington, Seattle, Washington 98104, USA
    Blood Coagul Fibrinolysis 14:729-33. 2003
    ..We conclude that elevated PAI-1 during acute peripheral arterial thrombolysis is associated with an increased risk of lysis failure due to reduced levels of circulating active t-PA or urokinase...
  35. ncbi request reprint More on: calibration for the measurement of microparticles: the authors respond
    W L Chandler
    Department of Laboratory Medicine, University of Washington, Seattle, WA, USA
    J Thromb Haemost 9:1681-2. 2011
    ..This issue, pp 1679-81.DOI: 10.1111/j.1538-7836.2011.04384.x...
  36. doi request reprint A new microparticle size calibration standard for use in measuring smaller microparticles using a new flow cytometer
    W L Chandler
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA
    J Thromb Haemost 9:1216-24. 2011
    ..Microparticle size measurements are often calibrated on flow cytometers using polystyrene microspheres that forward scatter more light vs. particle diameter than cellular microparticles...
  37. ncbi request reprint False negative factor V Leiden assay following allogeneic stem cell transplant
    K P Crookston
    Department of Laboratory Medicine, University of Washington, Seattle 98195, USA
    Br J Haematol 100:600-2. 1998
    ..The patient had undergone a stem cell transplant several months before, and the leucocytes in her blood were derived from the stem cell donor, which lacked the FV defect...
  38. ncbi request reprint Comparing the prothrombin time INR versus the APTT to evaluate the coagulopathy of acute trauma
    Shan Yuan
    Department of Laboratory Medicine, Box 357110, University of Washington, Seattle, WA 98195 7110, USA
    Thromb Res 120:29-37. 2007
    ..In trauma patients, PT/INR or aPTT cutoffs of > or =1.5x normal are often used as triggers for the transfusion of plasma...
  39. ncbi request reprint Ventricular cerebrospinal fluid hypocretin-1 inversely correlates with glucose levels in cerebrospinal fluid and serum from patients with neurological injuries
    Michael J Doherty
    Swedish Epilepsy Center, Swedish Medical Center, Seattle, WA, USA
    Neurocrit Care 3:230-3. 2005
    ....
  40. ncbi request reprint Cerebrospinal fluid creatine kinase-BB isoenzyme activity and outcome after subarachnoid hemorrhage
    W M Coplin
    Department of Neurology, School of Medicine, University of Washington, Seattle, USA
    Arch Neurol 56:1348-52. 1999
    ..Results of previous studies have shown that CK-BB can be detected in the CSF of patients with aneurysmal subarachnoid hemorrhage (SAH), but whether CK-BB levels correlate with patients' neurologic outcomes is unknown...
  41. ncbi request reprint Monitoring direct thrombin inhibitors with a plasma diluted thrombin time
    Jason E Love
    Department of Laboratory Medicine, Box 357110, University of Washington, Seattle, WA 98195, USA
    Thromb Haemost 98:234-42. 2007
    ..In conclusion, the plasma diluted thrombin time appears to be a viable alternative to the aPTT for monitoring DTI levels, especially in patients with lupus inhibitors or low levels of vitamin K-dependent factors...
  42. ncbi request reprint Comparison of three methods for measuring factor VIII levels in plasma
    Wayne L Chandler
    Dept of Laboratory Medicine, Box 357110, University of Washington, Seattle, WA 98195, USA
    Am J Clin Pathol 120:34-9. 2003
    ....
  43. doi request reprint Procoagulant activity in trauma patients
    Wayne L Chandler
    Dept of Laboratory Medicine, University of Washington, Seattle, 98195, USA
    Am J Clin Pathol 134:90-6. 2010
    ..Tissue factor activity was 3- to 4-fold higher in trauma patients with coagulopathy vs patients without coagulopathy (P = .002). Trauma patients with coagulopathy have increased circulating tissue factor activity...
  44. pmc Adipokines, inflammation, and visceral adiposity across the menopausal transition: a prospective study
    Christine G Lee
    Department of Medicine, Division of Metabolism, Endocrinology, and Nutrition, University of Washington, Seattle, Washington 98195 4626, USA
    J Clin Endocrinol Metab 94:1104-10. 2009
    ..Postmenopausal women have greater visceral adiposity compared with premenopausal women. Adipokines are associated with increased adiposity, insulin resistance, and atherosclerosis...
  45. ncbi request reprint Cardiac ischemia during hemolytic uremic syndrome
    Meena Thayu
    Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington, USA
    Pediatr Nephrol 18:286-9. 2003
    ..It is possible that myocardial ischemia and secondary arrhythmias account for some sudden deaths that occur during acute HUS...
  46. doi request reprint Comparison of plasma with whole blood prothrombin time and fibrinogen on the same instrument
    TIMOTHY K AMUKELE
    Department of Laboratory Medicine, University of Washington, Seattle, USA
    Am J Clin Pathol 133:550-6. 2010
    ..Accuracy is limited by variations in hematocrit with worsening accuracy for samples with high INRs or low fibrinogen levels...
  47. doi request reprint Optimization of plasma fluorogenic thrombin-generation assays
    Wayne L Chandler
    Department of Laboratory Medicine, Box 357110, University of Washington, Seattle, WA 98195, USA
    Am J Clin Pathol 132:169-79. 2009
    ....
  48. ncbi request reprint Quality assurance in hemostasis: the perspective from the College of American Pathologists proficiency testing program
    Mark T Cunningham
    Department of Pathology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Semin Thromb Hemost 33:250-8. 2007
    ....
  49. ncbi request reprint Laboratory reporting of the international normalized ratio: progress and problems
    John D Olson
    Department of Pathology, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Arch Pathol Lab Med 131:1641-7. 2007
    ..The international normalized ratio (INR) is widely used to monitor oral anticoagulation and to evaluate patients with coagulation disorders...
  50. ncbi request reprint Thrombotic microangiopathies
    Phillip I Tarr
    N Engl J Med 347:2171-3; author reply 2171-3. 2002
  51. ncbi request reprint Effect of fondaparinux on coagulation assays: results of College of American Pathologists proficiency testing
    Agata Smogorzewska
    Department of Pathology and Laboratory Medicine, Harvard Medical School, Massachusetts General Hospital, Boston 02114, USA
    Arch Pathol Lab Med 130:1605-11. 2006
    ..It may also be efficacious, safe, and cost-effective for other patients; thus, more widespread use of fondaparinux is likely. The effect of fondaparinux on coagulation testing needs to be thoroughly examined...
  52. ncbi request reprint Antithrombin reduces monocyte and neutrophil CD11b up regulation in addition to blocking platelet activation during extracorporeal circulation
    Christine S Rinder
    Department of Anesthesiology, Yale University School of Medicine, New Haven, Connecticut 06520 8051, USA
    Transfusion 46:1130-7. 2006
    ....
  53. ncbi request reprint The effect of submaximal exercise on fibrinolysis
    Zlatko Fras
    University Medical Center Ljubljana, Department for Vascular Medicine, Ljubljana, Slovenia
    Blood Coagul Fibrinolysis 15:227-34. 2004
    ....
  54. ncbi request reprint Coagulation analyzers
    Kandice Kottke-Marchant
    Department of Clinical Pathology, Cleveland Clinic Foundation, USA
    CAP Today 17:18-22, 26-8, 30-3. 2003