Research Topics
| Britton ChanceSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Detail Information
Publications
Was Warburg right? Or was it that simple?Britton Chance
Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia 19104 6059, USA
Cancer Biol Ther 4:125-6. 2005- A wearable brain imagerBritton Chance
Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia 19104-6059, USA
IEEE Eng Med Biol Mag 26:30-7. 2007 - Breast cancer detection based on incremental biochemical and physiological properties of breast cancers: a six-year, two-site studyBritton Chance
University of Pennsylvania, Department of Biochemistry, Philadelphia, 19104 6059, USA
Acad Radiol 12:925-33. 2005.... - Skeletal muscle energetics with PNMR: personal views and historic perspectivesBritton Chance
Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104 6059, USA
NMR Biomed 19:904-26. 2006..Some of the research has been introduced in exercise physiology. Future directions of NMR on bioenergetics, as a part of system biological approaches, are indicated... 
Quantitative mitochondrial redox imaging of breast cancer metastatic potentialHe N Xu
University of Pennsylvania, School of Medicine, Department of Radiology, B6 Blockley Hall, 423 Guardian Drive, Philadelphia, Pennsylvania 19104 6069, USA
J Biomed Opt 15:036010. 2010..Mitochondrial redox imaging can be clinically implemented utilizing cryogenic biopsy specimens and is useful for drug development and for clinical diagnosis of breast cancer...- Quantitative magnetic resonance and optical imaging biomarkers of melanoma metastatic potentialLin Z Li
Department of Radiology, School of Medicine, University of Pennsylvania, B6 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 106:6608-13. 2009..This study shows that a harsh microenvironment may promote melanoma metastasis and provides potential biomarkers of metastatic potential... 
Lipoprotein nanoplatform for targeted delivery of diagnostic and therapeutic agentsJerry D Glickson
Molecular Imaging Laboratory, Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6069, USA
Adv Exp Med Biol 645:227-39. 2009..These particles can be utilized for in situ loading of magnetite into cells for MRI monitored cell tracking or gene therapy...- Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomographyRegine Choe
University of Pennsylvania, Department of Physics, 209 S 33rd Street, Philadelphia, Pennsylvania 19104, USA
J Biomed Opt 14:024020. 2009..90 to 0.99, suggesting good discriminatory power. The data demonstrate that benign and malignant lesions can be distinguished by quantitative three-dimensional DOT... - Evaluation of bacteriochlorophyll-reconstituted low-density lipoprotein nanoparticles for photodynamic therapy efficacy in vivoDiane E Marotta
Department of Radiation Oncology, School of Medicine, University of Pennsylvania, PA 19104, USA
Nanomedicine (Lond) 6:475-87. 2011..To evaluate the novel nanoparticle reconstituted bacteriochlorin e6 bisoleate low-density lipoprotein (r-Bchl-BOA-LDL) for its efficacy as a photodynamic therapy agent delivery system in xenografts of human hepatoblastoma G2 (HepG2) tumors... - Development of high-sensitivity near-infrared fluorescence imaging device for early cancer detectionYu Chen
Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA
Biomed Instrum Technol 39:75-85. 2005..Also, this portable device would be complementary to x-ray mammography and provide add-on information on early diagnosis and localization of breast tumor... - Metabolic imaging of tumors using intrinsic and extrinsic fluorescent markersZhihong Zhang
Department of Biochemistry and Biophysics, University of Pennsylvania Medical School, Philadelphia, PA 19104, USA
Biosens Bioelectron 20:643-50. 2004.... - Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: a case study with comparison to MRIRegine Choe
Department of Physics and Astronomy, University of Pennsylvania, 209 South 33rd Street, Philadelphia, Pennsylvania 19104 6396, USA
Med Phys 32:1128-39. 2005..A decrease in total hemoglobin concentration contrast between tumor and normal tissue was also observed over time. The results demonstrate the potential of DOT for measuring physiological parameters of breast lesions during chemotherapy... - Simulation of Mb/Hb in NIRS and oxygen gradient in the human and canine skeletal muscles using H-NMR and NIRSShoko Nioka
Dept. of Biochemistry and Radiology, University of Pennsylvania, USA
Adv Exp Med Biol 578:223-8. 2006 - Time-dependent blood flow and oxygenation in human skeletal muscles measured with noninvasive near-infrared diffuse optical spectroscopiesGuoqiang Yu
University of Pennsylvania, Department of Physics and Astronomy, Philadelphia, Pennsylvania 19104, USA
J Biomed Opt 10:024027. 2005..The instrument thus provides a method for evaluation of microcirculation and muscle metabolism in patients with vascular diseases... - In vivo continuous-wave optical breast imaging enhanced with Indocyanine GreenXavier Intes
Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Med Phys 30:1039-47. 2003..These results provide further evidence that in vivo pharmacokinetics of ICG in breast tumors may be a useful diagnostic tool for differentiation of benign and malignant pathologies... - Correlation between near-infrared spectroscopy and magnetic resonance imaging of rat brain oxygenation modulationYu Chen
Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104, USA
Phys Med Biol 48:417-27. 2003..A linear relationship with high correlation coefficient between the relative changes in the BOLD MRI signal and the NIRS signal is observed... - Histological basis of MR/optical imaging of human melanoma mouse xenografts spanning a range of metastatic potentialsHe N Xu
Molecular Imaging Laboratory, Department of Radiology, Philadelphia, Pennsylvania 19104, USA
Adv Exp Med Biol 645:247-53. 2009..We are currently investigating whether these cells are in autophagic state, a possible cell survival mechanism under starvation conditions... - In vivo fluorometric assessment of cyclosporine on mitochondrial function during myocardial ischemia and reperfusionMuneaki Matsubara
Gorman Cardiovascular Research Group, University of Pennsylvania, Philadelphia, Pennsylvania 19036, USA
Ann Thorac Surg 89:1532-7. 2010..We hypothesized that CsA limits mitochondrial dysfunction and that fluorometry can quantify this influence... - Effect of errors in baseline optical properties on accuracy of transabdominal near-infrared spectroscopy in fetal sheep brain during hypoxic stressTheresa Mawn
University of Pennsylvania, Department of Bioengineering, Philadelphia, Pennsylvania 19104 6100, USA
J Biomed Opt 10:064001. 2005..Under hypoxic conditions, however, the variability of the NIR StO2 calculations with changes in the assumed reference properties became more significant... - Relationship between muscle architectural features and oxygenation status determined by near infrared deviceHajime Miura
Department of Biochemistry and Biophysics, School of Medicine, University of Pennsylvania, PA 19104, Philadelphia, USA
Eur J Appl Physiol 91:273-8. 2004..05), between DeltaNIR-blood volume and Deltafascicle angle ( r=-0.85, P<0.05). In conclusion, the plantar flexion exercise produced regional differences in oxygenation status consistent with regional differences in muscle architecture... - Modeling of oxygen diffusion and metabolism from capillary to musclePing Huang
University of Pennsylvania, Philadelphia, PA 19104, USA
Adv Exp Med Biol 540:325-30. 2003 - Diffuse optical tomography with physiological and spatial a priori constraintsXavier Intes
Department of Biophysics and Biochemistry, University of Pennsylvania, Philadelphia, PA 19104, USA
Phys Med Biol 49:N155-63. 2004..More accurate recovery of the two main functional parameters that are the blood volume and the relative saturation is demonstrated through simulations by using our method compared to actual techniques... - Reduced heterogeneity of muscle deoxygenation during heavy bicycle exerciseRyotaro Kime
Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, USA
Med Sci Sports Exerc 37:412-7. 2005..This study evaluated heterogeneity of muscle O2 dynamics in a single muscle during bicycle exercise using an eight-channel near-infrared continuous wave spectroscopy (NIRcws) mapping system... - Probing rat brain oxygenation with near-infrared spectroscopy (NIRS) and magnetic resonance imaging (MRI)Yu Chen
Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104, USA
Adv Exp Med Biol 510:199-204. 2003 - Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: a pilot studyUlas Sunar
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6396, USA
J Biomed Opt 11:064021. 2006..0+/-8.1) [microM] at the end of the fourth week of therapy. These preliminary results suggest daily diffuse-optics-based therapy monitoring is feasible during the first two weeks and may have clinical promise... - Fluorescence spectroscopy and imaging of myocardial apoptosisMahsa Ranji
Department of Electrical and Systems Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Biomed Opt 11:064036. 2006..This represents the first attempt to assess myocyte apoptosis in the beating heart... - Cyclophosphamide treatment modifies tumor oxygenation and glycolytic rates of RIF-1 tumors: 13C magnetic resonance spectroscopy, Eppendorf electrode, and redox scanningHarish Poptani
Departments of Radiology, Johnson Research Foundation, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Cancer Res 63:8813-20. 2003..Overall, these data indicate that the reduction in glycolytic rate of Cp-treated RIF-1 tumors is due to an increase in aerobic metabolism... - Lipoprotein nanoplatform for targeted delivery of diagnostic and therapeutic agentsJerry D Glickson
Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104 6069, USA
Mol Imaging 7:101-10. 2008..These particles can be used for in situ loading of magnetite into cells for MRI-monitored cell tracking or gene expression... - Impaired exercise-induced blood volume in type 2 diabetes with or without peripheral arterial disease measured by continuous-wave near-infrared spectroscopyEmile R Mohler
Cardiovascular Division, Vascular Medicine Section, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
Diabetes Care 29:1856-9. 2006..However, the pathophysiology involved in PAD is unclear. This study was conducted to evaluate the hemodynamic response to exercise of patients with and without diabetes and PAD... - Biomathematics in cancer detection: simulation of lipogenesis in cancerPing Huang
Department of Biophysics and Biochemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Adv Exp Med Biol 614:151-6. 2008..Simulation and discussion on lipogenesis by carbohydrate responsive element-binding protein (ChREBP) are given. Our model provides a potential way to analyze the experimental databank... - Investigation of the prefrontal cortex in response to duration-variable anagram tasks using functional near-infrared spectroscopyFenghua Tian
The University of Pennsylvania School of Medicine, Department of Biophysics and Biochemistry, Philadelphia, Pennsylvania 19104, USA
J Biomed Opt 14:054016. 2009..A better understanding of nonlinearity in fNIRS signals will have potential for us to investigate brain adaptation and to extrapolate neuronal activities from hemodynamic signals... - Analysis on performance and optimization of frequency-domain near-infrared instrumentsTao Tu
University of Pennsylvania, Department of Electrical Engineering, Department of Biochemistry and Biophysics, Philadelphia, Pennsylvania 19104, USA
J Biomed Opt 7:643-9. 2002..This kind of method can be used to design suitable instruments for various applications. We also analyze the selection of the instrument parameters to achieve optimal performance at an efficient cost using this analytical model... - Pyropheophorbide 2-deoxyglucosamide: a new photosensitizer targeting glucose transportersMin Zhang
Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Bioconjug Chem 14:709-14. 2003.... - Delayed reoxygenation after maximal isometric handgrip exercise in high oxidative capacity muscleRyotaro Kime
Department of Biochemistry and Biophysics, 250 Anatomy Chemistry Building, University of Pennsylvania, 37th and Hamilton Walk, Philadelphia, PA 19104 6059, USA
Eur J Appl Physiol 89:34-41. 2003.... - MRI-guided diffuse optical spectroscopy of malignant and benign breast lesionsVasilis Ntziachristos
Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104 6059, USA
Neoplasia 4:347-54. 2002..It is foreseen that the technique can play a major role in functional activation studies of brain and muscle as well... - Fetal transabdominal pulse oximeter studies using a hypoxic sheep modelShoko Nioka
Department of Biochem Biophysics, University of Pennsylvania, PA 19104, USA
J Matern Fetal Neonatal Med 17:393-9. 2005..This study investigates the validity of transabdominal pulse oximetry using a sheep fetal hypoxia model with fetal arterial hemoglobin saturation... - Three-dimensional diffuse optical tomography in the parallel plane transmission geometry: evaluation of a hybrid frequency domain/continuous wave clinical system for breast imagingJ P Culver
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6396, USA
Med Phys 30:235-47. 2003..In addition, we find that point spread function measurements provide a useful and comprehensive representation of system performance... - Heterogeneity of mitochondrial redox state in premalignant pancreas in a PTEN null transgenic mouse modelHe N Xu
Department of Radiology, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Adv Exp Med Biol 701:207-13. 2011.... - Adaptive calibration for object localization in turbid media with interfering diffuse photon density wavesYu Chen
Department of Biophysics and Biochemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Appl Opt 41:7325-33. 2002..Experimental data on human breast phantoms demonstrate that localization accuracy within several millimeters has been accomplished through this method... - Transabdominal near infrared oximetry of hypoxic stress in fetal sheep brain in uteroRegine Choe
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 100:12950-4. 2003..Fetal hypoxia was detected. Good agreement was found between fetal blood saturation determined by the transabdominal NIR method and arterial and venous fetal blood saturation quantified from fetal blood samples by using a hemoximeter... - Quantitative brain tissue oximetry, phase spectroscopy and imaging the range of homeostasis in piglet brainBritton Chance
Department of Biochemistry and Biophysics, Johnson Research Foundation, University of Pennsylvania, Center for Biomedical Optics, University City Science Center, Philadelphia, PA, USA
Adv Exp Med Biol 530:13-8. 2003..Beyond that range, the tissue oxygen is still correctly measured but, as expected, approaches the arterial saturation at low metabolic rates and the venous saturation at high metabolic rates of mitochondria... - Projection access order in algebraic reconstruction technique for diffuse optical tomographyXavier Intes
Department of Biophysics and Biochemistry, University of Pennsylvania, Philadelphia 19104, USA
Phys Med Biol 47:N1-10. 2002..We show that by selecting proper projection access order, the convergence speed can be significantly improved when ART is used to perform DOT. Moreover, low-contrast detection is improved... - Low-density lipoprotein reconstituted by pyropheophorbide cholesteryl oleate as target-specific photosensitizerGang Zheng
Department of Radiology, University of Pennsylvania Medical School, Philadelphia 19104, USA
Bioconjug Chem 13:392-6. 2002..Laser scanning confocal microscopy studies demonstrated that this photosensitizer-reconstituted LDL can be internalized via LDLr by human hepatoblastoma G(2) (HepG(2)) tumor cells... - Antepartum, transabdominal near infrared spectroscopy: feasibility of measuring photon migration through the fetal head in uteroN Ramanujam
University of Pennsylvania, Johnson Research Foundation, Philadelphia 19104, USA
J Matern Fetal Med 8:275-88. 1999..We report the feasibility of measuring photon migration through the fetal head in utero using antepartum, transabdominal, near infrared (NIR) spectroscopy... - Concurrent MRI and diffuse optical tomography of breast after indocyanine green enhancementV Ntziachristos
Departments of Bioengineering, Biochemistry Biophysics, University of Pennsylvania, Philadelphia, PA 19104 6089, USA
Proc Natl Acad Sci U S A 97:2767-72. 2000..Additionally our use of ICG, an albumin bound absorbing dye in plasma, demonstrates the potential to differentiate disease based on the quantified enhancement of suspicious lesions... - Bulk optical properties of healthy female breast tissueT Durduran
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia 19104, USA
Phys Med Biol 47:2847-61. 2002..The new information on healthy breast tissue provides insight about the potential contrasts available for diffuse optical tomography of breast tumours... - Oximetry based on diffuse photon density wave differentialsV Ntziachristos
Department of Bioengineering, University of Pennsylvania, Philadelphia 19104 6089, USA
Med Phys 27:410-21. 2000.... - Photon migration through fetal head in utero using continuous wave, near infrared spectroscopy: clinical and experimental model studiesN Ramanujam
University of Pennsylvania, Dept of Biochemistry and Biophysics, Philadelphia, USA
J Biomed Opt 5:173-84. 2000..The results of the comparison were used to provide insight into the optical properties and physical geometry of the maternal and fetal tissues in the photon migration path... - Preliminary evaluation of dual wavelength phased array imaging on neonatal brain functionY Chen
Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia 19104, USA
J Biomed Opt 5:194-200. 2000..Significant functional responses, particularly to parietal stimulation in normal and pathological states of neonatal brain, have been revealed in our study. The preliminary clinical results are presented in this article... - Near-field diffraction tomography with diffuse photon density wavesX Li
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics 61:4295-309. 2000..g., the slab medium). Limitations and potential improvements of the near-field diffraction tomography are also discussed... - Metabolism-enhanced tumor localization by fluorescence imaging: in vivo animal studiesY Chen
Department of Biophysics and Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Opt Lett 28:2070-2. 2003.... - NIR spectroscopic detection of breast cancerS Nioka
University of Pennsylvania, Department of Biochemistry and Biophysics, 250 Anatomy-Chemistry Bldg, Philadelphia, PA 19104-6059, USA
Technol Cancer Res Treat 4:497-512. 2005.... - Simultaneous fluorometry and phosphorometry of Langendorff perfused rat heart: ex vivo animal studiesMahsa Ranji
Complex Media Laboratory, Department of Electrical and Systems Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Opt Lett 31:2995-7. 2006.... - Near-infrared-emissive polymersomes: self-assembled soft matter for in vivo optical imagingP Peter Ghoroghchian
School of Engineering and Applied Science, Institute for Medicine and Engineering, Department of Chemistry, University of Pennsylvania, Philadelphia 19104, USA
Proc Natl Acad Sci U S A 102:2922-7. 2005..Robust NIR-emissive polymersomes thus define a soft matter platform with exceptional potential to facilitate deep-tissue fluorescence-based imaging for in vivo diagnostic and drug-delivery applications... - Oxygenation and blood concentration changes in human subject prefrontal activation by anagram solutionsBritton Chance
University of Pennsylvania, Department of Biochemistry and Biophysics, Philadelphia, PA 19104-6059, USA
Adv Exp Med Biol 510:397-401. 2003..A wearable NIR measurement of metabolic activation and blood flow may be a useful educational aid. In summary, the optical method focuses attention on cognition activated oxygenation of prefrontal cortex... - Predicting melanoma metastatic potential by optical and magnetic resonance imagingLin Z J Li
Department of Radiology, Philadelphia, Pennsylvania 19104, USA
Adv Exp Med Biol 599:67-78. 2007..These differences observed between these two types of tumors, one indolent and one aggressive, if generalizable, would be very valuable in predicting human melanoma metastatic potential... - Mitochondrial NADH redox state, monitoring discovery and deployment in tissueBritton Chance
Eldridge Reeves Johnson University, Philadelphia, PA 19104, USA
Methods Enzymol 385:361-70. 2004 - Protease-triggered photosensitizing beacon based on singlet oxygen quenching and activationJuan Chen
Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
J Am Chem Soc 126:11450-1. 2004..Upon caspase-3-induced cleavage, the 1O2 production increased markedly, as measured directly by 1O2 near-infrared luminescence and lifetime measurements... - Diffuse optical tomography of highly heterogeneous mediaV Ntziachristos
Department of Bioengineering, University of Pennsylvania, Philadelphia 19104, USA
IEEE Trans Med Imaging 20:470-8. 2001..To eliminate the artifacts and improve the overall image reconstruction, we apply a data-correction algorithm that yields superior reconstruction results and is virtually independent of the degree of the background heterogeneity... - Accuracy limits in the determination of absolute optical properties using time-resolved NIR spectroscopyV Ntziachristos
Departments of Bioengineering, Biochemistry Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6089
Med Phys 28:1115-24. 2001..In that sense this analysis can be used in time-resolved system design and in predicting the expected errors given the technology selected for time-resolved measurements... - Near infrared muscle spectroscopy in patients with Friedreich's ataxiaDavid R Lynch
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Muscle Nerve 25:664-73. 2002..These results suggest that NIRS may be an effective tool for monitoring the biochemical and functional features of Friedreich's ataxia in parallel... - Non-invasive and quantitative near-infrared haemoglobin spectrometry in the piglet brain during hypoxic stress, using a frequency-domain multidistance instrumentD M Hueber
University of Pennsylvania, School of Medicine in Philadelphia, USA
Phys Med Biol 46:41-62. 2001..The origin of this 'effective' background absorption may be real, an artefact caused by the application of a simplified model to a complex sample, or a combination of factors... - Probing physiology and molecular function using optical imaging: applications to breast cancerV Ntziachristos
Department of Bioengineering, University of Pennsylvania, Philadelphia, USA
Breast Cancer Res 3:41-6. 2001..These features could enhance diagnostic accuracy, lower the current state-of-the-art detection limits, and play a vital role in therapeutic strategy and monitoring... - Tricarbocyanine cholesteryl laurates labeled LDL: new near infrared fluorescent probes (NIRFs) for monitoring tumors and gene therapy of familial hypercholesterolemiaGang Zheng
Department of Radiology, University of Pennsylvania, Philadelphia 19104, USA
Bioorg Med Chem Lett 12:1485-8. 2002.... - Detection limit enhancement of fluorescent heterogeneities in turbid media by dual-interfering excitationXavier Intes
Department of Biophysics and Biochemistry, University of Pennsylvania, Philadelphia 19104, USA
Appl Opt 41:3999-4007. 2002..To detect the same inhomogeneity, less concentration and lifetime contrast is required with dual-interfering sources... - In vivo determination of altered hemoglobin saturation in dogs with M-type phosphofructokinase deficiencyK McCully
Division of Geriatric Medicine, Medical College of Pennsylvania and Hahnemann University, Philadelphia, Pennsylvania 19131, USA
Muscle Nerve 22:621-7. 1999..NIRS appears to be a useful noninvasive method of monitoring tissue oxygen saturation in normal or disease conditions... - Oxygen transport and intracellular bioenergetics on stimulated cat skeletal muscleS Nioka
Department of Biochemistry and Biophysics, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Adv Exp Med Biol 510:267-72. 2003..As cellular hypoxia causes decreases in muscle performance (moderate to severe hypoxia), NADH is being reduced rather than oxidized with increasing workloads... - Study of near infrared technology for intracranial hematoma detectionQ Zhang
Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia 19104 6089, USA
J Biomed Opt 5:206-13. 2000..Model inhomogeneity tests and animal hematoma tests showed the effectiveness of the improved hematoma detector for intracranial hematoma detection... - Extended kalman filtering for the modeling and analysis of ICG pharmacokinetics in cancerous tumors using NIR optical methodsBurak Alacam
Department of Electrical, Computer, and Systems Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180, USA
IEEE Trans Biomed Eng 53:1861-71. 2006..Our study indicates that, in addition to the pharmacokinetic rates, the EKF model may provide parameters that may be useful for tumor differentiation... - Reconstruction of spatially resolved pharmacokinetic rate images of fluorescence agents in FDOTBurak Alacam
Dept. of Electrical Computer and Systems Engineering, Rensselaer Polytechnic Institute, Troy, New York 19102, USA
Conf Proc IEEE Eng Med Biol Soc 1:5627-30. 2006.... - Characterization of breast tumors with NIR methods using optical indicesBurak Alacam
Dept of Electrical, Computer, and Systems Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180, USA
Conf Proc IEEE Eng Med Biol Soc 2007:5186-9. 2007..91 with a significance level of 0.05. Our results suggest that the features, relative blood concentration, and oxygen saturation can differentiate breast tumors with a relatively high precision... - Near-infrared spectroscopy/imaging for monitoring muscle oxygenation and oxidative metabolism in healthy and diseased humansTakafumi Hamaoka
National Institute of Fitness and Sports, Department of Exercise Science, Shiromizu 1, Kanoya, 891 2393 Japan
J Biomed Opt 12:062105. 2007..As NIRS technology continues to evolve, the study of skeletal muscle function with NIRS first illuminated by Jobsis continues to be bright... - Pharmacokinetic-rate images of indocyanine green for breast tumors using near-infrared optical methodsBurak Alacam
Department of Electrical, Computer, and Systems Engineering, Rensselaer Polytechnic Institute, Troy, NY, USA
Phys Med Biol 53:837-59. 2008..Our study indicates that the pharmacokinetic-rate images may provide superior information than single set of pharmacokinetic rates estimated from the entire breast tissue for breast cancer diagnosis... - Oxidation-reduction states of NADH in vivo: from animals to clinical useAvraham Mayevsky
The Mina and Everard Goodman Faculty of Life Sciences Bar Ilan University, Ramat Gan, Israel
Mitochondrion 7:330-9. 2007..The four detected parameters provide real time data on tissue viability, which is critical for patients monitoring... - Comparison of low- and high-intensity resistance exercise on lipid peroxidation: role of muscle oxygenationJay R Hoffman
College of New Jersey, Ewing 08628, USA
J Strength Cond Res 21:118-22. 2007..44). Results suggest that increases in MDA occur independently of exercise intensity, but tissue acidosis may have a larger influence on MDA formation... - Creatine supplementation enhances anaerobic ATP synthesis during a single 10 sec maximal handgrip exerciseYuko Kurosawa
Department of Preventive Medicine and Public Health, Tokyo Medical University, Shinjuku ku, Tokyo, Japan
Mol Cell Biochem 244:105-12. 2003..05). The results suggest that Cr supplementation enhanced PCr degradation during Ex10. It is strongly indicated that an improvement in performance during Ex10 was associated with the increased PCr availability for the synthesis of ATP... - Microcirculatory function, tissue oxygenation, microregional redox status and ATP distribution in tumors upon localized infrared-A-hyperthermia at 42 degrees COliver Thews
Institute of Physiology and Pathophysiology, University of Mainz, Duesbrgweg 6, 55099 Mainz, Germany
Adv Exp Med Biol 530:237-47. 2003..The latter finding can be explained by an equivalent increase in the oxygen consumption rate of the cells which increases by approx. 58% at 42 degrees C compared to normothermia... - Effect of muscle oxygenation during resistance exercise on anabolic hormone responseJay R Hoffman
The College of New Jersey, Ewing, NJ 08628, USA
Med Sci Sports Exerc 35:1929-34. 2003..This investigation examined the affects of two different resistance exercise protocols on muscle oxygenation, and the anabolic hormonal response to such exercise... - Carbocyanine labeled LDL for optical imaging of tumorsHui Li
Department of Radiology, University of Pennsylvania Medical School, Chemistry 1958 Wing, Room 284, Box 66, 250 South 33rd Street, Philadelphia, PA 19104 USA
Acad Radiol 11:669-77. 2004..3 times that of B16 cells. CONCLUSION: This study suggested that carbocyanine labeled LDL could be used for optical imaging of tumors overexpressing LDLr... - Redox ratio of mitochondria as an indicator for the response of photodynamic therapyZhihong Zhang
Huazhong University of Science and Technology, Key Laboratory of Biomedical Photonics, Ministry of Education, Wuhan, Hubei 430074, P.R. China
J Biomed Opt 9:772-8. 2004..In the PDT treated region of the tumor, highly oxidized flavoprotein and diminishing NADH fluorescence is detected, suggesting that flavoprotein and NADH are oxidized by singlet oxygen produced in the photosensitization process... - Inhibition of tumor necrosis factor-induced apoptosis in transgenic mouse liver expressing creatine kinaseEtsuro Hatano
Department of Gastroenterological Surgery, Kyoto University, Graduate School of Medicine, Sakyo ku, Japan
Liver Int 24:384-93. 2004..To clarify the effects of the enhanced mitochondrial function on tumor necrosis factoralpha (TNFalpha)-induced apoptosis, we studied hepatic injuries in transgenic mice whose livers express creatine kinase (CK)... - Photobiomodulation directly benefits primary neurons functionally inactivated by toxins: role of cytochrome c oxidaseMargaret T T Wong-Riley
Department of Cell Biology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
J Biol Chem 280:4761-71. 2005..The results are consistent with our hypothesis that the mechanism of photobiomodulation involves the up-regulation of cytochrome c oxidase, leading to increased energy metabolism in neurons functionally inactivated by toxins... - Transabdominal fetal pulse oximetry with near-infrared spectroscopyAnthony M Vintzileos
Department of Obstetrics, Gynecology and Reproductive Sciences, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ, USA
Am J Obstet Gynecol 192:129-33. 2005..Future studies should correlate transabdominally obtained measurements with those measurements that are obtained by transvaginal fetal pulse oximetry... - Non-PET functional imaging techniques: opticalXavier Intes
Biomedical Optical Imaging, Advanced Research Technologies ART, 2300 Alfred Nobel Boulevard, Saint Laurent, Quebec H4S 2A4, Canada
Radiol Clin North Am 43:221-34, xii. 2005..This is followed by a survey of the three main applications: brain imaging, muscle imaging, and breast imaging. Lastly, the future outlook of the technology is presented, highlighting the new promises based on recent breakthroughs... - Evaluation of physiological responses during recovery following three resistance exercise programsJie Kang
The College of New Jersey, Ewing, New Jersey 08628, USA
J Strength Cond Res 19:305-9. 2005..In addition, an exercise routine performed at low to moderate intensity coupled with a moderate to high exercise volume is most effective in maximizing caloric expenditure following resistance exercise... - Synergistic effects of light-emitting probes and peptides for targeting and monitoring integrin expressionSamuel Achilefu
Department of Radiology and Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA
Proc Natl Acad Sci U S A 102:7976-81. 2005.... - Diffuse optical tomography with a priori anatomical informationMurat Guven
Electrical, Computer, and Systems Engineering Department, Rensselaer Polytechnic Institute, Troy, NY, USA
Phys Med Biol 50:2837-58. 2005..Extensive numerical simulations demonstrate that the proposed method avoids undesirable bias towards anatomical prior information and leads to significantly improved spatial resolution and quantitative accuracy... - The effect of a competitive collegiate football season on power performance and muscle oxygen recovery kineticsJay R Hoffman
The College of New Jersey, Ewing, New Jersey 08628, USA
J Strength Cond Res 19:509-13. 2005..Results indicate that the extent of muscle deoxygenation is reduced during high-intensity exercise and that muscle oxygen recovery kinetics improves over the duration of a competitive season of football... - A novel approach to a bifunctional photosensitizer for tumor imaging and phototherapyYihui Chen
PDT Center, Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
Bioconjug Chem 16:1264-74. 2005.... - Simulation study of breast tissue hemodynamics during pressure perturbationShoko Nioka
Adv Exp Med Biol 566:17-22. 2005..The results showed that simulation can be used to obtain venous and average oxygen saturation as well as blood flow in compressed breast tissues... - Mitochondrial NADH as the bellwether of tissue O2 deliveryBritton Chance
Adv Exp Med Biol 566:231-42. 2005.... - Three-dimensional redox imaging of frozen-quenched brain and other organsAkihiko Shiino
Department of Neurosurgery, Shiga University of Medical Science, Ohtsu, Shiga, 520-2192, Japan
Methods Enzymol 352:475-82. 2002
Research Grants
- BREAST TUMOR DETECTION BY OPTICAL CONTRASTBritton Chance; Fiscal Year: 2000....
- BREAST CANCER HYPOXIA ASSESSED BY NITRIC OXIDEBritton Chance; Fiscal Year: 2002..If ourintended goals of demonstrating feasibility are achieved, then application for support through regular RO1channels would appear to be justified. ..
- COREGISTERED IMAGES OF BREAST TUMORS BY MRI AND OPTICALBritton Chance; Fiscal Year: 2003..Large scale tests are available under other support where a direct comparison with not only MRI but also digital mammography, ultrasound and PET will secure the validation studies. ..
- 2 & 3D Imaging of Contrast Agents in Animal ModelsBritton Chance; Fiscal Year: 2004..abstract_text> ..
- Images of Quantified Hypoxic Stress in MuscleBritton Chance; Fiscal Year: 2005..Our especial goals are improving geriatric performance and detecting mitochondrial disease. See Appendix A for Glossary. ..
- OPTICAL SPECTROSCOPY AND IMAGING OF HB/MB IN TISSUESBritton Chance; Fiscal Year: 1999..Furthermore, the application to medically needful populations where outcomes can be altered by quantitative localized studies is consonant with the goals of "Healthy People 2000". ..
- FUNCTIONAL OPTICAL IMAGING OF BRAIN INJURY (F NIRI)Britton Chance; Fiscal Year: 2001....
- FUNCTIONAL OPTICAL IMAGING OF BRAIN INJURY (fNIRI)Britton Chance; Fiscal Year: 2005..These projects represent logical continuations of current activities into new and related researches. ..