Britton Chance

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi Was Warburg right? Or was it that simple?
    Britton Chance
    Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia 19104 6059, USA
    Cancer Biol Ther 4:125-6. 2005
  2. ncbi A wearable brain imager
    Britton Chance
    Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia 19104 6059, USA
    IEEE Eng Med Biol Mag 26:30-7. 2007
  3. ncbi Breast cancer detection based on incremental biochemical and physiological properties of breast cancers: a six-year, two-site study
    Britton Chance
    University of Pennsylvania, Department of Biochemistry, Philadelphia, 19104 6059, USA
    Acad Radiol 12:925-33. 2005
  4. ncbi Skeletal muscle energetics with PNMR: personal views and historic perspectives
    Britton Chance
    Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104 6059, USA
    NMR Biomed 19:904-26. 2006
  5. pmc Quantitative mitochondrial redox imaging of breast cancer metastatic potential
    He N Xu
    University of Pennsylvania, School of Medicine, Department of Radiology, B6 Blockley Hall, 423 Guardian Drive, Philadelphia, Pennsylvania 19104 6069, USA
    J Biomed Opt 15:036010. 2010
  6. doi Lipoprotein nanoplatform for targeted delivery of diagnostic and therapeutic agents
    Jerry D Glickson
    Molecular Imaging Laboratory, Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6069, USA
    Adv Exp Med Biol 645:227-39. 2009
  7. pmc Quantitative magnetic resonance and optical imaging biomarkers of melanoma metastatic potential
    Lin Z Li
    Department of Radiology, School of Medicine, University of Pennsylvania, B6 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 106:6608-13. 2009
  8. pmc Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography
    Regine Choe
    University of Pennsylvania, Department of Physics, 209 S 33rd Street, Philadelphia, Pennsylvania 19104, USA
    J Biomed Opt 14:024020. 2009
  9. ncbi Development of high-sensitivity near-infrared fluorescence imaging device for early cancer detection
    Yu Chen
    Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA
    Biomed Instrum Technol 39:75-85. 2005
  10. ncbi Simulation of Mb/Hb in NIRS and oxygen gradient in the human and canine skeletal muscles using H-NMR and NIRS
    Shoko Nioka
    Dept of Biochemistry and Radiology, University of Pennsylvania, USA
    Adv Exp Med Biol 578:223-8. 2006

Research Grants

  1. BREAST TUMOR DETECTION BY OPTICAL CONTRAST
    Britton Chance; Fiscal Year: 2000
  2. FUNCTIONAL OPTICAL IMAGING OF BRAIN INJURY (F NIRI)
    Britton Chance; Fiscal Year: 1999
  3. COREGISTERED IMAGES OF BREAST TUMORS BY MRI AND OPTICAL
    Britton Chance; Fiscal Year: 2002
  4. BREAST CANCER HYPOXIA ASSESSED BY NITRIC OXIDE
    Britton Chance; Fiscal Year: 2002
  5. Images of Quantified Hypoxic Stress in Muscle
    Britton Chance; Fiscal Year: 2002
  6. Images of Quantified Hypoxic Stress in Muscle
    Britton Chance; Fiscal Year: 2003
  7. 2 & 3D Imaging of Contrast Agents in Animal Models
    Britton Chance; Fiscal Year: 2003
  8. COREGISTERED IMAGES OF BREAST TUMORS BY MRI AND OPTICAL
    Britton Chance; Fiscal Year: 2003
  9. FUNCTIONAL OPTICAL IMAGING OF BRAIN INJURY (fNIRI)
    Britton Chance; Fiscal Year: 2003
  10. Images of Quantified Hypoxic Stress in Muscle
    Britton Chance; Fiscal Year: 2004

Collaborators

Detail Information

Publications93

  1. ncbi Was Warburg right? Or was it that simple?
    Britton Chance
    Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia 19104 6059, USA
    Cancer Biol Ther 4:125-6. 2005
  2. ncbi A wearable brain imager
    Britton Chance
    Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia 19104 6059, USA
    IEEE Eng Med Biol Mag 26:30-7. 2007
  3. ncbi Breast cancer detection based on incremental biochemical and physiological properties of breast cancers: a six-year, two-site study
    Britton Chance
    University of Pennsylvania, Department of Biochemistry, Philadelphia, 19104 6059, USA
    Acad Radiol 12:925-33. 2005
    ....
  4. ncbi Skeletal muscle energetics with PNMR: personal views and historic perspectives
    Britton Chance
    Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104 6059, USA
    NMR Biomed 19:904-26. 2006
    ..Some of the research has been introduced in exercise physiology. Future directions of NMR on bioenergetics, as a part of system biological approaches, are indicated...
  5. pmc Quantitative mitochondrial redox imaging of breast cancer metastatic potential
    He N Xu
    University of Pennsylvania, School of Medicine, Department of Radiology, B6 Blockley Hall, 423 Guardian Drive, Philadelphia, Pennsylvania 19104 6069, USA
    J Biomed Opt 15:036010. 2010
    ..Mitochondrial redox imaging can be clinically implemented utilizing cryogenic biopsy specimens and is useful for drug development and for clinical diagnosis of breast cancer...
  6. doi Lipoprotein nanoplatform for targeted delivery of diagnostic and therapeutic agents
    Jerry D Glickson
    Molecular Imaging Laboratory, Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6069, USA
    Adv Exp Med Biol 645:227-39. 2009
    ..These particles can be utilized for in situ loading of magnetite into cells for MRI monitored cell tracking or gene therapy...
  7. pmc Quantitative magnetic resonance and optical imaging biomarkers of melanoma metastatic potential
    Lin Z Li
    Department of Radiology, School of Medicine, University of Pennsylvania, B6 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 106:6608-13. 2009
    ..This study shows that a harsh microenvironment may promote melanoma metastasis and provides potential biomarkers of metastatic potential...
  8. pmc Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography
    Regine Choe
    University of Pennsylvania, Department of Physics, 209 S 33rd Street, Philadelphia, Pennsylvania 19104, USA
    J Biomed Opt 14:024020. 2009
    ..90 to 0.99, suggesting good discriminatory power. The data demonstrate that benign and malignant lesions can be distinguished by quantitative three-dimensional DOT...
  9. ncbi Development of high-sensitivity near-infrared fluorescence imaging device for early cancer detection
    Yu Chen
    Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA
    Biomed Instrum Technol 39:75-85. 2005
    ..Also, this portable device would be complementary to x-ray mammography and provide add-on information on early diagnosis and localization of breast tumor...
  10. ncbi Simulation of Mb/Hb in NIRS and oxygen gradient in the human and canine skeletal muscles using H-NMR and NIRS
    Shoko Nioka
    Dept of Biochemistry and Radiology, University of Pennsylvania, USA
    Adv Exp Med Biol 578:223-8. 2006
  11. ncbi Metabolic imaging of tumors using intrinsic and extrinsic fluorescent markers
    Zhihong Zhang
    Department of Biochemistry and Biophysics, University of Pennsylvania Medical School, Philadelphia, PA 19104, USA
    Biosens Bioelectron 20:643-50. 2004
    ....
  12. pmc Evaluation of bacteriochlorophyll-reconstituted low-density lipoprotein nanoparticles for photodynamic therapy efficacy in vivo
    Diane E Marotta
    Department of Radiation Oncology, School of Medicine, University of Pennsylvania, PA 19104, USA
    Nanomedicine (Lond) 6:475-87. 2011
    ..To evaluate the novel nanoparticle reconstituted bacteriochlorin e6 bisoleate low-density lipoprotein (r-Bchl-BOA-LDL) for its efficacy as a photodynamic therapy agent delivery system in xenografts of human hepatoblastoma G2 (HepG2) tumors...
  13. ncbi Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: a case study with comparison to MRI
    Regine Choe
    Department of Physics and Astronomy, University of Pennsylvania, 209 South 33rd Street, Philadelphia, Pennsylvania 19104 6396, USA
    Med Phys 32:1128-39. 2005
    ..A decrease in total hemoglobin concentration contrast between tumor and normal tissue was also observed over time. The results demonstrate the potential of DOT for measuring physiological parameters of breast lesions during chemotherapy...
  14. ncbi Time-dependent blood flow and oxygenation in human skeletal muscles measured with noninvasive near-infrared diffuse optical spectroscopies
    Guoqiang Yu
    University of Pennsylvania, Department of Physics and Astronomy, Philadelphia, Pennsylvania 19104, USA
    J Biomed Opt 10:024027. 2005
    ..The instrument thus provides a method for evaluation of microcirculation and muscle metabolism in patients with vascular diseases...
  15. ncbi In vivo continuous-wave optical breast imaging enhanced with Indocyanine Green
    Xavier Intes
    Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Med Phys 30:1039-47. 2003
    ..These results provide further evidence that in vivo pharmacokinetics of ICG in breast tumors may be a useful diagnostic tool for differentiation of benign and malignant pathologies...
  16. doi Histological basis of MR/optical imaging of human melanoma mouse xenografts spanning a range of metastatic potentials
    He N Xu
    Molecular Imaging Laboratory, Department of Radiology, Philadelphia, Pennsylvania 19104, USA
    Adv Exp Med Biol 645:247-53. 2009
    ..We are currently investigating whether these cells are in autophagic state, a possible cell survival mechanism under starvation conditions...
  17. ncbi Correlation between near-infrared spectroscopy and magnetic resonance imaging of rat brain oxygenation modulation
    Yu Chen
    Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Phys Med Biol 48:417-27. 2003
    ..A linear relationship with high correlation coefficient between the relative changes in the BOLD MRI signal and the NIRS signal is observed...
  18. ncbi Effect of errors in baseline optical properties on accuracy of transabdominal near-infrared spectroscopy in fetal sheep brain during hypoxic stress
    Theresa Mawn
    University of Pennsylvania, Department of Bioengineering, Philadelphia, Pennsylvania 19104 6100, USA
    J Biomed Opt 10:064001. 2005
    ..Under hypoxic conditions, however, the variability of the NIR StO2 calculations with changes in the assumed reference properties became more significant...
  19. pmc In vivo fluorometric assessment of cyclosporine on mitochondrial function during myocardial ischemia and reperfusion
    Muneaki Matsubara
    Gorman Cardiovascular Research Group, University of Pennsylvania, Philadelphia, Pennsylvania 19036, USA
    Ann Thorac Surg 89:1532-7. 2010
    ..We hypothesized that CsA limits mitochondrial dysfunction and that fluorometry can quantify this influence...
  20. ncbi Modeling of oxygen diffusion and metabolism from capillary to muscle
    Ping Huang
    University of Pennsylvania, Philadelphia, PA 19104, USA
    Adv Exp Med Biol 540:325-30. 2003
  21. ncbi Fluorescence spectroscopy and imaging of myocardial apoptosis
    Mahsa Ranji
    Department of Electrical and Systems Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biomed Opt 11:064036. 2006
    ..This represents the first attempt to assess myocyte apoptosis in the beating heart...
  22. ncbi Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: a pilot study
    Ulas Sunar
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6396, USA
    J Biomed Opt 11:064021. 2006
    ..0+/-8.1) [microM] at the end of the fourth week of therapy. These preliminary results suggest daily diffuse-optics-based therapy monitoring is feasible during the first two weeks and may have clinical promise...
  23. ncbi Diffuse optical tomography with physiological and spatial a priori constraints
    Xavier Intes
    Department of Biophysics and Biochemistry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Phys Med Biol 49:N155-63. 2004
    ..More accurate recovery of the two main functional parameters that are the blood volume and the relative saturation is demonstrated through simulations by using our method compared to actual techniques...
  24. ncbi Reduced heterogeneity of muscle deoxygenation during heavy bicycle exercise
    Ryotaro Kime
    Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, USA
    Med Sci Sports Exerc 37:412-7. 2005
    ..This study evaluated heterogeneity of muscle O2 dynamics in a single muscle during bicycle exercise using an eight-channel near-infrared continuous wave spectroscopy (NIRcws) mapping system...
  25. ncbi Probing rat brain oxygenation with near-infrared spectroscopy (NIRS) and magnetic resonance imaging (MRI)
    Yu Chen
    Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Adv Exp Med Biol 510:199-204. 2003
  26. ncbi Relationship between muscle architectural features and oxygenation status determined by near infrared device
    Hajime Miura
    Department of Biochemistry and Biophysics, School of Medicine, University of Pennsylvania, PA 19104, Philadelphia, USA
    Eur J Appl Physiol 91:273-8. 2004
    ..05), between DeltaNIR-blood volume and Deltafascicle angle ( r=-0.85, P<0.05). In conclusion, the plantar flexion exercise produced regional differences in oxygenation status consistent with regional differences in muscle architecture...
  27. ncbi Impaired exercise-induced blood volume in type 2 diabetes with or without peripheral arterial disease measured by continuous-wave near-infrared spectroscopy
    Emile R Mohler
    Cardiovascular Division, Vascular Medicine Section, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Diabetes Care 29:1856-9. 2006
    ..However, the pathophysiology involved in PAD is unclear. This study was conducted to evaluate the hemodynamic response to exercise of patients with and without diabetes and PAD...
  28. ncbi Cyclophosphamide treatment modifies tumor oxygenation and glycolytic rates of RIF-1 tumors: 13C magnetic resonance spectroscopy, Eppendorf electrode, and redox scanning
    Harish Poptani
    Departments of Radiology, Johnson Research Foundation, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Cancer Res 63:8813-20. 2003
    ..Overall, these data indicate that the reduction in glycolytic rate of Cp-treated RIF-1 tumors is due to an increase in aerobic metabolism...
  29. doi Biomathematics in cancer detection: simulation of lipogenesis in cancer
    Ping Huang
    Department of Biophysics and Biochemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Adv Exp Med Biol 614:151-6. 2008
    ..Simulation and discussion on lipogenesis by carbohydrate responsive element-binding protein (ChREBP) are given. Our model provides a potential way to analyze the experimental databank...
  30. ncbi Lipoprotein nanoplatform for targeted delivery of diagnostic and therapeutic agents
    Jerry D Glickson
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104 6069, USA
    Mol Imaging 7:101-10. 2008
    ..These particles can be used for in situ loading of magnetite into cells for MRI-monitored cell tracking or gene expression...
  31. ncbi Breast cancer detection of large size to DCIS by hypoxia and angiogenesis using NIRS
    Shoko Nioka
    Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, USA
    Adv Exp Med Biol 789:211-9. 2013
    ..3 % and 85.3 %, respectively. In summary, smaller-size tumors are difficult to detect with NIRS, whereas DCIS can be detected by the same total hemoglobin and hypoxic score in our study...
  32. pmc Investigation of the prefrontal cortex in response to duration-variable anagram tasks using functional near-infrared spectroscopy
    Fenghua Tian
    The University of Pennsylvania School of Medicine, Department of Biophysics and Biochemistry, Philadelphia, Pennsylvania 19104, USA
    J Biomed Opt 14:054016. 2009
    ..A better understanding of nonlinearity in fNIRS signals will have potential for us to investigate brain adaptation and to extrapolate neuronal activities from hemodynamic signals...
  33. ncbi Analysis on performance and optimization of frequency-domain near-infrared instruments
    Tao Tu
    University of Pennsylvania, Department of Electrical Engineering, Department of Biochemistry and Biophysics, Philadelphia, Pennsylvania 19104, USA
    J Biomed Opt 7:643-9. 2002
    ..This kind of method can be used to design suitable instruments for various applications. We also analyze the selection of the instrument parameters to achieve optimal performance at an efficient cost using this analytical model...
  34. ncbi Delayed reoxygenation after maximal isometric handgrip exercise in high oxidative capacity muscle
    Ryotaro Kime
    Department of Biochemistry and Biophysics, 250 Anatomy Chemistry Building, University of Pennsylvania, 37th and Hamilton Walk, Philadelphia, PA 19104 6059, USA
    Eur J Appl Physiol 89:34-41. 2003
    ....
  35. ncbi Fetal transabdominal pulse oximeter studies using a hypoxic sheep model
    Shoko Nioka
    Department of Biochem Biophysics, University of Pennsylvania, PA 19104, USA
    J Matern Fetal Neonatal Med 17:393-9. 2005
    ..This study investigates the validity of transabdominal pulse oximetry using a sheep fetal hypoxia model with fetal arterial hemoglobin saturation...
  36. pmc MRI-guided diffuse optical spectroscopy of malignant and benign breast lesions
    Vasilis Ntziachristos
    Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104 6059, USA
    Neoplasia 4:347-54. 2002
    ..It is foreseen that the technique can play a major role in functional activation studies of brain and muscle as well...
  37. ncbi Pyropheophorbide 2-deoxyglucosamide: a new photosensitizer targeting glucose transporters
    Min Zhang
    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Bioconjug Chem 14:709-14. 2003
    ....
  38. ncbi Three-dimensional diffuse optical tomography in the parallel plane transmission geometry: evaluation of a hybrid frequency domain/continuous wave clinical system for breast imaging
    J P Culver
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6396, USA
    Med Phys 30:235-47. 2003
    ..In addition, we find that point spread function measurements provide a useful and comprehensive representation of system performance...
  39. ncbi Quantitative brain tissue oximetry, phase spectroscopy and imaging the range of homeostasis in piglet brain
    Britton Chance
    Department of Biochemistry and Biophysics, Johnson Research Foundation, University of Pennsylvania, Center for Biomedical Optics, University City Science Center, Philadelphia, PA, USA
    Adv Exp Med Biol 530:13-8. 2003
    ..Beyond that range, the tissue oxygen is still correctly measured but, as expected, approaches the arterial saturation at low metabolic rates and the venous saturation at high metabolic rates of mitochondria...
  40. doi Heterogeneity of mitochondrial redox state in premalignant pancreas in a PTEN null transgenic mouse model
    He N Xu
    Department of Radiology, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Adv Exp Med Biol 701:207-13. 2011
    ....
  41. ncbi Adaptive calibration for object localization in turbid media with interfering diffuse photon density waves
    Yu Chen
    Department of Biophysics and Biochemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Appl Opt 41:7325-33. 2002
    ..Experimental data on human breast phantoms demonstrate that localization accuracy within several millimeters has been accomplished through this method...
  42. pmc Transabdominal near infrared oximetry of hypoxic stress in fetal sheep brain in utero
    Regine Choe
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 100:12950-4. 2003
    ..Fetal hypoxia was detected. Good agreement was found between fetal blood saturation determined by the transabdominal NIR method and arterial and venous fetal blood saturation quantified from fetal blood samples by using a hemoximeter...
  43. ncbi Low-density lipoprotein reconstituted by pyropheophorbide cholesteryl oleate as target-specific photosensitizer
    Gang Zheng
    Department of Radiology, University of Pennsylvania Medical School, Philadelphia 19104, USA
    Bioconjug Chem 13:392-6. 2002
    ..Laser scanning confocal microscopy studies demonstrated that this photosensitizer-reconstituted LDL can be internalized via LDLr by human hepatoblastoma G(2) (HepG(2)) tumor cells...
  44. ncbi Projection access order in algebraic reconstruction technique for diffuse optical tomography
    Xavier Intes
    Department of Biophysics and Biochemistry, University of Pennsylvania, Philadelphia 19104, USA
    Phys Med Biol 47:N1-10. 2002
    ..We show that by selecting proper projection access order, the convergence speed can be significantly improved when ART is used to perform DOT. Moreover, low-contrast detection is improved...
  45. ncbi Photon migration through fetal head in utero using continuous wave, near infrared spectroscopy: clinical and experimental model studies
    N Ramanujam
    University of Pennsylvania, Dept of Biochemistry and Biophysics, Philadelphia, USA
    J Biomed Opt 5:173-84. 2000
    ..The results of the comparison were used to provide insight into the optical properties and physical geometry of the maternal and fetal tissues in the photon migration path...
  46. ncbi Preliminary evaluation of dual wavelength phased array imaging on neonatal brain function
    Y Chen
    Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia 19104, USA
    J Biomed Opt 5:194-200. 2000
    ..Significant functional responses, particularly to parietal stimulation in normal and pathological states of neonatal brain, have been revealed in our study. The preliminary clinical results are presented in this article...
  47. ncbi Oximetry based on diffuse photon density wave differentials
    V Ntziachristos
    Department of Bioengineering, University of Pennsylvania, Philadelphia 19104 6089, USA
    Med Phys 27:410-21. 2000
    ....
  48. pmc Concurrent MRI and diffuse optical tomography of breast after indocyanine green enhancement
    V Ntziachristos
    Departments of Bioengineering, Biochemistry Biophysics, University of Pennsylvania, Philadelphia, PA 19104 6089, USA
    Proc Natl Acad Sci U S A 97:2767-72. 2000
    ..Additionally our use of ICG, an albumin bound absorbing dye in plasma, demonstrates the potential to differentiate disease based on the quantified enhancement of suspicious lesions...
  49. ncbi Near-field diffraction tomography with diffuse photon density waves
    X Li
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics 61:4295-309. 2000
    ..g., the slab medium). Limitations and potential improvements of the near-field diffraction tomography are also discussed...
  50. ncbi NIR spectroscopic detection of breast cancer
    S Nioka
    University of Pennsylvania, Department of Biochemistry and Biophysics, 250 Anatomy Chemistry Bldg, Philadelphia, PA 19104 6059, USA
    Technol Cancer Res Treat 4:497-512. 2005
    ....
  51. ncbi Metabolism-enhanced tumor localization by fluorescence imaging: in vivo animal studies
    Y Chen
    Department of Biophysics and Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Opt Lett 28:2070-2. 2003
    ....
  52. ncbi Bulk optical properties of healthy female breast tissue
    T Durduran
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia 19104, USA
    Phys Med Biol 47:2847-61. 2002
    ..The new information on healthy breast tissue provides insight about the potential contrasts available for diffuse optical tomography of breast tumours...
  53. ncbi Antepartum, transabdominal near infrared spectroscopy: feasibility of measuring photon migration through the fetal head in utero
    N Ramanujam
    University of Pennsylvania, Johnson Research Foundation, Philadelphia 19104, USA
    J Matern Fetal Med 8:275-88. 1999
    ..We report the feasibility of measuring photon migration through the fetal head in utero using antepartum, transabdominal, near infrared (NIR) spectroscopy...
  54. ncbi Oxygenation and blood concentration changes in human subject prefrontal activation by anagram solutions
    Britton Chance
    University of Pennsylvania, Department of Biochemistry and Biophysics, Philadelphia, PA 19104 6059, USA
    Adv Exp Med Biol 510:397-401. 2003
    ..A wearable NIR measurement of metabolic activation and blood flow may be a useful educational aid. In summary, the optical method focuses attention on cognition activated oxygenation of prefrontal cortex...
  55. ncbi Predicting melanoma metastatic potential by optical and magnetic resonance imaging
    Lin Z J Li
    Department of Radiology, Philadelphia, Pennsylvania 19104, USA
    Adv Exp Med Biol 599:67-78. 2007
    ..These differences observed between these two types of tumors, one indolent and one aggressive, if generalizable, would be very valuable in predicting human melanoma metastatic potential...
  56. pmc Near-infrared-emissive polymersomes: self-assembled soft matter for in vivo optical imaging
    P Peter Ghoroghchian
    School of Engineering and Applied Science, Institute for Medicine and Engineering, Department of Chemistry, University of Pennsylvania, Philadelphia 19104, USA
    Proc Natl Acad Sci U S A 102:2922-7. 2005
    ..Robust NIR-emissive polymersomes thus define a soft matter platform with exceptional potential to facilitate deep-tissue fluorescence-based imaging for in vivo diagnostic and drug-delivery applications...
  57. ncbi Simultaneous fluorometry and phosphorometry of Langendorff perfused rat heart: ex vivo animal studies
    Mahsa Ranji
    Complex Media Laboratory, Department of Electrical and Systems Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Opt Lett 31:2995-7. 2006
    ....
  58. ncbi Mitochondrial NADH redox state, monitoring discovery and deployment in tissue
    Britton Chance
    Eldridge Reeves Johnson University, Philadelphia, PA 19104, USA
    Methods Enzymol 385:361-70. 2004
  59. ncbi Protease-triggered photosensitizing beacon based on singlet oxygen quenching and activation
    Juan Chen
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Am Chem Soc 126:11450-1. 2004
    ..Upon caspase-3-induced cleavage, the 1O2 production increased markedly, as measured directly by 1O2 near-infrared luminescence and lifetime measurements...
  60. ncbi Diffuse optical tomography of highly heterogeneous media
    V Ntziachristos
    Department of Bioengineering, University of Pennsylvania, Philadelphia 19104, USA
    IEEE Trans Med Imaging 20:470-8. 2001
    ..To eliminate the artifacts and improve the overall image reconstruction, we apply a data-correction algorithm that yields superior reconstruction results and is virtually independent of the degree of the background heterogeneity...
  61. ncbi Accuracy limits in the determination of absolute optical properties using time-resolved NIR spectroscopy
    V Ntziachristos
    Departments of Bioengineering, Biochemistry Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6089
    Med Phys 28:1115-24. 2001
    ..In that sense this analysis can be used in time-resolved system design and in predicting the expected errors given the technology selected for time-resolved measurements...
  62. ncbi Near infrared muscle spectroscopy in patients with Friedreich's ataxia
    David R Lynch
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Muscle Nerve 25:664-73. 2002
    ..These results suggest that NIRS may be an effective tool for monitoring the biochemical and functional features of Friedreich's ataxia in parallel...
  63. ncbi Non-invasive and quantitative near-infrared haemoglobin spectrometry in the piglet brain during hypoxic stress, using a frequency-domain multidistance instrument
    D M Hueber
    University of Pennsylvania, School of Medicine in Philadelphia, USA
    Phys Med Biol 46:41-62. 2001
    ..The origin of this 'effective' background absorption may be real, an artefact caused by the application of a simplified model to a complex sample, or a combination of factors...
  64. pmc Probing physiology and molecular function using optical imaging: applications to breast cancer
    V Ntziachristos
    Department of Bioengineering, University of Pennsylvania, Philadelphia, USA
    Breast Cancer Res 3:41-6. 2001
    ..These features could enhance diagnostic accuracy, lower the current state-of-the-art detection limits, and play a vital role in therapeutic strategy and monitoring...
  65. ncbi Tricarbocyanine cholesteryl laurates labeled LDL: new near infrared fluorescent probes (NIRFs) for monitoring tumors and gene therapy of familial hypercholesterolemia
    Gang Zheng
    Department of Radiology, University of Pennsylvania, Philadelphia 19104, USA
    Bioorg Med Chem Lett 12:1485-8. 2002
    ....
  66. ncbi Detection limit enhancement of fluorescent heterogeneities in turbid media by dual-interfering excitation
    Xavier Intes
    Department of Biophysics and Biochemistry, University of Pennsylvania, Philadelphia 19104, USA
    Appl Opt 41:3999-4007. 2002
    ..To detect the same inhomogeneity, less concentration and lifetime contrast is required with dual-interfering sources...
  67. ncbi In vivo determination of altered hemoglobin saturation in dogs with M-type phosphofructokinase deficiency
    K McCully
    Division of Geriatric Medicine, Medical College of Pennsylvania and Hahnemann University, Philadelphia, Pennsylvania 19131, USA
    Muscle Nerve 22:621-7. 1999
    ..NIRS appears to be a useful noninvasive method of monitoring tissue oxygen saturation in normal or disease conditions...
  68. ncbi Oxygen transport and intracellular bioenergetics on stimulated cat skeletal muscle
    S Nioka
    Department of Biochemistry and Biophysics, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Adv Exp Med Biol 510:267-72. 2003
    ..As cellular hypoxia causes decreases in muscle performance (moderate to severe hypoxia), NADH is being reduced rather than oxidized with increasing workloads...
  69. ncbi Study of near infrared technology for intracranial hematoma detection
    Q Zhang
    Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia 19104 6089, USA
    J Biomed Opt 5:206-13. 2000
    ..Model inhomogeneity tests and animal hematoma tests showed the effectiveness of the improved hematoma detector for intracranial hematoma detection...
  70. ncbi Three-dimensional redox imaging of frozen-quenched brain and other organs
    Akihiko Shiino
    Department of Neurosurgery, Shiga University of Medical Science, Ohtsu, Shiga, 520 2192, Japan
    Methods Enzymol 352:475-82. 2002
  71. ncbi Creatine supplementation enhances anaerobic ATP synthesis during a single 10 sec maximal handgrip exercise
    Yuko Kurosawa
    Department of Preventive Medicine and Public Health, Tokyo Medical University, Shinjuku ku, Tokyo, Japan
    Mol Cell Biochem 244:105-12. 2003
    ..05). The results suggest that Cr supplementation enhanced PCr degradation during Ex10. It is strongly indicated that an improvement in performance during Ex10 was associated with the increased PCr availability for the synthesis of ATP...
  72. ncbi Photobiomodulation directly benefits primary neurons functionally inactivated by toxins: role of cytochrome c oxidase
    Margaret T T Wong-Riley
    Department of Cell Biology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Biol Chem 280:4761-71. 2005
    ..The results are consistent with our hypothesis that the mechanism of photobiomodulation involves the up-regulation of cytochrome c oxidase, leading to increased energy metabolism in neurons functionally inactivated by toxins...
  73. doi Pharmacokinetic-rate images of indocyanine green for breast tumors using near-infrared optical methods
    Burak Alacam
    Department of Electrical, Computer, and Systems Engineering, Rensselaer Polytechnic Institute, Troy, NY, USA
    Phys Med Biol 53:837-59. 2008
    ..Our study indicates that the pharmacokinetic-rate images may provide superior information than single set of pharmacokinetic rates estimated from the entire breast tissue for breast cancer diagnosis...
  74. doi Near-infrared spectroscopy/imaging for monitoring muscle oxygenation and oxidative metabolism in healthy and diseased humans
    Takafumi Hamaoka
    National Institute of Fitness and Sports, Department of Exercise Science, Shiromizu 1, Kanoya, 891 2393 Japan
    J Biomed Opt 12:062105. 2007
    ..As NIRS technology continues to evolve, the study of skeletal muscle function with NIRS first illuminated by Jobsis continues to be bright...
  75. ncbi Characterization of breast tumors with NIR methods using optical indices
    Burak Alacam
    Dept of Electrical, Computer, and Systems Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180, USA
    Conf Proc IEEE Eng Med Biol Soc 2007:5186-9. 2007
    ..91 with a significance level of 0.05. Our results suggest that the features, relative blood concentration, and oxygen saturation can differentiate breast tumors with a relatively high precision...
  76. ncbi Reconstruction of spatially resolved pharmacokinetic rate images of fluorescence agents in FDOT
    Burak Alacam
    Dept of Electrical Computer and Systems Engineering, Rensselaer Polytechnic Institute, Troy, New York 19102, USA
    Conf Proc IEEE Eng Med Biol Soc 1:5627-30. 2006
    ....
  77. ncbi Microcirculatory function, tissue oxygenation, microregional redox status and ATP distribution in tumors upon localized infrared-A-hyperthermia at 42 degrees C
    Oliver Thews
    Institute of Physiology and Pathophysiology, University of Mainz, Duesbrgweg 6, 55099 Mainz, Germany
    Adv Exp Med Biol 530:237-47. 2003
    ..The latter finding can be explained by an equivalent increase in the oxygen consumption rate of the cells which increases by approx. 58% at 42 degrees C compared to normothermia...
  78. ncbi Effect of muscle oxygenation during resistance exercise on anabolic hormone response
    Jay R Hoffman
    The College of New Jersey, Ewing, NJ 08628, USA
    Med Sci Sports Exerc 35:1929-34. 2003
    ..This investigation examined the affects of two different resistance exercise protocols on muscle oxygenation, and the anabolic hormonal response to such exercise...
  79. ncbi The effect of a competitive collegiate football season on power performance and muscle oxygen recovery kinetics
    Jay R Hoffman
    The College of New Jersey, Ewing, New Jersey 08628, USA
    J Strength Cond Res 19:509-13. 2005
    ..Results indicate that the extent of muscle deoxygenation is reduced during high-intensity exercise and that muscle oxygen recovery kinetics improves over the duration of a competitive season of football...
  80. ncbi A novel approach to a bifunctional photosensitizer for tumor imaging and phototherapy
    Yihui Chen
    PDT Center, Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Bioconjug Chem 16:1264-74. 2005
    ....
  81. pmc Synergistic effects of light-emitting probes and peptides for targeting and monitoring integrin expression
    Samuel Achilefu
    Department of Radiology and Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 102:7976-81. 2005
    ....
  82. ncbi Evaluation of physiological responses during recovery following three resistance exercise programs
    Jie Kang
    The College of New Jersey, Ewing, New Jersey 08628, USA
    J Strength Cond Res 19:305-9. 2005
    ..In addition, an exercise routine performed at low to moderate intensity coupled with a moderate to high exercise volume is most effective in maximizing caloric expenditure following resistance exercise...
  83. ncbi Simulation study of breast tissue hemodynamics during pressure perturbation
    Shoko Nioka
    Adv Exp Med Biol 566:17-22. 2005
    ..The results showed that simulation can be used to obtain venous and average oxygen saturation as well as blood flow in compressed breast tissues...
  84. ncbi Mitochondrial NADH as the bellwether of tissue O2 delivery
    Britton Chance
    Adv Exp Med Biol 566:231-42. 2005
    ....
  85. ncbi Non-PET functional imaging techniques: optical
    Xavier Intes
    Biomedical Optical Imaging, Advanced Research Technologies ART, 2300 Alfred Nobel Boulevard, Saint Laurent, Quebec H4S 2A4, Canada
    Radiol Clin North Am 43:221-34, xii. 2005
    ..This is followed by a survey of the three main applications: brain imaging, muscle imaging, and breast imaging. Lastly, the future outlook of the technology is presented, highlighting the new promises based on recent breakthroughs...
  86. ncbi Transabdominal fetal pulse oximetry with near-infrared spectroscopy
    Anthony M Vintzileos
    Department of Obstetrics, Gynecology and Reproductive Sciences, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ, USA
    Am J Obstet Gynecol 192:129-33. 2005
    ..The purpose of this study was to determine the feasibility of noninvasive fetal pulse oximetry in the human fetus with transabdominal continuous-wave near-infrared spectroscopy...
  87. ncbi Extended kalman filtering for the modeling and analysis of ICG pharmacokinetics in cancerous tumors using NIR optical methods
    Burak Alacam
    Department of Electrical, Computer, and Systems Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180, USA
    IEEE Trans Biomed Eng 53:1861-71. 2006
    ..Our study indicates that, in addition to the pharmacokinetic rates, the EKF model may provide parameters that may be useful for tumor differentiation...
  88. ncbi Inhibition of tumor necrosis factor-induced apoptosis in transgenic mouse liver expressing creatine kinase
    Etsuro Hatano
    Department of Gastroenterological Surgery, Kyoto University, Graduate School of Medicine, Sakyo ku, Japan
    Liver Int 24:384-93. 2004
    ..To clarify the effects of the enhanced mitochondrial function on tumor necrosis factoralpha (TNFalpha)-induced apoptosis, we studied hepatic injuries in transgenic mice whose livers express creatine kinase (CK)...
  89. ncbi Redox ratio of mitochondria as an indicator for the response of photodynamic therapy
    Zhihong Zhang
    Huazhong University of Science and Technology, Key Laboratory of Biomedical Photonics, Ministry of Education, Wuhan, Hubei 430074, P R China
    J Biomed Opt 9:772-8. 2004
    ..In the PDT treated region of the tumor, highly oxidized flavoprotein and diminishing NADH fluorescence is detected, suggesting that flavoprotein and NADH are oxidized by singlet oxygen produced in the photosensitization process...
  90. ncbi Carbocyanine labeled LDL for optical imaging of tumors
    Hui Li
    Department of Radiology, University of Pennsylvania Medical School, Chemistry 1958 Wing, Room 284, Box 66, 250 South 33rd Street, Philadelphia, PA 19104 USA
    Acad Radiol 11:669-77. 2004
    ..The purpose of this study was to define and characterize carbocyanine labeled low-density lipoprotein (LDL) to be used in the optical imaging of LDL receptor (LDLr)-overexpressing tumor models...
  91. ncbi Comparison of low- and high-intensity resistance exercise on lipid peroxidation: role of muscle oxygenation
    Jay R Hoffman
    College of New Jersey, Ewing 08628, USA
    J Strength Cond Res 21:118-22. 2007
    ..44). Results suggest that increases in MDA occur independently of exercise intensity, but tissue acidosis may have a larger influence on MDA formation...
  92. ncbi Oxidation-reduction states of NADH in vivo: from animals to clinical use
    Avraham Mayevsky
    The Mina and Everard Goodman Faculty of Life Sciences Bar Ilan University, Ramat Gan, Israel
    Mitochondrion 7:330-9. 2007
    ..The four detected parameters provide real time data on tissue viability, which is critical for patients monitoring...
  93. ncbi Diffuse optical tomography with a priori anatomical information
    Murat Guven
    Electrical, Computer, and Systems Engineering Department, Rensselaer Polytechnic Institute, Troy, NY, USA
    Phys Med Biol 50:2837-58. 2005
    ..Extensive numerical simulations demonstrate that the proposed method avoids undesirable bias towards anatomical prior information and leads to significantly improved spatial resolution and quantitative accuracy...

Research Grants26

  1. BREAST TUMOR DETECTION BY OPTICAL CONTRAST
    Britton Chance; Fiscal Year: 2000
    ....
  2. FUNCTIONAL OPTICAL IMAGING OF BRAIN INJURY (F NIRI)
    Britton Chance; Fiscal Year: 1999
    ....
  3. COREGISTERED IMAGES OF BREAST TUMORS BY MRI AND OPTICAL
    Britton Chance; Fiscal Year: 2002
    ..Large scale tests are available under other support where a direct comparison with not only MRI but also digital mammography, ultrasound and PET will secure the validation studies. ..
  4. BREAST CANCER HYPOXIA ASSESSED BY NITRIC OXIDE
    Britton Chance; Fiscal Year: 2002
    ..If ourintended goals of demonstrating feasibility are achieved, then application for support through regular RO1channels would appear to be justified. ..
  5. Images of Quantified Hypoxic Stress in Muscle
    Britton Chance; Fiscal Year: 2002
    ..Our especial goals are improving geriatric performance and detecting mitochondrial disease. See Appendix A for Glossary. ..
  6. Images of Quantified Hypoxic Stress in Muscle
    Britton Chance; Fiscal Year: 2003
    ..Our especial goals are improving geriatric performance and detecting mitochondrial disease. See Appendix A for Glossary. ..
  7. 2 & 3D Imaging of Contrast Agents in Animal Models
    Britton Chance; Fiscal Year: 2003
    ..abstract_text> ..
  8. COREGISTERED IMAGES OF BREAST TUMORS BY MRI AND OPTICAL
    Britton Chance; Fiscal Year: 2003
    ..Large scale tests are available under other support where a direct comparison with not only MRI but also digital mammography, ultrasound and PET will secure the validation studies. ..
  9. FUNCTIONAL OPTICAL IMAGING OF BRAIN INJURY (fNIRI)
    Britton Chance; Fiscal Year: 2003
    ..These projects represent logical continuations of current activities into new and related researches. ..
  10. Images of Quantified Hypoxic Stress in Muscle
    Britton Chance; Fiscal Year: 2004
    ..Our especial goals are improving geriatric performance and detecting mitochondrial disease. See Appendix A for Glossary. ..
  11. FUNCTIONAL OPTICAL IMAGING OF BRAIN INJURY (fNIRI)
    Britton Chance; Fiscal Year: 2004
    ..These projects represent logical continuations of current activities into new and related researches. ..
  12. 2 & 3D Imaging of Contrast Agents in Animal Models
    Britton Chance; Fiscal Year: 2004
    ..abstract_text> ..
  13. Images of Quantified Hypoxic Stress in Muscle
    Britton Chance; Fiscal Year: 2005
    ..Our especial goals are improving geriatric performance and detecting mitochondrial disease. See Appendix A for Glossary. ..
  14. 2 & 3D Imaging of Contrast Agents in Animal Models
    Britton Chance; Fiscal Year: 2002
    ..abstract_text> ..
  15. FUNCTIONAL OPTICAL IMAGING OF BRAIN INJURY (fNIRI)
    Britton Chance; Fiscal Year: 2002
    ..These projects represent logical continuations of current activities into new and related researches. ..
  16. BREAST TUMOR DETECTION BY OPTICAL CONTRAST
    Britton Chance; Fiscal Year: 1999
    ....
  17. OPTICAL SPECTROSCOPY AND IMAGING OF HB/MB IN TISSUES
    Britton Chance; Fiscal Year: 1999
    ..Furthermore, the application to medically needful populations where outcomes can be altered by quantitative localized studies is consonant with the goals of "Healthy People 2000". ..
  18. COREGISTERED IMAGES OF BREAST TUMORS BY MRI AND OPTICAL
    Britton Chance; Fiscal Year: 2000
    ..Large scale tests are available under other support where a direct comparison with not only MRI but also digital mammography, ultrasound and PET will secure the validation studies. ..
  19. FUNCTIONAL OPTICAL IMAGING OF BRAIN INJURY (F NIRI)
    Britton Chance; Fiscal Year: 2000
    ....
  20. FUNCTIONAL OPTICAL IMAGING OF BRAIN INJURY (F NIRI)
    Britton Chance; Fiscal Year: 2000
    ....
  21. Images of Quantified Hypoxic Stress in Muscle
    Britton Chance; Fiscal Year: 2001
    ..Our especial goals are improving geriatric performance and detecting mitochondrial disease. See Appendix A for Glossary. ..
  22. COREGISTERED IMAGES OF BREAST TUMORS BY MRI AND OPTICAL
    Britton Chance; Fiscal Year: 2001
    ..Large scale tests are available under other support where a direct comparison with not only MRI but also digital mammography, ultrasound and PET will secure the validation studies. ..
  23. 2 & 3D Imaging of Contrast Agents in Animal Models
    Britton Chance; Fiscal Year: 2001
    ..abstract_text> ..
  24. FUNCTIONAL OPTICAL IMAGING OF BRAIN INJURY (F NIRI)
    Britton Chance; Fiscal Year: 2001
    ....
  25. FUNCTIONAL OPTICAL IMAGING OF BRAIN INJURY (fNIRI)
    Britton Chance; Fiscal Year: 2005
    ..These projects represent logical continuations of current activities into new and related researches. ..