Lawrence S Chan

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. doi request reprint Atopic dermatitis in 2008
    Lawrence S Chan
    University of Illinois College of Medicine, Chicago, IL 60612, USA
    Curr Dir Autoimmun 10:76-118. 2008
  2. doi request reprint Ocular and oral mucous membrane pemphigoid (cicatricial pemphigoid)
    Lawrence S Chan
    Department of Dermatology, University of Illinois College of Medicine, Chicago, USA
    Clin Dermatol 30:34-7. 2012
  3. ncbi request reprint The progression of inflammation parallels the dermal angiogenesis in a keratin 14 IL-4-transgenic model of atopic dermatitis
    Lin Chen
    Department of Dermatology, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Microcirculation 15:49-64. 2008
  4. pmc VCAM-1 blockade delays disease onset, reduces disease severity and inflammatory cells in an atopic dermatitis model
    Lin Chen
    Department of Dermatology, University of Illinois, Chicago, IL 60612, USA
    Immunol Cell Biol 88:334-42. 2010
  5. ncbi request reprint CCL27 is a critical factor for the development of atopic dermatitis in the keratin-14 IL-4 transgenic mouse model
    Lin Chen
    Department of Dermatology, University of Illinois at Chicago, College of Medicine, MC624, 808 South Wood Street, Room 376, 60612, USA
    Int Immunol 18:1233-42. 2006
  6. doi request reprint IL-4 up-regulates epidermal chemotactic, angiogenic, and pro-inflammatory genes and down-regulates antimicrobial genes in vivo and in vitro: relevant in the pathogenesis of atopic dermatitis
    Lei Bao
    Department of Dermatology, University of Illinois, Chicago, IL 60612, USA
    Cytokine 61:419-25. 2013
  7. doi request reprint Inflammation-driven dermal lymphangiogenesis in atopic dermatitis is associated with CD11b+ macrophage recruitment and VEGF-C up-regulation in the IL-4-transgenic mouse model
    Vivian Y Shi
    Department of Dermatology, University of Illinois College of Medicine, Chicago, Illinois 60612, USA
    Microcirculation 19:567-79. 2012
  8. ncbi request reprint An erythrodermic variant of pemphigus foliaceus with puzzling histologic and immunopathologic features
    Jennifer D Peterson
    Department of Dermatology, University of Illinois at Chicago, Chicago, IL, USA
    J Cutan Med Surg 11:179-84. 2007
  9. doi request reprint IL-4 regulates chemokine CCL26 in keratinocytes through the Jak1, 2/Stat6 signal transduction pathway: Implication for atopic dermatitis
    Lei Bao
    Department of Dermatology, University of Illinois, Chicago, IL, USA
    Mol Immunol 50:91-7. 2012
  10. ncbi request reprint Angiogenesis: the major abnormality of the keratin-14 IL-4 transgenic mouse model of atopic dermatitis
    Rania Agha-Majzoub
    Department of Dermatology, University of Illinois, Chicago, 60612, USA
    Microcirculation 12:455-76. 2005

Collaborators

Detail Information

Publications14

  1. doi request reprint Atopic dermatitis in 2008
    Lawrence S Chan
    University of Illinois College of Medicine, Chicago, IL 60612, USA
    Curr Dir Autoimmun 10:76-118. 2008
    ..Some recent advancements on the management options for atopic dermatitis are also discussed...
  2. doi request reprint Ocular and oral mucous membrane pemphigoid (cicatricial pemphigoid)
    Lawrence S Chan
    Department of Dermatology, University of Illinois College of Medicine, Chicago, USA
    Clin Dermatol 30:34-7. 2012
    ..Although the target antigens vary, subsets of patients affected exclusively by oral and ocular mucosal diseases have autoantibodies targeting α-6 and β-4 integrins, respectively...
  3. ncbi request reprint The progression of inflammation parallels the dermal angiogenesis in a keratin 14 IL-4-transgenic model of atopic dermatitis
    Lin Chen
    Department of Dermatology, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Microcirculation 15:49-64. 2008
    ..In conclusion, IL-6 and IFN-gamma may play important roles in upregulation of VEGF-A, along with other pro-angiogenic factors, to induce dermal microvascular angiogenesis...
  4. pmc VCAM-1 blockade delays disease onset, reduces disease severity and inflammatory cells in an atopic dermatitis model
    Lin Chen
    Department of Dermatology, University of Illinois, Chicago, IL 60612, USA
    Immunol Cell Biol 88:334-42. 2010
    ..VCAM-1 is more critical in developing skin inflammation in this model...
  5. ncbi request reprint CCL27 is a critical factor for the development of atopic dermatitis in the keratin-14 IL-4 transgenic mouse model
    Lin Chen
    Department of Dermatology, University of Illinois at Chicago, College of Medicine, MC624, 808 South Wood Street, Room 376, 60612, USA
    Int Immunol 18:1233-42. 2006
    ..In conclusion, CCL27 and CCR10 interaction is important for the development of skin inflammation in our AD model...
  6. doi request reprint IL-4 up-regulates epidermal chemotactic, angiogenic, and pro-inflammatory genes and down-regulates antimicrobial genes in vivo and in vitro: relevant in the pathogenesis of atopic dermatitis
    Lei Bao
    Department of Dermatology, University of Illinois, Chicago, IL 60612, USA
    Cytokine 61:419-25. 2013
    ..Detailed examination of these genes will delineate their specific roles in chemotaxis, inflammation, angiogenesis and AMP production, all of which may contribute to the development and progression of AD...
  7. doi request reprint Inflammation-driven dermal lymphangiogenesis in atopic dermatitis is associated with CD11b+ macrophage recruitment and VEGF-C up-regulation in the IL-4-transgenic mouse model
    Vivian Y Shi
    Department of Dermatology, University of Illinois College of Medicine, Chicago, Illinois 60612, USA
    Microcirculation 19:567-79. 2012
    ..To investigate the presence and extent of inflammatory lymphangiogenesis in AD and determine the role of IL-4 in lymphatic proliferation in both K14-IL-4 Tg mouse model of AD and cultured human epidermal cells...
  8. ncbi request reprint An erythrodermic variant of pemphigus foliaceus with puzzling histologic and immunopathologic features
    Jennifer D Peterson
    Department of Dermatology, University of Illinois at Chicago, Chicago, IL, USA
    J Cutan Med Surg 11:179-84. 2007
    ..Pemphigus foliaceus is an autoimmune blistering disorder that affects the skin owing to autoantibodies against desmoglein 1...
  9. doi request reprint IL-4 regulates chemokine CCL26 in keratinocytes through the Jak1, 2/Stat6 signal transduction pathway: Implication for atopic dermatitis
    Lei Bao
    Department of Dermatology, University of Illinois, Chicago, IL, USA
    Mol Immunol 50:91-7. 2012
    ..Taken together, results of this investigation reveal that IL-4 signals through the Jak1, 2/Stat6 pathway in keratinocytes to stimulate CCL26 expression and this may provide an explanation for the pathogenesis of AD...
  10. ncbi request reprint Angiogenesis: the major abnormality of the keratin-14 IL-4 transgenic mouse model of atopic dermatitis
    Rania Agha-Majzoub
    Department of Dermatology, University of Illinois, Chicago, 60612, USA
    Microcirculation 12:455-76. 2005
    ..The authors examined the dermal microvasculature of an IL-4 transgenic mouse model of atopic dermatitis to determine whether angiogenesis was present...
  11. ncbi request reprint Molecular cloning of a cDNA encoding the porcine type XVII collagen noncollagenous 16 A domain and localization of the domain to the upper part of porcine skin basement membrane zone
    Luting Xu
    Department of Dermatology, North Western University Medical School, Chicago, IL, USA
    Vet Dermatol 15:146-51. 2004
    ..Our data provide further information of the porcine bullous pemphigoid target antigen and may help investigators for their further studies of this disease...
  12. ncbi request reprint A comprehensive management guide for atopic dermatitis
    Jennifer D Peterson
    Department of Dermatology, University of Illinois at Chicago, Chicago, IL, USA
    Dermatol Nurs 18:531-42; quiz 543. 2006
  13. pmc Effectiveness and side effects of anti-CD20 therapy for autoantibody-mediated blistering skin diseases: A comprehensive survey of 71 consecutive patients from the Initial use to 2007
    Jennifer D Peterson
    Department of Dermatology, Texas Tech University Health Sciences, Center at Lubbock, Lubbock, TX, USA
    Ther Clin Risk Manag 5:1-7. 2009
    ..Therefore further investigation on rituximab with controlled clinical trial is a worthy pursuit...
  14. ncbi request reprint Incontinentia pigmenti: a review and update on the molecular basis of pathophysiology
    Alexander L Berlin
    Department of Dermatology, University of Illinois College of Medicine, 60612, USA
    J Am Acad Dermatol 47:169-87; quiz 188-90. 2002
    ..Additionally, participants will gain the most current knowledge of the genetic and molecular basis of cutaneous pathomechanism...