Francis Ka Ming Chan

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. ncbi request reprint A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses
    Francis Ka Ming Chan
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:51613-21. 2003
  2. pmc Preligand assembly domain-mediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis
    Lauren Clancy
    Department of Pathology, Immunology and Virology Program, University of Massachusetts Medical School, Worcester, 01655, USA
    Proc Natl Acad Sci U S A 102:18099-104. 2005
  3. pmc RIP1-dependent and independent effects of necrostatin-1 in necrosis and T cell activation
    Youngsik Cho
    Department of Pathology, Program in Immunology and Virology, The University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 6:e23209. 2011
  4. pmc Detection of necrosis by release of lactate dehydrogenase activity
    Francis Ka Ming Chan
    Immunology and Virology Program, Department of Pathology, Center for AIDS Research, University of Massachusetts Medical School, Worcester, MA, USA
    Methods Mol Biol 979:65-70. 2013
  5. pmc RIP3 finds partners in crime
    Francis Ka Ming Chan
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01505, USA
    Cell 148:17-8. 2012
  6. pmc Three is better than one: pre-ligand receptor assembly in the regulation of TNF receptor signaling
    Francis Ka Ming Chan
    Immunology and Virology Program, Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Cytokine 37:101-7. 2007
  7. ncbi request reprint Amelioration of inflammatory arthritis by targeting the pre-ligand assembly domain of tumor necrosis factor receptors
    Guo Min Deng
    Laboratory of Immunology, Building 10, Room 11N311, 10 Center Drive, MSC 1892, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Med 11:1066-72. 2005
  8. ncbi request reprint Monitoring molecular interactions in living cells using flow cytometric analysis of fluorescence resonance energy transfer
    Francis Ka Ming Chan
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA
    Methods Mol Biol 261:371-82. 2004
  9. pmc Viral cell death inhibitor MC159 enhances innate immunity against vaccinia virus infection
    Sreerupa Challa
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Virol 84:10467-76. 2010
  10. pmc Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation
    Young Sik Cho
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Cell 137:1112-23. 2009

Research Grants

  1. Programmed necrosis in Immune Responses
    Francis Ka Ming Chan; Fiscal Year: 2010
  2. Regulation of TRAIL-induced apoptosis
    Francis Chan; Fiscal Year: 2007
  3. Regulation of TRAIL-induced apoptosis
    Francis Chan; Fiscal Year: 2009
  4. Pre-association and Signaling by TNF-like Receptors
    Francis Chan; Fiscal Year: 2003
  5. Role of Programmed Necrosis in Immune Responses
    Francis Chan; Fiscal Year: 2006

Collaborators

Detail Information

Publications17

  1. ncbi request reprint A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses
    Francis Ka Ming Chan
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:51613-21. 2003
    ..Thus, TNF-induced programmed necrosis is facilitated by TNFR-2 signaling and caspase inhibition and may play a role in controlling viral infection...
  2. pmc Preligand assembly domain-mediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis
    Lauren Clancy
    Department of Pathology, Immunology and Virology Program, University of Massachusetts Medical School, Worcester, 01655, USA
    Proc Natl Acad Sci U S A 102:18099-104. 2005
    ..We propose that TR4 is a "regulatory" rather than "decoy" receptor that inhibits apoptosis signaling by TRAIL through this previously uncharacterized ligand-independent mechanism...
  3. pmc RIP1-dependent and independent effects of necrostatin-1 in necrosis and T cell activation
    Youngsik Cho
    Department of Pathology, Program in Immunology and Virology, The University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 6:e23209. 2011
    ..The protective effect conferred by Nec-1 and its derivatives in many experimental model systems was often attributed to the inhibition of RIP1 function...
  4. pmc Detection of necrosis by release of lactate dehydrogenase activity
    Francis Ka Ming Chan
    Immunology and Virology Program, Department of Pathology, Center for AIDS Research, University of Massachusetts Medical School, Worcester, MA, USA
    Methods Mol Biol 979:65-70. 2013
    ..In this chapter, we describe the step-by-step procedure for detection of LDH release from necrotic cells using a microtiter plate-based colorimetric absorbance assay...
  5. pmc RIP3 finds partners in crime
    Francis Ka Ming Chan
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01505, USA
    Cell 148:17-8. 2012
    ..Sun et al. and Wang et al. now identify critical factors downstream of RIP1 and RIP3 in programmed necrosis, extending our understanding of this form of cell death...
  6. pmc Three is better than one: pre-ligand receptor assembly in the regulation of TNF receptor signaling
    Francis Ka Ming Chan
    Immunology and Virology Program, Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Cytokine 37:101-7. 2007
    ..Thus, targeting pre-ligand assembly may offer new possibilities for therapeutic intervention in different pathological conditions involving TNF-like cytokines...
  7. ncbi request reprint Amelioration of inflammatory arthritis by targeting the pre-ligand assembly domain of tumor necrosis factor receptors
    Guo Min Deng
    Laboratory of Immunology, Building 10, Room 11N311, 10 Center Drive, MSC 1892, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Med 11:1066-72. 2005
    ..Thus, targeting the PLAD may have clinical value in the treatment of human arthritis and other disorders involving receptors of the TNFR superfamily...
  8. ncbi request reprint Monitoring molecular interactions in living cells using flow cytometric analysis of fluorescence resonance energy transfer
    Francis Ka Ming Chan
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA
    Methods Mol Biol 261:371-82. 2004
    ..The utility of this application in the study of protein-protein interaction is discussed...
  9. pmc Viral cell death inhibitor MC159 enhances innate immunity against vaccinia virus infection
    Sreerupa Challa
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Virol 84:10467-76. 2010
    ..These results show that MC159 is a dual-function immune modulator that regulates host cell death as well as NF-κB responses by innate immune signaling receptors...
  10. pmc Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation
    Young Sik Cho
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Cell 137:1112-23. 2009
    ..Our findings suggest that RIP3 controls programmed necrosis by initiating the pronecrotic kinase cascade, and that this is necessary for the inflammatory response against virus infections...
  11. pmc CYLD deubiquitinates RIP1 in the TNFα-induced necrosome to facilitate kinase activation and programmed necrosis
    David M Moquin
    Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 8:e76841. 2013
    ..Cylindromatosis (CYLD) is believed to promote programmed necrosis by facilitating RIP1 deubiquitination at this membrane receptor complex...
  12. pmc The molecular regulation of programmed necrotic cell injury
    David Moquin
    Department of Pathology, Immunology and Virology Program, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Trends Biochem Sci 35:434-41. 2010
    ..In this review, we discuss the molecular crosstalk between apoptosis and programmed necrosis, with a special emphasis on how caspases, protein ubiquitylation and phosphorylation regulate the induction of necrotic cell injury...
  13. pmc RIP3: a molecular switch for necrosis and inflammation
    Kenta Moriwaki
    Department of Pathology, Immunology and Microbiology Program, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Genes Dev 27:1640-9. 2013
    ..Here, we review our current understanding of the mechanisms that drive RIP3-dependent necrosis and its role in different inflammatory diseases. ..
  14. ncbi request reprint Transgenic expression of the viral FLIP MC159 causes lpr/gld-like lymphoproliferation and autoimmunity
    Melissa Woelfel
    Department of Pathology, Immunology and Virology Program, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 177:3814-20. 2006
    ..Thus, the MC159-Tg mice provide a model to study the effects of PCD in immune responses without hampering other important lymphocyte functions...
  15. ncbi request reprint Flow cytometric analysis of fluorescence resonance energy transfer: a tool for high-throughput screening of molecular interactions in living cells
    Francis Ka Ming Chan
    Department of Pathology, University of Massachusetts Medical School, Worchester, MA, USA
    Methods Mol Biol 263:281-92. 2004
    ....
  16. pmc Going up in flames: necrotic cell injury and inflammatory diseases
    Sreerupa Challa
    Department of Pathology, Immunology and Virology Program Diabetes and Endocrinology Center, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Cell Mol Life Sci 67:3241-53. 2010
    ..In this review, we will discuss the molecular mechanisms that regulate programmed necrosis/necroptosis and its biological significance in pathogen infections, drug-induced cell injury, and trauma-induced tissue damage...
  17. doi request reprint Positive and negative phosphorylation regulates RIP1- and RIP3-induced programmed necrosis
    Thomas McQuade
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, U S A
    Biochem J 456:409-15. 2013
    ..Our results show that programmed necrosis is regulated by positive and inhibitory phosphorylation events. ..

Research Grants7

  1. Programmed necrosis in Immune Responses
    Francis Ka Ming Chan; Fiscal Year: 2010
    ..These studies will allow us to better understand the signals that control inflammation and to develop strategies to control it in physiological and pathological conditions. ..
  2. Regulation of TRAIL-induced apoptosis
    Francis Chan; Fiscal Year: 2007
    ..Our experiments may also provide a useful diagnostic tool to determine response of cancers to treatments involving TRAIL or agonist TRAIL antibodies. ..
  3. Regulation of TRAIL-induced apoptosis
    Francis Chan; Fiscal Year: 2009
    ..Our experiments may also provide a useful diagnostic tool to determine response of cancers to treatments involving TRAIL or agonist TRAIL antibodies. ..
  4. Pre-association and Signaling by TNF-like Receptors
    Francis Chan; Fiscal Year: 2003
    ..The second part of this proposal attempts to elucidate the mechanism by which TNFR coordinates the recruitment of these signaling proteins. ..
  5. Role of Programmed Necrosis in Immune Responses
    Francis Chan; Fiscal Year: 2006
    ..Moreover, controlling cell death may offer a novel approach to treating autoimmune diseases. ..