Research Topics
Species | Lloyd E ChamblessSummaryAffiliation: University of North Carolina Country: USA Publications
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Publications
Short-term repeatability of electrocardiographic spatial T-wave axis and QT intervalGeorgeta D Vaidean
Department of Medicine, University of North Carolina Schools of Public Health and Medicine, Chapel Hill, NC 27514, USA
J Electrocardiol 38:139-47. 2005..We conclude that the spatial T-wave axis is as repeatable a measure of ventricular repolarization as the QT interval...- Estimation of time-dependent area under the ROC curve for long-term risk predictionLloyd E Chambless
Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27514, USA
Stat Med 25:3474-86. 2006..An illustration with data from a cardiovascular follow-up study is provided... 
Repeatability and measurement error in the assessment of choline and betaine dietary intake: the Atherosclerosis Risk in Communities (ARIC) studyAurelian Bidulescu
Cardiovascular Research Institute and Department of Community Health and Preventive Medicine, Morehouse School of Medicine, Atlanta, GA, USA
Nutr J 8:14. 2009....- Risk factors for progression of common carotid atherosclerosis: the Atherosclerosis Risk in Communities Study, 1987-1998Lloyd E Chambless
Department of Biostatistics, School of Public Health, University of North Carolina, Chapel Hill, NC 27514 4145, USA
Am J Epidemiol 155:38-47. 2002..In summary, established risk factors for coronary heart disease are associated with the rate of change of subclinical atherosclerosis... - Coronary heart disease risk prediction in the Atherosclerosis Risk in Communities (ARIC) studyLloyd E Chambless
Department of Biostatistics, University of North Carolina, CB 8300, 137 East Franklin Street, Suite 400, Bank of America Center, Chapel Hill, NC 27514 4145, USA
J Clin Epidemiol 56:880-90. 2003..These factors substantially improved prediction of future CHD for men, less for women, and also increased attributable risks... - Analysis of associations with change in a multivariate outcome variable when baseline is subject to measurement errorLloyd E Chambless
Collaborative Studies Coordinating Center, Department of Biostatistics, CB 8030, The University of North Carolina at Chapel Hill, Bank of America Building, Suite 400, 137 East Franklin Street, 27514 4145, USA
Stat Med 22:1041-67. 2003..Simulations indicate that under various conditions bias is much reduced, as is mean squared error, and coverage of 95 per cent confidence intervals is good... 
Several methods to assess improvement in risk prediction models: extension to survival analysisLloyd E Chambless
Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27514, USA
Stat Med 30:22-38. 2011..This experience should prepare us to not expect large values of the risk prediction improvement evaluation parameters for any new risk factor to be discovered...- Prediction of ischemic stroke risk in the Atherosclerosis Risk in Communities StudyLloyd E Chambless
Department of Biostatistics, School of Public Health, University of North Carolina, Chapel Hill, NC 27514 4145, USA
Am J Epidemiol 160:259-69. 2004..79 to 0.83 to 0.84; for men, it went from 0.76 to 0.78 to 0.80. These modest improvements are not enough to influence clinical and public health efforts to reduce the community burden of IS... - Risk factors for ischemic stroke subtypes: the Atherosclerosis Risk in Communities studyTetsuya Ohira
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 S 2nd St, Minneapolis, MN 55454-1015, USA
Stroke 37:2493-8. 2006..CONCLUSIONS: The impact of traditional and nontraditional risk factors other than hypertension on the incidence of ischemic stroke varied according to its subtype... - An assessment of incremental coronary risk prediction using C-reactive protein and other novel risk markers: the atherosclerosis risk in communities studyAaron R Folsom
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55454 1015, USA
Arch Intern Med 166:1368-73. 2006..There has been interest in recent years in whether additional, and in particular novel, risk factors or blood markers, such as C-reactive protein, can enhance existing coronary heart disease (CHD) prediction models... - Prediction of incident heart failure in general practice: the Atherosclerosis Risk in Communities (ARIC) StudySunil K Agarwal
Departments of Epidemiology and Biostatistics, University of North Carolina, Chapel Hill, NC 27514, USA
Circ Heart Fail 5:422-9. 2012..We examined the external validity of existing HF risk scores, optimized a 10-year HF risk function, and examined the incremental value of several biomarkers, including N-terminal pro-brain natriuretic peptide... - Military combat and burden of subclinical atherosclerosis in middle aged men: the ARIC studyAnna M Johnson
Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27514, USA
Prev Med 50:277-81. 2010..Studies of the cardiovascular consequences of combat stress are few and inconclusive... - Absolute and attributable risks of cardiovascular disease incidence in relation to optimal and borderline risk factors: comparison of African American with white subjects--Atherosclerosis Risk in Communities StudyAtsushi Hozawa
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55454 1015, USA
Arch Intern Med 167:573-9. 2007..Among white Americans, a large proportion of cardiovascular disease (CVD) events is explained by borderline or any elevated CVD risk factor levels. The degree to which this is true among African American subjects is unclear... - Long-term association between self-reported signs and symptoms and heart failure hospitalizations: the Atherosclerosis Risk In Communities (ARIC) StudyChristy L Avery
Department of Epidemiology, University of North Carolina at Chapel Hill, Bank of America Center, 137 E Franklin St, Suite 306, Chapel Hill, NC 27514, USA
Eur J Heart Fail 12:232-8. 2010..Although studies of the accuracy of heart failure (HF) classification scoring systems are available, few have examined their performance when restricted to self-reported items... - Risk factors for cardiovascular event recurrence in the Atherosclerosis Risk in Communities (ARIC) studyKeattiyoat Wattanakit
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minn 55454-1015, USA
Am Heart J 149:606-12. 2005..CONCLUSION: Established risk factors, but only a few of novel risk factors and markers, were independent predictors of recurrent CVD events... - Airflow obstruction, lung function, and risk of incident heart failure: the Atherosclerosis Risk in Communities (ARIC) studySunil K Agarwal
Department of Epidemiology, University of North Carolina, 137 E Franklin Street, Chapel Hill, NC 27514, USA
Eur J Heart Fail 14:414-22. 2012..We examined the relationship between forced expiratory volume in 1 s (FEV(1)), airflow obstruction, and incident heart failure (HF) in black and white, middle-aged men and women in four US communities... - Twenty-two-year trends in incidence of myocardial infarction, coronary heart disease mortality, and case fatality in 4 US communities, 1987-2008Wayne D Rosamond
Departments of Epidemiology, School of Medicine, University of North Carolina, Chapel Hill, USA
Circulation 125:1848-57. 2012..Knowledge of trends in the incidence of and survival after myocardial infarction (MI) in a community setting is important to understanding trends in coronary heart disease (CHD) mortality rates... - Dietary phosphorus, blood pressure, and incidence of hypertension in the atherosclerosis risk in communities study and the multi-ethnic study of atherosclerosisAlvaro Alonso
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 S 2nd St, Suite 300, Minneapolis, MN 55454, USA
Hypertension 55:776-84. 2010..04 (0.93 to 1.17; P for trend=0.48) for phosphorus from other foods. These findings could indicate an effect of phosphorus in conjunction with other dairy constituents or of dairy itself without involvement of phosphorus... - Transcription factor 7-like 2 (TCF7L2) polymorphism and context-specific risk of type 2 diabetes in African American and Caucasian adults: the Atherosclerosis Risk in Communities studyYu Yan
Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA
Diabetes 58:285-9. 2009..Moreover, few studies have investigated the effects of TCF7L2 on type 2 diabetes in the context of metabolic risk factors of type 2 diabetes... - Association of multiple anthropometrics of overweight and obesity with incident heart failure: the Atherosclerosis Risk in Communities studyLaura R Loehr
University of North Carolina, Chapel Hill, NC, USA
Circ Heart Fail 2:18-24. 2009..The association of central adiposity with incident heart failure (HF) has yet to be studied in a large population-based study... - Prediction of coronary heart disease in middle-aged adults with diabetesAaron R Folsom
University of Minnesota, School of Public Health, Division of Epidemiology, Minneapolis, Minnesota 55454 1015, USA
Diabetes Care 26:2777-84. 2003..To determine the 10-year probability of coronary heart disease (CHD) in diabetic adults and how well basic and novel risk factors predict CHD risk... - Classification of heart failure in the atherosclerosis risk in communities (ARIC) study: a comparison of diagnostic criteriaWayne D Rosamond
Departments of Epidemiology, University of North Carolina at Chapel Hill, 137 E Franklin St, Suite 203, Chapel Hill, NC 27514, USA
Circ Heart Fail 5:152-9. 2012..We developed a new classification protocol for identifying ADHF in the Atherosclerosis Risk in Communities (ARIC) Study and compared it with these other schemes... - Hypertension, blood pressure, and heart rate variability: the Atherosclerosis Risk in Communities (ARIC) studyEmily B Schroeder
Department of Epidemiology, School of Public Health, University of North Carolina, 137 E Franklin St, Ste 306, Chapel Hill, NC 27514, USA
Hypertension 42:1106-11. 2003..These findings thus support the thesis that the autonomic nervous system is involved in the development of hypertension, yet suggest that differences in the autonomic profile of hypertensives and normotensives do not increase with time... - Using the whole cohort in the analysis of case-cohort dataNorman E Breslow
Department of Biostatistics, University of Washington, Seattle, Washington 98195 7232, USA
Am J Epidemiol 169:1398-405. 2009..Epidemiologists are encouraged to consider use of these methods to enhance the accuracy of results reported from case-cohort analyses... - Usual choline and betaine dietary intake and incident coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) studyAurelian Bidulescu
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
BMC Cardiovasc Disord 7:20. 2007..S. nutrient composition database. Our objective was to assess the association of dietary intake of choline and betaine with incident coronary heart disease (CHD), adjusting for dietary intake measurement error... - Military combat and risk of coronary heart disease and ischemic stroke in aging men: The Atherosclerosis Risk in Communities (ARIC) studyAnna M Johnson
Department of Epidemiology, University of North Carolina, Chapel Hill, 27514, USA
Ann Epidemiol 20:143-50. 2010..To assess the long-term association of military combat stress with coronary heart disease (CHD) and ischemic stroke (IS)... - Does the impact of smoking on coronary heart disease differ by low-density lipoprotein cholesterol level?: the Atherosclerosis Risk in Communities (ARIC) StudyAtsushi Hozawa
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, MN, USA
Circ J 70:1105-10. 2006.... - B vitamin status and inflammatory markersAaron R Folsom
Division of Epidemiology, School of Public Health, University of Minnesota, 1300 South Second Street, Suite 300, Minneapolis, MN 55454 1015, USA
Atherosclerosis 169:169-74. 2003..In ostensibly healthy adults, B-vitamin status is not a strong correlate of circulating levels of inflammatory markers, cellular adhesion molecules, or thrombogenic factors... - Trends in the sensitivity, positive predictive value, false-positive rate, and comparability ratio of hospital discharge diagnosis codes for acute myocardial infarction in four US communities, 1987-2000Wayne D Rosamond
Department of Epidemiology, Cardiovascular Disease Epidemiology Program, School of Public Health, University of North Carolina at Chapel Hill, 137 East Franklin Street, Chapel Hill, NC 27514, USA
Am J Epidemiol 160:1137-46. 2004.... - Absolute and attributable risks of heart failure incidence in relation to optimal risk factorsAaron R Folsom
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minn 55454, USA
Circ Heart Fail 2:11-7. 2009..The degree to which this applies to heart failure incidence is not well documented... - Occurrence of unrecognized myocardial infarction in subjects aged 45 to 65 years (the ARIC study)Lori L Boland
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55454-1015, USA
Am J Cardiol 90:927-31. 2002..The percentage of unrecognized MIs in men and women was similar. The percentage of unrecognized MIs in the ARIC sample between 1987 and 1998 was slightly lower than previous estimates from other populations... - Risk of atherosclerosis: interaction of smoking and glutathione S-transferase genesAndrew F Olshan
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7435, USA
Epidemiology 14:321-7. 2003..Enzymes including glutathione S-transferase mu (GSTM1) and theta (GSTT1) are involved in the metabolism of tobacco smoke chemicals and are expressed in human vessels and smooth muscle cells... - The association of spatial T wave axis deviation with incident coronary events. The ARIC cohortGeorgeta D Vaidean
Department of Epidemiology, University of North Carolina at Chapel Hill, USA
BMC Cardiovasc Disord 5:2. 2005.... - Heart failure incidence and survival (from the Atherosclerosis Risk in Communities study)Laura R Loehr
University of North Carolina at Chapel Hill, NC, USA
Am J Cardiol 101:1016-22. 2008..The greater HF incidence in African-Americans than in Caucasians is largely explained by African-Americans' greater levels of atherosclerotic risk factors... - Association between symptoms reported in a population questionnaire and future ischemic stroke: the ARIC studyLloyd E Chambless
Department of Biostatistics, School of Public Health, University of North Carolina, Chapel Hill, NC 27514, USA
Neuroepidemiology 23:33-7. 2004..9-4.1. Greater relative risk was found among younger individuals, women, African-Americans, persons not current smokers, and those with lower white blood cell count... - Correlates of the shift in heart rate variability with an active postural change in a healthy population sample: The Atherosclerosis Risk In Communities studyMercedes R Carnethon
Stanford Center for Research in Disease Prevention, Stanford University School of Medicine, Palo Alto, CA, USA
Am Heart J 143:808-13. 2002..CONCLUSIONS: These simple noninvasive measures can be used to detect differences in cardiac autonomic balance that may be markers for autonomic impairment in healthy adults... - Risk prediction of coronary heart disease based on retinal vascular caliber (from the Atherosclerosis Risk In Communities [ARIC] Study)Kevin McGeechan
School of Public Health, University of Sydney, Sydney, Australia
Am J Cardiol 102:58-63. 2008..In conclusion, although retinal vascular caliber independently predicted CHD risk in women, the incremental predictive ability over that of the Framingham model was modest and unlikely to translate meaningfully into clinical practice... - Prediction of coronary events in a low incidence population. Assessing accuracy of the CUORE Cohort Study prediction equationMarco Ferrario
Dipartimento di Scienze Cliniche e Biologiche, Universita degli Studi dell Insubria, Varese 21100, Italy
Int J Epidemiol 34:413-21. 2005..The aims of this paper are to derive a 10-year coronary risk predictive equation for adult Italian men, and to assess its accuracy in comparison with the Framingham Heart Study (FHS) and PROCAM study equations... - Does the cardiac autonomic response to postural change predict incident coronary heart disease and mortality? The Atherosclerosis Risk in Communities StudyMercedes R Carnethon
Stanford Center for Research in Disease Prevention, Stanford University School of Medicine, Palo Alto, CA, USA
Am J Epidemiol 155:48-56. 2002.... - Prediction of coronary heart disease risk using a genetic risk score: the Atherosclerosis Risk in Communities StudyAlanna C Morrison
Human Genetics Center and Division of Epidemiology, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
Am J Epidemiol 166:28-35. 2007..This study demonstrates the concept of aggregating information from multiple single nucleotide polymorphisms into a risk score and indicates that it can improve prediction of incident CHD in the ARIC study... - Risk factors for coronary heart disease in African Americans: the atherosclerosis risk in communities study, 1987-1997Daniel W Jones
Division of Hypertension, Department of Medicine, The University of Mississippi Medical Center, 2500 N State St, Jackson, MS 39216 4505, USA
Arch Intern Med 162:2565-71. 2002.... - Reduced kidney function as a risk factor for incident heart failure: the atherosclerosis risk in communities (ARIC) studyAnna Kottgen
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21287, USA
J Am Soc Nephrol 18:1307-15. 2007..In summary, middle-aged adults with moderately/severely reduced kidney function are at high risk for developing HF... - Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trialJames F Toole
Stroke Research Center, Department of Neurology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
JAMA 291:565-75. 2004.... - Synergism between smoking and vital exhaustion in the risk of ischemic stroke: evidence from the ARIC studySkai W Schwartz
Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL 33612, USA
Ann Epidemiol 14:416-24. 2004..Vital exhaustion (VE), a state characterized by unusual fatigue, irritability, and feelings of demoralization, is measured by the Maastricht questionnaire (MQ), a 21-item inventory of symptoms... - Diabetes, glucose, insulin, and heart rate variability: the Atherosclerosis Risk in Communities (ARIC) studyEmily B Schroeder
Duke University School of Medicine, Duke University, Durham, North Carolina, USA
Diabetes Care 28:668-74. 2005..The degree to which pre-diabetic metabolic impairments in insulin and glucose metabolism contribute to decreases in cardiac autonomic function remains to be determined... - Association between alcoholic beverage consumption and incidence of coronary heart disease in whites and blacks: the Atherosclerosis Risk in Communities StudyFlavio D Fuchs
Division of Cardiology, Clinical Hospital of Porto Alegre, Federal University of Rio Grande do Sul, Ramiro Barcelos 2350, Porto Alegre 90035903, Rio Grande do Sul, Brazil
Am J Epidemiol 160:466-74. 2004..61, 95% CI: 1.11, 6.17). The contrasting findings in Whites and Black men in this cohort raise the question of whether the cardioprotective effect of alcohol is real or may be confounded by lifestyle characteristics of drinkers... - Vitamin Intervention For Stroke Prevention trial: an efficacy analysisJ David Spence
The Stroke Prevention and Atherosclerosis Research Centre, Robarts Research Institute, London, Ontario, Canada
Stroke 36:2404-9. 2005..The criteria for this subgroup were defined before any data analysis... - The reliability of the ankle-brachial index in the Atherosclerosis Risk in Communities (ARIC) study and the NHLBI Family Heart Study (FHS)Beth D Weatherley
Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA
BMC Cardiovasc Disord 6:7. 2006..The R for the ABI computed from DINAMAP readings of the ankle and brachial SBP is not known... - Lipoprotein(a) and incident ischemic stroke: the Atherosclerosis Risk in Communities (ARIC) studyTetsuya Ohira
Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA
Stroke 37:1407-12. 2006..CONCLUSIONS: A high Lp(a) concentration is associated with a higher incidence of ischemic stroke in blacks and white women, but not in white men... - The association of the ankle-brachial index with incident coronary heart disease: the Atherosclerosis Risk In Communities (ARIC) study, 1987-2001Beth D Weatherley
Duke Clinical Research Institute, Duke University Medical Center, P, O, Box 17969, Durham, NC 27715, USA
BMC Cardiovasc Disord 7:3. 2007.... - Risk factors for progression to incident hyperinsulinemia: the Atherosclerosis Risk in Communities Study, 1987-1998Mercedes R Carnethon
Stanford Center for Research in Disease Prevention, Stanford University School of Medicine, Palo Alto, CA, USA
Am J Epidemiol 158:1058-67. 2003..The associations were similar across race and gender groups. These data suggest that, in addition to weight gain, hyperuricemia, dyslipidemia, and smoking can be detected prior to development of hyperinsulinemia... - LPL polymorphism predicts stroke risk in menAlanna C Morrison
Human Genetics Center, University of Texas Houston Health Science Center, Houston, Texas 77030, USA
Genet Epidemiol 22:233-42. 2002..This association does not appear to be mediated by triglyceride, high-density lipoprotein (HDL)- and low-density lipoprotein (LDL)-cholesterol levels, or additional stroke risk factors... - Plasma lipid profile and incident ischemic stroke: the Atherosclerosis Risk in Communities (ARIC) studyEyal Shahar
Division of Epidemiology, University of Minnesota, 1300 South Second St, Suite 300, Minneapolis, MN 55454, USA
Stroke 34:623-31. 2003..The role of circulating lipids and lipoproteins in the pathogenesis of ischemic stroke remains uncertain despite 3 decades of research. We examined this issue in a large population-based cohort... - Repeatability of heart rate variability measuresEmily B Schroeder
Duke University School of Medicine, Durham, NC, USA
J Electrocardiol 37:163-72. 2004..Researchers using 10-second records should consider taking the mean of several recordings, when possible, or using statistical methods to correct for measurement error... - Identifying individuals at high risk for diabetes: The Atherosclerosis Risk in Communities studyMaria Ines Schmidt
Graduate Studies Program in Epidemiology, School of Medicine, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
Diabetes Care 28:2013-8. 2005..To develop and evaluate clinical rules to predict risk for diabetes in middle-aged adults... - Lipoprotein-associated phospholipase A2, high-sensitivity C-reactive protein, and risk for incident ischemic stroke in middle-aged men and women in the Atherosclerosis Risk in Communities (ARIC) studyChristie M Ballantyne
Section of Atherosclerosis and Lipoprotein Research, Department of Medicine, Baylor College of Medicine, and Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart Center, Houston, Tex 77030, USA
Arch Intern Med 165:2479-84. 2005..We assessed Lp-PLA2 and C-reactive protein (CRP) levels along with traditional risk factors to examine their relation to ischemic stroke... - Inflammation markers predict increased weight gain in smoking quittersBruce B Duncan
Graduate Studies Program in Epidemiology, School of Medicine, Federal University of Rio Grande do Sul, Av Luiz Manoel Gonzaga, 630 8, Porto Alegre, RS 90470 280, Brazil
Obes Res 11:1339-44. 2003..Undesirable weight gain often follows smoking cessation. We investigated whether weight gain after smoking cessation is greater in those with higher levels of inflammatory markers... - Is the cardioprotective effect of alcohol real?Flavio D Fuchs
Division of Cardiology, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos, 2350, 90035 903, Porto Alegre, RS, Brazil
Alcohol 41:399-402. 2007..In view of the potential risks of alcohol, a more cautious view about the beneficial effects of alcoholic beverages is warranted... - Lower extremity arterial disease assessed by ankle-brachial index in a middle-aged population of African Americans and whites: the Atherosclerosis Risk in Communities (ARIC) StudyZhi Jie Zheng
Division for Heart Disease and Stroke Prevention, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30341 3717, USA
Am J Prev Med 29:42-9. 2005..Our purpose was to estimate the prevalence of LEAD and its associations with cardiovascular risk factors in a biracial population of men and women aged 45 to 64 years... - Plasma total homocysteine levels in stroke patients screened for the vitamin intervention for stroke prevention clinical trial in the era of folate fortificationHelmi L Lutsep
Oregon Stroke Center, OHSU, Portland, OR 97239, USA
Neuroepidemiology 26:45-51. 2006..06 overall, 0.0003 in the oldest age group). US levels were 0.39 micromol/l (95% CI: -0.08, 0.85) lower than in Canada. Neither fasting nor time since stroke affected the results...