H F Chambers

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Contribution of Panton-Valentine leukocidin in community-associated methicillin-resistant Staphylococcus aureus pathogenesis
    Binh An Diep
    Division of Infectious Diseases, Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 3:e3198. 2008
  2. pmc Waves of resistance: Staphylococcus aureus in the antibiotic era
    Henry F Chambers
    Division of Infectious Diseases, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California 94110, USA
    Nat Rev Microbiol 7:629-41. 2009
  3. pmc Relationship between susceptibility to daptomycin in vitro and activity in vivo in a rabbit model of aortic valve endocarditis
    H F Chambers
    San Francisco General Hospital, University of California San Francisco, San Francisco, California 94110, USA
    Antimicrob Agents Chemother 53:1463-7. 2009
  4. ncbi request reprint Ceftobiprole: in-vivo profile of a bactericidal cephalosporin
    H F Chambers
    University of California, San Francisco School of Medicine, San Francisco, California 94143, USA
    Clin Microbiol Infect 12:17-22. 2006
  5. pmc Ceftobiprole is superior to vancomycin, daptomycin, and linezolid for treatment of experimental endocarditis in rabbits caused by methicillin-resistant Staphylococcus aureus
    P Tattevin
    Division of Infectious Diseases, San Francisco General Hospital, University of California, San Francisco, Room 3400, Building 30, 1001 Potrero Avenue, San Francisco, CA 94110, USA
    Antimicrob Agents Chemother 54:610-3. 2010
  6. pmc Efficacy of levofloxacin for experimental aortic-valve endocarditis in rabbits infected with viridans group streptococcus or Staphylococcus aureus
    H F Chambers
    Department of Medicine, University of California, Division of Infectious Diseases, San Francisco General Hospital, San Francisco, California, USA
    Antimicrob Agents Chemother 43:2742-6. 1999
  7. ncbi request reprint A proteolytic transmembrane signaling pathway and resistance to beta-lactams in staphylococci
    H Z Zhang
    Division of Infectious Diseases, San Francisco General Hospital, Department of Medicine, University of California at San Francisco, 1001 Potrero Avenue, San Francisco, CA 94110, USA
    Science 291:1962-5. 2001
  8. pmc Gyrase mutations in laboratory-selected, fluoroquinolone-resistant mutants of Mycobacterium tuberculosis H37Ra
    T Kocagoz
    Department of Medicine, University of California, San Francisco 94110, USA
    Antimicrob Agents Chemother 40:1768-74. 1996
  9. pmc The changing epidemiology of Staphylococcus aureus?
    H F Chambers
    University of California San Francisco and San Francisco General Hospital, San Francisco, California, USA
    Emerg Infect Dis 7:178-82. 2001
  10. pmc Comparative activity of CGP 31608, nafcillin, cefamandole, imipenem, and vancomycin against methicillin-susceptible and methicillin-resistant staphylococci
    M Sachdeva
    Medical Service, San Francisco General Hospital, California 94110
    Antimicrob Agents Chemother 31:1549-52. 1987

Research Grants

Collaborators

Detail Information

Publications18

  1. pmc Contribution of Panton-Valentine leukocidin in community-associated methicillin-resistant Staphylococcus aureus pathogenesis
    Binh An Diep
    Division of Infectious Diseases, Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 3:e3198. 2008
    ..Taken together, our data indicate a modest and transient positive effect of PVL in the acute phase of bacteremia, thereby providing evidence that PVL contributes to CA-MRSA pathogenesis...
  2. pmc Waves of resistance: Staphylococcus aureus in the antibiotic era
    Henry F Chambers
    Division of Infectious Diseases, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California 94110, USA
    Nat Rev Microbiol 7:629-41. 2009
    ..Here, we review the molecular epidemiology of the epidemic waves of penicillin- and methicillin-resistant strains of S. aureus that have occurred since 1940, with a focus on the clinical and molecular epidemiology of CA-MRSA...
  3. pmc Relationship between susceptibility to daptomycin in vitro and activity in vivo in a rabbit model of aortic valve endocarditis
    H F Chambers
    San Francisco General Hospital, University of California San Francisco, San Francisco, California 94110, USA
    Antimicrob Agents Chemother 53:1463-7. 2009
    ..Increasing the dose of daptomycin may improve its efficacy for infections caused by strains with reduced daptomycin susceptibility...
  4. ncbi request reprint Ceftobiprole: in-vivo profile of a bactericidal cephalosporin
    H F Chambers
    University of California, San Francisco School of Medicine, San Francisco, California 94143, USA
    Clin Microbiol Infect 12:17-22. 2006
    ..The broad spectrum of activity may allow ceftobiprole to be used as monotherapy for serious hospital-acquired infections where combination therapy would otherwise be required...
  5. pmc Ceftobiprole is superior to vancomycin, daptomycin, and linezolid for treatment of experimental endocarditis in rabbits caused by methicillin-resistant Staphylococcus aureus
    P Tattevin
    Division of Infectious Diseases, San Francisco General Hospital, University of California, San Francisco, Room 3400, Building 30, 1001 Potrero Avenue, San Francisco, CA 94110, USA
    Antimicrob Agents Chemother 54:610-3. 2010
    ..05 for each comparison). Anti-MRSA beta lactam agents such as ceftobiprole may represent a significant therapeutic advance over currently available agents for the treatment of MRSA endocarditis...
  6. pmc Efficacy of levofloxacin for experimental aortic-valve endocarditis in rabbits infected with viridans group streptococcus or Staphylococcus aureus
    H F Chambers
    Department of Medicine, University of California, Division of Infectious Diseases, San Francisco General Hospital, San Francisco, California, USA
    Antimicrob Agents Chemother 43:2742-6. 1999
    ..aureus but not viridans group streptococcal infections in humans...
  7. ncbi request reprint A proteolytic transmembrane signaling pathway and resistance to beta-lactams in staphylococci
    H Z Zhang
    Division of Infectious Diseases, San Francisco General Hospital, Department of Medicine, University of California at San Francisco, 1001 Potrero Avenue, San Francisco, CA 94110, USA
    Science 291:1962-5. 2001
    ..Compounds that disrupt this regulatory pathway could restore the activity of beta-lactam antibiotics against drug-resistant strains of staphylococci...
  8. pmc Gyrase mutations in laboratory-selected, fluoroquinolone-resistant mutants of Mycobacterium tuberculosis H37Ra
    T Kocagoz
    Department of Medicine, University of California, San Francisco 94110, USA
    Antimicrob Agents Chemother 40:1768-74. 1996
    ..Because sparfloxacin is more active in vitro and selection of resistance appears to be less likely to occur, it may have important advantage over ofloxacin or ciprofloxacin for the treatment of tuberculosis...
  9. pmc The changing epidemiology of Staphylococcus aureus?
    H F Chambers
    University of California San Francisco and San Francisco General Hospital, San Francisco, California, USA
    Emerg Infect Dis 7:178-82. 2001
    ..aureus decades ago. Even though the origin (hospital or the community) of the emerging MRSA strains is not known, the prevalence of these strains in the community seems likely to increase substantially...
  10. pmc Comparative activity of CGP 31608, nafcillin, cefamandole, imipenem, and vancomycin against methicillin-susceptible and methicillin-resistant staphylococci
    M Sachdeva
    Medical Service, San Francisco General Hospital, California 94110
    Antimicrob Agents Chemother 31:1549-52. 1987
    ..aureus and S. epidermidis that were resistant to all the beta-lactam antibiotics tested at 5 micrograms/ml. This resistant subpopulation produced progeny that were uniformly resistant to high concentrations of each of the beta-lactams...
  11. pmc The abilities of a Staphylococcus epidermidis wild-type strain and its slime-negative mutant to induce endocarditis in rabbits are comparable
    F Perdreau-Remington
    Institute of Medical Microbiology and Hygiene, University of Cologne, Cologne, Germany
    Infect Immun 66:2778-81. 1998
    ..Adhesion was equally promoted by addition of fibronectin. These data suggest that the in vitro phenomenon of accumulation described as slime production in the absence of serum may not be an important virulence determinant in vivo...
  12. pmc Methicillin resistance in staphylococci: molecular and biochemical basis and clinical implications
    H F Chambers
    Medical Service, San Francisco General Hospital 94143, USA
    Clin Microbiol Rev 10:781-91. 1997
    ..Investigational agents that bind PBP 2a at low concentrations appear promising but have not been tested in humans. Alternatives to vancomycin are few due to the multiple drug resistances typical of methicillin-resistant staphylococci...
  13. ncbi request reprint A randomized clinical trial of mupirocin in the eradication of Staphylococcus aureus nasal carriage in human immunodeficiency virus disease
    J N Martin
    Center for AIDS Prevention Studies, AIDS Research Institute, and Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94105, USA
    J Infect Dis 180:896-9. 1999
    ..Five days of treatment with mupirocin eliminated S. aureus nasal carriage in HIV-infected patients for several weeks; however, since the effect waned over time, intermittent dosing regimens should be considered for long-term eradication...
  14. doi request reprint Methicillin-resistant Staphylococcus aureus. Mechanisms of resistance and implications for treatment
    H F Chambers
    Division of Infectious Diseases, Department of Medicine, University of California San Francisco, 3rd and Parnassus Aves, San Francisco, CA 94143, USA
    Postgrad Med 109:43-50. 2001
    ..Given the increasing prevalence of MRSA in hospitals and in community settings, alternative approaches are needed for treatment of infections caused by MRSA...
  15. pmc Chemokine receptor 2 serves an early and essential role in resistance to Mycobacterium tuberculosis
    W Peters
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94141 9100, USA
    Proc Natl Acad Sci U S A 98:7958-63. 2001
    ..These data demonstrate that cellular responses mediated by activation of CCR2 are essential in the initial immune response and control of infection with M. tuberculosis...
  16. ncbi request reprint Identifying pulmonary tuberculosis in patients with negative sputum smear results
    A M Kanaya
    Divisions of General Internal Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA
    Chest 120:349-55. 2001
    ..Study objective: To identify the clinical, demographic, and radiographic characteristics that identify smear-negative patients who have TB, and to create a TB prediction rule...
  17. pmc Cloning and sequence analysis of a class A beta-lactamase from Mycobacterium tuberculosis H37Ra
    C J Hackbarth
    Department of Medicine, University of California, San Francisco 94143, USA
    Antimicrob Agents Chemother 41:1182-5. 1997
    ..tuberculosis-derived beta-lactamase in one of these recombinant clones. A sequence analysis identified it as a class A beta-lactamase whose expression correlated with the increased resistance phenotype...
  18. pmc Point mutations in Staphylococcus aureus PBP 2 gene affect penicillin-binding kinetics and are associated with resistance
    C J Hackbarth
    Division of Infectious Diseases, San Francisco General Hospital, California 94110
    Antimicrob Agents Chemother 39:103-6. 1995
    ..These structural and biochemical changes may contribute to the strains' resistance to beta-lactam antibiotics...

Research Grants6

  1. PENICILLIN INTERACTIVE PROTEINS OF STAPHYLOCOCCUS AUREUS
    Henry Chambers; Fiscal Year: 2003
    ..To augment information about where PBPs localize, when they are expressed during the cell cycle will be determined by Northern blotting. ..
  2. Genetic Basis of Virulence of Community MRSA Clone USA300
    Henry F Chambers; Fiscal Year: 2010
    ..By knocking each of these genes out and testing for loss of virulence, we hope to learn which genes code for virulence. Once these genes are identified, strategies to block their effects may be developed. ..