Cynthia A Chambers

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. ncbi The expanding world of co-stimulation: the two-signal model revisited
    C A Chambers
    Department of Pathology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA
    Trends Immunol 22:217-23. 2001
  2. ncbi The lymphoproliferative defect in CTLA-4-deficient mice is ameliorated by an inhibitory NK cell receptor
    Cynthia A Chambers
    Department of Pathology, University of Massachusetts Medical School, Worcester, 01655, USA
    Blood 99:4509-16. 2002
  3. ncbi CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance
    Randall H Friedline
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Exp Med 206:421-34. 2009
  4. ncbi Regulation of gammadelta versus alphabeta T lymphocyte differentiation by the transcription factor SOX13
    Heather J Melichar
    Department of Pathology, Graduate Program in Immunology and Virology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Science 315:230-3. 2007
  5. ncbi Cutting edge: Dab2 is a FOXP3 target gene required for regulatory T cell function
    Nitya Jain
    Department of Pathology, Graduate Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 183:4192-6. 2009
  6. ncbi CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapy
    C A Chambers
    University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Annu Rev Immunol 19:565-94. 2001
  7. ncbi Cutting edge: two distinct mechanisms lead to impaired T cell homeostasis in Janus kinase 3- and CTLA-4-deficient mice
    S Gozalo-Sanmillan
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 166:727-30. 2001
  8. ncbi STAT5 is required for thymopoiesis in a development stage-specific manner
    Joonsoo Kang
    Department of Pathology, Graduate Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 173:2307-14. 2004

Collaborators

Detail Information

Publications8

  1. ncbi The expanding world of co-stimulation: the two-signal model revisited
    C A Chambers
    Department of Pathology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA
    Trends Immunol 22:217-23. 2001
    ..Understanding these processes will be crucial for designing clinically relevant approaches to manipulate the adaptive immune system...
  2. ncbi The lymphoproliferative defect in CTLA-4-deficient mice is ameliorated by an inhibitory NK cell receptor
    Cynthia A Chambers
    Department of Pathology, University of Massachusetts Medical School, Worcester, 01655, USA
    Blood 99:4509-16. 2002
    ..These results demonstrate the importance of inhibitory signals in T-cell homeostasis and suggest the common biochemical basis of inhibitory signaling pathways in T lymphocytes...
  3. ncbi CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance
    Randall H Friedline
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Exp Med 206:421-34. 2009
    ..These results demonstrate that CTLA-4 is absolutely required for FOXP3(+) regulatory T cell function in vivo...
  4. ncbi Regulation of gammadelta versus alphabeta T lymphocyte differentiation by the transcription factor SOX13
    Heather J Melichar
    Department of Pathology, Graduate Program in Immunology and Virology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Science 315:230-3. 2007
    ..Our data thus reveal a dominant pathway regulating the developmental fate of these two lineages of T lymphocytes...
  5. ncbi Cutting edge: Dab2 is a FOXP3 target gene required for regulatory T cell function
    Nitya Jain
    Department of Pathology, Graduate Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 183:4192-6. 2009
    ..However, not all aspects of Treg cell function are perturbed, and DAB2 appears to be dispensable for Treg cell function in maintaining naive T cell homeostasis...
  6. ncbi CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapy
    C A Chambers
    University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Annu Rev Immunol 19:565-94. 2001
    ..This review primarily focuses on the cellular and molecular mechanisms of regulation by CTLA-4 and its manipulation as a strategy for tumor immunotherapy...
  7. ncbi Cutting edge: two distinct mechanisms lead to impaired T cell homeostasis in Janus kinase 3- and CTLA-4-deficient mice
    S Gozalo-Sanmillan
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 166:727-30. 2001
    ..These findings provide insight into the diverse mechanisms controlling T cell homeostasis...
  8. ncbi STAT5 is required for thymopoiesis in a development stage-specific manner
    Joonsoo Kang
    Department of Pathology, Graduate Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 173:2307-14. 2004
    ....