Research Topics
| LEO CHALUPASummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Nitric oxide differentially modulates ON and OFF responses of retinal ganglion cellsGuo-Yong Wang
Section of Neurobiology, Physiology and Behavior, Division of Biological Sciences and Ophthalmology Department, School of Medicine, University of California, Davis, California 95616, USA
J Neurophysiol 90:1304-13. 2003..The off responses that were blocked by NO were also blocked by DL-2-amino-phosphonobutyric acid (APB) and strychnine, suggesting the involvement of the APB-sensitive rod pathway...- Topographic specificity in the retinocollicular projection of the developing ferret: an anterograde tracing studyL M Chalupa
Department of Psychology and Center for Neuroscience, University of California, Davis 95616, USA
J Comp Neurol 392:35-47. 1998.... - A reassessment of the role of activity in the formation of eye-specific retinogeniculate projectionsLeo M Chalupa
Department of Ophthalmology and Vision Science, School of Medicine and Neurobiology, Physiology and Behavior, College of Biological Sciences, University of California, Davis, CA 95616, USA
Brain Res Rev 55:228-36. 2007.... 
Retinal waves are unlikely to instruct the formation of eye-specific retinogeniculate projectionsLeo M Chalupa
Department of Neurobiology, Physiology and Behavior, College of Biological Sciences, School of Medicine, University of California, Davis, CA 95616, USA
Neural Dev 4:25. 2009....- Development of On and Off retinal pathways and retinogeniculate projectionsLeo M Chalupa
Department of Ophthalmology, School of Medicine and Section of Neurobiology, Physiology and Behavior, Division of Biological Sciences, University of California, 1 Shields Avenue, Davis, CA 95616, USA
Prog Retin Eye Res 23:31-51. 2004.... - Eye-specific retinogeniculate segregation independent of normal neuronal activityAndrew D Huberman
Center for Neuroscience, School of Medicine, University of California, Davis, CA 95616, USA
Science 300:994-8. 2003..Thus, certain features of normal neural activity patterns are not required for the formation of eye-specific projections to the DLGN... - Expression and purification of cysteine introduced recombinant saporinEmine Gunhan
Department of Neurobiology, Physiology, and Behavior, University of California, One Shields Avenue, 196 Briggs Hall, Davis, CA 95616, USA
Protein Expr Purif 58:203-9. 2008..We have found that a single cysteine within saporin provides a method for antibody conjugation that ensures a uniform and reproducible modification of a saporin variant retaining high activity... - Dynamics of spontaneous activity in the fetal macaque retina during development of retinogeniculate pathwaysDavid K Warland
Department of Ophthalmology and Visual Science, University of California, Davis, California 95616, USA
J Neurosci 26:5190-7. 2006.... 
The sensitivity of light-evoked responses of retinal ganglion cells is decreased in nitric oxide synthase gene knockout miceGuo Yong Wang
Department of Structural and Cellular Biology, School of Medicine, Tulane University, New Orleans, LA 70112, USA
J Vis 7:7.1-13. 2007..Thus, NO levels in the retina are capable of modulating the information that ganglion cells convey to the visual centers of the brain...- Spontaneous activity of morphologically identified ganglion cells in the developing ferret retinaLauren C Liets
Section of Neurobiology, Physiology and Behavior, Division of Biological Sciences, School of Medicine, University of California, Davis, California 95616, USA
J Neurosci 23:7343-50. 2003.... - Epibatidine application in vitro blocks retinal waves without silencing all retinal ganglion cell action potentials in developing retina of the mouse and ferretChao Sun
Department of Neurobiology, Physiology, and Behavior, School of Medicine, University of California, Davis, CA 95616, USA
J Neurophysiol 100:3253-63. 2008..These results have important implications for interpreting the results of previous studies that relied on this cholinergic agonist to perturb retinal activity... - Developing dendrites demonstrate unexpected specificityLeo M Chalupa
Neurobiology, Physiology and Behavior, College of Biological Sciences, Department of Ophthalmology and Vision Science, School of Medicine, University of California, Davis, California 95616, USA
Neuron 52:567-8. 2006..In this issue of Neuron, Mumm et al. rely on time-lapsed analysis of ingrowing dendrites of retinal ganglion cells in transgenic zebrafish to show that this process is much more specific than has been suspected... - Morphological properties of mouse retinal ganglion cells during postnatal developmentJulie L Coombs
Neurobiology, Physiology and Behavior, College of Biological Sciences, University of California, Davis, California 95616, USA
J Comp Neurol 503:803-14. 2007..Our results also suggest that dendritic stratification may be more highly specified in the developing mammalian retina than has been previously realized... - Molecular correlates of laminar differences in the macaque dorsal lateral geniculate nucleusKarl D Murray
Center for Neuroscience and Department of Psychiatry and Behavioral Sciences, University of California, Davis, Davis, California 95616, USA
J Neurosci 28:12010-22. 2008..These results provide new evidence for the molecular differentiation of magnocellular and parvocellular streams through the primate dLGN... - Depletion of cholinergic amacrine cells by a novel immunotoxin does not perturb the formation of segregated on and off cone bipolar cell projectionsEmine Gunhan
Department of Ophthalmology, School of Medicine, University of California, Davis, California 95616, USA
J Neurosci 22:2265-73. 2002..These findings demonstrate that the presence of cholinergic amacrine cells is not required for the segregation of recoverin-positive On and Off cone bipolar cell projections... - Ectopic photoreceptors and cone bipolar cells in the developing and mature retinaEmine Gunhan
Section of Neurobiology, Physiology, and Behavior, Division of Biological Sciences, School of Medicine, University of California, Davis, California 95616, USA
J Neurosci 23:1383-9. 2003..Collectively, the results provide evidence for photoreceptors in the ganglion cell and inner nuclear layers of the developing retina, and a more permanent subpopulation of cone bipolar cells displaced to the ganglion cell layer... - Early and rapid targeting of eye-specific axonal projections to the dorsal lateral geniculate nucleus in the fetal macaqueAndrew D Huberman
Center for Neuroscience, University of California, Davis, Davis, California 95616, USA
J Neurosci 25:4014-23. 2005.... - Cellular reorganization in the human retina during normal agingKasra Eliasieh
Section of Neurobiology, Physiology and Behavior, College of Biological Science, University of California, CA 95616, USA
Invest Ophthalmol Vis Sci 48:2824-30. 2007..To characterize the nature and extent of neuronal reorganization in the human retina during normal aging... - Dendrites of rod bipolar cells sprout in normal aging retinaLauren C Liets
Section of Neurobiology, Physiology, and Behavior, University of California, Davis, CA 95616, USA
Proc Natl Acad Sci U S A 103:12156-60. 2006..Such dendritic sprouting increased with age and was evident at all retinal eccentricities. These results provide evidence of retinal plasticity associated with normal aging... - Retinal waves in mice lacking the beta2 subunit of the nicotinic acetylcholine receptorChao Sun
Departments of Neurobiology, Physiology, and Behavior, and Ophthalmology and Vision Science, University of California, Davis, CA 95616, USA
Proc Natl Acad Sci U S A 105:13638-43. 2008.... - Long-term treatment of the developing retina with the metabotropic glutamate agonist APB induces long-term changes in the stratification of retinal ganglion cell dendritesStefania Deplano
Dipartimento DIBISAA, , Vle. Benedetto XV, Genova, Italy
Dev Neurosci 26:396-405. 2004.... - Complete restoration of visual cortical responses is possible late in development. Focus on "recovery of cortical binocularity and orientation selectivity after the critical period for ocular dominance plasticity"Leo M Chalupa
J Neurophysiol 92:1969-70. 2004
Research Grants
- DEVELOPMENT AND REORGANIZATION OF PRENATAL VISUAL SYSTEMLEO CHALUPA; Fiscal Year: 2005....
- A Novel Immunotoxin for Treatment and Cure of StrabismusLEO CHALUPA; Fiscal Year: 2005..The use of IX-146 could be extended in the future to a wider variety of ophthalmologic, neurologic, and neuromuscular disorders, including blepharospasm as well as other types of dystonias. ..
- Prenatal Development of Visual SystemLEO CHALUPA; Fiscal Year: 2007..The proposed research program will break new ground by increasing our understanding of the mechanisms underlying the formation of M and P pathways which are a distinguishing feature of the primate visual system. ..
- DEVELOPMENT AND REORGANIZATION OF PRENATAL VISUAL SYSTEMLEO CHALUPA; Fiscal Year: 2007..This information will be useful in devising empirically based treatments of the myriad ontogenetic disorders than adversely impact the human visual system. ..
- DEVELOPMENT AND REORGANIZATION OF PRENATAL VISUAL SYSTEMLEO CHALUPA; Fiscal Year: 2000..The results of this research program will significantly enhance our understanding of the events and mechanisms shaping the normal development of mammalian retinal ganglion cells. ..
- DEVELOPMENT AND REORGANIZATION OF PRENATAL VISUAL SYSTEMLEO CHALUPA; Fiscal Year: 1990..These results will also provide new knowledge of general principles governing the development of the mammalian brain...
- DEVELOPMENT AND REORGANIZATION OF PRENATAL VISUAL SYSTEMLEO CHALUPA; Fiscal Year: 1993..The results of this research program would increase the understanding of the events underlying the organization and the normal development of the mammalian visual system...
- DEVELOPMENT AND REORGANIZATION OF PRENATAL VISUAL SYSTEMLEO CHALUPA; Fiscal Year: 2009..This information will be useful in devising empirically based treatments of the myriad ontogenetic disorders than adversely impact the human visual system. ..