Y Chai

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi request reprint A mouse mandibular culture model permits the study of neural crest cell migration and tooth development
    Y Chai
    Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles 90033, USA
    Int J Dev Biol 42:87-94. 1998
  2. ncbi request reprint Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis
    Y Chai
    Center for Craniofacial Molecular Biology School of Dentistry University of Southern California, CSA 103, Los Angeles, CA 90033, USA
    Development 127:1671-9. 2000
  3. ncbi request reprint Inhibition of transforming growth factor-beta type II receptor signaling accelerates tooth formation in mouse first branchial arch explants
    Y Chai
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
    Mech Dev 86:63-74. 1999
  4. ncbi request reprint Antagonistic effects of Smad2 versus Smad7 are sensitive to their expression level during tooth development
    Y Ito
    Center for Craniofacial Molecular Biology School of Dentistry, University of Southern California, Los Angeles, California 90033, USA
    J Biol Chem 276:44163-72. 2001
  5. ncbi request reprint TGF-beta signaling and its functional significance in regulating the fate of cranial neural crest cells
    Y Chai
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
    Crit Rev Oral Biol Med 14:78-88. 2003
  6. ncbi request reprint Smad7 is a TGF-beta-inducible attenuator of Smad2/3-mediated inhibition of embryonic lung morphogenesis
    J Zhao
    Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles 90033, USA
    Mech Dev 93:71-81. 2000
  7. pmc TGF-beta receptor II in epithelia versus mesenchyme plays distinct roles in the developing lung
    H Chen
    Developmental Biology Program, Dept of Surgery, Childrens Hospital Los Angeles, 4650 Sunset Blvd, MS 35, Los Angeles, CA 90027, USA
    Eur Respir J 32:285-95. 2008
  8. ncbi request reprint Overexpression of Smad2 reveals its concerted action with Smad4 in regulating TGF-beta-mediated epidermal homeostasis
    Y Ito
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, California 90033, USA
    Dev Biol 236:181-94. 2001
  9. ncbi request reprint PDGF-A and PDGFR-alpha regulate tooth formation via autocrine mechanism during mandibular morphogenesis in vitro
    Y Chai
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles 90033, USA
    Dev Dyn 213:500-11. 1998
  10. ncbi request reprint Epithelial fibroblast growth factor receptor 1 regulates enamel formation
    K Takamori
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, CA 90033, USA
    J Dent Res 87:238-43. 2008

Collaborators

Detail Information

Publications18

  1. ncbi request reprint A mouse mandibular culture model permits the study of neural crest cell migration and tooth development
    Y Chai
    Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles 90033, USA
    Int J Dev Biol 42:87-94. 1998
    ....
  2. ncbi request reprint Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis
    Y Chai
    Center for Craniofacial Molecular Biology School of Dentistry University of Southern California, CSA 103, Los Angeles, CA 90033, USA
    Development 127:1671-9. 2000
    ..Furthermore, this transgenic model also provides a new tool for cell lineage analysis and genetic manipulation of neural-crest-derived components in normal and abnormal embryogenesis...
  3. ncbi request reprint Inhibition of transforming growth factor-beta type II receptor signaling accelerates tooth formation in mouse first branchial arch explants
    Y Chai
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
    Mech Dev 86:63-74. 1999
    ....
  4. ncbi request reprint Antagonistic effects of Smad2 versus Smad7 are sensitive to their expression level during tooth development
    Y Ito
    Center for Craniofacial Molecular Biology School of Dentistry, University of Southern California, Los Angeles, California 90033, USA
    J Biol Chem 276:44163-72. 2001
    ..The results indicate that Smads are critical factors in orchestrating TGF-beta-mediated gene regulation during embryonic tooth development. The effectiveness of TGF-beta signaling is highly sensitive to the level of Smad gene expression...
  5. ncbi request reprint TGF-beta signaling and its functional significance in regulating the fate of cranial neural crest cells
    Y Chai
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
    Crit Rev Oral Biol Med 14:78-88. 2003
    ..The biological function of TGF-beta is carried out through the regulation of transcriptional factors during embryogenesis...
  6. ncbi request reprint Smad7 is a TGF-beta-inducible attenuator of Smad2/3-mediated inhibition of embryonic lung morphogenesis
    J Zhao
    Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles 90033, USA
    Mech Dev 93:71-81. 2000
    ..The optimization of TGF-beta signaling during early lung development therefore requires a finely-regulated competitive balance between both permissive and inhibitory members of the Smad family...
  7. pmc TGF-beta receptor II in epithelia versus mesenchyme plays distinct roles in the developing lung
    H Chen
    Developmental Biology Program, Dept of Surgery, Childrens Hospital Los Angeles, 4650 Sunset Blvd, MS 35, Los Angeles, CA 90027, USA
    Eur Respir J 32:285-95. 2008
    ....
  8. ncbi request reprint Overexpression of Smad2 reveals its concerted action with Smad4 in regulating TGF-beta-mediated epidermal homeostasis
    Y Ito
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, California 90033, USA
    Dev Biol 236:181-94. 2001
    ..Collectively, our study presents the first in vivo evidence that, by providing an auto-feedback in TGF-beta signaling, Smad2 plays a pivotal role in regulating TGF-beta-mediated epidermal homeostasis...
  9. ncbi request reprint PDGF-A and PDGFR-alpha regulate tooth formation via autocrine mechanism during mandibular morphogenesis in vitro
    Y Chai
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles 90033, USA
    Dev Dyn 213:500-11. 1998
    ..These data suggest that PDGF-A and its cognate receptor (PDGFR-alpha) regulate the size and stage of tooth development via an autocrine mechanism during odontogenesis in vitro...
  10. ncbi request reprint Epithelial fibroblast growth factor receptor 1 regulates enamel formation
    K Takamori
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, CA 90033, USA
    J Dent Res 87:238-43. 2008
    ..Loss of Fgfr1 affects ameloblast organization at the enamel-secretory stage and, hence, the formation of enamel...
  11. pmc Molecular and cellular regulatory mechanisms of tongue myogenesis
    C Parada
    Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA 90033, USA
    J Dent Res 91:528-35. 2012
    ....
  12. ncbi request reprint Specific transforming growth factor-beta subtypes regulate embryonic mouse Meckel's cartilage and tooth development
    Y Chai
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles 90033
    Dev Biol 162:85-103. 1994
    ..TGF-beta 3 appears to regulate Meckel's cartilage size without altering tooth size or shape. The results are discussed in terms of the regulatory functions of the TGF-beta subtypes during embryonic craniofacial morphogenesis...
  13. pmc The mechanism of TGF-β signaling during palate development
    J Iwata
    Center for Craniofacial Molecular Biology, Ostrow School of Dentistry, University of Southern California, Los Angeles, CA 90033, USA
    Oral Dis 17:733-44. 2011
    ..Here, we highlight recent advances in our understanding of TGF-β signaling during palate development...
  14. ncbi request reprint Heterozygous loss of Six5 in mice is sufficient to cause ocular cataracts
    P S Sarkar
    Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Nat Genet 25:110-4. 2000
    ..Our data support the hypothesis that DM is a contiguous gene syndrome associated with the partial loss of both DMPK and SIX5...
  15. ncbi request reprint The role of protein composition in specifying nuclear inclusion formation in polyglutamine disease
    Y Chai
    Department of Neurology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Biol Chem 276:44889-97. 2001
    ..These results suggest that protein context-dependent recruitment of nuclear proteins to intranuclear microaggregates, and subsequently to NI, may contribute to selective neurotoxicity in polyQ diseases...
  16. ncbi request reprint c-Fos oncogene regulator Elk-1 interacts with BRCA1 splice variants BRCA1a/1b and enhances BRCA1a/1b-mediated growth suppression in breast cancer cells
    Y Chai
    Department of Medicine, Program of Cancer Genetics, Cancer Center, MCP Hahnemann University, 245 North 15th Street, New College Building, M S 481, Philadelphia, Pennsylvania 19102, USA
    Oncogene 20:1357-67. 2001
    ..All these results taken together suggest that one of the mechanisms by which BRCA1a/1b proteins function as growth/tumor suppressors is through inhibition of the expression of Elk-1 target genes like c-Fos...
  17. ncbi request reprint [Identification and characterization of differentially expressed ESTs of Gossypium barbadense infected by Verticillium dahliae with suppression subtractive hybridization]
    K Zuo
    Mol Biol (Mosk) 39:214-23. 2005
    ..dahliae. To our knowledge, this is the first report on the isolation of global ESTs during sea-island cotton defense reaction...
  18. ncbi request reprint Induction of apoptosis by Elk-1 and deltaElk-1 proteins
    N Shao
    Department of Human Genetics, Allegheny University of the Health Sciences, Philadelphia, Pennsylvania 19102, USA
    Oncogene 17:527-32. 1998
    ..These results indicate that constitutive expression of Elk-1 and deltaElk-1 proteins triggers apoptosis in Rat-1 fibroblasts and breast cancer cells when treated with calcium ionophore...