Affiliation: University of Nebraska
Cerutti H, Casas Mollano J. On the origin and functions of RNA-mediated silencing: from protists to man. Curr Genet. 2006;50:81-99 pubmed
Kim E, Ma X, Cerutti H. Gene silencing in microalgae: mechanisms and biological roles. Bioresour Technol. 2015;184:23-32 pubmed publisher
Voshall A, Kim E, Ma X, Moriyama E, Cerutti H. Identification of AGO3-associated miRNAs and computational prediction of their targets in the green alga Chlamydomonas reinhardtii. Genetics. 2015;200:105-21 pubmed publisher
..Our results emphasize the difficulty in identifying genuine miRNA targets in Chlamydomonas and suggest that miRNAs, under standard laboratory conditions, might have mainly a modulatory role in endogenous gene regulation in this alga. ..
Kim Y, Terng E, Riekhof W, Cahoon E, Cerutti H. Endoplasmic reticulum acyltransferase with prokaryotic substrate preference contributes to triacylglycerol assembly in Chlamydomonas. Proc Natl Acad Sci U S A. 2018;115:1652-1657 pubmed publisher
..Our findings suggest that Chlamydomonas has a distinct glycerolipid assembly pathway that relies on CrLPAAT2 to generate prokaryotic-like TAG precursors in the ER. ..
Cerutti H. RNA interference: traveling in the cell and gaining functions?. Trends Genet. 2003;19:39-46 pubmed
..These findings imply that RNA-mediated mechanisms can control gene expression at both the transcriptional and the post-transcriptional level, and that they can operate in the nuclear and the cytoplasmic compartments. ..
Wang Z, Casas Mollano J, Xu J, Riethoven J, Zhang C, Cerutti H. Osmotic stress induces phosphorylation of histone H3 at threonine 3 in pericentromeric regions of Arabidopsis thaliana. Proc Natl Acad Sci U S A. 2015;112:8487-92 pubmed publisher
Voshall A, Kim E, Ma X, Yamasaki T, Moriyama E, Cerutti H. miRNAs in the alga Chlamydomonas reinhardtii are not phylogenetically conserved and play a limited role in responses to nutrient deprivation. Sci Rep. 2017;7:5462 pubmed publisher
..Our results suggest that, in C. reinhardtii, miRNAs might be subject to relatively fast evolution and have only a minor, largely modulatory role in gene regulation under diverse trophic states. ..