Heriberto Cerutti

Summary

Affiliation: University of Nebraska
Country: USA

Publications

  1. pmc SET3p monomethylates histone H3 on lysine 9 and is required for the silencing of tandemly repeated transgenes in Chlamydomonas
    J Armando Casas-Mollano
    School of Biological Sciences and Plant Science Initiative, University of Nebraska, Lincoln, NE 68588 0666, USA
    Nucleic Acids Res 35:939-50. 2007
  2. ncbi request reprint Turnover of mature miRNAs and siRNAs in plants and algae
    Heriberto Cerutti
    School of Biological Sciences and Center for Plant Science Innovation, University of Nebraska, P O Box 880666, Lincoln, Nebraska 68588, USA
    Adv Exp Med Biol 700:124-39. 2010
  3. ncbi request reprint Histone H3 phosphorylation: universal code or lineage specific dialects?
    Heriberto Cerutti
    School of Biological Sciences and Center for Plant Science Innovation, University of Nebraska, Lincoln, NE 68588, USA
    Epigenetics 4:71-5. 2009
  4. ncbi request reprint RNA interference: traveling in the cell and gaining functions?
    Heriberto Cerutti
    School of Biological Sciences and Plant Science Initiative, University of Nebraska Lincoln, E211 Beadle Center, Post Office Box 880666, Lincoln, NE 68588 0666, USA
    Trends Genet 19:39-46. 2003
  5. pmc RNA-mediated silencing in Algae: biological roles and tools for analysis of gene function
    Heriberto Cerutti
    School of Biological Sciences and Center for Plant Science Innovation, University of Nebraska Lincoln, E211 Beadle Center, P O Box 880666, Lincoln, NE 68588 0666, USA
    Eukaryot Cell 10:1164-72. 2011
  6. pmc On the origin and functions of RNA-mediated silencing: from protists to man
    Heriberto Cerutti
    School of Biological Sciences and Plant Science Initiative, University of Nebraska, Lincoln, 68588 0666, USA
    Curr Genet 50:81-99. 2006
  7. ncbi request reprint Origin of the polycomb repressive complex 2 and gene silencing by an E(z) homolog in the unicellular alga Chlamydomonas
    Scott Shaver
    School of Biological Sciences and Center for Plant Science Innovation, University of Nebraska, Lincoln, NE, USA
    Epigenetics 5:301-12. 2010
  8. pmc The MUT9p kinase phosphorylates histone H3 threonine 3 and is necessary for heritable epigenetic silencing in Chlamydomonas
    J Armando Casas-Mollano
    School of Biological Sciences and Plant Science Initiative and Department of Chemistry, University of Nebraska, Lincoln, NE 68588 0666, USA
    Proc Natl Acad Sci U S A 105:6486-91. 2008
  9. pmc Monomethyl histone H3 lysine 4 as an epigenetic mark for silenced euchromatin in Chlamydomonas
    Karin van Dijk
    Department of Plant Pathology and Plant Science Initiative, University of Nebraska, Lincoln, Nebraska 68588 0666, USA
    Plant Cell 17:2439-53. 2005
  10. pmc Functional specialization of Chlamydomonas reinhardtii cytosolic thioredoxin h1 in the response to alkylation-induced DNA damage
    Nandita Sarkar
    School of Biological Sciences and Plant Science Initiative, University of Nebraska Lincoln, Lincoln, NE 68588 0666, USA
    Eukaryot Cell 4:262-73. 2005

Collaborators

  • Jianping Xu
  • Karin van Dijk
  • Hideaki Moriyama
  • Etsuko Moriyama
  • Fangrui Ma
  • Tala Awada
  • Edgar B Cahoon
  • Alexey V Lobanov
  • Annkatrin Rose
  • D Stern
  • I T Paulsen
  • Guillaume F Chanfreau
  • I Dubchak
  • Pierre Cardol
  • Vadim N Gladyshev
  • Jakob Waterborg
  • Wallace Marshall
  • David R Nelson
  • A M Nedelcu
  • J Armando Casas-Mollano
  • Eun Jeong Kim
  • Fadia Ibrahim
  • Jennifer Rohr
  • Xinrong Ma
  • Nandita Sarkar
  • Byeong Ryool Jeong
  • Joseph Msanne
  • Scott Shaver
  • Eniko Balassa
  • Chaomei Zhang
  • Sabeeha S Merchant
  • Byeong ryool Jeong Br
  • Dancia Wu-Scharf
  • Adam Voshall
  • Insun Kook
  • Di Xu
  • Anji Reddy Konda
  • Ronald L Cerny
  • Pamela J Green
  • Linda A Rymarquis
  • James Becker
  • Karla Gendler
  • Lukasz Szajkowski
  • Telsa Mittelmeier
  • Susan M Lucas
  • Jun Minagawa
  • Sergey V Novoselov
  • Vladimir V Kapitonov
  • Bernd Mueller-Roeber
  • Richard Jorgensen
  • George B Witman
  • Pamela Green
  • Jean Philippe Ral
  • Erika Lindquist
  • Marc Hanikenne
  • Chris Bowler
  • Nedra Wilson
  • William Inwood
  • Diego Mauricio Riaño-Pachón
  • Alexander Poliakov
  • Kemin Zhou
  • Yigong Luo
  • Charles Hauser
  • Wing Chi Abby Ngau
  • Maria Mittag
  • Leila Hornick
  • BOBBY OTILLAR
  • Greg Pazour
  • Diego González-Halphen
  • Chun Long Chen
  • Katerina Bisova
  • Daniel S Rokhsar
  • M Dudley Page
  • Iris Meier
  • Patrick Ferris
  • Eric Stahlberg
  • Richard T Sayre
  • Laurence Maréchal-Drouard
  • Ming Kalanon
  • Jinal Jhaveri
  • Emilio Fernandez
  • Carol L Dieckmann
  • Kamel Jabbari
  • Carolyn Napoli
  • Jeffrey Moseley
  • Liang Hu Qu
  • Chong Jian Chen
  • Olivier Vallon
  • Pinfen Yang
  • Steven Ball

Detail Information

Publications21

  1. pmc SET3p monomethylates histone H3 on lysine 9 and is required for the silencing of tandemly repeated transgenes in Chlamydomonas
    J Armando Casas-Mollano
    School of Biological Sciences and Plant Science Initiative, University of Nebraska, Lincoln, NE 68588 0666, USA
    Nucleic Acids Res 35:939-50. 2007
    ..Thus, our observations are consistent with a role for monomethyl H3K9 as an epigenetic mark of repressed chromatin and raise questions as to the functional distinctiveness of different H3K9 methylation states...
  2. ncbi request reprint Turnover of mature miRNAs and siRNAs in plants and algae
    Heriberto Cerutti
    School of Biological Sciences and Center for Plant Science Innovation, University of Nebraska, P O Box 880666, Lincoln, Nebraska 68588, USA
    Adv Exp Med Biol 700:124-39. 2010
    ..We anticipate that understanding the mechanisms of mature miRNA and siRNA turnover will have direct implications for fundamental biology as well as for applications of RNA interference technology...
  3. ncbi request reprint Histone H3 phosphorylation: universal code or lineage specific dialects?
    Heriberto Cerutti
    School of Biological Sciences and Center for Plant Science Innovation, University of Nebraska, Lincoln, NE 68588, USA
    Epigenetics 4:71-5. 2009
    ..Thus, a detailed understanding of the influence of histone H3 phosphorylation on biological processes may require learning organismal dialects of the histone code...
  4. ncbi request reprint RNA interference: traveling in the cell and gaining functions?
    Heriberto Cerutti
    School of Biological Sciences and Plant Science Initiative, University of Nebraska Lincoln, E211 Beadle Center, Post Office Box 880666, Lincoln, NE 68588 0666, USA
    Trends Genet 19:39-46. 2003
    ..These findings imply that RNA-mediated mechanisms can control gene expression at both the transcriptional and the post-transcriptional level, and that they can operate in the nuclear and the cytoplasmic compartments...
  5. pmc RNA-mediated silencing in Algae: biological roles and tools for analysis of gene function
    Heriberto Cerutti
    School of Biological Sciences and Center for Plant Science Innovation, University of Nebraska Lincoln, E211 Beadle Center, P O Box 880666, Lincoln, NE 68588 0666, USA
    Eukaryot Cell 10:1164-72. 2011
    ..The development of RNAi technology in conjunction with system level "omics" approaches may provide the tools needed to advance our understanding of algal physiological and metabolic processes...
  6. pmc On the origin and functions of RNA-mediated silencing: from protists to man
    Heriberto Cerutti
    School of Biological Sciences and Plant Science Initiative, University of Nebraska, Lincoln, 68588 0666, USA
    Curr Genet 50:81-99. 2006
    ....
  7. ncbi request reprint Origin of the polycomb repressive complex 2 and gene silencing by an E(z) homolog in the unicellular alga Chlamydomonas
    Scott Shaver
    School of Biological Sciences and Center for Plant Science Innovation, University of Nebraska, Lincoln, NE, USA
    Epigenetics 5:301-12. 2010
    ....
  8. pmc The MUT9p kinase phosphorylates histone H3 threonine 3 and is necessary for heritable epigenetic silencing in Chlamydomonas
    J Armando Casas-Mollano
    School of Biological Sciences and Plant Science Initiative and Department of Chemistry, University of Nebraska, Lincoln, NE 68588 0666, USA
    Proc Natl Acad Sci U S A 105:6486-91. 2008
    ..Our results suggest that H3T3ph and H3K4me1 function as reinforcing epigenetic marks for the silencing of euchromatic loci in Chlamydomonas...
  9. pmc Monomethyl histone H3 lysine 4 as an epigenetic mark for silenced euchromatin in Chlamydomonas
    Karin van Dijk
    Department of Plant Pathology and Plant Science Initiative, University of Nebraska, Lincoln, Nebraska 68588 0666, USA
    Plant Cell 17:2439-53. 2005
    ..Together, our results suggest functional differentiation between dimethyl H3K4 and monomethyl H3K4, with the latter operating as an epigenetic mark for repressed euchromatin...
  10. pmc Functional specialization of Chlamydomonas reinhardtii cytosolic thioredoxin h1 in the response to alkylation-induced DNA damage
    Nandita Sarkar
    School of Biological Sciences and Plant Science Initiative, University of Nebraska Lincoln, Lincoln, NE 68588 0666, USA
    Eukaryot Cell 4:262-73. 2005
    ..These observations also suggest functional specialization among cytosolic thioredoxins since another Chlamydomonas isoform (Trxh2) does not compensate for the lack of Trxh1...
  11. pmc Diversification of the core RNA interference machinery in Chlamydomonas reinhardtii and the role of DCL1 in transposon silencing
    J Armando Casas-Mollano
    School of Biological Sciences and Plant Science Initiative, University of Nebraska, Lincoln, NE 68588, USA
    Genetics 179:69-81. 2008
    ..Our results suggest that multiple, partly redundant epigenetic processes are involved in preventing transposon mobilization in this green alga...
  12. ncbi request reprint A WD40-repeat containing protein, similar to a fungal co-repressor, is required for transcriptional gene silencing in Chlamydomonas
    Chaomei Zhang
    School of Biological Sciences and Plant Science Initiative, University of Nebraska Lincoln, E211 Beadle Center, Post Office Box 880666, Lincoln, NE 68588 0666, USA
    Plant J 31:25-36. 2002
    ..Our results also support the existence, in methylation-competent organisms, of a mechanism(s) of transcriptional (trans)gene silencing that is independent of DNA methylation...
  13. pmc Uridylation of mature miRNAs and siRNAs by the MUT68 nucleotidyltransferase promotes their degradation in Chlamydomonas
    Fadia Ibrahim
    School of Biological Sciences, University of Nebraska, Lincoln, NE 68588, USA
    Proc Natl Acad Sci U S A 107:3906-11. 2010
    ..We propose that MUT68 and RRP6 cooperate in the degradation of mature miRNAs and siRNAs, as a quality control mechanism to eliminate dysfunctional or damaged small RNA molecules...
  14. doi request reprint Targeted gene silencing by RNA interference in Chlamydomonas
    Eun Jeong Kim
    School of Biological Sciences and Center for Plant Science Innovation, University of Nebraska, Lincoln, Nebraska 68588, USA
    Methods Cell Biol 93:99-110. 2009
    ..We demonstrate this approach for the characterization of a gene of unknown function in Chlamydomonas, encoding a predicted exoribonuclease with weak similarity to 3'hExo/ERI-1...
  15. pmc Small interfering RNA-mediated translation repression alters ribosome sensitivity to inhibition by cycloheximide in Chlamydomonas reinhardtii
    Xinrong Ma
    School of Biological Sciences and Center for Plant Science Inovation, University of Nebraska, Lincoln, Nebraska 68588, USA
    Plant Cell 25:985-98. 2013
    ..Additionally, sRNA-mediated translation inhibition is now known to occur in a number of phylogenetically diverse eukaryotes, suggesting that this mechanism may have been a feature of an ancestral RNA interference machinery...
  16. doi request reprint Metabolic and gene expression changes triggered by nitrogen deprivation in the photoautotrophically grown microalgae Chlamydomonas reinhardtii and Coccomyxa sp. C-169
    Joseph Msanne
    School of Natural Resources, University of Nebraska Lincoln, Lincoln, NE 68588, USA
    Phytochemistry 75:50-9. 2012
    ..Understanding the interdependence of these anabolic and catabolic processes and their regulation may allow the engineering of algal strains with improved capacity to convert their biomass into useful biofuel precursors...
  17. ncbi request reprint Untemplated oligoadenylation promotes degradation of RISC-cleaved transcripts
    Fadia Ibrahim
    Biological Sciences and Plant Science Initiative, University of Nebraska, Lincoln, NE 68588, USA
    Science 314:1893. 2006
    ..MUT68 encodes a noncanonical polyadenylate polymerase that adds untemplated adenines to the 5' RNA fragments after siRNA-mediated cleavage and appears to stimulate their exosome-dependent degradation...
  18. ncbi request reprint Tandem inverted repeat system for selection of effective transgenic RNAi strains in Chlamydomonas
    Jennifer Rohr
    School of Biological Sciences and Plant Science Initiative, University of Nebraska Lincoln, E215 Beadle Center, PO Box 880666, Lincoln, NE 68588, USA
    Plant J 40:611-21. 2004
    ..We anticipate that this approach will be useful for generating stable hypomorphic epi-mutants in high-throughput phenotypic screens...
  19. pmc Suppressors of transcriptional transgenic silencing in Chlamydomonas are sensitive to DNA-damaging agents and reactivate transposable elements
    Byeong ryool Jeong Br
    School of Biological Sciences and Plant Science Initiative, University of Nebraska, E211 Beadle Center, Post Office Box 880666, Lincoln, NE 68588 0666, USA
    Proc Natl Acad Sci U S A 99:1076-81. 2002
    ..Our results also raise the possibility of mechanistic connections between epigenetic transcriptional silencing and DNA double-strand break repair...
  20. doi request reprint Turnover of Mature miRNAs and siRNAs in Plants and Algae
    Heriberto Cerutti
    School of Biological Sciences and Center for Plant Science Innovation, University of Nebraska, P O Box 880666, Lincoln, Nebraska, 68588, USA
    Adv Exp Med Biol 700:124-39. 2011
    ..We anticipate that understanding the mechanisms of mature miRNA and siRNA turnover will have direct implications for fundamental biology as well as for applications of RNA interference technology...
  21. pmc The Chlamydomonas genome reveals the evolution of key animal and plant functions
    Sabeeha S Merchant
    Department of Chemistry and Biochemistry, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Science 318:245-50. 2007
    ....

Research Grants8

  1. RNA-Mediated Silencing: Mechanisms and Biological Roles in Chlamydomonas
    Heriberto Cerutti; Fiscal Year: 2009
    ..The overall findings are expected to improve our ability to exploit RNAi as an experimental and/or therapeutic tool, with likely impacts in both medicine and agriculture. ..
  2. Mechanisms of Posttranscriptional Gene Silencing
    Heriberto Cerutti; Fiscal Year: 2004
    ..If the silencing mechanisms are indeed effective as anti-transposon and anti-viral agents, their further elucidation will have impact not only in basic biology but also in medicine and agriculture. ..
  3. RNA-Mediated Silencing: Mechanisms and Biological Roles in Chlamydomonas
    Heriberto Cerutti; Fiscal Year: 2007
    ..The overall findings are expected to improve our ability to exploit RNAi as an experimental and/or therapeutic tool, with likely impacts in both medicine and agriculture. ..
  4. RNA-Mediated Silencing: Mechanisms and Biological Roles in Chlamydomonas
    Heriberto Cerutti; Fiscal Year: 2006
    ..The overall findings are expected to improve our ability to exploit RNAi as an experimental and/or therapeutic tool, with likely impacts in both medicine and agriculture. ..
  5. Mechanisms of Posttranscriptional Gene Silencing
    Heriberto Cerutti; Fiscal Year: 2001
    ..If the silencing mechanisms are indeed effective as anti-transposon and anti-viral agents, their further elucidation will have impact not only in basic biology but also in medicine and agriculture. ..
  6. Mechanisms of Posttranscriptional Gene Silencing
    Heriberto Cerutti; Fiscal Year: 2002
    ..If the silencing mechanisms are indeed effective as anti-transposon and anti-viral agents, their further elucidation will have impact not only in basic biology but also in medicine and agriculture. ..
  7. Mechanisms of Posttranscriptional Gene Silencing
    Heriberto Cerutti; Fiscal Year: 2003
    ..If the silencing mechanisms are indeed effective as anti-transposon and anti-viral agents, their further elucidation will have impact not only in basic biology but also in medicine and agriculture. ..