Research Topics
Genomes and Genes | Heriberto CeruttiSummaryAffiliation: University of Nebraska Country: USA Publications
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Publications
Histone H3 phosphorylation: universal code or lineage specific dialects?Heriberto Cerutti
School of Biological Sciences and Center for Plant Science Innovation, University of Nebraska, Lincoln, NE 68588, USA
Epigenetics 4:71-5. 2009..Thus, a detailed understanding of the influence of histone H3 phosphorylation on biological processes may require learning organismal dialects of the histone code...- RNA interference: traveling in the cell and gaining functions?Heriberto Cerutti
School of Biological Sciences and Plant Science Initiative, University of Nebraska Lincoln, E211 Beadle Center, Post Office Box 880666, Lincoln, NE 68588 0666, USA
Trends Genet 19:39-46. 2003..These findings imply that RNA-mediated mechanisms can control gene expression at both the transcriptional and the post-transcriptional level, and that they can operate in the nuclear and the cytoplasmic compartments... - Turnover of mature miRNAs and siRNAs in plants and algaeHeriberto Cerutti
School of Biological Sciences and Center for Plant Science Innovation, University of Nebraska, P O Box 880666, Lincoln, Nebraska 68588, USA
Adv Exp Med Biol 700:124-39. 2010..We anticipate that understanding the mechanisms of mature miRNA and siRNA turnover will have direct implications for fundamental biology as well as for applications of RNA interference technology... 
RNA-mediated silencing in Algae: biological roles and tools for analysis of gene functionHeriberto Cerutti
School of Biological Sciences and Center for Plant Science Innovation, University of Nebraska Lincoln, E211 Beadle Center, P O Box 880666, Lincoln, NE 68588 0666, USA
Eukaryot Cell 10:1164-72. 2011..The development of RNAi technology in conjunction with system level "omics" approaches may provide the tools needed to advance our understanding of algal physiological and metabolic processes...- On the origin and functions of RNA-mediated silencing: from protists to manHeriberto Cerutti
School of Biological Sciences and Plant Science Initiative, University of Nebraska, Lincoln, 68588 0666, USA
Curr Genet 50:81-99. 2006.... - Origin of the polycomb repressive complex 2 and gene silencing by an E(z) homolog in the unicellular alga ChlamydomonasScott Shaver
School of Biological Sciences and Center for Plant Science Innovation, University of Nebraska, Lincoln, NE, USA
Epigenetics 5:301-12. 2010.... - The MUT9p kinase phosphorylates histone H3 threonine 3 and is necessary for heritable epigenetic silencing in ChlamydomonasJ Armando Casas-Mollano
School of Biological Sciences and Plant Science Initiative and Department of Chemistry, University of Nebraska, Lincoln, NE 68588 0666, USA
Proc Natl Acad Sci U S A 105:6486-91. 2008..Our results suggest that H3T3ph and H3K4me1 function as reinforcing epigenetic marks for the silencing of euchromatic loci in Chlamydomonas... - SET3p monomethylates histone H3 on lysine 9 and is required for the silencing of tandemly repeated transgenes in ChlamydomonasJ Armando Casas-Mollano
School of Biological Sciences and Plant Science Initiative, University of Nebraska, Lincoln, NE 68588 0666, USA
Nucleic Acids Res 35:939-50. 2007..Thus, our observations are consistent with a role for monomethyl H3K9 as an epigenetic mark of repressed chromatin and raise questions as to the functional distinctiveness of different H3K9 methylation states... - Monomethyl histone H3 lysine 4 as an epigenetic mark for silenced euchromatin in ChlamydomonasKarin van Dijk
Department of Plant Pathology and Plant Science Initiative, University of Nebraska, Lincoln, Nebraska 68588 0666, USA
Plant Cell 17:2439-53. 2005..Together, our results suggest functional differentiation between dimethyl H3K4 and monomethyl H3K4, with the latter operating as an epigenetic mark for repressed euchromatin... - Diversification of the core RNA interference machinery in Chlamydomonas reinhardtii and the role of DCL1 in transposon silencingJ Armando Casas-Mollano
School of Biological Sciences and Plant Science Initiative, University of Nebraska, Lincoln, NE 68588, USA
Genetics 179:69-81. 2008..Our results suggest that multiple, partly redundant epigenetic processes are involved in preventing transposon mobilization in this green alga... - Uridylation of mature miRNAs and siRNAs by the MUT68 nucleotidyltransferase promotes their degradation in ChlamydomonasFadia Ibrahim
School of Biological Sciences, University of Nebraska, Lincoln, NE 68588, USA
Proc Natl Acad Sci U S A 107:3906-11. 2010..We propose that MUT68 and RRP6 cooperate in the degradation of mature miRNAs and siRNAs, as a quality control mechanism to eliminate dysfunctional or damaged small RNA molecules... - Functional specialization of Chlamydomonas reinhardtii cytosolic thioredoxin h1 in the response to alkylation-induced DNA damageNandita Sarkar
School of Biological Sciences and Plant Science Initiative, University of Nebraska-Lincoln, Lincoln, NE 68588-0666, USA
Eukaryot Cell 4:262-73. 2005..These observations also suggest functional specialization among cytosolic thioredoxins since another Chlamydomonas isoform (Trxh2) does not compensate for the lack of Trxh1... 
Targeted gene silencing by RNA interference in ChlamydomonasEun Jeong Kim
School of Biological Sciences and Center for Plant Science Innovation, University of Nebraska, Lincoln, Nebraska 68588, USA
Methods Cell Biol 93:99-110. 2009..We demonstrate this approach for the characterization of a gene of unknown function in Chlamydomonas, encoding a predicted exoribonuclease with weak similarity to 3'hExo/ERI-1...- Metabolic and gene expression changes triggered by nitrogen deprivation in the photoautotrophically grown microalgae Chlamydomonas reinhardtii and Coccomyxa sp. C-169Joseph Msanne
School of Natural Resources, University of Nebraska Lincoln, Lincoln, NE 68588, USA
Phytochemistry 75:50-9. 2012..Understanding the interdependence of these anabolic and catabolic processes and their regulation may allow the engineering of algal strains with improved capacity to convert their biomass into useful biofuel precursors... - Untemplated oligoadenylation promotes degradation of RISC-cleaved transcriptsFadia Ibrahim
Biological Sciences and Plant Science Initiative, University of Nebraska, Lincoln, NE 68588, USA
Science 314:1893. 2006..MUT68 encodes a noncanonical polyadenylate polymerase that adds untemplated adenines to the 5' RNA fragments after siRNA-mediated cleavage and appears to stimulate their exosome-dependent degradation... - Tandem inverted repeat system for selection of effective transgenic RNAi strains in ChlamydomonasJennifer Rohr
School of Biological Sciences and Plant Science Initiative, University of Nebraska-Lincoln, E215 Beadle Center, PO Box 880666, Lincoln, NE 68588, USA
Plant J 40:611-21. 2004..We anticipate that this approach will be useful for generating stable hypomorphic epi-mutants in high-throughput phenotypic screens... - Small Interfering RNA-Mediated Translation Repression Alters Ribosome Sensitivity to Inhibition by Cycloheximide in Chlamydomonas reinhardtiiXinrong Ma
School of Biological Sciences and Center for Plant Science Inovation, University of Nebraska, Lincoln, Nebraska 68588
Plant Cell 25:985-98. 2013..Additionally, sRNA-mediated translation inhibition is now known to occur in a number of phylogenetically diverse eukaryotes, suggesting that this mechanism may have been a feature of an ancestral RNA interference machinery... - Turnover of Mature miRNAs and siRNAs in Plants and AlgaeHeriberto Cerutti
School of Biological Sciences and Center for Plant Science Innovation, University of Nebraska, P O Box 880666, Lincoln, Nebraska, 68588, USA
Adv Exp Med Biol 700:124-39. 2011..We anticipate that understanding the mechanisms of mature miRNA and siRNA turnover will have direct implications for fundamental biology as well as for applications of RNA interference technology... - A WD40-repeat containing protein, similar to a fungal co-repressor, is required for transcriptional gene silencing in ChlamydomonasChaomei Zhang
School of Biological Sciences and Plant Science Initiative, University of Nebraska - Lincoln, E211 Beadle Center, Post Office Box 880666, Lincoln, NE 68588-0666, USA
Plant J 31:25-36. 2002..Our results also support the existence, in methylation-competent organisms, of a mechanism(s) of transcriptional (trans)gene silencing that is independent of DNA methylation... - Suppressors of transcriptional transgenic silencing in Chlamydomonas are sensitive to DNA-damaging agents and reactivate transposable elementsByeong-ryool Jeong Br
School of Biological Sciences and Plant Science Initiative, University of Nebraska, E211 Beadle Center, Post Office Box 880666, Lincoln, NE 68588-0666, USA
Proc Natl Acad Sci U S A 99:1076-81. 2002..Our results also raise the possibility of mechanistic connections between epigenetic transcriptional silencing and DNA double-strand break repair... - The Chlamydomonas genome reveals the evolution of key animal and plant functionsSabeeha S Merchant
Department of Chemistry and Biochemistry, University of California at Los Angeles, Los Angeles, CA 90095, USA
Science 318:245-50. 2007....
Research Grants
- RNA-Mediated Silencing: Mechanisms and Biological Roles in ChlamydomonasHeriberto Cerutti; Fiscal Year: 2009..The overall findings are expected to improve our ability to exploit RNAi as an experimental and/or therapeutic tool, with likely impacts in both medicine and agriculture. ..
- Mechanisms of Posttranscriptional Gene SilencingHeriberto Cerutti; Fiscal Year: 2004..If the silencing mechanisms are indeed effective as anti-transposon and anti-viral agents, their further elucidation will have impact not only in basic biology but also in medicine and agriculture. ..
- RNA-Mediated Silencing: Mechanisms and Biological Roles in ChlamydomonasHeriberto Cerutti; Fiscal Year: 2007..The overall findings are expected to improve our ability to exploit RNAi as an experimental and/or therapeutic tool, with likely impacts in both medicine and agriculture. ..