Research Topics
| Albert E CerussiSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Frequent optical imaging during breast cancer neoadjuvant chemotherapy reveals dynamic tumor physiology in an individual patientAlbert E Cerussi
Beckman Laser Institute, University of California, Irvine, 92612, USA
Acad Radiol 17:1031-9. 2010..Because optical methods provide functional imaging end points, our objective is to develop a low-barrier-to-access bedside approach that can be used for frequent, functional assessment of dynamic tumor physiology in individual patients...- Effect of contact force on breast tissue optical property measurements using a broadband diffuse optical spectroscopy handheld probeAlbert Cerussi
Laser Medical and Microbeam Program, Beckman Laser Institute, University of California, Irvine, 1110 Health Sciences Road, East, Irvine, California 92612, USA
Appl Opt 48:4270-7. 2009..Contact force is not a significant source of variation, most likely because of a relatively wide probe surface area and the stability of the DOS method for calculating tissue optical properties... - Predicting response to breast cancer neoadjuvant chemotherapy using diffuse optical spectroscopyAlbert Cerussi
Laser Medical and Microbeam Program, Beckman Laser Institute and Medical Clinic, University of California Irvine, 1002 Health Sciences Road East, Irvine, CA 92612, USA
Proc Natl Acad Sci U S A 104:4014-9. 2007..44) vs. nonresponders (1.82 +/- 0.49). These results highlight DOS sensitivity to tumor cellular metabolism and biochemical composition and demonstrate its potential for predicting and monitoring an individual's response to treatment... 
Noninvasive monitoring of red blood cell transfusion in very low birthweight infants using diffuse optical spectroscopyAlbert Cerussi
University of California, Irvine, Beckman Laser Institute, 1002 Health Sciences Road, East Irvine, California 92612, USA
J Biomed Opt 10:051401. 2005..DOS may serve as a noninvasive bedside tool to assess tissue oxygenation in infants and provide a functionally based transfusion trigger...- Diffuse optical spectroscopic imaging correlates with final pathological response in breast cancer neoadjuvant chemotherapyAlbert E Cerussi
Laser Microbeam and Medical Program, Beckman Laser Institute and Medical Clinic, University of California, Irvine, 1002 Health Sciences Road, East, Irvine, CA 92612, USA
Philos Trans A Math Phys Eng Sci 369:4512-30. 2011..This approach is well suited to monitoring breast tumour response and may provide feedback for optimizing therapeutic outcomes and minimizing side-effects... - Spatial variations in optical and physiological properties of healthy breast tissueNatasha Shah
Beckman Laser Institute, University of California-Irvine, 1002 Health Sciences Road, Irvine, CA 92612, USA
J Biomed Opt 9:534-40. 2004.... - Monitoring neoadjuvant chemotherapy in breast cancer using quantitative diffuse optical spectroscopy: a case studyDorota B Jakubowski
Beckman Laser Institute, Laser Microbeam and Medical Program, University of California-Irvine, 1002 Health Sciences Road East, Irvine, CA 92612, USA
J Biomed Opt 9:230-8. 2004..These data suggest that noninvasive, quantitative optical methods that characterize tumor physiology may be useful in assessing and optimizing individual response to neoadjuvant chemotherapy... - The role of diffuse optical spectroscopy in the clinical management of breast cancerNatasha Shah
Laser Microbeam and Medical Program (LAMMP, Beckman Laser Institute, University of California, Irvine, CA 92612, USA
Dis Markers 19:95-105. 2003.... - Noninvasive in vivo monitoring of methemoglobin formation and reduction with broadband diffuse optical spectroscopyJangwoen Lee
Laser Microbeam and Medical Program, Beckman Laser Institute, 1002 Health Sciences Rd. East, University of California, Irvine, CA 92612-1475, USA
J Appl Physiol 100:615-22. 2006..These techniques are expected to be useful in evaluating dynamics of drug delivery and therapeutic efficacy in blood chemistry, human, and preclinical animal models... - Imaging breast cancer chemotherapy response with light. Commentary on Soliman et al., p. 2605Bruce J Tromberg
Laser Microbeam and Medical Program, Beckman Laser Institute and Medical Clinic, University of California, Irvine, CA 92715, USA
Clin Cancer Res 16:2486-8. 2010..Although investigational, DOS may provide a cost-effective, risk-free method for optimizing NAC drug and dosing strategies for individual patients... - Characterization of metabolic differences between benign and malignant tumors: high-spectral-resolution diffuse optical spectroscopyShwayta Kukreti
Beckman Laser Institute, University of California, Irvine, CA 92612, USA
Radiology 254:277-84. 2010..To develop a near-infrared spectroscopic method to identify breast cancer biomarkers and to retrospectively determine if benign and malignant breast lesions could be distinguished by using this method... - Impact of contralateral and ipsilateral reference tissue selection on self-referencing differential spectroscopy for breast cancer detectionAnais Leproux
University of California, Irvine, Beckman Laser Institute, Irvine, California 92612, USA
J Biomed Opt 16:116019. 2011..This also indicates that bilateral measurements are not required for lesion identification using the STC method... - Assessing the future of diffuse optical imaging technologies for breast cancer managementBruce J Tromberg
Beckman Laser Institute and Medical Clinic, University of California Irvine, Irvine, California 92612, USA
Med Phys 35:2443-51. 2008.... - Assessing the spatial extent of breast tumor intrinsic optical contrast using ultrasound and diffuse optical spectroscopyAng Li
University of California, Irvine, Beckman Laser Institute and Medical Clinic, Laser Microbeam and Medical Program, Irvine, California 92612, USA
J Biomed Opt 13:030504. 2008..Analysis indicates that invasive breast tumors with anatomical dimensions of 1 cm may still be detectable at depths of 30 mm or more (the center of the lesion to the surface of tissue) using DOS in a reflectance geometry... - Hemoglobin measurement patterns during noninvasive diffuse optical spectroscopy monitoring of hypovolemic shock and fluid replacementJangwoen Lee
University of California, Irvine, Beckman Laser Institute, Laser Microbeam and Medical Program, Irvine, California 92612 1475, USA
J Biomed Opt 12:024001. 2007..Further studies are needed to confirm potential clinical utility and accuracy under more complex clinical conditions in animal models and patients... - In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopyAlbert Cerussi
University of California Irvine, Beckman Laser Institute, Laser Medical and Microbeam Program, 1002 Health Sciences Road East, Irvine, California 92612, USA
J Biomed Opt 11:044005. 2006..Our findings further underscore the importance of broadband measurements and patient age stratification in breast cancer DOI... - Coregistration of dynamic contrast enhanced MRI and broadband diffuse optical spectroscopy for characterizing breast cancerDavid Hsiang
Chao Comprehensive Cancer Center, Division of Oncological Surgery, University of California, Irvine Medical Center, 101 The City Drive, Orange, CA 92868, USA
Technol Cancer Res Treat 4:549-58. 2005..These results provide qualitative confirmation of the common signal origin and complementary information content that can be achieved by combining optical and MR imaging for breast cancer detection and clinical management... - Combined diffuse optical spectroscopy and contrast-enhanced magnetic resonance imaging for monitoring breast cancer neoadjuvant chemotherapy: a case studyNatasha Shah
University of California-Irvine, Beckman Laser Institute and Medical Clinic, Laser Microbeam and Medical Program, Irvine, California 92162-1475, USA
J Biomed Opt 10:051503. 2005..7% drop in mean total hemoglobin content (THC, 41.6 versus 23.4 microM). These data provide in vivo validation of the accuracy of broadband DOS and the sensitivity of optical methods to changes in tumor physiology... - Imaging in breast cancer: diffuse optics in breast cancer: detecting tumors in pre-menopausal women and monitoring neoadjuvant chemotherapyBruce J Tromberg
Laser Microbeam and Medical Program, Beckman Laser Institute, University of California, Irvine, CA, USA
Breast Cancer Res 7:279-85. 2005..These results suggest a potential role for diffuse optics as a bedside monitoring tool that could aid the development of new strategies for individualized patient care... - Intrinsic near-infrared spectroscopic markers of breast tumorsShwayta Kukreti
Beckman Laser Institute, University of California, Irvine CA, USA
Dis Markers 25:281-90. 2008..The STC index, combined with other previously described tissue optical indices, further improves the diagnostic power of NIR for breast cancer detection... - Diffuse optical spectroscopy measurements of healing in breast tissue after core biopsy: case studyWendy Tanamai
University of California, Irvine, Beckman Laser Institute, Laser Medical and Microbeam Program, 1002 Health Sciences Road East, Irvine, California 92612, USA
J Biomed Opt 14:014024. 2009..DOS could therefore be useful in evaluating both wound-healing response and the effects of hormone and hormonal therapies in vivo... - Intrinsic tumor biomarkers revealed by novel double-differential spectroscopic analysis of near-infrared spectraShwayta Kukreti
University of California, Irvine, Beckman Laser Institute, Irvine, California 92612, USA
J Biomed Opt 12:020509. 2007..To quantify spectral variation in the absorption bands, we construct the specific tumor component (STC) index. The STC index identifies regions of the breast with tumors... - Diffuse optical imaging using spatially and temporally modulated lightThomas D O'Sullivan
University of California, Irvine, Laser Microbeam and Medical Program LAMMP, Beckman Laser Institute and Medical Clinic, Irvine, California, USA
J Biomed Opt 17:071311. 2012.... 
Design and testing of a miniature broadband frequency domain photon migration instrumentKeun Sik No
University of California, Irvine, Beackman Laser Institute Laser Medical and Microbeam Program, 1110 Health Sciences Road, East, Irvine, California 92612, USA
J Biomed Opt 13:050509. 2008..e., breast/skin cancer, brain activation, and exercise physiology)...- Method for recovering quantitative broadband diffuse optical spectra from layered mediaAng Li
Beckman Laser Institute and Medical Clinic, University of California Irvine, 92612, USA
Appl Opt 46:4828-33. 2007..In addition to spectra, the algorithm recovers the top layer thickness up to 12 mm within 10% error. It is insensitive to initial guesses of both layers' optical properties as long as the layer thickness initial guess is within +/-2 mm... - Tissue phantoms in multicenter clinical trials for diffuse optical technologiesAlbert E Cerussi
Beckman Laser Institute, University of California Irvine, Irvine, California 92617, USA
Biomed Opt Express 3:966-71. 2012..Phantom measurements are used to determine absolute instrument response functions during each measurement session and assess both long and short-term operator and instrument reliability... - Near-infrared imaging of the sinuses: preliminary evaluation of a new technology for diagnosing maxillary sinusitisUsama Mahmood
University of California at Irvine, Department of Biomedical Engineering, Beckman Laser Institute, 1002 Health Sciences Road, Irvine, California 92612, USA
J Biomed Opt 15:036011. 2010..Long-term, significant device refinement and large clinical trials will be needed to determine the diagnostic accuracy of this technique... - Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapyChao Zhou
University of Pennsylvania, Department of Physics and Astronomy, Philadelphia, Pennsylvania 19104, USA
J Biomed Opt 12:051903. 2007..The hybrid approach also enables construction of indices reflecting tissue metabolic rate of oxygen, which may provide new insights about therapy mechanisms...