Research Topics
| Albert CerussiSummaryAffiliation: University of California Country: USA Publications
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Publications
In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopyAlbert Cerussi
University of California Irvine, Beckman Laser Institute, Laser Medical and Microbeam Program, 1002 Health Sciences Road East, Irvine, California 92612, USA
J Biomed Opt 11:044005. 2006..Our findings further underscore the importance of broadband measurements and patient age stratification in breast cancer DOI...
Predicting response to breast cancer neoadjuvant chemotherapy using diffuse optical spectroscopyAlbert Cerussi
Laser Medical and Microbeam Program, Beckman Laser Institute and Medical Clinic, University of California Irvine, 1002 Health Sciences Road East, Irvine, CA 92612, USA
Proc Natl Acad Sci U S A 104:4014-9. 2007..44) vs. nonresponders (1.82 +/- 0.49). These results highlight DOS sensitivity to tumor cellular metabolism and biochemical composition and demonstrate its potential for predicting and monitoring an individual's response to treatment...- Baseline tumor oxygen saturation correlates with a pathologic complete response in breast cancer patients undergoing neoadjuvant chemotherapyShigeto Ueda
Laser Microbeam and Medical Program LAMMP, Beckman Laser Institute and Medical Clinic, University of California, Irvine, USA
Cancer Res 72:4318-28. 2012..Noninvasive DOSI scans combined with histopathology subtyping may aid in stratification of individual patients with breast cancer before neoadjuvant chemotherapy... - Diffuse optical spectroscopy measurements of healing in breast tissue after core biopsy: case studyWendy Tanamai
University of California, Irvine, Beckman Laser Institute, Laser Medical and Microbeam Program, 1002 Health Sciences Road East, Irvine, California 92612, USA
J Biomed Opt 14:014024. 2009..DOS could therefore be useful in evaluating both wound-healing response and the effects of hormone and hormonal therapies in vivo... - Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatmentDarren Roblyer
Laser Microbeam and Medical Program, Beckman Laser Institute and Medical Clinic, University of California, Irvine, CA 92617, USA
Proc Natl Acad Sci U S A 108:14626-31. 2011..Very early measures of chemotherapy response are clinically convenient and offer the potential to alter treatment strategies, resulting in improved patient outcomes... - Effect of contact force on breast tissue optical property measurements using a broadband diffuse optical spectroscopy handheld probeAlbert Cerussi
Laser Medical and Microbeam Program, Beckman Laser Institute, University of California, Irvine, 1110 Health Sciences Road, East, Irvine, California 92612, USA
Appl Opt 48:4270-7. 2009..Contact force is not a significant source of variation, most likely because of a relatively wide probe surface area and the stability of the DOS method for calculating tissue optical properties... - Intrinsic near-infrared spectroscopic markers of breast tumorsShwayta Kukreti
Beckman Laser Institute, University of California, Irvine CA, USA
Dis Markers 25:281-90. 2008..The STC index, combined with other previously described tissue optical indices, further improves the diagnostic power of NIR for breast cancer detection... - Breast cancer spatial heterogeneity in near-infrared spectra and the prediction of neoadjuvant chemotherapy responseYlenia Santoro
University of California, Irvine, Biomedical Engineering Department, Irvine, California 92697, USA
J Biomed Opt 16:097007. 2011..We conclude that the HS function is a biomarker that can be used to visualize spatial heterogeneities in lesions, and the baseline HI prior to therapy correlates with chemotherapy pathological response... - Imaging in breast cancer: diffuse optics in breast cancer: detecting tumors in pre-menopausal women and monitoring neoadjuvant chemotherapyBruce J Tromberg
Laser Microbeam and Medical Program, Beckman Laser Institute, University of California, Irvine, CA, USA
Breast Cancer Res 7:279-85. 2005..These results suggest a potential role for diffuse optics as a bedside monitoring tool that could aid the development of new strategies for individualized patient care... - Intrinsic tumor biomarkers revealed by novel double-differential spectroscopic analysis of near-infrared spectraShwayta Kukreti
University of California, Irvine, Beckman Laser Institute, Irvine, California 92612, USA
J Biomed Opt 12:020509. 2007..To quantify spectral variation in the absorption bands, we construct the specific tumor component (STC) index. The STC index identifies regions of the breast with tumors... 
Design and testing of a miniature broadband frequency domain photon migration instrumentKeun Sik No
University of California, Irvine, Beackman Laser Institute Laser Medical and Microbeam Program, 1110 Health Sciences Road, East, Irvine, California 92612, USA
J Biomed Opt 13:050509. 2008..e., breast/skin cancer, brain activation, and exercise physiology)...- Coregistration of dynamic contrast enhanced MRI and broadband diffuse optical spectroscopy for characterizing breast cancerDavid Hsiang
Chao Comprehensive Cancer Center, Division of Oncological Surgery, University of California, Irvine Medical Center, 101 The City Drive, Orange, CA 92868, USA
Technol Cancer Res Treat 4:549-58. 2005..These results provide qualitative confirmation of the common signal origin and complementary information content that can be achieved by combining optical and MR imaging for breast cancer detection and clinical management... - Noninvasive monitoring of red blood cell transfusion in very low birthweight infants using diffuse optical spectroscopyAlbert Cerussi
University of California, Irvine, Beckman Laser Institute, 1002 Health Sciences Road, East Irvine, California 92612, USA
J Biomed Opt 10:051401. 2005..DOS may serve as a noninvasive bedside tool to assess tissue oxygenation in infants and provide a functionally based transfusion trigger... - Method for recovering quantitative broadband diffuse optical spectra from layered mediaAng Li
Beckman Laser Institute and Medical Clinic, University of California Irvine, 92612, USA
Appl Opt 46:4828-33. 2007..In addition to spectra, the algorithm recovers the top layer thickness up to 12 mm within 10% error. It is insensitive to initial guesses of both layers' optical properties as long as the layer thickness initial guess is within +/-2 mm... - Near-infrared imaging of the sinuses: preliminary evaluation of a new technology for diagnosing maxillary sinusitisUsama Mahmood
University of California at Irvine, Department of Biomedical Engineering, Beckman Laser Institute, 1002 Health Sciences Road, Irvine, California 92612, USA
J Biomed Opt 15:036011. 2010..Long-term, significant device refinement and large clinical trials will be needed to determine the diagnostic accuracy of this technique... - Combined diffuse optical spectroscopy and contrast-enhanced magnetic resonance imaging for monitoring breast cancer neoadjuvant chemotherapy: a case studyNatasha Shah
University of California-Irvine, Beckman Laser Institute and Medical Clinic, Laser Microbeam and Medical Program, Irvine, California 92162-1475, USA
J Biomed Opt 10:051503. 2005..7% drop in mean total hemoglobin content (THC, 41.6 versus 23.4 microM). These data provide in vivo validation of the accuracy of broadband DOS and the sensitivity of optical methods to changes in tumor physiology... - Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapyChao Zhou
University of Pennsylvania, Department of Physics and Astronomy, Philadelphia, Pennsylvania 19104, USA
J Biomed Opt 12:051903. 2007..The hybrid approach also enables construction of indices reflecting tissue metabolic rate of oxygen, which may provide new insights about therapy mechanisms...