Research Topics
Genomes and Genes | B P CeresaSummaryAffiliation: University of Oklahoma Health Sciences Center Country: USA Publications
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Publications
rab7 activity affects epidermal growth factor:epidermal growth factor receptor degradation by regulating endocytic trafficking from the late endosomeBrian P Ceresa
Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, 73190, USA
J Biol Chem 281:1099-106. 2006..EGFR complex accumulates in high-density endosomes that are characteristic of the late endocytic pathway. Thus, we conclude that rab7 regulates the endocytic trafficking of the EGF.EGFR complex by regulating its lysosomal degradation...- Regulation of EGFR endocytic trafficking by rab proteinsB P Ceresa
Department of Cell Biology, University of Oklahoma Health Sciences Center, College of Medicine, Oklahoma City, OK 73190, USA
Histol Histopathol 21:987-93. 2006..In this review, the role of rabs, a family of small molecular weight guanine nucleotide binding proteins, is examined in how they regulate endocytic trafficking... - Expression of dominant negative rab5 in HeLa cells regulates endocytic trafficking distal from the plasma membraneJennifer L Dinneen
Department of Cell Biology, College of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA
Exp Cell Res 294:509-22. 2004..Taken together, these data are consistent with rab5 functioning to regulate intracellular endocytic trafficking distal from the plasma membrane... 
Rab7 regulates late endocytic trafficking downstream of multivesicular body biogenesis and cargo sequestrationPhillip A Vanlandingham
Department of Cell Biology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73126, USA
J Biol Chem 284:12110-24. 2009..Together, these data provide evidence that RAB7 is required for the transfer of cargo from the LE/MVB to the lysosome and for endocytic organelle maintenance...- Cellular localization of the activated EGFR determines its effect on cell growth in MDA-MB-468 cellsDustin C Hyatt
Department of Cell Biology, University of Oklahoma Health Sciences Center, 940 Stanton L Young Blvd, Oklahoma City, OK 73190, USA
Exp Cell Res 314:3415-25. 2008..Thus, through endocytosis, the activated EGFR can differentially regulate cell growth in MDA-MB-468 cells... - Receptor and membrane recycling can occur with unaltered efficiency despite dramatic Rab5(q79l)-induced changes in endosome geometryB P Ceresa
Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
J Biol Chem 276:9649-54. 2001..These results suggest that GTP hydrolysis by Rab5 is rate-limiting for endosome fusion but not for endocytic trafficking and that early endosome geometry may be a less critical determinant of sorting efficiencies than previously thought... - Expression of constitutively active Rab5 uncouples maturation of the Salmonella-containing vacuole from intracellular replicationM E Baldeon
Department of Cell Biology, Box 800732, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
Cell Microbiol 3:473-86. 2001..These findings raise the possibility that all the SCV-associated LAMP could be derived by endocytosis from the cell surface... - Continual expression of Rab5(Q79L) causes a ligand-independent EGFR internalization and diminishes EGFR activityJennifer L Dinneen
Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA
Traffic 5:606-15. 2004..The net result is a decrease in the level of cell-surface EGFRs available for ligand stimulation. Thus, rab5 activation regulates EGFR signaling by facilitating the internalization of the unliganded EGFR... - Transforming growth factor-{alpha} enhances corneal epithelial cell migration by promoting EGFR recyclingJennifer L McClintock
Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
Invest Ophthalmol Vis Sci 51:3455-61. 2010..This sequence of events provides the receptor multiple opportunities for stimulation. Thus, stimulation with TGF-alpha prolongs EGFR signaling compared with EGF... - Synip: a novel insulin-regulated syntaxin 4-binding protein mediating GLUT4 translocation in adipocytesJ Min
Department of Cell Biology, Parke Davis Pharmaceutical Research Division, Warner Lambert Company, Ann Arbor, Michigan 48105, USA
Mol Cell 3:751-60. 1999..These data implicate Synip as an insulin-regulated syntaxin 4-binding protein directly involved in the control of glucose transport and GLUT4 vesicle translocation... - Histamine stimulation of MMP-1(collagenase-1) secretion and gene expression in gastric epithelial cells: role of EGFR transactivation and the MAP kinase pathwayHanumantha R Ancha
Division of Gastroenterology, Department of Medicine, University of Oklahoma Health Sciences Center and Oklahoma City Department of Veterans Affairs Medical Center, Oklahoma City, OK 73104, United States
Int J Biochem Cell Biol 39:2143-52. 2007..This study examines the functional interactions between the H2 receptor and the EGFR in the regulation of matrix metalloproteinase-1 (MMP-1) secretion and gene expressions in cultured gastric epithelial cells... - Rab5-stimulated up-regulation of the endocytic pathway increases intracellular beta-cleaved amyloid precursor protein carboxyl-terminal fragment levels and Abeta productionOlivera M Grbovic
Center for Dementia Research, Nathan Kline Institute, Orangeburg, New York 10962, USA
J Biol Chem 278:31261-8. 2003..Our findings in this model system suggest that the endosomal pathology seen at the earliest stage of sporadic AD may contribute to APP proteolysis along a beta-amyloidogenic pathway...
Research Grants
- Regulation of EGFR Signaling by the Endocytic PathwayBrian P Ceresa; Fiscal Year: 2010..The immediate goal of this research is to better understand the molecular mechanisms that regulate the biological and pathological functions of the EGFR and use that information for treatment of diseases associated with the EGFR. ..