Carlos Cepeda

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Enhanced epileptogenic susceptibility in a genetic model of reactive synaptogenesis: the spastic Han-Wistar rat
    Carlos Cepeda
    Mental Retardation Research Center, University of California, Los Angeles, Calif 90095, USA
    Dev Neurosci 24:262-71. 2002
  2. doi request reprint Differential electrophysiological properties of dopamine D1 and D2 receptor-containing striatal medium-sized spiny neurons
    Carlos Cepeda
    Mental Retardation Research Center, David Geffen School of Medicine, NPI Room 58 258, 760 Westwood Plaza, University of California, Los Angeles, CA 90095, USA
    Eur J Neurosci 27:671-82. 2008
  3. ncbi request reprint Dopamine modulation of excitatory currents in the striatum is dictated by the expression of D1 or D2 receptors and modified by endocannabinoids
    Veronique M Andre
    Mental Retardation Research Center, David Geffen School of Medicine at UCLA, Semel Institute for Neuroscience and Human Behavior, 760 Westwood Plaza, NPI 58 258, Los Angeles, CA 90095, USA
    Eur J Neurosci 31:14-28. 2010
  4. pmc Alpha-synuclein overexpression in mice alters synaptic communication in the corticostriatal pathway
    Nanping Wu
    Intellectual Developmental Disabilities Research Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    J Neurosci Res 88:1764-76. 2010
  5. ncbi request reprint Immature neurons and GABA networks may contribute to epileptogenesis in pediatric cortical dysplasia
    Carlos Cepeda
    Mental Retardation Research Center, David Geffen School of Medicine, University of California, Los Angeles, California 90024, USA
    Epilepsia 48:79-85. 2007
  6. ncbi request reprint Alterations in N-methyl-D-aspartate receptor sensitivity and magnesium blockade occur early in development in the R6/2 mouse model of Huntington's disease
    Amaal J Starling
    Mental Retardation Research Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA
    J Neurosci Res 82:377-86. 2005
  7. ncbi request reprint Cytomegalic interneurons: a new abnormal cell type in severe pediatric cortical dysplasia
    Veronique M Andre
    Mental Retardation Research Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
    J Neuropathol Exp Neurol 66:491-504. 2007
  8. pmc Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice
    Michelle Gray
    Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 28:6182-95. 2008
  9. ncbi request reprint Altered corticostriatal neurotransmission and modulation in dopamine transporter knock-down mice
    Nanping Wu
    Mental Retardation Research Center, David Geffen School of Medicine, UCLA School of Medicine, Los Angeles, CA 90024, USA
    J Neurophysiol 98:423-32. 2007
  10. ncbi request reprint A hypothesis regarding the pathogenesis and epileptogenesis of pediatric cortical dysplasia and hemimegalencephaly based on MRI cerebral volumes and NeuN cortical cell densities
    Gary W Mathern
    Division of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, California, USA 90095 1769
    Epilepsia 48:74-8. 2007

Collaborators

Detail Information

Publications56

  1. ncbi request reprint Enhanced epileptogenic susceptibility in a genetic model of reactive synaptogenesis: the spastic Han-Wistar rat
    Carlos Cepeda
    Mental Retardation Research Center, University of California, Los Angeles, Calif 90095, USA
    Dev Neurosci 24:262-71. 2002
    ..Our data also underscore the usefulness of this natural model of cell degeneration and reactive synaptogenesis for understanding the mechanisms of neuronal hyperexcitability...
  2. doi request reprint Differential electrophysiological properties of dopamine D1 and D2 receptor-containing striatal medium-sized spiny neurons
    Carlos Cepeda
    Mental Retardation Research Center, David Geffen School of Medicine, NPI Room 58 258, 760 Westwood Plaza, University of California, Los Angeles, CA 90095, USA
    Eur J Neurosci 27:671-82. 2008
    ..This could help to explain the increased vulnerability of D2 MSSNs in neurodegenerative disorders...
  3. ncbi request reprint Dopamine modulation of excitatory currents in the striatum is dictated by the expression of D1 or D2 receptors and modified by endocannabinoids
    Veronique M Andre
    Mental Retardation Research Center, David Geffen School of Medicine at UCLA, Semel Institute for Neuroscience and Human Behavior, 760 Westwood Plaza, NPI 58 258, Los Angeles, CA 90095, USA
    Eur J Neurosci 31:14-28. 2010
    ..We suggest that activation of postsynaptic dopamine receptors controls endocannabinoid mobilization, acting on presynaptic CB1Rs, thus modulating glutamate release differently in glutamate terminals projecting to D1 and D2 cells...
  4. pmc Alpha-synuclein overexpression in mice alters synaptic communication in the corticostriatal pathway
    Nanping Wu
    Intellectual Developmental Disabilities Research Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    J Neurosci Res 88:1764-76. 2010
    ....
  5. ncbi request reprint Immature neurons and GABA networks may contribute to epileptogenesis in pediatric cortical dysplasia
    Carlos Cepeda
    Mental Retardation Research Center, David Geffen School of Medicine, University of California, Los Angeles, California 90024, USA
    Epilepsia 48:79-85. 2007
    ..These results could partially explain the increased excitability of the cortical network in pediatric CD...
  6. ncbi request reprint Alterations in N-methyl-D-aspartate receptor sensitivity and magnesium blockade occur early in development in the R6/2 mouse model of Huntington's disease
    Amaal J Starling
    Mental Retardation Research Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA
    J Neurosci Res 82:377-86. 2005
    ..These alterations may contribute to an enhancement of NMDA responses at hyperpolarized membrane potentials that may be a key factor in striatal neuronal dysfunction...
  7. ncbi request reprint Cytomegalic interneurons: a new abnormal cell type in severe pediatric cortical dysplasia
    Veronique M Andre
    Mental Retardation Research Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
    J Neuropathol Exp Neurol 66:491-504. 2007
    ....
  8. pmc Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice
    Michelle Gray
    Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 28:6182-95. 2008
    ..In summary, the BACHD model constitutes a novel and robust in vivo paradigm for the investigation of HD pathogenesis and treatment...
  9. ncbi request reprint Altered corticostriatal neurotransmission and modulation in dopamine transporter knock-down mice
    Nanping Wu
    Mental Retardation Research Center, David Geffen School of Medicine, UCLA School of Medicine, Los Angeles, CA 90024, USA
    J Neurophysiol 98:423-32. 2007
    ..These findings have implications for understanding mechanisms underlying attention deficit hyperactivity disorder and Tourette's syndrome and may provide insights into novel therapeutic approaches...
  10. ncbi request reprint A hypothesis regarding the pathogenesis and epileptogenesis of pediatric cortical dysplasia and hemimegalencephaly based on MRI cerebral volumes and NeuN cortical cell densities
    Gary W Mathern
    Division of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, California, USA 90095 1769
    Epilepsia 48:74-8. 2007
    ....
  11. pmc Age-dependent alterations of corticostriatal activity in the YAC128 mouse model of Huntington disease
    Prasad R Joshi
    Mental Retardation Research Center, The David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 29:2414-27. 2009
    ....
  12. pmc Enhanced GABAergic network and receptor function in pediatric cortical dysplasia Type IIB compared with Tuberous Sclerosis Complex
    Carlos Cepeda
    Intellectual and Developmental Disabilities Research Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90024, USA
    Neurobiol Dis 45:310-21. 2012
    ..These differences support the notion that the mechanisms of epileptogenesis could differ in patients with TSC and CDIIB. Consequently, pharmacologic therapies should take these findings into consideration...
  13. pmc Differential electrophysiological changes in striatal output neurons in Huntington's disease
    Veronique M Andre
    Department of Psychiatry and Biobehavioral Sciences, University of California, LA, CA 90095, USA
    J Neurosci 31:1170-82. 2011
    ..Stereotypic behavior at an early stage could be explained by increased glutamate activity and DA tone in direct pathway neurons, whereas hypokinesia at later stages could result from reduced input onto these neurons...
  14. ncbi request reprint Where do you think you are going? The NMDA-D1 receptor trap
    Carlos Cepeda
    Mental Retardation Research Center, Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA
    Sci STKE 2006:pe20. 2006
    ..Together, these mechanisms provide a basis for understanding the increasing complexity of D1-NMDA receptor interactions and their importance in physiological and pathological processes...
  15. doi request reprint Neuronal coupling via connexin36 contributes to spontaneous synaptic currents of striatal medium-sized spiny neurons
    Damian M Cummings
    Mental Retardation Research Center, University of California at Los Angeles, Los Angeles, California 90095, USA
    J Neurosci Res 86:2147-58. 2008
    ..Taken together, the present findings demonstrate that electrical coupling of neuronal populations is important for the maintenance of normal chemical synaptic interactions within the striatum...
  16. ncbi request reprint Altered cortical glutamate receptor function in the R6/2 model of Huntington's disease
    Veronique M Andre
    Mental Retardation Research Center, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Neurophysiol 95:2108-19. 2006
    ..Altered glutamate receptor function could contribute to changes in cortical output and may underlie some of the cognitive and motor impairments in this animal model of HD...
  17. ncbi request reprint Are cytomegalic neurons and balloon cells generators of epileptic activity in pediatric cortical dysplasia?
    Carlos Cepeda
    Mental Retardation Research Center, David Geffen School of Medicine, University of California Los Angeles, California 90024, USA
    Epilepsia 46:82-8. 2005
    ..These aberrant cells could participate in the generation of epileptic activity. The aim of this study was to morphologically and electrophysiologically characterize cells in pediatric CD tissue...
  18. ncbi request reprint Striatal potassium channel dysfunction in Huntington's disease transgenic mice
    Marjorie A Ariano
    Mental Retardation Research Center, NPI Room 58 258, 760 Westwood Plaza, University of California, Los Angeles, CA 90095, USA
    J Neurophysiol 93:2565-74. 2005
    ..Attenuation in K+ conductances and channel subunit expression contribute to altered electrophysiological properties of MSNs and may partially account for selective cellular vulnerability in the striatum...
  19. ncbi request reprint Increased GABAergic function in mouse models of Huntington's disease: reversal by BDNF
    Carlos Cepeda
    Mental Retardation Research Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA
    J Neurosci Res 78:855-67. 2004
    ..In conjunction, both changes will severely alter striatal outputs to target areas involved in the control of movement...
  20. ncbi request reprint Epileptogenesis in pediatric cortical dysplasia: the dysmature cerebral developmental hypothesis
    Carlos Cepeda
    Division of Neurosurgery, Department of Neurology, The Brain Research Institute and The Mental Retardation Research Center, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Epilepsy Behav 9:219-35. 2006
    ..We propose that local interactions of dysmature cells with normal postnatal neurons produce seizures. This hypothesis will drive future studies aimed at elucidating mechanisms of epileptogenesis in pediatric CD tissue...
  21. pmc Interneurons, GABAA currents, and subunit composition of the GABAA receptor in type I and type II cortical dysplasia
    Veronique M Andre
    Intellectual and Developmental Disabilities Research Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA
    Epilepsia 51:166-70. 2010
    ..These findings support the hypothesis that patients with type I and type II CD will respond differently to GABA receptor-mediated antiepileptic drugs and that cytomegalic neurons have features similar to immature neurons...
  22. pmc Multiple sources of striatal inhibition are differentially affected in Huntington's disease mouse models
    Carlos Cepeda
    Intellectual and Developmental Disabilities Research Center, Brain Research Institute, Semel Institute for Neuroscience, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 33:7393-406. 2013
    ..These findings provide strong evidence that both feedforward and to a lesser extent feedback inhibition to MSNs in HD can potentially be sources for the increased GABA synaptic activity of indirect pathway MSNs...
  23. ncbi request reprint Modulation of AMPA currents by D2 dopamine receptors in striatal medium-sized spiny neurons: are dendrites necessary?
    Elizabeth Hernandez-Echeagaray
    Mental Retardation Research Center, David Geffen School of Medicine, NPI, Room 58 258, 760 Westwood Plaza, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Eur J Neurosci 19:2455-63. 2004
    ..In addition, they indicate that the dendrites and/or the amplitude of the current are important variables for DA modulation of AMPA currents in MSNs...
  24. ncbi request reprint Morphological and electrophysiological characterization of abnormal cell types in pediatric cortical dysplasia
    Carlos Cepeda
    Mental Retardation Research Center, University of California, Los Angeles, California 90095, USA
    J Neurosci Res 72:472-86. 2003
    ..Cytomegalic neurons could play an important role in the generation of epileptic activity...
  25. ncbi request reprint Dopamine reduction of GABA currents in striatal medium-sized spiny neurons is mediated principally by the D(1) receptor subtype
    Elizabeth Hernandez-Echeagaray
    Mental Retardation Research Center, Room 58 258 David Geffen School of Medicine, University of California Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90024, USA
    Neurochem Res 32:229-40. 2007
    ..We conclude that D(1) receptors are the main D1-like receptor subtype involved in the modulation of GABA currents and that D(5) receptors contribute to the normal expression of these currents in the striatum...
  26. pmc Neuronal targets for reducing mutant huntingtin expression to ameliorate disease in a mouse model of Huntington's disease
    Nan Wang
    1 Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, California, USA 2 Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, California, USA 3
    Nat Med 20:536-41. 2014
    ..Our study demonstrates distinct but interacting roles of cortical and striatal mHTT in HD pathogenesis and suggests that optimal HD therapeutics may require targeting mHTT in both cortical and striatal neurons. ..
  27. ncbi request reprint Human cortical dysplasia and epilepsy: an ontogenetic hypothesis based on volumetric MRI and NeuN neuronal density and size measurements
    Marissa Andres
    Division of Neurosurgery, University of California, Los Angeles, CA 90005, USA
    Cereb Cortex 15:194-210. 2005
    ....
  28. ncbi request reprint Pyramidal cell responses to gamma-aminobutyric acid differ in type I and type II cortical dysplasia
    Veronique M Andre
    Mental Retardation Research Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    J Neurosci Res 86:3151-62. 2008
    ....
  29. pmc Comparative study of cellular and synaptic abnormalities in brain tissue samples from pediatric tuberous sclerosis complex and cortical dysplasia type II
    Carlos Cepeda
    Intellectual and Developmental Disabilities Research Center, David Geffen School of Medicine, University of California, Los Angeles, California 90024, USA
    Epilepsia 51:160-5. 2010
    ..These differences may contribute to variable mechanisms of epileptogenesis in patients with TSC compared with CD type II...
  30. pmc Targeted expression of μ-opioid receptors in a subset of striatal direct-pathway neurons restores opiate reward
    Yijun Cui
    1 Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California, USA 2 Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California, USA 3 Brain Research Institute, University of California, Los Angeles, Los Angeles, California, USA 4 David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
    Nat Neurosci 17:254-61. 2014
    ....
  31. ncbi request reprint Contralateral hemimicrencephaly and clinical-pathological correlations in children with hemimegalencephaly
    Noriko Salamon
    Division of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Brain 129:352-65. 2006
    ..In addition, our findings support the hypothesis that HME pathogenesis probably involves somatic mutations that affect each developing cerebral hemisphere differently with more neurons than expected on the HME side...
  32. doi request reprint Elevated tonic extracellular dopamine concentration and altered dopamine modulation of synaptic activity precede dopamine loss in the striatum of mice overexpressing human α-synuclein
    Hoa A Lam
    Hatos Center, University of California Los Angeles, Los Angeles, California, USA
    J Neurosci Res 89:1091-102. 2011
    ..Together, these data further validate this transgenic mouse line as a slowly progressing model of Parkinson's disease and provide evidence for early dopamine synaptic dysfunction prior to loss of striatal dopamine...
  33. pmc Dopamine and glutamate in Huntington's disease: A balancing act
    Veronique M Andre
    Intellectual and Developmental Disabilities Research Center, Semel Institute, Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, USA
    CNS Neurosci Ther 16:163-78. 2010
    ..Restoring the balance between glutamate and dopamine could be helpful to treat HD symptoms...
  34. pmc Alterations in cortical excitation and inhibition in genetic mouse models of Huntington's disease
    Damian M Cummings
    Mental Retardation Research Center, David Geffen School of Medicine, Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, CA 90095, USA
    J Neurosci 29:10371-86. 2009
    ..Furthermore, the differences between synaptic phenotypes in cortex and striatum are important for the development of future therapeutic approaches, which may need to be targeted early in the development of the phenotype...
  35. pmc The corticostriatal pathway in Huntington's disease
    Carlos Cepeda
    Mental Retardation Research Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Prog Neurobiol 81:253-71. 2007
    ..Finally, as changes in cortical and striatal circuitry are complex and in some cases biphasic, therapeutic interventions should be regionally specific and take into account the temporal progression of the phenotype...
  36. ncbi request reprint Status epilepticus and frequent seizures: incidence and clinical characteristics in pediatric epilepsy surgery patients
    Susan Koh
    Division of Pediatric Neurology, UCLA Medical Center, Los Angeles, CA 90095, USA
    Epilepsia 46:1950-4. 2005
    ..However, this concept is based on case reports, and the incidence and clinical characteristics of these patients have not been systematically assessed...
  37. ncbi request reprint NMDA receptor alterations in neurons from pediatric cortical dysplasia tissue
    Veronique M Andre
    Mental Retardation Research Center, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Cereb Cortex 14:634-46. 2004
    ..Taken together, these results demonstrate the presence of NMDA receptors with altered subunit composition and Mg(2+) sensitivity that could contribute to functional abnormalities in CD...
  38. ncbi request reprint Transient and progressive electrophysiological alterations in the corticostriatal pathway in a mouse model of Huntington's disease
    Carlos Cepeda
    Mental Retardation Research Center, University of California at Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 23:961-9. 2003
    ..These alterations are likely to contribute to the selective vulnerability of striatal medium-sized spiny neurons...
  39. ncbi request reprint Activation, proliferation and commitment of endogenous stem/progenitor cells to the oligodendrocyte lineage by TS1 in a rat model of dysmyelination
    Araceli Espinosa-Jeffrey
    Mental Retardation Research Center, Semel Institute for Neuroscience and Human Behavior and Department of Neurobiology, University of California, Los Angeles, 90095 7332, USA
    Dev Neurosci 28:488-98. 2006
    ..This strategy offers for the first time the possibility of myelin restoration to treat myelin disorders...
  40. pmc Location, location, location: contrasting roles of synaptic and extrasynaptic NMDA receptors in Huntington's disease
    Michael S Levine
    Intellectual and Developmental Disabilities Research Center, Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Neuron 65:145-7. 2010
    ....
  41. pmc Dissecting the contribution of individual receptor subunits to the enhancement of N-methyl-d-aspartate currents by dopamine D1 receptor activation in striatum
    Emily L Jocoy
    Intellectual and Developmental Disabilities Research Center, Semel Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
    Front Syst Neurosci 5:28. 2011
    ..The differential contribution of discrete receptor subunits to NMDA responses and dopamine modulation in the striatum has important implications for synaptic plasticity and selective neuronal vulnerability in disease states...
  42. ncbi request reprint Electrophysiological alterations in subthalamic neurons after unilateral dopamine depletion in the rat
    Mahadevan Gajendiran
    Mental Retardation Research Center, UCLA David Geffen School of Medicine, Los Angeles, California 90024, USA
    J Neurosci Res 80:203-10. 2005
    ..These data suggest that unilateral degeneration of DA neurons in the SNc changes firing properties and enhances electrophysiological responsiveness of STN neurons to activation of DA D1 receptors...
  43. pmc Drug-primed reinstatement of cocaine seeking in mice: increased excitability of medium-sized spiny neurons in the nucleus accumbens
    Yao Ying Ma
    Stefan and Shirley Hatos Center for Neuropharmacology, University of California, Los Angeles, California, U S A
    ASN Neuro 5:257-71. 2013
    ..Reversing these functional alterations in NAc could represent a rational target for the treatment of some reward-related behaviors, including drug addiction...
  44. pmc Opioid self-administration results in cell-type specific adaptations of striatal medium spiny neurons
    Alex S James
    Department of Psychology, University of California, Los Angeles, Los Angeles, CA, USA
    Behav Brain Res 256:279-83. 2013
    ..Remifentanil exposure also altered the probability of glutamate release onto D1-, but not D2-MSNs. Together these results suggest a D1-pathway specific effect associated with the acquisition of opioid-seeking behaviors. ..
  45. doi request reprint The role of striatal NMDA receptors in drug addiction
    Yao Ying Ma
    Stefan and Shirley Hatos Center for Neuropharmacology, University of California Los Angeles, Los Angeles, California, USA
    Int Rev Neurobiol 89:131-46. 2009
    ..Understanding the mechanisms regulating striatal NMDA receptor changes in drug addiction will provide more specific and rational targets to counteract the deleterious effects of drug addiction...
  46. pmc Genetic mouse models of Huntington's disease: focus on electrophysiological mechanisms
    Carlos Cepeda
    Intellectual and Developmental Disabilities Research Center, David Geffen School of Medicine, University of California Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90095, USA
    ASN Neuro 2:e00033. 2010
    ..Mounting evidence points to synaptic abnormalities in communication between the cortex and striatum and cell-cell interactions as major determinants of HD symptoms, even in the absence of severe neuronal degeneration and death...
  47. pmc Functional Differences Between Direct and Indirect Striatal Output Pathways in Huntington's Disease
    Laurie Galvan
    Intellectual and Developmental Disabilities Research Center, Semel Institute for Neuroscience and Human Behavior and the Brain Research Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
    J Huntingtons Dis 1:17-25. 2012
    ..In the future, the use of combined optogenetics with identified neurons in each pathway will help unravel the next set of questions about how the output nuclei are affected in HD. ..
  48. ncbi request reprint Genetic mouse models of Huntington's and Parkinson's diseases: illuminating but imperfect
    Michael S Levine
    Mental Retardation Research Center, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Trends Neurosci 27:691-7. 2004
    ....
  49. ncbi request reprint Assessment and surgical outcomes for mild type I and severe type II cortical dysplasia: a critical review and the UCLA experience
    Jason T Lerner
    Department of Pediatric Neurology, University of California, Los Angeles, California, USA
    Epilepsia 50:1310-35. 2009
    ..The authors discuss future challenges to identifying and treating medically refractory epilepsy patients with cortical dysplasia...
  50. ncbi request reprint The role of dopamine in Huntington's disease
    Carlos Cepeda
    Intellectual and Developmental Disabilities Research Center, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Prog Brain Res 211:235-54. 2014
    ..Targeting both DA and glutamate receptor dysfunction could be the best strategy to treat HD symptoms. ..
  51. ncbi request reprint 2B or not 2B: a tail of two NMDA receptor subunits
    Carlos Cepeda
    Intellectual and Developmental Disabilities Research Center, Semel Institute for Neuroscience and Human Behavior, Brain Research Institute, The David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Neuron 74:426-8. 2012
    ..NMDA receptor subunits containing the GluN2B C-terminal are more lethal than those containing the GluN2A tails, regardless of location...
  52. ncbi request reprint Dysfunctional channels are making noise in CAG triplet repeat disorders
    Carlos Cepeda
    Mental Retardation Research Center, Semel Neuroscience Institute Room 58 258, 760 Westwood Plaza, University of California Los Angeles, Los Angeles, CA 90095, USA
    Exp Neurol 202:267-70. 2006
  53. ncbi request reprint Dopamine enhancement of NMDA currents in dissociated medium-sized striatal neurons: role of D1 receptors and DARPP-32
    Jorge Flores-Hernandez
    Mental Retardation Research Center, University of California, Geffen School of Medicine, Los Angeles, California 90095, USA
    J Neurophysiol 88:3010-20. 2002
    ....
  54. ncbi request reprint Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons
    Matthew S Goldberg
    Center for Neurologic Diseases, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 278:43628-35. 2003
    ..Together these findings provide the first evidence for a novel role of parkin in dopamine regulation and nigrostriatal function, and a non-essential role of parkin in the survival of nigral neurons in mice...
  55. ncbi request reprint Heterosynaptic dopamine neurotransmission selects sets of corticostriatal terminals
    Nigel S Bamford
    Department of Neurology, University of Washington, Children s Hospital and Regional Medical Center, Seattle, WA 98105 USA
    Neuron 42:653-63. 2004
    ..Thus, dopamine, by filtering less active inputs, appears to reinforce specific sets of corticostriatal synaptic connections...
  56. pmc Repeated exposure to methamphetamine causes long-lasting presynaptic corticostriatal depression that is renormalized with drug readministration
    Nigel S Bamford
    Department of Neurology, University of Washington, Seattle, WA 98105, USA
    Neuron 58:89-103. 2008
    ..These mechanisms might provide a synaptic basis that underlies addiction and habit learning and their long-term maintenance...