Research Topics
| C L CelumSummaryAffiliation: University of Washington Country: USA Publications
Research Grants
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Detail Information
Publications
Risk Factors for HSV-2 Infection among Sexual Partners of HSV-2/HIV-1 Co-Infected PersonsAndrew Mujugira
Department of Global Health, University of Washington, Seattle, WA, USA
BMC Res Notes 4:64. 2011..abstract:..
The interaction between herpes simplex virus and human immunodeficiency virusConnie L Celum
University of Washington, Seattle, WA 98104, USA
Herpes 11:36A-45A. 2004..HSV-2 infection should be targeted as a modifiable risk factor for HIV acquisition by testing, counselling and preventing acquisition through behavioural interventions, treatment and antiviral suppression...- Early human immunodeficiency virus (HIV) infection in the HIV Network for Prevention Trials Vaccine Preparedness Cohort: risk behaviors, symptoms, and early plasma and genital tract virus loadC L Celum
University of Washington HIV Prevention Trials Unit, Harborview Medical Center, Seattle, WA 98104, USA
J Infect Dis 183:23-35. 2001..Most subjects had several relatively stable virus loads before initiation of antiretrovirals, indicating feasibility of assessing HIV vaccines on virus set point in efficacy trials... - Potential effect of HIV type 1 antiretroviral and herpes simplex virus type 2 antiviral therapy on transmission and acquisition of HIV type 1 infectionConnie L Celum
Department of Medicine, University of Washington, Seattle, WA 98104, USA
J Infect Dis 191:S107-14. 2005..The rationale for antiretroviral and HSV-2-specific interventions and studies to test these strategies are described... - Herpes simplex virus (HSV) suppression with valacyclovir reduces rectal and blood plasma HIV-1 levels in HIV-1/HSV-2-seropositive men: a randomized, double-blind, placebo-controlled crossover trialRichard A Zuckerman
Section of Infectious Disease and International Health, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
J Infect Dis 196:1500-8. 2007..We studied HIV-1 levels during HSV suppression in coinfected persons in a placebo-controlled crossover trial... - Effect of aciclovir on HIV-1 acquisition in herpes simplex virus 2 seropositive women and men who have sex with men: a randomised, double-blind, placebo-controlled trialConnie Celum
Department of Global Health, University of Washington, Seattle, WA, USA
Lancet 371:2109-19. 2008..We investigated whether HSV-2 suppression with aciclovir would reduce the risk of HIV-1 acquisition... - Antiretroviral therapy for HIV-1 vaccine efficacy trial participants who seroconvertH Nina Kim
Departments of Medicine, University of Washington, Seattle, WA, USA
Vaccine 24:532-9. 2006..A standardized HAART protocol for HIV-1 vaccine efficacy trial participants who become HIV-infected is essential to the evaluation of CTL-based HIV-1 vaccines on the natural history of HIV-1 infection... - Sexually transmitted diseases and human immunodeficiency virus-discordant partnerships among men who have sex with menWilliam L H Whittington
Center for AIDS and STD, Department of Medicine, University of Washington, Seattle, WA 98104, USA
Clin Infect Dis 35:1010-7. 2002..High prevalences of bacterial STDs and HIV-discordant partnerships emphasize the need for interventions to foster serostatus discussion, condom use, fewer anonymous partners, and STD screening... 
The association between lack of circumcision and HIV, HSV-2, and other sexually transmitted infections among men who have sex with menDamon R Jameson
Department of Epidemiology, University of Washington, 404 E Harrison St 301, Seattle, WA 98102, USA
Sex Transm Dis 37:147-52. 2010..We examined the relationship between circumcision and HIV, herpes simplex virus type-2 (HSV-2), syphilis, urethral gonorrhea, and urethral chlamydia among MSM stratified by anal sexual role...- Prediction of HIV acquisition among men who have sex with menTimothy W Menza
Center for AIDS and STD, University of Washington, Harborview Medical Center, 325 Ninth Ave, Seattle, WA 98104, USA
Sex Transm Dis 36:547-55. 2009..To develop and validate an easy-to-use prediction model for HIV acquisition among men who have sex with men (MSM)... - Frequent detection of human adenovirus from the lower gastrointestinal tract in men who have sex with menMarcel E Curlin
Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
PLoS ONE 5:e11321. 2010.... - Higher concentration of HIV RNA in rectal mucosa secretions than in blood and seminal plasma, among men who have sex with men, independent of antiretroviral therapyRichard A Zuckerman
Department of Medicine, University of Washington, Seattle 98104, USA
J Infect Dis 190:156-61. 2004..Thus, controlling for plasma HIV RNA, ART had an independent effect on seminal, but not rectal, HIV levels... - Serological immunity to adenovirus serotype 5 is not associated with risk of HIV infection: a case-control studyMarcel E Curlin
Vaccine and Infectious Diseases Institute, Fred Hutchinson Cancer Research Center, USA
AIDS 25:153-8. 2011..We examined the association between adenovirus serostatus and the rate of incident HIV infection in populations at elevated risk of HIV acquisition... - The effects of herpes simplex virus-2 on HIV-1 acquisition and transmission: a review of two overlapping epidemicsLawrence Corey
Department of Medicine, University of Washington Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
J Acquir Immune Defic Syndr 35:435-45. 2004.... - Factors associated with oropharyngeal human immunodeficiency virus sheddingRichard A Zuckerman
Department of Medicine, University of Washington, Seattle, Washington 98104, USA
J Infect Dis 188:142-5. 2003..In multivariate analysis, receipt of antiretroviral therapy, higher CD4 cell count, and history of tonsillectomy were predictors of lower pharyngeal HIV RNA levels... - Overcoming barriers to HIV testing: preferences for new strategies among clients of a needle exchange, a sexually transmitted disease clinic, and sex venues for men who have sex with menFreya Spielberg
University of Washington, Seattle, WA, USA
J Acquir Immune Defic Syndr 32:318-27. 2003..To determine strategies to overcome barriers to HIV testing among persons at risk... - Pilot study of COBAS PCR and ligase chain reaction for detection of rectal infections due to Chlamydia trachomatisMatthew R Golden
Division of Infectious Diseases and the Center for AIDS and STD, University of Washington, and Public Health Seattle and King County STD Program, Seattle, USA
J Clin Microbiol 41:2174-5. 2003..Chlamydiae were detected by one or more procedures in 22 of 186 specimens. All three PCR tests were positive for 17 specimens, all of which also tested positive by LCR... - Correlates of prevalent and incident Kaposi's sarcoma-associated herpesvirus infection in men who have sex with menCorey Casper
Department of Medicine, University of Washington, Seattle, WA 98195, USA
J Infect Dis 185:990-3. 2002..Reporting > or =1 HIV-positive partner (OR, 5.9; 95% CI, 1.8-19.3), amyl nitrite use (OR, 7.0; 95% CI, 2.1-23.0), and lymphadenopathy in the past 6 months (OR, 7.7; 95% CI, 1.9-31.0) correlated with KSHV seroconversion... - Global risk of sexually transmitted diseasesC C Wang
Department of Medicine, University of Washington, Seattle, USA
Med Clin North Am 83:975-95, vi. 1999..Diseases that mimic STDs are presented. The authors also discuss the importance of preventative measures and pre-travel counseling... - Use of a glycoprotein G-based type-specific assay to detect antibodies to herpes simplex virus type 2 among persons attending sexually transmitted disease clinicsW L Whittington
Center for AIDS and STD, Department of Medicine, University of Washington, Seattle 98104, USA
Sex Transm Dis 28:99-104. 2001..This assay could be useful in the screening of sexually active adults to detect unrecognized HSV-2 infection... - Safety and acceptability of the Reality condom for anal sex among men who have sex with menCristina Renzi
Department of Medicine, University of Washington, Seattle 98104, USA
AIDS 17:727-31. 2003..Design modifications, training, and research on the clinical significance of safety outcomes are needed for use of Reality condoms with anal sex... - Herpes simplex virus type 2 infection as a risk factor for human immunodeficiency virus acquisition in men who have sex with menCristina Renzi
Department of Medicine, University of Washington, Seattle, USA
J Infect Dis 187:19-25. 2003..HSV-2 increases the risk of HIV acquisition, independent of recognized herpes lesions and behaviors reflecting potential HIV exposure. HSV-2 suppression with antiviral therapy should be evaluated as an HIV prevention strategy among MSM... - Partner-specific sexual behavioral differences between phase 3 HIV vaccine efficacy trial participants and controls: Project VISIONWilliam L H Whittington
Department of Medicine, University of Washington, Seattle, WA 98104, USA
J Acquir Immune Defic Syndr 43:234-8. 2006..Partner level data are useful in refining risk assessment, which is important in the evaluation of HIV vaccine and other prevention trials... - Risk factors for repeatedly reactive HIV-1 EIA and indeterminate western blots. A population-based case-control studyC L Celum
Department of Medicine, University of Washington, Seattle
Arch Intern Med 154:1129-37. 1994..This case-control study assessed risk factors for IWB results, including early HIV infection, other retroviral infection, autoantibodies, and other medical conditions... - Urine-based screening for Chlamydia trachomatis in men attending sexually transmitted disease clinicsJ M Marrazzo
Department of Medicine, University of Washington School of Medicine, Seattle, USA
Sex Transm Dis 28:219-25. 2001..Nucleic acid-amplified tests for Chlamydia trachomatis are accurate but costly. Screening strategies for asymptomatic men are needed... - Breakthrough infections during phase 1 and 2 prime-boost HIV-1 vaccine trials with canarypox vectors (ALVAC) and booster dose of recombinant gp120 or gp160Deborah Lee
Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
J Infect Dis 190:903-7. 2004..4, P =.1, and P =.7, respectively). Persons who acquire HIV-1 infection while enrolled in HIV-1 vaccine trials can be successfully followed after infection, to determine whether vaccines alter the course of HIV-1 infection... - The clinical manifestations and treatment of sexually transmitted diseases in human immunodeficiency virus-positive menT K Collis
Department of Medicine, University of Washington Medical Center, Seattle, WA, USA
Clin Infect Dis 32:611-22. 2001..The clinical manifestations and treatment of several common STDs in HIV-positive men are reviewed. Further research is needed to define effective management and screening strategies for STDs in men with HIV infection... - Association of herpes simplex virus type 2 infection and syphilis with human immunodeficiency virus infection among men who have sex with men in PeruJavier R Lama
Asociacion Civil Impacta Salud y Educacion, Ministry of Health of Peru, Lima, Peru
J Infect Dis 194:1459-66. 2006.... - High-risk behaviors among men who have sex with men in 6 US cities: baseline data from the EXPLORE StudyBeryl A Koblin
New York Blood Center, New York, NY 10021, USA
Am J Public Health 93:926-32. 2003..We describe the prevalence of risk behaviors at baseline among men who have sex with men (MSM) who were enrolled in a randomized behavioral intervention trial conducted in 6 US cities... - An individually tailored intervention for HIV prevention: baseline data from the EXPLORE StudyMargaret A Chesney
School of Medicine, University of California, San Francisco, USA
Am J Public Health 93:933-8. 2003..We describe the intervention tested in EXPLORE, an HIV prevention trial aimed at men who have sex with men (MSM), and test the empirical basis of the individually tailored intervention... - Sexual risk, nitrite inhalant use, and lack of circumcision associated with HIV seroconversion in men who have sex with men in the United StatesSusan P Buchbinder
AIDS Office, San Francisco Department of Public Health, San Francisco, CA, USA
J Acquir Immune Defic Syndr 39:82-9. 2005..8, PAR = 7%). Having a large number of male sex partners, nitrite inhalant use, and engaging in receptive anal sex explained the majority of infections in this cohort and should be targeted in prevention strategies for MSM...
Research Grants
- Multi-component, Targeted HIV Prevention for sub-Saharan Africa: PreventionRxConnie Celum; Fiscal Year: 2009....
- Acylovir to prevent HIV acquisition in HSV-2+personsConnie Celum; Fiscal Year: 2004..abstract_text> ..
- Acyclovir to Prevent HIV Acquisition in HSV-2+ PersonsConnie Celum; Fiscal Year: 2007..Given high HSV-2 infection rates globally in persons at risk for HIV, this approach could have great public health impact by providing a safe, acceptable and cost-effective method to reduce HIV susceptibility. ..
- STDS AND HETEROSEXUAL 'BRIDGING' AMONG MEN WHO HAVE SEXConnie Celum; Fiscal Year: 2006....
- Multi-component, Targeted HIV Prevention for sub-Saharan Africa: PreventionRxConnie L Celum; Fiscal Year: 2010....
- Multi-component, Targeted HIV Prevention for sub-Saharan Africa: PreventionRxConnie L Celum; Fiscal Year: 2010....