C L Celum

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Mortality in members of HIV-1 serodiscordant couples in Africa and implications for antiretroviral therapy initiation: results of analyses from a multicenter randomized trial
    Guy de Bruyn
    Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa
    BMC Infect Dis 12:277. 2012
  2. pmc Risk Factors for HSV-2 Infection among Sexual Partners of HSV-2/HIV-1 Co-Infected Persons
    Andrew Mujugira
    Department of Global Health, University of Washington, Seattle, WA, USA
    BMC Res Notes 4:64. 2011
  3. pmc Effect of aciclovir on HIV-1 acquisition in herpes simplex virus 2 seropositive women and men who have sex with men: a randomised, double-blind, placebo-controlled trial
    Connie Celum
    Department of Global Health, University of Washington, Seattle, WA, USA
    Lancet 371:2109-19. 2008
  4. ncbi request reprint Herpes simplex virus (HSV) suppression with valacyclovir reduces rectal and blood plasma HIV-1 levels in HIV-1/HSV-2-seropositive men: a randomized, double-blind, placebo-controlled crossover trial
    Richard A Zuckerman
    Section of Infectious Disease and International Health, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    J Infect Dis 196:1500-8. 2007
  5. ncbi request reprint Potential effect of HIV type 1 antiretroviral and herpes simplex virus type 2 antiviral therapy on transmission and acquisition of HIV type 1 infection
    Connie L Celum
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    J Infect Dis 191:S107-14. 2005
  6. ncbi request reprint The interaction between herpes simplex virus and human immunodeficiency virus
    Connie L Celum
    University of Washington, Seattle, WA 98104, USA
    Herpes 11:36A-45A. 2004
  7. ncbi request reprint Early human immunodeficiency virus (HIV) infection in the HIV Network for Prevention Trials Vaccine Preparedness Cohort: risk behaviors, symptoms, and early plasma and genital tract virus load
    C L Celum
    University of Washington HIV Prevention Trials Unit, Harborview Medical Center, Seattle, WA 98104, USA
    J Infect Dis 183:23-35. 2001
  8. ncbi request reprint Antiretroviral therapy for HIV-1 vaccine efficacy trial participants who seroconvert
    H Nina Kim
    Departments of Medicine, University of Washington, Seattle, WA, USA
    Vaccine 24:532-9. 2006
  9. doi request reprint The association between lack of circumcision and HIV, HSV-2, and other sexually transmitted infections among men who have sex with men
    Damon R Jameson
    Department of Epidemiology, University of Washington, 404 E Harrison St 301, Seattle, WA 98102, USA
    Sex Transm Dis 37:147-52. 2010
  10. ncbi request reprint Sexually transmitted diseases and human immunodeficiency virus-discordant partnerships among men who have sex with men
    William L H Whittington
    Center for AIDS and STD, Department of Medicine, University of Washington, Seattle, WA 98104, USA
    Clin Infect Dis 35:1010-7. 2002

Detail Information

Publications32

  1. pmc Mortality in members of HIV-1 serodiscordant couples in Africa and implications for antiretroviral therapy initiation: results of analyses from a multicenter randomized trial
    Guy de Bruyn
    Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa
    BMC Infect Dis 12:277. 2012
    ....
  2. pmc Risk Factors for HSV-2 Infection among Sexual Partners of HSV-2/HIV-1 Co-Infected Persons
    Andrew Mujugira
    Department of Global Health, University of Washington, Seattle, WA, USA
    BMC Res Notes 4:64. 2011
    ..abstract:..
  3. pmc Effect of aciclovir on HIV-1 acquisition in herpes simplex virus 2 seropositive women and men who have sex with men: a randomised, double-blind, placebo-controlled trial
    Connie Celum
    Department of Global Health, University of Washington, Seattle, WA, USA
    Lancet 371:2109-19. 2008
    ..We investigated whether HSV-2 suppression with aciclovir would reduce the risk of HIV-1 acquisition...
  4. ncbi request reprint Herpes simplex virus (HSV) suppression with valacyclovir reduces rectal and blood plasma HIV-1 levels in HIV-1/HSV-2-seropositive men: a randomized, double-blind, placebo-controlled crossover trial
    Richard A Zuckerman
    Section of Infectious Disease and International Health, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    J Infect Dis 196:1500-8. 2007
    ..We studied HIV-1 levels during HSV suppression in coinfected persons in a placebo-controlled crossover trial...
  5. ncbi request reprint Potential effect of HIV type 1 antiretroviral and herpes simplex virus type 2 antiviral therapy on transmission and acquisition of HIV type 1 infection
    Connie L Celum
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    J Infect Dis 191:S107-14. 2005
    ..The rationale for antiretroviral and HSV-2-specific interventions and studies to test these strategies are described...
  6. ncbi request reprint The interaction between herpes simplex virus and human immunodeficiency virus
    Connie L Celum
    University of Washington, Seattle, WA 98104, USA
    Herpes 11:36A-45A. 2004
    ..HSV-2 infection should be targeted as a modifiable risk factor for HIV acquisition by testing, counselling and preventing acquisition through behavioural interventions, treatment and antiviral suppression...
  7. ncbi request reprint Early human immunodeficiency virus (HIV) infection in the HIV Network for Prevention Trials Vaccine Preparedness Cohort: risk behaviors, symptoms, and early plasma and genital tract virus load
    C L Celum
    University of Washington HIV Prevention Trials Unit, Harborview Medical Center, Seattle, WA 98104, USA
    J Infect Dis 183:23-35. 2001
    ..Most subjects had several relatively stable virus loads before initiation of antiretrovirals, indicating feasibility of assessing HIV vaccines on virus set point in efficacy trials...
  8. ncbi request reprint Antiretroviral therapy for HIV-1 vaccine efficacy trial participants who seroconvert
    H Nina Kim
    Departments of Medicine, University of Washington, Seattle, WA, USA
    Vaccine 24:532-9. 2006
    ..A standardized HAART protocol for HIV-1 vaccine efficacy trial participants who become HIV-infected is essential to the evaluation of CTL-based HIV-1 vaccines on the natural history of HIV-1 infection...
  9. doi request reprint The association between lack of circumcision and HIV, HSV-2, and other sexually transmitted infections among men who have sex with men
    Damon R Jameson
    Department of Epidemiology, University of Washington, 404 E Harrison St 301, Seattle, WA 98102, USA
    Sex Transm Dis 37:147-52. 2010
    ..We examined the relationship between circumcision and HIV, herpes simplex virus type-2 (HSV-2), syphilis, urethral gonorrhea, and urethral chlamydia among MSM stratified by anal sexual role...
  10. ncbi request reprint Sexually transmitted diseases and human immunodeficiency virus-discordant partnerships among men who have sex with men
    William L H Whittington
    Center for AIDS and STD, Department of Medicine, University of Washington, Seattle, WA 98104, USA
    Clin Infect Dis 35:1010-7. 2002
    ..High prevalences of bacterial STDs and HIV-discordant partnerships emphasize the need for interventions to foster serostatus discussion, condom use, fewer anonymous partners, and STD screening...
  11. ncbi request reprint Overcoming barriers to HIV testing: preferences for new strategies among clients of a needle exchange, a sexually transmitted disease clinic, and sex venues for men who have sex with men
    Freya Spielberg
    University of Washington, Seattle, WA, USA
    J Acquir Immune Defic Syndr 32:318-27. 2003
    ..To determine strategies to overcome barriers to HIV testing among persons at risk...
  12. ncbi request reprint Higher concentration of HIV RNA in rectal mucosa secretions than in blood and seminal plasma, among men who have sex with men, independent of antiretroviral therapy
    Richard A Zuckerman
    Department of Medicine, University of Washington, Seattle 98104, USA
    J Infect Dis 190:156-61. 2004
    ..Thus, controlling for plasma HIV RNA, ART had an independent effect on seminal, but not rectal, HIV levels...
  13. pmc Prediction of HIV acquisition among men who have sex with men
    Timothy W Menza
    Center for AIDS and STD, University of Washington, Harborview Medical Center, 325 Ninth Ave, Seattle, WA 98104, USA
    Sex Transm Dis 36:547-55. 2009
    ..To develop and validate an easy-to-use prediction model for HIV acquisition among men who have sex with men (MSM)...
  14. ncbi request reprint The effects of herpes simplex virus-2 on HIV-1 acquisition and transmission: a review of two overlapping epidemics
    Lawrence Corey
    Department of Medicine, University of Washington Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Acquir Immune Defic Syndr 35:435-45. 2004
    ....
  15. ncbi request reprint Factors associated with oropharyngeal human immunodeficiency virus shedding
    Richard A Zuckerman
    Department of Medicine, University of Washington, Seattle, Washington 98104, USA
    J Infect Dis 188:142-5. 2003
    ..In multivariate analysis, receipt of antiretroviral therapy, higher CD4 cell count, and history of tonsillectomy were predictors of lower pharyngeal HIV RNA levels...
  16. pmc Frequent detection of human adenovirus from the lower gastrointestinal tract in men who have sex with men
    Marcel E Curlin
    Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 5:e11321. 2010
    ....
  17. pmc Pilot study of COBAS PCR and ligase chain reaction for detection of rectal infections due to Chlamydia trachomatis
    Matthew R Golden
    Division of Infectious Diseases and the Center for AIDS and STD, University of Washington, and Public Health Seattle and King County STD Program, Seattle, USA
    J Clin Microbiol 41:2174-5. 2003
    ..Chlamydiae were detected by one or more procedures in 22 of 186 specimens. All three PCR tests were positive for 17 specimens, all of which also tested positive by LCR...
  18. pmc Serological immunity to adenovirus serotype 5 is not associated with risk of HIV infection: a case-control study
    Marcel E Curlin
    Vaccine and Infectious Diseases Institute, Fred Hutchinson Cancer Research Center, USA
    AIDS 25:153-8. 2011
    ..We examined the association between adenovirus serostatus and the rate of incident HIV infection in populations at elevated risk of HIV acquisition...
  19. ncbi request reprint Correlates of prevalent and incident Kaposi's sarcoma-associated herpesvirus infection in men who have sex with men
    Corey Casper
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    J Infect Dis 185:990-3. 2002
    ..Reporting > or =1 HIV-positive partner (OR, 5.9; 95% CI, 1.8-19.3), amyl nitrite use (OR, 7.0; 95% CI, 2.1-23.0), and lymphadenopathy in the past 6 months (OR, 7.7; 95% CI, 1.9-31.0) correlated with KSHV seroconversion...
  20. ncbi request reprint Global risk of sexually transmitted diseases
    C C Wang
    Department of Medicine, University of Washington, Seattle, USA
    Med Clin North Am 83:975-95, vi. 1999
    ..Diseases that mimic STDs are presented. The authors also discuss the importance of preventative measures and pre-travel counseling...
  21. ncbi request reprint Use of a glycoprotein G-based type-specific assay to detect antibodies to herpes simplex virus type 2 among persons attending sexually transmitted disease clinics
    W L Whittington
    Center for AIDS and STD, Department of Medicine, University of Washington, Seattle 98104, USA
    Sex Transm Dis 28:99-104. 2001
    ..This assay could be useful in the screening of sexually active adults to detect unrecognized HSV-2 infection...
  22. ncbi request reprint Partner-specific sexual behavioral differences between phase 3 HIV vaccine efficacy trial participants and controls: Project VISION
    William L H Whittington
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    J Acquir Immune Defic Syndr 43:234-8. 2006
    ..To assess and compare sexual behaviors using partner-specific data between HIV-negative men who have sex with men (MSM) recruited for an HIV vaccine efficacy trial and a control group...
  23. ncbi request reprint Herpes simplex virus type 2 infection as a risk factor for human immunodeficiency virus acquisition in men who have sex with men
    Cristina Renzi
    Department of Medicine, University of Washington, Seattle, USA
    J Infect Dis 187:19-25. 2003
    ..HSV-2 increases the risk of HIV acquisition, independent of recognized herpes lesions and behaviors reflecting potential HIV exposure. HSV-2 suppression with antiviral therapy should be evaluated as an HIV prevention strategy among MSM...
  24. ncbi request reprint Safety and acceptability of the Reality condom for anal sex among men who have sex with men
    Cristina Renzi
    Department of Medicine, University of Washington, Seattle 98104, USA
    AIDS 17:727-31. 2003
    ..To assess safety and acceptability of Reality condoms for anal sex among men who have sex with men...
  25. ncbi request reprint Risk factors for repeatedly reactive HIV-1 EIA and indeterminate western blots. A population-based case-control study
    C L Celum
    Department of Medicine, University of Washington, Seattle
    Arch Intern Med 154:1129-37. 1994
    ..This case-control study assessed risk factors for IWB results, including early HIV infection, other retroviral infection, autoantibodies, and other medical conditions...
  26. ncbi request reprint Urine-based screening for Chlamydia trachomatis in men attending sexually transmitted disease clinics
    J M Marrazzo
    Department of Medicine, University of Washington School of Medicine, Seattle, USA
    Sex Transm Dis 28:219-25. 2001
    ..Nucleic acid-amplified tests for Chlamydia trachomatis are accurate but costly. Screening strategies for asymptomatic men are needed...
  27. ncbi request reprint Breakthrough infections during phase 1 and 2 prime-boost HIV-1 vaccine trials with canarypox vectors (ALVAC) and booster dose of recombinant gp120 or gp160
    Deborah Lee
    Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    J Infect Dis 190:903-7. 2004
    ..4, P =.1, and P =.7, respectively). Persons who acquire HIV-1 infection while enrolled in HIV-1 vaccine trials can be successfully followed after infection, to determine whether vaccines alter the course of HIV-1 infection...
  28. ncbi request reprint The clinical manifestations and treatment of sexually transmitted diseases in human immunodeficiency virus-positive men
    T K Collis
    Department of Medicine, University of Washington Medical Center, Seattle, WA, USA
    Clin Infect Dis 32:611-22. 2001
    ..The clinical manifestations and treatment of several common STDs in HIV-positive men are reviewed. Further research is needed to define effective management and screening strategies for STDs in men with HIV infection...
  29. pmc An individually tailored intervention for HIV prevention: baseline data from the EXPLORE Study
    Margaret A Chesney
    School of Medicine, University of California, San Francisco, USA
    Am J Public Health 93:933-8. 2003
    ..We describe the intervention tested in EXPLORE, an HIV prevention trial aimed at men who have sex with men (MSM), and test the empirical basis of the individually tailored intervention...
  30. pmc High-risk behaviors among men who have sex with men in 6 US cities: baseline data from the EXPLORE Study
    Beryl A Koblin
    New York Blood Center, New York, NY 10021, USA
    Am J Public Health 93:926-32. 2003
    ..We describe the prevalence of risk behaviors at baseline among men who have sex with men (MSM) who were enrolled in a randomized behavioral intervention trial conducted in 6 US cities...
  31. ncbi request reprint Association of herpes simplex virus type 2 infection and syphilis with human immunodeficiency virus infection among men who have sex with men in Peru
    Javier R Lama
    Asociacion Civil Impacta Salud y Educacion, Ministry of Health of Peru, Lima, Peru
    J Infect Dis 194:1459-66. 2006
    ..We evaluated associations between human immunodeficiency virus (HIV) infection, herpes simplex virus type 2 (HSV-2) infection, and syphilis among men who have sex with men (MSM) in Peru...
  32. ncbi request reprint Sexual risk, nitrite inhalant use, and lack of circumcision associated with HIV seroconversion in men who have sex with men in the United States
    Susan P Buchbinder
    AIDS Office, San Francisco Department of Public Health, San Francisco, CA, USA
    J Acquir Immune Defic Syndr 39:82-9. 2005
    ..8, PAR = 7%). Having a large number of male sex partners, nitrite inhalant use, and engaging in receptive anal sex explained the majority of infections in this cohort and should be targeted in prevention strategies for MSM...

Research Grants9

  1. Multi-component, Targeted HIV Prevention for sub-Saharan Africa: PreventionRx
    Connie Celum; Fiscal Year: 2009
    ....
  2. Acylovir to prevent HIV acquisition in HSV-2+persons
    Connie Celum; Fiscal Year: 2004
    ..abstract_text> ..
  3. Acyclovir to Prevent HIV Acquisition in HSV-2+ Persons
    Connie Celum; Fiscal Year: 2007
    ..Given high HSV-2 infection rates globally in persons at risk for HIV, this approach could have great public health impact by providing a safe, acceptable and cost-effective method to reduce HIV susceptibility. ..
  4. STDS AND HETEROSEXUAL 'BRIDGING' AMONG MEN WHO HAVE SEX
    Connie Celum; Fiscal Year: 2006
    ....
  5. Multi-component, Targeted HIV Prevention for sub-Saharan Africa: PreventionRx
    Connie L Celum; Fiscal Year: 2010
    ....
  6. Multi-component, Targeted HIV Prevention for sub-Saharan Africa: PreventionRx
    Connie L Celum; Fiscal Year: 2010
    ....