William T Cefalu

Summary

Affiliation: University of Vermont
Country: USA

Publications

  1. ncbi request reprint Glycemic control and cardiovascular disease--should we reassess clinical goals?
    William T Cefalu
    N Engl J Med 353:2707-9. 2005
  2. ncbi request reprint Oral chromium picolinate improves carbohydrate and lipid metabolism and enhances skeletal muscle Glut-4 translocation in obese, hyperinsulinemic (JCR-LA corpulent) rats
    William T Cefalu
    Department of Medicine, University of Vermont College of Medicine, Burlington, VT, USA
    J Nutr 132:1107-14. 2002
  3. ncbi request reprint Effect of combination glipizide GITS/metformin on fibrinolytic and metabolic parameters in poorly controlled type 2 diabetic subjects
    William T Cefalu
    Department of Medicine, University of Vermont College of Medicine, Burlington 05401, USA
    Diabetes Care 25:2123-8. 2002
  4. ncbi request reprint Evaluation of alternative strategies for optimizing glycemia: progress to date
    William T Cefalu
    University of Vermont College of Medicine, Burlington, Vermont 05401, USA
    Am J Med 113:23S-35S. 2002
  5. ncbi request reprint Exubera. Inhale therapeutic systems
    Sanjit Bindra
    University of Vermont College of Medicine, Department of Medicine, Burlington 05405, USA
    Curr Opin Investig Drugs 3:758-62. 2002
  6. ncbi request reprint Chromium picolinate supplementation attenuates body weight gain and increases insulin sensitivity in subjects with type 2 diabetes
    Julie Martin
    Division of Endocrinology and Metabolism, University of Vermont, Burlington, USA
    Diabetes Care 29:1826-32. 2006
  7. ncbi request reprint Concept, strategies, and feasibility of noninvasive insulin delivery
    William T Cefalu
    University of Vermont College of Medicine, Burlington, Vermont, USA
    Diabetes Care 27:239-46. 2004
  8. ncbi request reprint Overcoming the barriers for achieving standards of diabetes care: the formation of CADRE
    William T Cefalu
    University of Vermont College of Medicine, Burlington, Vermont 05401, USA
    Diabetes Technol Ther 5:385-92. 2003
  9. pmc Adipocyte iron regulates adiponectin and insulin sensitivity
    J Scott Gabrielsen
    Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    J Clin Invest 122:3529-40. 2012
  10. ncbi request reprint Inhaled insulin: a novel route for insulin delivery
    William T Cefalu
    University of Vermont College of Medicine, Burlington, VT, USA
    Expert Opin Investig Drugs 11:687-91. 2002

Collaborators

Detail Information

Publications50

  1. ncbi request reprint Glycemic control and cardiovascular disease--should we reassess clinical goals?
    William T Cefalu
    N Engl J Med 353:2707-9. 2005
  2. ncbi request reprint Oral chromium picolinate improves carbohydrate and lipid metabolism and enhances skeletal muscle Glut-4 translocation in obese, hyperinsulinemic (JCR-LA corpulent) rats
    William T Cefalu
    Department of Medicine, University of Vermont College of Medicine, Burlington, VT, USA
    J Nutr 132:1107-14. 2002
    ..Thus, CrPic supplementation enhances insulin sensitivity and glucose disappearance, and improves lipids in male obese hyperinsulinemic JCR:LA-corpulent rats...
  3. ncbi request reprint Effect of combination glipizide GITS/metformin on fibrinolytic and metabolic parameters in poorly controlled type 2 diabetic subjects
    William T Cefalu
    Department of Medicine, University of Vermont College of Medicine, Burlington 05401, USA
    Diabetes Care 25:2123-8. 2002
    ..We sought to determine whether metabolic control, independent of its oral mode of implementation, affects PAI-1 in patients with marked hyperglycemia...
  4. ncbi request reprint Evaluation of alternative strategies for optimizing glycemia: progress to date
    William T Cefalu
    University of Vermont College of Medicine, Burlington, Vermont 05401, USA
    Am J Med 113:23S-35S. 2002
    ..These innovative delivery systems may help overcome the barriers to insulin use...
  5. ncbi request reprint Exubera. Inhale therapeutic systems
    Sanjit Bindra
    University of Vermont College of Medicine, Department of Medicine, Burlington 05405, USA
    Curr Opin Investig Drugs 3:758-62. 2002
    ..By October 2001, Deutsche Bank predicted sales of $50 million in 2004 and $250 million in 2005. In September 2001, Morgan Stanley predicted sales of $500 million in 2002, rising to $1250 million in 2006...
  6. ncbi request reprint Chromium picolinate supplementation attenuates body weight gain and increases insulin sensitivity in subjects with type 2 diabetes
    Julie Martin
    Division of Endocrinology and Metabolism, University of Vermont, Burlington, USA
    Diabetes Care 29:1826-32. 2006
    ..We sought to determine the effect of CrPic on insulin sensitivity, glycemic control, and body composition in subjects with type 2 diabetes...
  7. ncbi request reprint Concept, strategies, and feasibility of noninvasive insulin delivery
    William T Cefalu
    University of Vermont College of Medicine, Burlington, Vermont, USA
    Diabetes Care 27:239-46. 2004
    ..To comprehensively review the progress to date on the development of alternative routes for insulin delivery...
  8. ncbi request reprint Overcoming the barriers for achieving standards of diabetes care: the formation of CADRE
    William T Cefalu
    University of Vermont College of Medicine, Burlington, Vermont 05401, USA
    Diabetes Technol Ther 5:385-92. 2003
    ..This article will focus on the formation of CADRE, and, in particular, identification of the problem contributing to the obstacles of care, and review various surveys conducted by CADRE designed in an effort to identify the problem...
  9. pmc Adipocyte iron regulates adiponectin and insulin sensitivity
    J Scott Gabrielsen
    Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    J Clin Invest 122:3529-40. 2012
    ..These findings demonstrate a causal role for iron as a risk factor for metabolic syndrome and a role for adipocytes in modulating metabolism through adiponectin in response to iron stores...
  10. ncbi request reprint Inhaled insulin: a novel route for insulin delivery
    William T Cefalu
    University of Vermont College of Medicine, Burlington, VT, USA
    Expert Opin Investig Drugs 11:687-91. 2002
    ..The pharmacokinetics of inhaled insulin show a more physiological profile compared to conventional insulin; however, further studies to confirm long-term pulmonary safety and efficacy are needed...
  11. pmc Two-year pulmonary safety and efficacy of inhaled human insulin (Exubera) in adult patients with type 2 diabetes
    Julio Rosenstock
    Dallas Diabetes and Endocrine Center, Dallas, Texas, USA
    Diabetes Care 31:1723-8. 2008
    ..The purpose of this study was to evaluate the 2-year pulmonary safety of inhaled human insulin (Exubera [EXU]) in 635 nonsmoking adults with type 2 diabetes...
  12. ncbi request reprint Inactivation of PKCtheta leads to increased susceptibility to obesity and dietary insulin resistance in mice
    Zhanguo Gao
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Am J Physiol Endocrinol Metab 292:E84-91. 2007
    ..This study suggests that loss of PKCtheta reduces energy expenditure and increases the risk of dietary obesity and insulin resistance in mice...
  13. ncbi request reprint Phenotype of subjects with type 2 diabetes mellitus may determine clinical response to chromium supplementation
    Zhong Q Wang
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Metabolism 56:1652-5. 2007
    ..4038) (P = .0004). Subject phenotype appears to be very important when assessing the clinical response to Cr because baseline insulin sensitivity was found to account for nearly 40% of the variance in the clinical response to Cr...
  14. ncbi request reprint Point: Pulmonary inhalation of insulin: another "brick in the wall"
    William T Cefalu
    Division of Nutrition and Chronic Diseases, Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Diabetes Care 30:439-41. 2007
  15. ncbi request reprint The new diabetes inhalers: new tools for the clinician
    William T Cefalu
    Division of Nutrition and Chronic Diseases, Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Curr Diab Rep 7:165-7. 2007
  16. ncbi request reprint Clinical research observations with use of exubera in patients with type 1 and 2 diabetes
    William T Cefalu
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808, USA
    Diabetes Technol Ther 9:S28-40. 2007
  17. pmc Effects of dietary fibers on weight gain, carbohydrate metabolism, and gastric ghrelin gene expression in mice fed a high-fat diet
    Zhong Q Wang
    Pennington Biomedical Research Center, Division of Nutrition and Chronic Diseases, Louisiana State University System, Baton Rouge, LA 70808, USA
    Metabolism 56:1635-42. 2007
    ....
  18. ncbi request reprint Clinical management strategies for type 2 diabetes
    William T Cefalu
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA
    JAAPA . 2007
    ..The possibility that they may also be able to affect the course of this devastating metabolic disorder should also be fully explored...
  19. doi request reprint Patients' perceptions of subcutaneous insulin in the OPTIMIZE study: a multicenter follow-up study
    William T Cefalu
    Division of Nutrition and Chronic Diseases, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Diabetes Technol Ther 10:25-38. 2008
    ....
  20. pmc Human adenovirus type 36 enhances glucose uptake in diabetic and nondiabetic human skeletal muscle cells independent of insulin signaling
    Zhong Q Wang
    Division of Nutrition and Chronic Diseases, Louisiana State University System, Baton Rouge, Louisiana, USA
    Diabetes 57:1805-13. 2008
    ..Human adenovirus type 36 (Ad-36) increases adiposity but improves insulin sensitivity in experimentally infected animals. We determined the ability of Ad-36 to increase glucose uptake by human primary skeletal muscle (HSKM) cells...
  21. pmc Bioactives of Artemisia dracunculus L enhance cellular insulin signaling in primary human skeletal muscle culture
    Zhong Q Wang
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Metabolism 57:S58-64. 2008
    ....
  22. doi request reprint Glycemic targets and cardiovascular disease
    William T Cefalu
    N Engl J Med 358:2633-5. 2008
  23. pmc Effects of chromium picolinate on food intake and satiety
    Stephen D Anton
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA
    Diabetes Technol Ther 10:405-12. 2008
    ..Chromium picolinate (CrPic) has been shown to attenuate weight gain, but the mechanism underlying this effect is unknown...
  24. ncbi request reprint Animal models of type 2 diabetes: clinical presentation and pathophysiological relevance to the human condition
    William T Cefalu
    Division of Nutrition and Chronic Diseases, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA
    ILAR J 47:186-98. 2006
    ..Use of the appropriate animal model based on these similarities can provide much needed data on pathophysiological mechanisms operative in human T2D...
  25. ncbi request reprint Chromium picolinate enhances skeletal muscle cellular insulin signaling in vivo in obese, insulin-resistant JCR:LA-cp rats
    Zhong Q Wang
    Pennington Biomedical Research Center, Division of Nutrition and Chronic Diseases, Louisiana State University System, Baton Rouge, LA, USA
    J Nutr 136:415-20. 2006
    ..Our data suggest that chromium supplementation of obese, insulin-resistant rats may improve insulin action by enhancing intracellular signaling...
  26. ncbi request reprint Evolving strategies for insulin delivery and therapy
    William T Cefalu
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA
    Drugs 64:1149-61. 2004
    ..Recent evidence shows that delivery of insulin via the oral cavity with uptake occurring in the pulmonary alveoli may be the most viable clinical option in the future...
  27. ncbi request reprint Improved glucose control decreases the interaction of plasma low-density lipoproteins with arterial proteoglycans
    Iris J Edwards
    Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Metabolism 51:1223-9. 2002
    ..05). These data demonstrate that combination treatment with glipizide GITS/metformin will further improve glucose control in type 2 diabetic subjects and may favorably improve diabetes-associated modification of LDL-arterial PG binding...
  28. ncbi request reprint Efficacy of inhaled insulin in patients with type 2 diabetes not controlled with diet and exercise: a 12-week, randomized, comparative trial
    Ralph A DeFronzo
    University of Texas Health Science Center, Diabetes Division, 7703 Floyd Curl Dr, San Antonio, TX 78284, USA
    Diabetes Care 28:1922-8. 2005
    ..This study investigates whether inhaled insulin (INH; Exubera) can achieve target glycemic control in patients failing on diet and exercise...
  29. ncbi request reprint Treatment satisfaction in type 2 diabetes: a comparison between an inhaled insulin regimen and a subcutaneous insulin regimen
    Joseph C Cappelleri
    Pfizer Inc, Global Research and Development, Groton, Connecticut 06340, USA
    Clin Ther 24:552-64. 2002
    ..It is unknown whether inhalation delivery of insulin improves patient satisfaction...
  30. ncbi request reprint Controlling hypoglycemia in type 2 diabetes: which agent for which patient?
    Charles A Cefalu
    Section of Geriatric Medicine, Department of Family Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70808, USA
    J Fam Pract 54:855-62. 2005
  31. ncbi request reprint Inhaled insulin improves glycemic control when substituted for or added to oral combination therapy in type 2 diabetes: a randomized, controlled trial
    Julio Rosenstock
    Dallas Diabetes and Endocrine Center at Medical City, Dallas, Texas 75230, USA
    Ann Intern Med 143:549-58. 2005
    ..Patients with type 2 diabetes who do not achieve glycemic control with oral agent therapy eventually require insulin...
  32. ncbi request reprint Long-term glycemic control measurements in diabetic patients receiving hemodialysis
    Melanie S Joy
    Division of Nephrology and Hypertension, University of North Carolina, School of Medicine, Chapel Hill, NC 27599 7155, USA
    Am J Kidney Dis 39:297-307. 2002
    ..Thus, diabetic patients receiving hemodialysis may have long-term BG that are more properly controlled than previously determined, reducing their risks of the macro- and microvascular complications of diabetes mellitus...
  33. ncbi request reprint The Hurricane Katrina aftermath and its impact on diabetes care: observations from "ground zero": lessons in disaster preparedness of people with diabetes
    William T Cefalu
    Division of Nutrition and Chronic Diseases, Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Rd, Baton Rouge, Louisiana 70808, USA
    Diabetes Care 29:158-60. 2006
  34. ncbi request reprint Caloric restriction and cardiovascular aging in cynomolgus monkeys (Macaca fascicularis): metabolic, physiologic, and atherosclerotic measures from a 4-year intervention trial
    William T Cefalu
    Division of Nutrition and Chronic Diseases, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA
    J Gerontol A Biol Sci Med Sci 59:1007-14. 2004
    ..Thus, further studies are needed to determine if improved insulin sensitivity might decrease arterial inflammation and improve endothelial function, despite no changes in atherosclerosis extent...
  35. pmc Modulation of peroxisome proliferator-activated receptor gamma stability and transcriptional activity in adipocytes by resveratrol
    Z Elizabeth Floyd
    Ubiquitin Biology Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Metabolism 57:S32-8. 2008
    ..These results indicate that the resveratrol-mediated effects in adipocytes involve regulation of PPARgamma expression and transcriptional activity along with decreased responsiveness to insulin...
  36. pmc Quercetin transiently increases energy expenditure but persistently decreases circulating markers of inflammation in C57BL/6J mice fed a high-fat diet
    Laura K Stewart
    Division of Experimental Obesity, Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Metabolism 57:S39-46. 2008
    ..However, quercetin at the levels provided was effective in reducing circulating markers of inflammation observed in animals on an HF diet at 8W...
  37. pmc Effect of Shilianhua extract and its fractions on body weight of obese mice
    Jun Yin
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Metabolism 57:S47-51. 2008
    ..The weight reduction observed with the over-the-counter SLH tablet in the pilot studies may be secondary to other components in the tablet, but not from the SLH extract...
  38. ncbi request reprint Models of growth hormone and IGF-1 deficiency: applications to studies of aging processes and life-span determination
    Christy S Carter
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1083, USA
    J Gerontol A Biol Sci Med Sci 57:B177-88. 2002
    ..Finally, we propose an integrated explanation of growth hormone and IGF-1's contribution to the aging phenotype and life-span determination...
  39. pmc Metabolically favorable remodeling of human adipose tissue by human adenovirus type 36
    Pamela M Rogers
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA
    Diabetes 57:2321-31. 2008
    ..To exploit the potential of the viral proteins as a therapeutic target for treating insulin resistance, this study investigated the ability of Ad-36 to induce metabolically favorable changes in human adipose tissue...
  40. doi request reprint Multidisciplinary interventions: mapping new horizons in diabetes care
    Edward Horton
    Vice President and Director of Clinical Research, Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA
    Diabetes Educ 34:78S-89S. 2008
    ....
  41. doi request reprint Botanicals as epigenetic modulators for mechanisms contributing to development of metabolic syndrome
    Heather Kirk
    Botanical Research Center, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Metabolism 57:S16-23. 2008
    ....
  42. doi request reprint Botanicals and cardiometabolic risk: positioning science to address the hype
    William T Cefalu
    NIH Center for the Study of Botanicals and Metabolic Syndrome, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Metabolism 57:S1-2. 2008
  43. ncbi request reprint Role of chromium in human health and in diabetes
    William T Cefalu
    Division of NutritionChronic Disease, The Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Diabetes Care 27:2741-51. 2004
  44. ncbi request reprint Botanicals and the metabolic syndrome
    William T Cefalu
    Division of Nutrition and Chronic Diseases, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 87:481S-7S. 2008
    ..With the completion of our research, we anticipate a better understanding of the cellular mechanisms by which insulin resistance develops and the role of botanicals in modulating the progression to metabolic syndrome...
  45. pmc Technologies and experimental approaches at the National Institutes of Health Botanical Research Centers
    Stephen Barnes
    Botanical Center for Age Related Disease, Purdue University University of Alabama at Birmingham, West Lafayette, IN, USA
    Am J Clin Nutr 87:476S-80S. 2008
    ..In summary, the skills needed to carry out botanical centers' research are extensive and may exceed those practiced by most NIH investigators...
  46. ncbi request reprint Elevated pregnancy losses at high and low extremes of maternal glucose in early normal and diabetic pregnancy: evidence for a protective adaptation in diabetes
    Lois Jovanovic
    University of Washington, 325 Ninth Ave, Box 359720, Seattle, WA 98104, USA
    Diabetes Care 28:1113-7. 2005
    ..To test this hypothesis, we examined relationships of proximate measures of prior glycemia, glycated protein and fructosamine, to pregnancy loss...
  47. pmc Increased hypothalamic protein tyrosine phosphatase 1B contributes to leptin resistance with age
    Christopher D Morrison
    Neurosignaling Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    Endocrinology 148:433-40. 2007
    ..05). These data are consistent with the hypothesis that increases in PTP1B contribute to hypothalamic leptin resistance as rats transition into middle age...
  48. ncbi request reprint Polyphenolic compounds from Artemisia dracunculus L. inhibit PEPCK gene expression and gluconeogenesis in an H4IIE hepatoma cell line
    Dmitry Govorko
    Rutgers University, Biotech Center, 59 Dudley Road, New Brunswick, NJ 08901, USA
    Am J Physiol Endocrinol Metab 293:E1503-10. 2007
    ..These results indicate that the isolated compounds may be responsible for much of the glucose-lowering activity of the Artemisia dracunculus extract...
  49. ncbi request reprint Diabetes, the metabolic syndrome, and angiographic progression of coronary arterial disease in postmenopausal women
    Philip B Mellen
    Department of Internal Medicine Cardiology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Arterioscler Thromb Vasc Biol 26:189-93. 2006
    ..We sought to determine whether the MS predicts angiographic progression of coronary heart disease in a cohort of postmenopausal women...
  50. ncbi request reprint Intensive glycemic control and cardiovascular disease observations from the ACCORD study: now what can a clinician possibly think?
    William T Cefalu
    Diabetes 57:1163-5. 2008