Research Topics
| William T CefaluSummaryAffiliation: University of Vermont Country: USA Publications
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Detail Information
Publications
Glycemic control and cardiovascular disease--should we reassess clinical goals?William T Cefalu
N Engl J Med 353:2707-9. 2005- Oral chromium picolinate improves carbohydrate and lipid metabolism and enhances skeletal muscle Glut-4 translocation in obese, hyperinsulinemic (JCR-LA corpulent) ratsWilliam T Cefalu
Department of Medicine, University of Vermont College of Medicine, Burlington, VT, USA
J Nutr 132:1107-14. 2002..Thus, CrPic supplementation enhances insulin sensitivity and glucose disappearance, and improves lipids in male obese hyperinsulinemic JCR:LA-corpulent rats... - Effect of combination glipizide GITS/metformin on fibrinolytic and metabolic parameters in poorly controlled type 2 diabetic subjectsWilliam T Cefalu
Department of Medicine, University of Vermont College of Medicine, Burlington 05401, USA
Diabetes Care 25:2123-8. 2002..We sought to determine whether metabolic control, independent of its oral mode of implementation, affects PAI-1 in patients with marked hyperglycemia... - Evaluation of alternative strategies for optimizing glycemia: progress to dateWilliam T Cefalu
University of Vermont College of Medicine, Burlington, Vermont 05401, USA
Am J Med 113:23S-35S. 2002..These innovative delivery systems may help overcome the barriers to insulin use... - Exubera. Inhale therapeutic systemsSanjit Bindra
University of Vermont College of Medicine, Department of Medicine, Burlington 05405, USA
Curr Opin Investig Drugs 3:758-62. 2002..By October 2001, Deutsche Bank predicted sales of $50 million in 2004 and $250 million in 2005. In September 2001, Morgan Stanley predicted sales of $500 million in 2002, rising to $1250 million in 2006... - Chromium picolinate supplementation attenuates body weight gain and increases insulin sensitivity in subjects with type 2 diabetesJulie Martin
Division of Endocrinology and Metabolism, University of Vermont, Burlington, USA
Diabetes Care 29:1826-32. 2006..Further, CrPic supplementation significantly attenuated body weight gain and visceral fat accumulation compared with the placebo group... - Concept, strategies, and feasibility of noninvasive insulin deliveryWilliam T Cefalu
University of Vermont College of Medicine, Burlington, Vermont, USA
Diabetes Care 27:239-46. 2004..To comprehensively review the progress to date on the development of alternative routes for insulin delivery... - Overcoming the barriers for achieving standards of diabetes care: the formation of CADREWilliam T Cefalu
University of Vermont College of Medicine, Burlington, Vermont 05401, USA
Diabetes Technol Ther 5:385-92. 2003..This article will focus on the formation of CADRE, and, in particular, identification of the problem contributing to the obstacles of care, and review various surveys conducted by CADRE designed in an effort to identify the problem... 
Adipocyte iron regulates adiponectin and insulin sensitivityJ Scott Gabrielsen
Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
J Clin Invest 122:3529-40. 2012..These findings demonstrate a causal role for iron as a risk factor for metabolic syndrome and a role for adipocytes in modulating metabolism through adiponectin in response to iron stores...- Inhaled insulin: a novel route for insulin deliveryWilliam T Cefalu
University of Vermont College of Medicine, Burlington, VT, USA
Expert Opin Investig Drugs 11:687-91. 2002..The pharmacokinetics of inhaled insulin show a more physiological profile compared to conventional insulin; however, further studies to confirm long-term pulmonary safety and efficacy are needed... - Two-year pulmonary safety and efficacy of inhaled human insulin (Exubera) in adult patients with type 2 diabetesJulio Rosenstock
Dallas Diabetes and Endocrine Center, Dallas, Texas, USA
Diabetes Care 31:1723-8. 2008..The purpose of this study was to evaluate the 2-year pulmonary safety of inhaled human insulin (Exubera [EXU]) in 635 nonsmoking adults with type 2 diabetes... - Inactivation of PKCtheta leads to increased susceptibility to obesity and dietary insulin resistance in miceZhanguo Gao
Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
Am J Physiol Endocrinol Metab 292:E84-91. 2007..This study suggests that loss of PKCtheta reduces energy expenditure and increases the risk of dietary obesity and insulin resistance in mice... - Phenotype of subjects with type 2 diabetes mellitus may determine clinical response to chromium supplementationZhong Q Wang
Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
Metabolism 56:1652-5. 2007..4038) (P = .0004). Subject phenotype appears to be very important when assessing the clinical response to Cr because baseline insulin sensitivity was found to account for nearly 40% of the variance in the clinical response to Cr... - Point: Pulmonary inhalation of insulin: another "brick in the wall"William T Cefalu
Division of Nutrition and Chronic Diseases, Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA
Diabetes Care 30:439-41. 2007 - The new diabetes inhalers: new tools for the clinicianWilliam T Cefalu
Division of Nutrition and Chronic Diseases, Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA
Curr Diab Rep 7:165-7. 2007 - Clinical research observations with use of exubera in patients with type 1 and 2 diabetesWilliam T Cefalu
Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808, USA
Diabetes Technol Ther 9:S28-40. 2007 - Effects of dietary fibers on weight gain, carbohydrate metabolism, and gastric ghrelin gene expression in mice fed a high-fat dietZhong Q Wang
Pennington Biomedical Research Center, Division of Nutrition and Chronic Diseases, Louisiana State University System, Baton Rouge, LA 70808, USA
Metabolism 56:1635-42. 2007.... - Clinical management strategies for type 2 diabetesWilliam T Cefalu
Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA
JAAPA . 2007..The possibility that they may also be able to affect the course of this devastating metabolic disorder should also be fully explored... 
Patients' perceptions of subcutaneous insulin in the OPTIMIZE study: a multicenter follow-up studyWilliam T Cefalu
Division of Nutrition and Chronic Diseases, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
Diabetes Technol Ther 10:25-38. 2008....- Human adenovirus type 36 enhances glucose uptake in diabetic and nondiabetic human skeletal muscle cells independent of insulin signalingZhong Q Wang
Division of Nutrition and Chronic Diseases, Louisiana State University System, Baton Rouge, Louisiana, USA
Diabetes 57:1805-13. 2008..Human adenovirus type 36 (Ad-36) increases adiposity but improves insulin sensitivity in experimentally infected animals. We determined the ability of Ad-36 to increase glucose uptake by human primary skeletal muscle (HSKM) cells... - Bioactives of Artemisia dracunculus L enhance cellular insulin signaling in primary human skeletal muscle cultureZhong Q Wang
Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
Metabolism 57:S58-64. 2008.... - Glycemic targets and cardiovascular diseaseWilliam T Cefalu
N Engl J Med 358:2633-5. 2008 - Effects of chromium picolinate on food intake and satietyStephen D Anton
Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA
Diabetes Technol Ther 10:405-12. 2008..Chromium picolinate (CrPic) has been shown to attenuate weight gain, but the mechanism underlying this effect is unknown... - Animal models of type 2 diabetes: clinical presentation and pathophysiological relevance to the human conditionWilliam T Cefalu
Division of Nutrition and Chronic Diseases, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA
ILAR J 47:186-98. 2006..Use of the appropriate animal model based on these similarities can provide much needed data on pathophysiological mechanisms operative in human T2D... - Chromium picolinate enhances skeletal muscle cellular insulin signaling in vivo in obese, insulin-resistant JCR:LA-cp ratsZhong Q Wang
Pennington Biomedical Research Center, Division of Nutrition and Chronic Diseases, Louisiana State University System, Baton Rouge, LA, USA
J Nutr 136:415-20. 2006..Our data suggest that chromium supplementation of obese, insulin-resistant rats may improve insulin action by enhancing intracellular signaling... - Evolving strategies for insulin delivery and therapyWilliam T Cefalu
Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA
Drugs 64:1149-61. 2004..Recent evidence shows that delivery of insulin via the oral cavity with uptake occurring in the pulmonary alveoli may be the most viable clinical option in the future... - Improved glucose control decreases the interaction of plasma low-density lipoproteins with arterial proteoglycansIris J Edwards
Department of Pathology/Section on Comparative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
Metabolism 51:1223-9. 2002..05). These data demonstrate that combination treatment with glipizide GITS/metformin will further improve glucose control in type 2 diabetic subjects and may favorably improve diabetes-associated modification of LDL-arterial PG binding... - Efficacy of inhaled insulin in patients with type 2 diabetes not controlled with diet and exercise: a 12-week, randomized, comparative trialRalph A DeFronzo
University of Texas Health Science Center, Diabetes Division, 7703 Floyd Curl Dr, San Antonio, TX 78284, USA
Diabetes Care 28:1922-8. 2005..This study investigates whether inhaled insulin (INH; Exubera) can achieve target glycemic control in patients failing on diet and exercise... - Treatment satisfaction in type 2 diabetes: a comparison between an inhaled insulin regimen and a subcutaneous insulin regimenJoseph C Cappelleri
Pfizer Inc, Global Research and Development, Groton, Connecticut 06340, USA
Clin Ther 24:552-64. 2002..It is unknown whether inhalation delivery of insulin improves patient satisfaction... - Controlling hypoglycemia in type 2 diabetes: which agent for which patient?Charles A Cefalu
Section of Geriatric Medicine, Department of Family Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70808, USA
J Fam Pract 54:855-62. 2005 - Inhaled insulin improves glycemic control when substituted for or added to oral combination therapy in type 2 diabetes: a randomized, controlled trialJulio Rosenstock
Dallas Diabetes and Endocrine Center at Medical City, Dallas, Texas 75230, USA
Ann Intern Med 143:549-58. 2005..Patients with type 2 diabetes who do not achieve glycemic control with oral agent therapy eventually require insulin... - Long-term glycemic control measurements in diabetic patients receiving hemodialysisMelanie S Joy
Division of Nephrology and Hypertension, University of North Carolina, School of Medicine, Chapel Hill, NC 27599 7155, USA
Am J Kidney Dis 39:297-307. 2002..Thus, diabetic patients receiving hemodialysis may have long-term BG that are more properly controlled than previously determined, reducing their risks of the macro- and microvascular complications of diabetes mellitus... - The Hurricane Katrina aftermath and its impact on diabetes care: observations from "ground zero": lessons in disaster preparedness of people with diabetesWilliam T Cefalu
Division of Nutrition and Chronic Diseases, Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Rd, Baton Rouge, Louisiana 70808, USA
Diabetes Care 29:158-60. 2006 - Caloric restriction and cardiovascular aging in cynomolgus monkeys (Macaca fascicularis): metabolic, physiologic, and atherosclerotic measures from a 4-year intervention trialWilliam T Cefalu
Division of Nutrition and Chronic Diseases, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA
J Gerontol A Biol Sci Med Sci 59:1007-14. 2004..Thus, further studies are needed to determine if improved insulin sensitivity might decrease arterial inflammation and improve endothelial function, despite no changes in atherosclerosis extent... - Modulation of peroxisome proliferator-activated receptor gamma stability and transcriptional activity in adipocytes by resveratrolZ Elizabeth Floyd
Ubiquitin Biology Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
Metabolism 57:S32-8. 2008..These results indicate that the resveratrol-mediated effects in adipocytes involve regulation of PPARgamma expression and transcriptional activity along with decreased responsiveness to insulin... - Quercetin transiently increases energy expenditure but persistently decreases circulating markers of inflammation in C57BL/6J mice fed a high-fat dietLaura K Stewart
Division of Experimental Obesity, Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
Metabolism 57:S39-46. 2008..However, quercetin at the levels provided was effective in reducing circulating markers of inflammation observed in animals on an HF diet at 8W... - Effect of Shilianhua extract and its fractions on body weight of obese miceJun Yin
Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
Metabolism 57:S47-51. 2008..The weight reduction observed with the over-the-counter SLH tablet in the pilot studies may be secondary to other components in the tablet, but not from the SLH extract... - Models of growth hormone and IGF-1 deficiency: applications to studies of aging processes and life-span determinationChristy S Carter
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1083, USA
J Gerontol A Biol Sci Med Sci 57:B177-88. 2002..Finally, we propose an integrated explanation of growth hormone and IGF-1's contribution to the aging phenotype and life-span determination... - Metabolically favorable remodeling of human adipose tissue by human adenovirus type 36Pamela M Rogers
Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA
Diabetes 57:2321-31. 2008..To exploit the potential of the viral proteins as a therapeutic target for treating insulin resistance, this study investigated the ability of Ad-36 to induce metabolically favorable changes in human adipose tissue... - Multidisciplinary interventions: mapping new horizons in diabetes careEdward Horton
Vice President and Director of Clinical Research, Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA
Diabetes Educ 34:78S-89S. 2008.... - Botanicals as epigenetic modulators for mechanisms contributing to development of metabolic syndromeHeather Kirk
Botanical Research Center, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
Metabolism 57:S16-23. 2008.... - Botanicals and cardiometabolic risk: positioning science to address the hypeWilliam T Cefalu
NIH Center for the Study of Botanicals and Metabolic Syndrome, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
Metabolism 57:S1-2. 2008 - Role of chromium in human health and in diabetesWilliam T Cefalu
Division of NutritionChronic Disease, The Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
Diabetes Care 27:2741-51. 2004 - Botanicals and the metabolic syndromeWilliam T Cefalu
Division of Nutrition and Chronic Diseases, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
Am J Clin Nutr 87:481S-7S. 2008..With the completion of our research, we anticipate a better understanding of the cellular mechanisms by which insulin resistance develops and the role of botanicals in modulating the progression to metabolic syndrome... - Technologies and experimental approaches at the National Institutes of Health Botanical Research CentersStephen Barnes
Botanical Center for Age Related Disease, Purdue University University of Alabama at Birmingham, West Lafayette, IN, USA
Am J Clin Nutr 87:476S-80S. 2008..In summary, the skills needed to carry out botanical centers' research are extensive and may exceed those practiced by most NIH investigators... - Elevated pregnancy losses at high and low extremes of maternal glucose in early normal and diabetic pregnancy: evidence for a protective adaptation in diabetesLois Jovanovic
University of Washington, 325 Ninth Ave, Box 359720, Seattle, WA 98104, USA
Diabetes Care 28:1113-7. 2005..CONCLUSIONS: Pregnancy losses are increased at the extremes of glycemia in both normal and diabetic pregnancy but at higher levels in diabetic pregnancy. The data suggest defensive adaptations against hyperglycemia in diabetic pregnancy... - Increased hypothalamic protein tyrosine phosphatase 1B contributes to leptin resistance with ageChristopher D Morrison
Neurosignaling Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
Endocrinology 148:433-40. 2007..05). These data are consistent with the hypothesis that increases in PTP1B contribute to hypothalamic leptin resistance as rats transition into middle age... - Polyphenolic compounds from Artemisia dracunculus L. inhibit PEPCK gene expression and gluconeogenesis in an H4IIE hepatoma cell lineDmitry Govorko
Rutgers University, Biotech Center, 59 Dudley Road, New Brunswick, NJ 08901, USA
Am J Physiol Endocrinol Metab 293:E1503-10. 2007..These results indicate that the isolated compounds may be responsible for much of the glucose-lowering activity of the Artemisia dracunculus extract... - Diabetes, the metabolic syndrome, and angiographic progression of coronary arterial disease in postmenopausal womenPhilip B Mellen
Department of Internal Medicine/Cardiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
Arterioscler Thromb Vasc Biol 26:189-93. 2006..02)], and the MS demonstrated a similar trend [odds ratio, 1.98 (95% CI, 0.90 to 4.33)]. CONCLUSIONS: Among postmenopausal women with coronary heart disease, the presence of diabetes predicted disease progression, but the MS did not... - Intensive glycemic control and cardiovascular disease observations from the ACCORD study: now what can a clinician possibly think?William T Cefalu
Diabetes 57:1163-5. 2008