Nadja B Cech

Summary

Affiliation: University of North Carolina at Greensboro
Country: USA

Publications

  1. ncbi Quorum quenching and antimicrobial activity of goldenseal (Hydrastis canadensis) against methicillin-resistant Staphylococcus aureus (MRSA)
    Nadja B Cech
    Department of Chemistry Biochemistry, The University of North Carolina Greensboro, Greensboro, NC, USA
    Planta Med 78:1556-61. 2012
  2. ncbi High performance liquid chromatography/electrospray ionization mass spectrometry for simultaneous analysis of alkamides and caffeic acid derivatives from Echinacea purpurea extracts
    Nadja B Cech
    Department of Chemistry and Biochemistry, University of North Carolina Greensboro, 435 New Science Bldg, Greensboro, NC 27402, USA
    J Chromatogr A 1103:219-28. 2006
  3. ncbi Liver enzyme-mediated oxidation of Echinacea purpurea alkylamides: production of novel metabolites and changes in immunomodulatory activity
    Nadja B Cech
    Department of Chemistry and Biochemistry, The University of North Carolina Greensboro, Greensboro, NC 27402, USA
    Planta Med 72:1372-7. 2006
  4. ncbi Echinacea and its alkylamides: effects on the influenza A-induced secretion of cytokines, chemokines, and PGE₂ from RAW 264.7 macrophage-like cells
    Nadja B Cech
    Department of Chemistry and Biochemistry, The University of North Carolina Greensboro, Box 26170, Greensboro, NC 27402, USA
    Int Immunopharmacol 10:1268-78. 2010
  5. ncbi Synergy-directed fractionation of botanical medicines: a case study with goldenseal (Hydrastis canadensis)
    Hiyas A Junio
    Department of Chemistry and Biochemistry, The University of North Carolina Greensboro, P O Box 26170, Greensboro, North Carolina 27402, USA
    J Nat Prod 74:1621-9. 2011
  6. ncbi Effects of herbal products and their constituents on human cytochrome P450(2E1) activity
    Gregory M Raner
    The University of North Carolina at Greensboro, Department of Chemistry and Biochemistry, 414 Science Building, Greensboro, NC 27402, USA
    Food Chem Toxicol 45:2359-65. 2007
  7. ncbi Goldenseal (Hydrastis canadensis L.) extracts synergistically enhance the antibacterial activity of berberine via efflux pump inhibition
    Keivan A Ettefagh
    Department of Chemistry Biochemistry, The University of North Carolina Greensboro, Greensboro, NC 27402, USA
    Planta Med 77:835-40. 2011
  8. ncbi Comparison of alkylamide yield in ethanolic extracts prepared from fresh versus dry Echinacea purpurea utilizing HPLC-ESI-MS
    Kevin Spelman
    Department of Chemistry and Biochemistry, The University of North Carolina Greensboro, P O Box 26170, Greensboro, NC 27402, USA
    J Pharm Biomed Anal 49:1141-9. 2009
  9. ncbi Role for PPARgamma in IL-2 inhibition in T cells by Echinacea-derived undeca-2E-ene-8,10-diynoic acid isobutylamide
    Kevin Spelman
    University of North Carolina Greensboro, Department of Chemistry and Biochemistry, P O Box 26170, Greensboro, NC 27405, USA
    Int Immunopharmacol 9:1260-4. 2009
  10. ncbi Sarothrin from Alkanna orientalis Is an Antimicrobial Agent and Efflux Pump Inhibitor
    Jessica R Bame
    Department of Chemistry and Biochemistry, The University of North Carolina Greensboro, Greensboro, NC, USA
    Planta Med 79:327-9. 2013

Collaborators

  • Kevin Spelman
  • Nicholas H Oberlies
  • G M Raner
  • Dean Gray
  • Hiyas A Junio
  • Keivan A Ettefagh
  • Jessica R Bame
  • Tyler N Graf
  • Johnna T Burns
  • Stacy S Bae
  • Masa Sasagawa
  • Joseph O Falkinham
  • Richard A Cech
  • Scott A Jarmusch
  • Tamam El-Elimat
  • R Owen Bussey
  • Scott J Richter
  • Kathryn T Micko
  • Arlene A Sy-Cordero
  • Robert E Cannon
  • Glenn W Kaatz
  • Brandie M Ehrmann
  • Gary W Elmer
  • Cynthia A Wenner

Detail Information

Publications12

  1. ncbi Quorum quenching and antimicrobial activity of goldenseal (Hydrastis canadensis) against methicillin-resistant Staphylococcus aureus (MRSA)
    Nadja B Cech
    Department of Chemistry Biochemistry, The University of North Carolina Greensboro, Greensboro, NC, USA
    Planta Med 78:1556-61. 2012
    ..These findings lend support for the traditional application of crude H. canadensis extracts in the prevention of infection...
  2. ncbi High performance liquid chromatography/electrospray ionization mass spectrometry for simultaneous analysis of alkamides and caffeic acid derivatives from Echinacea purpurea extracts
    Nadja B Cech
    Department of Chemistry and Biochemistry, University of North Carolina Greensboro, 435 New Science Bldg, Greensboro, NC 27402, USA
    J Chromatogr A 1103:219-28. 2006
    ..purpurea extracts that have been stored for 18 months indicate that they contain caftaric acid, cichoric acid, and undeca-2Z,4E-diene-8,10-diynoic acid isobutylamide at concentrations of 0.7, 0.71 and 2.0mg/mL, respectively...
  3. ncbi Liver enzyme-mediated oxidation of Echinacea purpurea alkylamides: production of novel metabolites and changes in immunomodulatory activity
    Nadja B Cech
    Department of Chemistry and Biochemistry, The University of North Carolina Greensboro, Greensboro, NC 27402, USA
    Planta Med 72:1372-7. 2006
    ..These findings highlight the importance of considering the influence of liver enzyme metabolism when evaluating the immunomodulatory effects of alkylamides...
  4. ncbi Echinacea and its alkylamides: effects on the influenza A-induced secretion of cytokines, chemokines, and PGE₂ from RAW 264.7 macrophage-like cells
    Nadja B Cech
    Department of Chemistry and Biochemistry, The University of North Carolina Greensboro, Box 26170, Greensboro, NC 27402, USA
    Int Immunopharmacol 10:1268-78. 2010
    ....
  5. ncbi Synergy-directed fractionation of botanical medicines: a case study with goldenseal (Hydrastis canadensis)
    Hiyas A Junio
    Department of Chemistry and Biochemistry, The University of North Carolina Greensboro, P O Box 26170, Greensboro, North Carolina 27402, USA
    J Nat Prod 74:1621-9. 2011
    ..canadensis roots. Thus, it may be possible to produce an extract with optimal activity against S. aureus using a combination of goldenseal roots and leaves...
  6. ncbi Effects of herbal products and their constituents on human cytochrome P450(2E1) activity
    Gregory M Raner
    The University of North Carolina at Greensboro, Department of Chemistry and Biochemistry, 414 Science Building, Greensboro, NC 27402, USA
    Food Chem Toxicol 45:2359-65. 2007
    ..Commercial green tea preparations, along with four of the individual tea catechins, were also examined and were found to have no effect on the activity of P450(2E1)...
  7. ncbi Goldenseal (Hydrastis canadensis L.) extracts synergistically enhance the antibacterial activity of berberine via efflux pump inhibition
    Keivan A Ettefagh
    Department of Chemistry Biochemistry, The University of North Carolina Greensboro, Greensboro, NC 27402, USA
    Planta Med 77:835-40. 2011
    ..The three most abundant H. canadensis alkaloids, berberine, hydrastine, and canadine, are not responsible for the efflux pump inhibitory activity of the extracts from H. canadensis aerial portions...
  8. ncbi Comparison of alkylamide yield in ethanolic extracts prepared from fresh versus dry Echinacea purpurea utilizing HPLC-ESI-MS
    Kevin Spelman
    Department of Chemistry and Biochemistry, The University of North Carolina Greensboro, P O Box 26170, Greensboro, NC 27402, USA
    J Pharm Biomed Anal 49:1141-9. 2009
    ..These results demonstrate the differences of the described extractions and utility of the analytical methods used to determine the wide-ranging individual alkylamide content of commonly consumed Echinacea extracts...
  9. ncbi Role for PPARgamma in IL-2 inhibition in T cells by Echinacea-derived undeca-2E-ene-8,10-diynoic acid isobutylamide
    Kevin Spelman
    University of North Carolina Greensboro, Department of Chemistry and Biochemistry, P O Box 26170, Greensboro, NC 27405, USA
    Int Immunopharmacol 9:1260-4. 2009
    ..These experiments demonstrate that PPARgamma is involved in T cell IL-2 inhibition by undeca-2-ene-8,10-diynoic acid and suggest that cytokine modulation by the alkylamides is due to polyvalent activity...
  10. ncbi Sarothrin from Alkanna orientalis Is an Antimicrobial Agent and Efflux Pump Inhibitor
    Jessica R Bame
    Department of Chemistry and Biochemistry, The University of North Carolina Greensboro, Greensboro, NC, USA
    Planta Med 79:327-9. 2013
    ..orientalis. Our findings suggest that the effectiveness of A. orientalis extracts is due to a combination of multiple constituents, including sarothrin...
  11. ncbi A validated liquid chromatography-electrospray ionization-mass spectrometry method for quantification of spilanthol in Spilanthes acmella (L.) Murr
    Stacy S Bae
    Department of Chemistry and Biochemistry, The University of North Carolina Greensboro, 435 Sullivan Science Bldg, 301 McIver St, Greensboro, NC 27412, USA
    Phytochem Anal 21:438-43. 2010
    ..Recently this plant has been of interest due to its potential for the treatment and prevention of malaria...
  12. ncbi Echinacea alkylamides inhibit interleukin-2 production by Jurkat T cells
    Masa Sasagawa
    Bastyr University, Department of Basic Sciences, School of Natural Health Sciences, Kenmore, WA 98028, USA
    Int Immunopharmacol 6:1214-21. 2006
    ..Thus, alkylamides present in E. purpurea suppress the ability of activated Jurkat T cells to produce IL-2 independently of direct, cytotoxic effects...