Research Topics
| GARY L CECCHINISummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Succinate dehydrogenase and fumarate reductase from Escherichia coliGary Cecchini
Molecular Biology Division, VA Medical Center, San Francisco, CA 94121, USA
Biochim Biophys Acta 1553:140-57. 2002..The structure and function of SQR and QFR are briefly summarized in this communication and the similarities and differences in the membrane domain of the two enzymes are discussed...- Variation in proton donor/acceptor pathways in succinate:quinone oxidoreductasesGary Cecchini
Molecular Biology Division 151 S, VA Medical Center and Department of Biochemistry and Biophysics, University of California, San Francisco, CA, USA
FEBS Lett 545:31-8. 2003..These results suggest that the anaerobic and aerobic forms of complex II have evolved different mechanisms for electron and proton transfer in their respective membrane domains... - Function and structure of complex II of the respiratory chainGary Cecchini
Molecular Biology Division, Veterans Administration Medical Center, San Francisco, California 94121, USA
Annu Rev Biochem 72:77-109. 2003..Exciting recent developments in relation to disease in humans and the formation of reactive oxygen species by complex II point to its overall importance in cellular physiology... - Architecture of succinate dehydrogenase and reactive oxygen species generationVictoria Yankovskaya
Molecular Biology Division, VA Medical Center, San Francisco, CA 94121, USA
Science 299:700-4. 2003..Furthermore, symptoms of genetic disorders associated with mitochondrial SQR mutations may be a result of ROS formation resulting from impaired electron transport in the enzyme... - Fumarate reductase and succinate oxidase activity of Escherichia coli complex II homologs are perturbed differently by mutation of the flavin binding domainElena Maklashina
Molecular Biology Division, Veterans Affairs Medical Center, San Francisco, California 94121, USA
J Biol Chem 281:11357-65. 2006.... - Differences in protonation of ubiquinone and menaquinone in fumarate reductase from Escherichia coliElena Maklashina
Molecular Biology Division, Veterans Affairs Medical Center, San Francisco, California, 94121, USA
J Biol Chem 281:26655-64. 2006..These findings represent an example of how enzymes that are designed to accommodate either UQ or MQ at a single Q binding site may nevertheless develop sufficient plasticity at the binding pocket to react differently with MQ and UQ... - Active/de-active transition of respiratory complex I in bacteria, fungi, and animalsElena Maklashina
Molecular Biology Division 151 S, VA Medical Center, San Francisco, CA 94121, USA
Biochim Biophys Acta 1606:95-103. 2003..The A/D transitions of complex I as they relate to structure and regulation of enzymatic activity are discussed... - Effect of anoxia/reperfusion on the reversible active/de-active transition of NADH-ubiquinone oxidoreductase (complex I) in rat heartElena Maklashina
Molecular Biology Division 151 S, VA Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
Biochim Biophys Acta 1556:6-12. 2002..Abrupt alternation of anoxic and normoxic perfusion allows cycling between the two states of the enzyme. The possible role in the physiological regulation of complex I activity is discussed... - Effect of oxygen on activation state of complex I and lack of oxaloacetate inhibition of complex II in Langendorff perfused rat heartElena Maklashina
Molecular Biology Division, VA Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
FEBS Lett 556:64-8. 2004..In addition, these studies show that complex II is fully active in the mitochondrion and not inhibited by OAA regardless of the oxygen concentration... - Poly(ADP-ribose) polymerase-1 hyperactivation and impairment of mitochondrial respiratory chain complex I function in reperfused mouse heartsHui Zhong Zhou
Department of Medicine, University of California, San Francisco, California, USA
Am J Physiol Heart Circ Physiol 291:H714-23. 2006..Our findings advance understanding of metabolic regulation in myocardium and identify potential therapeutic targets for prevention and treatment of ischemic heart disease... - A novel strong competitive inhibitor of complex IAlexander B Kotlyar
Molecular Biology Division 151 S, VA Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
FEBS Lett 579:4861-6. 2005.... - Absence of NADH channeling in coupled reaction of mitochondrial malate dehydrogenase and complex I in alamethicin-permeabilized rat liver mitochondriaAlexander B Kotlyar
Molecular Biology Division 151 S, VA Medical Center, San Francisco, CA 94121, USA
Biochem Biophys Res Commun 318:987-91. 2004..These data are in agreement with the free diffusion of NADH and do not support the suggestion of direct channeling of NADH from MDH to complex I... - Comparison of pyrroloquinoline quinone and/or metoprolol on myocardial infarct size and mitochondrial damage in a rat model of ischemia/reperfusion injuryBo-qing Zhu
Cardiology Section, VA Medical Center, Department of Medicine, University of California-San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
J Cardiovasc Pharmacol Ther 11:119-28. 2006..Combination therapy further reduces infarct size. PQQ is superior to metoprolol in protecting mitochondria from ischemia/reperfusion oxidative damage... 
Transgenic MMP-2 expression induces latent cardiac mitochondrial dysfunctionHui Zhong Zhou
Cardiology Section, Department of Medicine, UCSF, VA Medical Center, 4150 Clement Street, 111C 5, San Francisco, CA 94121, USA
Biochem Biophys Res Commun 358:189-95. 2007..We conclude that MMP-2 functions not only as a proteolytic enzyme but also as a previously unrecognized active negative regulator of mitochondrial function during superimposed oxidative stress...- MnSOD in mouse heart: acute responses to ischemic preconditioning and ischemia-reperfusion injuryZhu Qiu Jin
Cardiology Section 111C 4150 Clement St, San Francisco, CA 94121, USA
Am J Physiol Heart Circ Physiol 288:H2986-94. 2005..In contrast, fresh preparations exhibit early MnSOD release into the cytosol after I/R that is prevented by IPC and cyclosporin A administration... - Cardioprotective activity of a novel and potent competitive inhibitor of lactate dehydrogenaseAlexander B Kotlyar
Molecular Biology Division, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
FEBS Lett 584:159-65. 2010..In isolated mouse hearts, addition of the inhibitor results in a substantial reduction of myocardial infarct size caused by global ischemia/reperfusion injury...