E L Cavalieri

Summary

Affiliation: University of Nebraska Medical Center
Country: USA

Publications

  1. ncbi request reprint Ortho-quinones of benzene and estrogens induce hyperproliferation of human peripheral blood mononuclear cells
    Dhrubajyoti Chakravarti
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Leuk Lymphoma 47:2635-44. 2006
  2. pmc Novel biomarkers for risk of prostate cancer: results from a case-control study
    Li Yang
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
    Prostate 69:41-8. 2009
  3. doi request reprint The molecular etiology and prevention of estrogen-initiated cancers: Ockham's Razor: Pluralitas non est ponenda sine necessitate. Plurality should not be posited without necessity
    Ercole Cavalieri
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA Department of Environmental, Agricultural and Occupational Health, College of Public Health, University of Nebraska Medical Center, 984388 Nebraska Medical Center, Omaha, NE 68198 4388, USA Electronic address
    Mol Aspects Med 36:1-55. 2014
  4. pmc Molecular origin of cancer: catechol estrogen-3,4-quinones as endogenous tumor initiators
    E L Cavalieri
    Eppley Institute for Research in Cancer, University of Nebraska Medical Center, 600 South 42nd Street, Omaha, NE 68198 6805, USA
    Proc Natl Acad Sci U S A 94:10937-42. 1997
  5. ncbi request reprint Identification and quantification of the depurinating DNA adducts formed in mouse skin treated with dibenzo[a,l]pyrene (DB[a,l]P) or its metabolites and in rat mammary gland treated with DB[a,l]P
    Ercole L Cavalieri
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Chem Res Toxicol 18:976-83. 2005
  6. ncbi request reprint Catechol estrogen quinones as initiators of breast and other human cancers: implications for biomarkers of susceptibility and cancer prevention
    Ercole Cavalieri
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Biochim Biophys Acta 1766:63-78. 2006
  7. ncbi request reprint Catechol quinones of estrogens in the initiation of breast, prostate, and other human cancers: keynote lecture
    Ercole Cavalieri
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 8198 6805, USA
    Ann N Y Acad Sci 1089:286-301. 2006
  8. ncbi request reprint Catechol ortho-quinones: the electrophilic compounds that form depurinating DNA adducts and could initiate cancer and other diseases
    Ercole L Cavalieri
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Carcinogenesis 23:1071-7. 2002
  9. ncbi request reprint Initiation of cancer and other diseases by catechol ortho-quinones: a unifying mechanism
    E L Cavalieri
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha 68198 6805, USA
    Cell Mol Life Sci 59:665-81. 2002
  10. doi request reprint Depurinating estrogen-DNA adducts in the etiology and prevention of breast and other human cancers
    Ercole L Cavalieri
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Future Oncol 6:75-91. 2010

Research Grants

Collaborators

Detail Information

Publications50

  1. ncbi request reprint Ortho-quinones of benzene and estrogens induce hyperproliferation of human peripheral blood mononuclear cells
    Dhrubajyoti Chakravarti
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Leuk Lymphoma 47:2635-44. 2006
    ..Thus, DNA damage induced by the ortho-quinones of benzene and estradiol may promote the growth of human blood mononuclear cells, including those that appear in large numbers in leukemia and lymphoma...
  2. pmc Novel biomarkers for risk of prostate cancer: results from a case-control study
    Li Yang
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
    Prostate 69:41-8. 2009
    ..The goal of this case-control study was to detect and identify potential biomarkers of Pca...
  3. doi request reprint The molecular etiology and prevention of estrogen-initiated cancers: Ockham's Razor: Pluralitas non est ponenda sine necessitate. Plurality should not be posited without necessity
    Ercole Cavalieri
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA Department of Environmental, Agricultural and Occupational Health, College of Public Health, University of Nebraska Medical Center, 984388 Nebraska Medical Center, Omaha, NE 68198 4388, USA Electronic address
    Mol Aspects Med 36:1-55. 2014
    ..Therefore, resveratrol and N-acetylcysteine provide a widely applicable, inexpensive approach to preventing many of the prevalent types of human cancer. ..
  4. pmc Molecular origin of cancer: catechol estrogen-3,4-quinones as endogenous tumor initiators
    E L Cavalieri
    Eppley Institute for Research in Cancer, University of Nebraska Medical Center, 600 South 42nd Street, Omaha, NE 68198 6805, USA
    Proc Natl Acad Sci U S A 94:10937-42. 1997
    ..4 micromol of adduct/mol DNA-phosphate. In each case, the level of stable adducts was negligible. These results, complemented by other data, strongly support the hypothesis that CE-3,4-Q are endogenous tumor initiators...
  5. ncbi request reprint Identification and quantification of the depurinating DNA adducts formed in mouse skin treated with dibenzo[a,l]pyrene (DB[a,l]P) or its metabolites and in rat mammary gland treated with DB[a,l]P
    Ercole L Cavalieri
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Chem Res Toxicol 18:976-83. 2005
    ..Only one depurinating diol epoxide adduct was formed. Tumorigenicity, mutations, and DNA adduct data suggest that depurinating Ade adducts play a major role in the initiation of tumors by DB[a,l]P...
  6. ncbi request reprint Catechol estrogen quinones as initiators of breast and other human cancers: implications for biomarkers of susceptibility and cancer prevention
    Ercole Cavalieri
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Biochim Biophys Acta 1766:63-78. 2006
    ..Initiated cells may be promoted by a number of processes, including hormone receptor stimulated proliferation. These results lay the groundwork for assessing risk and preventing disease...
  7. ncbi request reprint Catechol quinones of estrogens in the initiation of breast, prostate, and other human cancers: keynote lecture
    Ercole Cavalieri
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 8198 6805, USA
    Ann N Y Acad Sci 1089:286-301. 2006
    ..This unifying mechanism of the origin of cancer and other diseases suggests preventive strategies based on the level of depurinating DNA adducts that generate the first critical step in the initiation of diseases...
  8. ncbi request reprint Catechol ortho-quinones: the electrophilic compounds that form depurinating DNA adducts and could initiate cancer and other diseases
    Ercole L Cavalieri
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Carcinogenesis 23:1071-7. 2002
    ..These data suggest that there is a unifying molecular mechanism, namely, formation of specific depurinating DNA adducts at the N-7 of guanine and N-3 of adenine, that could initiate many cancers and neurodegenerative diseases...
  9. ncbi request reprint Initiation of cancer and other diseases by catechol ortho-quinones: a unifying mechanism
    E L Cavalieri
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha 68198 6805, USA
    Cell Mol Life Sci 59:665-81. 2002
    ..These data suggest a unifying molecular mechanism of initiation for many cancers and neurodegenerative diseases and lay the groundwork for designing strategies to assess risk and prevent these diseases...
  10. doi request reprint Depurinating estrogen-DNA adducts in the etiology and prevention of breast and other human cancers
    Ercole L Cavalieri
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Future Oncol 6:75-91. 2010
    ..Two antioxidants, N-acetylcysteine and resveratrol, are prime candidates to prevent breast and other human cancers because in various M in vitro and in vivo experiments, they reduce the formation of estrogen-DNA adducts...
  11. ncbi request reprint A unifying mechanism in the initiation of cancer and other diseases by catechol quinones
    Ercole L Cavalieri
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Ann N Y Acad Sci 1028:247-57. 2004
    ..In summary, the apurinic sites produced in DNA from the loss of these depurinating adducts can be converted into mutations by error-prone repair, which may initiate cancer and other diseases...
  12. doi request reprint Is bisphenol A a weak carcinogen like the natural estrogens and diethylstilbestrol?
    Ercole L Cavalieri
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    IUBMB Life 62:746-51. 2010
    ..Knowledge of these mechanisms would allow us to begin to understand how BPA may act as a weak carcinogen and would be useful for regulating its use...
  13. ncbi request reprint Imbalance of estrogen homeostasis in kidney and liver of hamsters treated with estradiol: implications for estrogen-induced initiation of renal tumors
    E L Cavalieri
    The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Chem Res Toxicol 14:1041-50. 2001
    ..Thus, formation of depurinating DNA adducts by CE-3,4-Q may be the first critical event in the initiation of estrogen-induced kidney tumors...
  14. doi request reprint Mechanism of DNA depurination by carcinogens in relation to cancer initiation
    Ercole Cavalieri
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    IUBMB Life 64:169-79. 2012
    ..Understanding why the depurinating estrogen-DNA adducts come from DNA, and not from RNA, underscores the critical role that these adducts play in initiating cancer...
  15. doi request reprint Unbalanced metabolism of endogenous estrogens in the etiology and prevention of human cancer
    Ercole L Cavalieri
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, United States
    J Steroid Biochem Mol Biol 125:169-80. 2011
    ..Specific antioxidants, such as N-acetylcysteine and resveratrol, can block the oxidation of catechol estrogens to their quinones and their reaction with DNA. As a result, the initiation of cancer can be prevented...
  16. ncbi request reprint A unified mechanism in the initiation of cancer
    Ercole L Cavalieri
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
    Ann N Y Acad Sci 959:341-54. 2002
    ..Thus, a unifying mechanism, namely formation of catechol quinones and reaction with DNA, could initiate not only cancer by oxidation of specific endogenous estrogen metabolites, but also leukemia by oxidation of benzene...
  17. ncbi request reprint Catechol estrogen conjugates and DNA adducts in the kidney of male Syrian golden hamsters treated with 4-hydroxyestradiol: potential biomarkers for estrogen-initiated cancer
    P Devanesan
    Eppley Institute for Research in Cancer and Allied Diseases, 986805 Nebraska Medical Center, Omaha, NE 68198-6805, USA
    Carcinogenesis 22:489-97. 2001
    ..We conclude that GSH and Cys conjugates of the 4-OHE and the 4-OHE-N7Gua adducts can be utilized as biomarkers to detect estrogenic imbalance and potential susceptibility to tumor initiation...
  18. ncbi request reprint Metabolic activation and formation of DNA adducts of hexestrol, a synthetic nonsteroidal carcinogenic estrogen
    S T Jan
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 600 South 42nd Street, Omaha, Nebraska 68198 6805, USA
    Chem Res Toxicol 11:412-9. 1998
    ....
  19. ncbi request reprint Evidence that a burst of DNA depurination in SENCAR mouse skin induces error-prone repair and forms mutations in the H-ras gene
    D Chakravarti
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
    Oncogene 20:7945-53. 2001
    ..These results also suggest that E(2)-3,4-Q, a suspected endogenous carcinogen, is a genotoxic compound and could cause mutations...
  20. ncbi request reprint Evidence that error-prone DNA repair converts dibenzo[a,l]pyrene-induced depurinating lesions into mutations: formation, clonal proliferation and regression of initiated cells carrying H-ras oncogene mutations in early preneoplasia
    D Chakravarti
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Mutat Res 456:17-32. 2000
    ..The multiplication of initiated stem cells during transient clonoplasia may be a factor determining the tumor-initiating potential of some PAH carcinogens...
  21. ncbi request reprint Analysis of potential biomarkers of estrogen-initiated cancer in the urine of Syrian golden hamsters treated with 4-hydroxyestradiol
    R Todorovic
    Eppley Institute for Research in Cancer and Allied Diseases, 986805 Nebraska Medical Center, Omaha, NE 68198-6805, USA
    Carcinogenesis 22:905-11. 2001
    ..The estrogen metabolites, conjugates and adducts can be used as biomarkers for detecting enzymatic oxidation of estrogens to reactive electrophilic metabolites and possible susceptibility to estrogen-induced cancer...
  22. pmc Benzene and dopamine catechol quinones could initiate cancer or neurogenic disease
    Muhammad Zahid
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Free Radic Biol Med 48:318-24. 2010
    ..Reaction of catechol quinones of natural and synthetic estrogens, benzene, naphthalene, and dopamine with DNA to form depurinating adducts is a common feature that may lead to initiation of cancer or neurodegenerative disease...
  23. ncbi request reprint Profiles of cytokine mRNAs in the skin and lymph nodes of SENCAR mice treated epicutaneously with dibenzo[a,l]pyrene or dimethylbenz[a]anthracene reveal a direct correlation between carcinogen-induced contact hypersensitivity and epidermal hyperplasia
    G P Casale
    Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha 68198 6805, USA
    Mol Carcinog 27:125-40. 2000
    ..In conclusion, our data support carcinogen-specific CHS as a mechanism by which the very potent carcinogen DB[a,l]P induces epidermal hyperplasia, a requirement for tumor promotion in mouse skin...
  24. pmc Reduction of estrogen-induced transformation of mouse mammary epithelial cells by N-acetylcysteine
    Divya Venugopal
    Eppley Institute for Research in Cancer and Allied Diseases, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, United States
    J Steroid Biochem Mol Biol 109:22-30. 2008
    ..These results strongly implicate estrogen genotoxicity in mammary cell transformation. Since N-acetylcysteine is well tolerated in clinical studies, it may be a promising candidate for breast cancer prevention...
  25. pmc N-acetylcysteine blocks formation of cancer-initiating estrogen-DNA adducts in cells
    Muhammad Zahid
    Eppley Institute for Research in Cancer and Allied Diseases, College of Public Health, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Free Radic Biol Med 49:392-400. 2010
    ..This finding suggests that NAcCys, a common dietary supplement, could be used as a potential chemopreventive agent to block the initial step in the genotoxicity caused by catechol estrogen quinones...
  26. ncbi request reprint Role of human cytochrome P450 1A1, 1A2, 1B1, and 3A4 in the 2-, 4-, and 16alpha-hydroxylation of 17beta-estradiol
    A F Badawi
    Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Metabolism 50:1001-3. 2001
    ....
  27. ncbi request reprint Large-scale synthesis of the catechol metabolites of diethylstilbestrol and hexestrol
    S T Jan
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 600 South 42nd Street, Omaha, Nebraska 68198 6805, USA
    Chem Res Toxicol 11:408-11. 1998
    ..Using commercially inexpensive starting materials, this compound was synthesized in four steps, and the cis and trans isomers were separated and identified. Following the same synthetic route, 3'-OH-HES was synthesized in five steps...
  28. pmc Evidence for NQO2-mediated reduction of the carcinogenic estrogen ortho-quinones
    Nilesh W Gaikwad
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Free Radic Biol Med 46:253-62. 2009
    ..Both UV and liquid chromatography-tandem mass spectrometry assays unequivocally corroborate the reduction of estrogen ortho-quinones by NQO2, indicating that it could be a novel target for prevention of breast cancer initiation...
  29. doi request reprint Urinary biomarkers suggest that estrogen-DNA adducts may play a role in the aetiology of non-Hodgkin lymphoma
    Nilesh W Gaikwad
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Biomarkers 14:502-12. 2009
    ..Thus, formation of estrogen-DNA adducts may play a critical role in the aetiology of NHL, and these adducts could be potential biomarkers of NHL risk...
  30. pmc Prevention of estrogen-DNA adduct formation in MCF-10F cells by resveratrol
    Muhammad Zahid
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Free Radic Biol Med 45:136-45. 2008
    ..We conclude that Resv can protect breast cells from carcinogenic estrogen metabolites, suggesting that it could be used in breast cancer prevention...
  31. ncbi request reprint Metabolism and DNA binding studies of 4-hydroxyestradiol and estradiol-3,4-quinone in vitro and in female ACI rat mammary gland in vivo
    Kai Ming Li
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Carcinogenesis 25:289-97. 2004
    ..These adducts can generate the critical mutations that initiate cancer (Chakravarti et al., Oncogene, 2001, 20, 7945; Chakravarti et al., Proc. Am. Assoc. Cancer Res., 2003, 44, 180)...
  32. ncbi request reprint Relative imbalances in the expression of estrogen-metabolizing enzymes in the breast tissue of women with breast carcinoma
    Seema Singh
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Oncol Rep 14:1091-6. 2005
    ..These unbalances appear to be instrumental in causing excessive formation of catechol estrogen quinones that, by reacting with DNA, initiate the series of events leading to breast cancer...
  33. ncbi request reprint Detection and quantification of depurinated benzo[a]pyrene-adducted DNA bases in the urine of cigarette smokers and women exposed to household coal smoke
    G P Casale
    Eppley Institute for Research in Cancer, 986805, University of Nebraska Medical Center, Omaha, Nebraska 68198-6805, USA
    Chem Res Toxicol 14:192-201. 2001
    ..These results justify more extensive studies of depurinated BP-adducted DNA bases as potential biomarkers of PAH-associated cancer risk...
  34. doi request reprint Resveratrol prevents estrogen-DNA adduct formation and neoplastic transformation in MCF-10F cells
    Fang Lu
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Cancer Prev Res (Phila) 1:135-45. 2008
    ..Resveratrol also suppressed TCDD and/or estradiol-induced cell transformation. Thus, resveratrol can prevent breast cancer initiation by blocking multiple sites in the estrogen genotoxicity pathway...
  35. ncbi request reprint Catechol estrogen metabolites and conjugates in different regions of the prostate of Noble rats treated with 4-hydroxyestradiol: implications for estrogen-induced initiation of prostate cancer
    Ercole L Cavalieri
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Carcinogenesis 23:329-33. 2002
    ....
  36. ncbi request reprint Estrogen metabolites, conjugates, and DNA adducts: possible biomarkers for risk of breast, prostate, and other human cancers
    Eleanor G Rogan
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    Adv Clin Chem 38:135-49. 2004
  37. ncbi request reprint Inhibition of depurinating estrogen-DNA adduct formation by natural compounds
    Muhammad Zahid
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha 68198 6805, USA
    Chem Res Toxicol 20:1947-53. 2007
    ..This approach is highly useful for identifying agents to prevent the initiation of human cancers, especially breast and prostate cancer...
  38. pmc The role of polycyclic aromatic hydrocarbon-DNA adducts in inducing mutations in mouse skin
    Dhrubajyoti Chakravarti
    Eppley Institute for Research in Cancer and Allied Diseases, Omaha, NE 68198 6805, USA
    Mutat Res 649:161-78. 2008
    ..In conclusion, this study suggests that depurinating adducts play a major role in PAH mutagenesis...
  39. pmc Estrogen metabolism and formation of estrogen-DNA adducts in estradiol-treated MCF-10F cells. The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin induction and catechol-O-methyltransferase inhibition
    Fang Lu
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    J Steroid Biochem Mol Biol 105:150-8. 2007
    ..We conclude that low COMT activity and increased formation of depurinating adducts can be critical factors leading to initiation of breast cancer...
  40. ncbi request reprint Improved measurement of dibenzo[a,l]pyrene-induced abasic sites by the aldehyde-reactive probe assay
    Dhrubajyoti Chakravarti
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Mutat Res 588:158-65. 2005
    ..In summary, the inclusion of ARP in the DB[a,l]P-DNA adduct-forming reaction traps and protects the nascent abasic sites, allowing an improved quantification of abasic sites...
  41. ncbi request reprint Relative imbalances in estrogen metabolism and conjugation in breast tissue of women with carcinoma: potential biomarkers of susceptibility to cancer
    Eleanor G Rogan
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha 68198 6805, USA
    Carcinogenesis 24:697-702. 2003
    ..The levels of 4-CE and quinone conjugates were highly significant predictors of breast cancer. These results suggest that some catechol estrogen metabolites and conjugates could serve as biomarkers to predict risk of breast cancer...
  42. doi request reprint NAD(P)H:quinone oxidoreductase 1 Arg139Trp and Pro187Ser polymorphisms imbalance estrogen metabolism towards DNA adduct formation in human mammary epithelial cells
    Seema Singh
    Eppley Institute for Research in Cancer and Allied Diseases, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, United States
    J Steroid Biochem Mol Biol 117:56-66. 2009
    ..Therefore, the inheritance of these NQO1 polymorphisms may favor the estrogen genotoxic mechanism of breast cancer...
  43. ncbi request reprint Cytochrome P450 isoforms catalyze formation of catechol estrogen quinones that react with DNA
    Yan Zhang
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Metabolism 56:887-94. 2007
    ....
  44. ncbi request reprint The molecular etiology of breast cancer: evidence from biomarkers of risk
    Nilesh W Gaikwad
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Int J Cancer 122:1949-57. 2008
    ..Thus, the depurinating estrogen-DNA adducts are possible biomarkers for early detection of breast cancer risk and response to preventive treatment...
  45. ncbi request reprint Repair of short oligodeoxyribonucleotides containing a stable adduct and an apurinic site by extracts of MCF-10A1 cells
    Kimberly A Chapman
    Eppley Institute for Research in Cancer and Allied Diseases and Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
    Anticancer Res 24:117-21. 2004
    ..DNA with two sites of damage in close proximity might not be repaired as efficiently as DNA with a single damage site...
  46. pmc Evidence from ESI-MS for NQO1-catalyzed reduction of estrogen ortho-quinones
    Nilesh W Gaikwad
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Free Radic Biol Med 43:1289-98. 2007
    ..Thus, clear evidence for the catalytic reduction of estrogen ortho-quinones by NQO1 has been obtained; its mechanism and implications are discussed...
  47. ncbi request reprint Spectroscopic characterization of the 4-hydroxy catechol estrogen quinones-derived GSH and N-acetylated Cys conjugates
    Ryszard Jankowiak
    Ames Laboratory, US Department of Energy and Department of Chemistry, Iowa State University, Ames, Iowa 50011, USA
    Chem Res Toxicol 16:304-11. 2003
    ..The concentration LOD is approximately 10(-9) M. Therefore, we propose that capillary electrophoresis interfaced with low temperature phosphorescence detection can be used to test for human exposure to CEQs by analyzing urine...
  48. ncbi request reprint Fluorobenzo[a]pyrenes as probes of the mechanism of cytochrome P450-catalyzed oxygen transfer in aromatic oxygenations
    Patrick P J Mulder
    Leiden Institute of Chemistry, Gorlaeus Laboratories, Leiden University, Leiden, The Netherlands
    Free Radic Biol Med 34:734-45. 2003
    ....
  49. ncbi request reprint Mutagenic activity of 4-hydroxyestradiol, but not 2-hydroxyestradiol, in BB rat2 embryonic cells, and the mutational spectrum of 4-hydroxyestradiol
    Zhonglin Zhao
    New York University Dental School, New York, New York 10010, USA
    Chem Res Toxicol 19:475-9. 2006
    ..Thus, the results of this study support the proposal that estradiol can contribute to carcinogenesis via a genotoxic pathway...
  50. doi request reprint Possible genotoxic modes of action for naphthalene
    David Brusick
    Department of Environmental Engineering, Carnegie Mellon University, USA
    Regul Toxicol Pharmacol 51:S43-50. 2008
    ..The report also outlines a set of six studies that could resolve some of these key uncertainties...

Research Grants13

  1. MOLECULAR ORIGIN OF CANCER--CATECHOL/SEMIQUINOE/QUINONE
    Ercole Cavalieri; Fiscal Year: 2003
    ..In addition, we will identify biomarkers for use in diagnosis and in studies of prevention of breast cancer and other diseases. ..
  2. Molecular Orgin Cancer--Catechol Estrogen 3 4 Quinones
    Ercole Cavalieri; Fiscal Year: 2004
    ..The knowledge acquired from these studies will be essential for developing preventive strategies. ..
  3. MECHANISMS OF CARCINOGENESIS OF DIBENZO(A,1)PYRENE
    Ercole Cavalieri; Fiscal Year: 1993
    ..The data obtained from the chemistry, tumorigenicity, DNA-binding studies and oncogene activation will provide significant clues concerning the mechanism of carcinogenesis of DB[a,l]P...