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Genomes and GenesSpecies | Jane CauleySummaryAffiliation: University of Pittsburgh Country: USA Publications
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Bone mineral density and the risk of incident nonspinal fractures in black and white womenJane A Cauley
Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
JAMA 293:2102-8. 2005..Black women have a lower rate of fracture than white women, but whether bone mineral density (BMD) predicts fracture risk as well in black women as it does in white women is not established...
Defining ethnic and racial differences in osteoporosis and fragility fracturesJane A Cauley
Department of Epidemiology, University of Pittsburgh, 130 DeSoto Street, Crabtree A543, Pittsburgh, PA 15261, USA
Clin Orthop Relat Res 469:1891-9. 2011..Osteoporotic fractures are a major public health issue. The literature suggests there are variations in occurrence of fractures by ethnicity and race...- Longitudinal study of changes in hip bone mineral density in Caucasian and African-American womenJane A Cauley
Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
J Am Geriatr Soc 53:183-9. 2005..To determine whether changes in hip bone mineral density (BMD) differ in Caucasian and African American women... - Bone mineral density and prevalent vertebral fractures in men and womenJane A Cauley
Department of Epidemiology, University of Pittsburgh, 130 DeSoto Street, Crabtree Hall A524, Pittsburgh, PA 15261, USA
Osteoporos Int 15:32-7. 2004..Measures of bone mass that partially correct for gender differences in bone size may yield universal estimates of fracture risk. Prospective studies are needed to confirm this observation... - Lipid-lowering drug use and breast cancer in older women: a prospective studyJane A Cauley
Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Womens Health (Larchmt) 12:749-56. 2003..To test the hypothesis that use of lipid-lowering drugs reduces the risk of breast cancer in older women... - Estrogen metabolites and the risk of breast cancer in older womenJane A Cauley
Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Epidemiology 14:740-4. 2003..The objective of this study was to test the hypothesis that serum concentrations of 2-hydroxyestrone (2-OHE1) and 16alpha-hydroxyestrone (16alpha-OHE1), as well as their ratio, predict the risk of breast cancer in older women... - Effects of estrogen plus progestin on risk of fracture and bone mineral density: the Women's Health Initiative randomized trialJane A Cauley
Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
JAMA 290:1729-38. 2003..In the Women's Health Initiative trial of estrogen-plus-progestin therapy, women assigned to active treatment had fewer fractures... - Factors associated with the lumbar spine and proximal femur bone mineral density in older menJane A Cauley
Department of Epidemiology, University of Pittsburgh, 130 DeSoto Street, Crabtree Hall A524, Pittsburgh, PA 15261, USA
Osteoporos Int 16:1525-37. 2005..Identification of these correlates could improve methods to identify men at risk for fracture and improve our understanding of fracture etiology... - Statin use and breast cancer: prospective results from the Women's Health InitiativeJane A Cauley
Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
J Natl Cancer Inst 98:700-7. 2006.... 
FRAX® International Task Force of the 2010 Joint International Society for Clinical Densitometry & International Osteoporosis Foundation Position Development ConferenceJane A Cauley
Department of Epidemiology, University of Pittsburgh, PA, USA
J Clin Densitom 14:237-9. 2011..This synthesis was presented to the expert panel and constitutes the data on which the subsequent Official Positions are predicated. A summary of the International Task Force composition and charge is presented here...- Influence of estrogen plus testosterone supplementation on breast cancerRoberta B Ness
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Arch Intern Med 169:41-6. 2009..We sought to examine the relationship between the use of estrogen plus testosterone (E + T) therapy (esterified estradiol plus methyltestosterone) and the occurrence of breast cancer... - Effect of raloxifene on sexual function in older postmenopausal women with osteoporosisFrancesmary Modugno
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Obstet Gynecol 101:353-61. 2003..To assess the effect of raloxifene compared with placebo on sexual function in older postmenopausal women undergoing therapy for the treatment of osteoporosis... - Inflammation and thrombosis biomarkers and incident frailty in postmenopausal womenAlexander P Reiner
Women s Health Initiative Clinical Coordinating Center, Fred Hutchinson Cancer Research Center, Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195, USA
Am J Med 122:947-54. 2009.... - Nontraumatic fracture risk with diabetes mellitus and impaired fasting glucose in older white and black adults: the health, aging, and body composition studyElsa S Strotmeyer
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA
Arch Intern Med 165:1612-7. 2005..Fracture prevention needs to target specific risk factors found in older adults with DM... - Kidney function predicts the rate of bone loss in older individuals: the Cardiovascular Health StudyLinda F Fried
VA Pittsburgh Healthcare System, Pittsburgh, PA 15240, USA
J Gerontol A Biol Sci Med Sci 61:743-8. 2006.... - Natural history and correlates of hip BMD loss with aging in men of African ancestry: the Tobago Bone Health StudyYahtyng Sheu
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
J Bone Miner Res 24:1290-8. 2009..Additional studies are needed to better define the natural history and factors underlying bone loss with aging in men of African ancestry... - Familial resemblance and shared latent familial variance in recurrent fall risk in older womenKimberly A Faulkner
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto St, A 551, Pittsburgh, PA 15261, USA
J Appl Physiol 108:1142-7. 2010..A possible familial component to fracture risk may be mediated through a genetic liability to fall recurrently... - Nuclear receptor coactivator-3 alleles are associated with serum bioavailable testosterone, insulin-like growth factor-1, and vertebral bone mass in menYah Tyng Sheu
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
J Clin Endocrinol Metab 91:307-12. 2006..Nuclear receptor coactivator-3 (NCOA3) is a member of the steroid receptor coactivator family that interacts with nuclear hormone receptors to enhance their transcriptional activation function and may play a role in somatic growth... - Association of lipoprotein(a), insulin resistance, and reproductive hormones in a multiethnic cohort of pre- and perimenopausal women (The SWAN Study)MaryFran Sowers
Department of Epidemiology, University of Michigan, Ann Arbor, Michigan 48109, USA
Am J Cardiol 92:533-7. 2003..Lp(a) was very modestly associated (r = -0.04) with insulin resistance after adjusting for ethnicity and BMI, and this association was not modified by reproductive hormones, including androgens... - Poor sleep is associated with poorer physical performance and greater functional limitations in older womenSuzanne E Goldman
Department of Epidemiology, University ofPittsburgh, Pittsburgh, PA, USA
Sleep 30:1317-24. 2007..This study examined the association between disturbed sleep and poorer daytime function in older women... - Vitamin D receptor and aromatase gene interaction and bone mass in older African-American womenJoseph M Zmuda
Departments of Epidemiology and Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
Metabolism 52:521-3. 2003..05 for interaction). We conclude that VDR and CYP19 gene polymorphisms may jointly influence bone mass and the rate of bone loss in older African-American women... - Diabetes is associated independently of body composition with BMD and bone volume in older white and black men and women: The Health, Aging, and Body Composition StudyElsa S Strotmeyer
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Bone Miner Res 19:1084-91. 2004..01) and higher hip BMD for each race-gender group (p < or = 0.01). Type 2 diabetes was associated with a 4-5% higher total hip BMD in all race-gender groups of elderly adults, independent of body composition and fasting insulin levels... - Foot and ankle fractures in elderly white women. Incidence and risk factorsCarl T Hasselman
University of Pittsburgh, Pennsylvania, USA
J Bone Joint Surg Am 85:820-4. 2003..8%) and to be using either long or short-acting benzodiazepines. CONCLUSIONS: Overall, foot fractures appeared to be typical osteoporotic fractures, whereas ankle fractures occurred in younger women with a relatively high body mass index... - The association of bone mineral density with prostate cancer risk in the Osteoporotic Fractures in Men (MrOS) StudyGhada N Farhat
University of Pittsburgh, Department of Epidemiology and Division of Cancer Prevention and Population Science, University of Pittsburgh Medical Center, Cancer Pavilion, Suite 4C, 5150 Centre Avenue, Pittsburgh, PA 15232, USA
Cancer Epidemiol Biomarkers Prev 18:148-54. 2009..However, no associations were observed with low-grade disease. Our results provide support for an inverse association between BMD and PCa risk. Possible pathophyisological mechanisms linking BMD and PCa should be elucidated... - Once-yearly zoledronic acid and days of disability, bed rest, and back pain: randomized, controlled HORIZON Pivotal Fracture TrialJane A Cauley
Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
J Bone Miner Res 26:984-92. 2011.... - Relationship of blood lead levels to incident nonspine fractures and falls in older women: the study of osteoporotic fracturesNaila Khalil
Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
J Bone Miner Res 23:1417-25. 2008..07, 2.45; p trend = 0.014) compared with women with lowest lead level. Blood lead levels are associated with an increased risk of falls and fractures, extending the negative health consequences of lead to include osteoporotic fractures... - Functional characterization of genetic variation in the Frizzled 1 (FZD1) promoter and association with bone phenotypes: more to the LRP5 story?Laura M Yerges
Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
J Bone Miner Res 24:87-96. 2009..This study indicates that a cis-regulatory polymorphism in the FZD1 promoter region may have a functional role in determining bone structural geometry... - Correlates of bone mineral density among postmenopausal women of African Caribbean ancestry: Tobago women's health studyDeanna D Hill
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, Pennsylvania 15261, USA
Bone 43:156-61. 2008..This may reflect low European admixture. Correlates of BMD among Caribbean women of West African ancestry were similar to those reported for U.S. Black and White women... - Candidate gene analysis of femoral neck trabecular and cortical volumetric bone mineral density in older menLaura M Yerges
Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
J Bone Miner Res 25:330-8. 2010..These findings identify novel genetic variants for cortical and trabecular vBMD and raise the possibility that some genetic loci may be unique for each bone compartment... - Longitudinal physical activity changes in older men in the Osteoporotic Fractures in Men StudyCarol A Janney
Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Am Geriatr Soc 58:1128-33. 2010..To describe the change in physical activity (total, leisure, household, occupational) in men over a mean 5-year follow-up period and to identify sociodemographic and health factors associated with change in physical activity... - Vitamin D receptor genotype is associated with fat-free mass and sarcopenia in elderly menStephen M Roth
Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, PA, USA
J Gerontol A Biol Sci Med Sci 59:10-5. 2004..19-3.85; p =.03) compared to men with one or more f alleles. The VDR translation start site (FokI) polymorphism is significantly associated with FFM and sarcopenia in this cohort of older Caucasian men... - Association of kidney function with incident hip fracture in older adultsLinda F Fried
VA Pittsburgh Healthcare System, Pittsburgh, PA 15240, USA
J Am Soc Nephrol 18:282-6. 2007..Further studies are needed to evaluate potential mediators of this relationship and to assess whether interventions can decrease this risk... - Sex hormones and cognitive function in older menKristine Yaffe
Department of Psychiatry, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Am Geriatr Soc 50:707-12. 2002..We investigated whether serum level of testosterone and estradiol is associated with cognition in older community-dwelling men... - Gait speed and survival in older adultsStephanie Studenski
Department of Medicine, Division of Geratric Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
JAMA 305:50-8. 2011..Physical performance measures, such as gait speed, might help account for variability, allowing clinicians to make more individualized estimates... - High bone density is associated with prostate cancer in older Afro-Caribbean men: Tobago prostate surveyClareann H Bunker
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
Cancer Causes Control 17:1083-9. 2006..To test the hypothesis that bone mineral density (BMD), a possible surrogate of lifetime exposure to hormone/growth factor/vitamin D/calcium exposure, is higher in prostate cancer cases than controls... - Volumetric BMD and vascular calcification in middle-aged women: the Study of Women's Health Across the NationGhada N Farhat
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
J Bone Miner Res 21:1839-46. 2006..Lower vBMD was related to high AC, but not to CAC, independent of age and shared risk factors between osteoporosis and cardiovascular disease... - Osteoporosis in men: prevalence and investigationJane A Cauley
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
Clin Cornerstone 8:S20-5. 2006..Routine analyses of blood and biochemistry should be carried out in any older male patient with newly diagnosed osteoporosis. Dual x-ray energy absorptiometry should be performed on every new patient with newly diagnosed osteoporosis... - Multitasking: association between poorer performance and a history of recurrent fallsKimberly A Faulkner
Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Am Geriatr Soc 55:570-6. 2007..To examine the association between poorer performance on concurrent walking and reaction time and recurrent falls... - Clinical risk factors for fractures in multi-ethnic women: the Women's Health InitiativeJane A Cauley
Department of Epidemiology, University of Pittsburgh, Graduate School of Public Health, Pittsburgh, Pennsylvania, USA
J Bone Miner Res 22:1816-26. 2007..However, irrespective of their ethnicity, women with multiple risk factors have a high risk of fracture. Targeting these high-risk women for screening and intervention could reduce fractures... - The effect of androgen deprivation therapy on periodontal disease in men with prostate cancerPouran Famili
Department of Periodontics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
J Urol 177:921-4. 2007..We tested the hypothesis that men undergoing androgen deprivation therapy as treatment for prostate cancer are at greater risk for periodontitis and tooth loss... - Body mass index and mortality among older breast cancer survivors in the Study of Osteoporotic FracturesKatherine W Reeves
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 516A Parran Hall, 130 DeSoto Street, Pittsburgh, PA 15261, USA
Cancer Epidemiol Biomarkers Prev 16:1468-73. 2007..This study investigated the association between BMI and mortality after breast cancer diagnosis in a cohort of older Caucasian women enrolled in the Study of Osteoporotic Fractures... - Diabetes mellitus, bone mineral density, and fracture riskElsa S Strotmeyer
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Curr Opin Endocrinol Diabetes Obes 14:429-35. 2007..To review recent research on type 1 and 2 diabetes mellitus, bone mineral density, and fractures and to identify high-priority research areas... - Successful skeletal aging: a marker of low fracture risk and longevity. The Study of Osteoporotic Fractures (SOF)Jane A Cauley
University of Pittsburgh, Department of Epidemiology, Pittsburgh, Pennsylvania 15261, USA
J Bone Miner Res 24:134-43. 2009..These women experienced a lower risk of fractures, disability, and mortality, suggesting that this phenotype may be a marker of successful aging... - Low prevalence of vitamin D deficiency in elderly Afro-Caribbean menIva Miljkovic
Department of Epidemiology, Graduate School of Public Health, Pittsburgh, University of Pittsburgh, PA 15213, USA
Ethn Dis 21:79-84. 2011..Longitudinal studies are needed to delineate the possible effects of high vitamin D levels in this population on major diseases hypothesized to be associated with vitamin D deficiency... - Bone strength measured by peripheral quantitative computed tomography and the risk of nonvertebral fractures: the osteoporotic fractures in men (MrOS) studyYahtyng Sheu
Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15213, USA
J Bone Miner Res 26:63-71. 2011..73 to 0.80). Peripheral bone strength measures are associated with fracture risk and may improve our ability to identify older men at high risk of fracture... - Correlates of trabecular and cortical volumetric bone mineral density at the femoral neck and lumbar spine: the osteoporotic fractures in men study (MrOS)Jane A Cauley
Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
J Bone Miner Res 25:1958-71. 2010..There was no relationship between sex hormones and femoral neck trabecular vBMD. Our conclusion is that correlates of trabecular vBMD and cortical vBMD appear to differ in older men... - Sex steroid hormones in older men: longitudinal associations with 4.5-year change in hip bone mineral density--the osteoporotic fractures in men studyJane A Cauley
University of Pittsburgh, Department of Epidemiology, 130 DeSoto Street, Crabtree A524, Pittsburgh, Pennsylvania 15261, USA
J Clin Endocrinol Metab 95:4314-23. 2010..There is limited information on the association between sex hormones and bone loss in older men... - Correlates of trabecular and cortical volumetric bone mineral density of the radius and tibia in older men: the Osteoporotic Fractures in Men StudyKamil E Barbour
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA
J Bone Miner Res 25:1017-28. 2010..An ascertainment of potential risk factors associated with trabecular and cortical vBMD may lead to better understanding and preventive efforts for osteoporosis in men... - Serum 25-hydroxyvitamin D and the risk of hip and nonspine fractures in older menJane A Cauley
University of Pittsburgh, Department of Epidemiology, Pittsburgh, Pennsylvania 15261, USA
J Bone Miner Res 25:545-53. 2010..065 for trend). Low serum 25(OH)D concentrations are associated with a higher risk of hip fracture in older men. Measurement of 25(OH)D may be useful in identifying men at high risk of hip fracture... - Association of the G-174C variant in the interleukin-6 promoter region with bone loss and fracture risk in older womenSusan P Moffett
Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Bone Miner Res 19:1612-8. 2004..Variation at the IL-6 locus may contribute to the genetic susceptibility to bone fragility... - Leukocyte Telomere Length Is Not Associated With BMD, Osteoporosis, or Fracture in Older Adults: Results From the Health, Aging and Body Composition StudyJason L Sanders
Medical Scientist Training Program, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Bone Miner Res 24:1531-6. 2009..TL is not associated with BMD, osteoporosis, or fracture in older men or women in this sample... - Association of cumulative lead and neurocognitive function in an occupational cohortNaila Khalil
Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
Neuropsychology 23:10-9. 2009..Finally, there was no association with bone lead level and recency of exposure, suggesting that cumulative body burden is most likely responsible for the progressive cognitive decrement evidenced with vulnerability because of aging... - Risk factors for severity and type of the hip fractureJane A Cauley
University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Bone Miner Res 24:943-55. 2009..Little difference was reported in the self-reported circumstances surrounding each type of fracture. In conclusion, the lower the BMD, the greater the likelihood of experiencing a hip fracture that is less displaced and more stable... - Association analysis of WNT10B with bone mass and structure among individuals of African ancestryJoseph M Zmuda
Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
J Bone Miner Res 24:437-47. 2009..This analysis implicates the WNT10B locus as a genetic element in the regulation of bone mass and structural geometry... - Greater adipose tissue infiltration in skeletal muscle among older men of African ancestryIva Miljkovic
Department of Epidemiology, Center for Aging and Population Health, University of Pittsburgh, 130 North Bellefield Avenue, Room 542, Pittsburgh, PA 15213, USA
J Clin Endocrinol Metab 94:2735-42. 2009..Skeletal muscle fat has been identified as an important depot that increases with aging and may contribute to the development of diabetes... - Middle-aged premenopausal women with type 1 diabetes have lower bone mineral density and calcaneal quantitative ultrasound than nondiabetic womenElsa S Strotmeyer
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 North Bellefield Ave, Room 519, Pittsburgh, PA 15213, USA
Diabetes Care 29:306-11. 2006..To determine whether middle-aged premenopausal women with type 1 diabetes had more self-reported fractures and lower bone mineral density (BMD) compared with nondiabetic women... - Breast cancer risk factors and mammographic breast density in women over age 70Francesmary Modugno
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
Breast Cancer Res Treat 97:157-66. 2006..Breast density is a strong risk factor for breast cancer, but little is known about factors associated with breast density in women over 70... - Is social integration associated with the risk of falling in older community-dwelling women?Kimberly A Faulkner
Department of Epidemiology, University of Pittsburgh, Pennsylvania 15261, USA
J Gerontol A Biol Sci Med Sci 58:M954-9. 2003..Social integration may lead to social support and influence that may in turn protect older community-dwelling adults from falls... - Physical activity and decreased risk of clinical gallstone disease among post-menopausal womenKristi L Storti
Department of Epidemiology, 505 Parran Hall, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261, USA
Prev Med 41:772-7. 2005..Physical activity may play a role in preventing gallstone disease... - Hearing sensitivity and the risk of incident falls and fracture in older women: the study of osteoporotic fracturesElizabeth L Purchase-Helzner
Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
Ann Epidemiol 14:311-8. 2004..We further hypothesized that decreased bone mineral density would be associated with hearing loss... - Inflammatory markers and incident fracture risk in older men and women: the Health Aging and Body Composition StudyJane A Cauley
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
J Bone Miner Res 22:1088-95. 2007..We tested this hypothesis in relationship to fractures in 2985 men and women enrolled in the Health ABC study. Results showed that subjects with the greatest number of inflammatory markers have the highest risk of fracture... - Reciprocal influence of concurrent walking and cognitive testing on performance in older adultsKimberly A Faulkner
University of Pittsburgh, 130 DeSoto Street, Parran 509, Pittsburgh, PA 15261, USA
Gait Posture 24:182-9. 2006..062). Findings suggest that walking requires significant cognitive resources among older adults and slower-walking adults and weaker adults may require higher cognitive loading while walking... - Physical activity and risk of revision total knee arthroplasty in individuals with knee osteoarthritis: a matched case-control studyDina L Jones
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
J Rheumatol 31:1384-90. 2004..To determine if physical activity was a risk factor for revision arthroplasty after primary total knee arthroplasty (TKA) due to osteoarthritis (OA) within the previous 15 years... - Estrogen metabolizing polymorphisms and breast cancer risk among older white womenFrancesmary Modugno
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA, USA
Breast Cancer Res Treat 93:261-70. 2005..To investigate breast cancer risk according to metabolizing genes polymorphisms in older women... - Association of estrogen receptor alpha polymorphisms with breast cancer risk in older Caucasian womenFrancesmary Modugno
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
Int J Cancer 116:984-91. 2005..60 vs. 1.12 for nulliparous vs. parous women; interaction p = 0.03). ESR1 polymorphisms in combination with lifestyle factors may be associated with breast cancer risk in older Caucasian women... - Hearing sensitivity and bone mineral density in older adults: the Health, Aging and Body Composition StudyElizabeth P Helzner
Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA
Osteoporos Int 16:1675-82. 2005..These results suggest that axial and appendicular bone parameters may be modestly associated with hearing loss in older men, but not in women... - Race and sex differences in age-related hearing loss: the Health, Aging and Body Composition StudyElizabeth P Helzner
Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
J Am Geriatr Soc 53:2119-27. 2005..To determine the prevalence of and risk factors for hearing loss in a sample of 2,052 older adults (aged 73-84; 46.9% male, 37.3% black) enrolled in the Health, Aging and Body Composition (Health ABC) Study... - Peroxisome proliferator-activated receptor-gamma polymorphism, body mass and prostate cancer risk: evidence for gene-environment interactionJoseph M Zmuda
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
Oncology 70:185-9. 2006..Peroxisome proliferator-activated receptor (PPAR)-gamma has been implicated in prostate cancer. In the present case-control study, we tested if a common Pro12Ala polymorphism in PPAR-gamma is associated with the risk of prostate cancer... - Serum 25-hydroxyvitamin D concentrations and risk for hip fracturesJane A Cauley
University of Pittsburgh, Department of Epidemiology, 130 DeSoto Street, Crabtree A524, Pittsburgh, PA 15261, USA
Ann Intern Med 149:242-50. 2008..The relationship between serum 25-hydroxyvitamin D [25(OH) vitamin D] concentration and hip fractures is unclear... - Long-term risk of incident vertebral fracturesJane A Cauley
Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
JAMA 298:2761-7. 2007..Women with low bone mineral density (BMD) and prevalent vertebral fractures have a greater risk of incident vertebral fractures over the short-term, but their absolute risk of vertebral fracture over the long-term is uncertain... - Association of the VDR translation start site polymorphism and fracture risk in older womenSusan P Moffett
Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
J Bone Miner Res 22:730-6. 2007..The high frequency of this variant confers a population attributable risk that is similar to several established risk factors for fracture... - Prevalent vertebral fractures in black women and white womenJane A Cauley
Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
J Bone Miner Res 23:1458-67. 2008..The prevalence of vertebral fractures is lower in black compared with white women but increases with age, low BMD, and number of risk factors... - Reduced peripheral nerve function is related to lower hip BMD and calcaneal QUS in older white and black adults: the Health, Aging, and Body Composition StudyElsa S Strotmeyer
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Bone Miner Res 21:1803-10. 2006..Poor peripheral nerve function may directly affect bone... - Ethnic differences in the frequency and circumstances of falling in older community-dwelling womenKimberly A Faulkner
Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
J Am Geriatr Soc 53:1774-9. 2005..To examine ethnic differences in fall rates and fall circumstances in older community-dwelling Caucasian and African-American women... - Risk factors for breast cancer in older women: the relative contribution of bone mineral density and other established risk factorsJane A Cauley
Department of Epidemiology, University of Pittsburgh, Crabtree Hall A524, Pittsburgh, PA 15261, USA
Breast Cancer Res Treat 102:181-8. 2007..To determine the contribution of bone mineral density (BMD) to breast cancer risk relative to other established breast cancer risk factors in postmenopausal women with osteoporosis... - Raloxifene reduces risk of vertebral fractures [corrected] in postmenopausal women regardless of prior hormone therapyOlaf Johnell
Department of Orthopedics, Universitetssjukhuset MAS, SE 20502 Malmo, Sweden
J Fam Pract 53:789-96. 2004..We examined whether past use of hormone therapy influences the effects of raloxifene on the risk of new vertebral fracture, cardiovascular events, or breast cancer... - Continuing outcomes relevant to Evista: breast cancer incidence in postmenopausal osteoporotic women in a randomized trial of raloxifeneSilvana Martino
Cancer Institute Medical Group, 2001 Santa Monica Blvd, Ste 560W, Santa Monica, CA 90404, USA
J Natl Cancer Inst 96:1751-61. 2004..We conducted the Continuing Outcomes Relevant to Evista (CORE) trial to examine the effect of 4 additional years of raloxifene therapy on the incidence of invasive breast cancer in women in MORE who agreed to continue in CORE... - Diabetes and bone loss at the hip in older black and white adultsAnn V Schwartz
Department of Epidemiology and Biostatistics, University of California, San Francisco, California 94105, USA
J Bone Miner Res 20:596-603. 2005.... - Ethnic variation in bone turnover in pre- and early perimenopausal women: effects of anthropometric and lifestyle factorsJoel S Finkelstein
Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA. org
J Clin Endocrinol Metab 87:3051-6. 2002..Other factors, such as differences in bone accretion, are likely responsible for much of the ethnic variation in adult BMD... - Postmenopausal bilateral oophorectomy is not associated with increased fracture risk in older womenDiana M Antoniucci
Division of Endocrinology, Department of Medicine, University of California, San Francisco, California 94105, USA
J Bone Miner Res 20:741-7. 2005..There was no association between postmenopausal oophorectomy and the risk of hip or vertebral fractures... - Serum estradiol level and risk of breast cancer during treatment with raloxifeneSteven R Cummings
Coordinating Center, University of California, Suite 600, 74 New Montgomery St, San Francisco, CA 94105, USA
JAMA 287:216-20. 2002..Raloxifene competes with endogenous estrogen for binding to estrogen receptors in breast tissue. A woman's estradiol level may alter the effects of raloxifene on breast cancer and other outcomes... - Diabetes and incidence of functional disability in older womenEdward W Gregg
Division of Diabetes Translation, National Center for Chronic Disease and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
Diabetes Care 25:61-7. 2002..To examine the relationship between diabetes and the incidence of functional disability and to determine the predictors of functional disability among older women with diabetes... - Risk-benefit profile for raloxifene: 4-year data From the Multiple Outcomes of Raloxifene Evaluation (MORE) randomized trialElizabeth Barrett-Connor
Division of Epidemiology, Department of Family and Preventive Medicine, University of California at San Diego, La Jolla, California 92093 0607, USA
J Bone Miner Res 19:1270-5. 2004..39% and 1.83% in the raloxifene and placebo groups, respectively (HR, 0.75; 95% CI, 0.62-0.92), compatible with a favorable risk-benefit profile for raloxifene for treating postmenopausal osteoporosis... - One- and two-year change in body composition as measured by DXA in a population-based cohort of older men and womenMarjolein Visser
Institute for Research in Extramural Medicine, Vrije University Medical Center, 1081 BT Amsterdam, The Netherlands
J Appl Physiol 94:2368-74. 2003..Loss of ALST was greater in men compared with women, and greater in blacks compared with whites, suggesting that men and blacks may be more prone to muscle loss... - Statin use, clinical fracture, and bone density in postmenopausal women: results from the Women's Health Initiative Observational StudyAndrea Z LaCroix
Women's Health Initiative Clinical Coordinating Center, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, MP-1002, PO Box 19024, Seattle, Washington 98109-1024, USA
Ann Intern Med 139:97-104. 2003..CONCLUSION: Statin use did not improve fracture risk or bone density in the Women's Health Initiative Observational Study. The cumulative evidence does not warrant use of statins to prevent or treat osteoporosis... - Lower extremity physical performance and hip bone mineral density in elderly black and white men and women: cross-sectional associations in the Health ABC StudyDennis R Taaffe
The Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, USA
J Gerontol A Biol Sci Med Sci 58:M934-42. 2003..However, it is unclear if these factors coexist or are independent in elderly people, and if a relationship does exist, whether it varies by sex and/or race... - Bone loss predicts subsequent cognitive decline in older women: the study of osteoporotic fracturesLi Yung Lui
Department of Medicine, University of California at San Francisco, San Francisco, California 94105, USA
J Am Geriatr Soc 51:38-43. 2003..To determine whether the rate of bone loss predicts subsequent cognitive decline independently of baseline bone mass and whether apolipoprotein E (ApoE) genotype explains the association... - Glycemic effects of postmenopausal hormone therapy: the Heart and Estrogen/progestin Replacement Study. A randomized, double-blind, placebo-controlled trialAlka M Kanaya
Division of General Internal Medicine, University of California, San Francisco, 1701 Divisadero Street, Suite 536, San Francisco, CA 94143 1732, USA
Ann Intern Med 138:1-9. 2003..Randomized trials of postmenopausal hormone therapy have found differing effects on fasting glucose levels. No trial has evaluated the effect of hormone therapy on diabetes incidence... - Menopausal symptoms in older women and the effects of treatment with hormone therapyVanessa M Barnabei
Medical College of Wisconsin, Milwaukee 53226, USA
Obstet Gynecol 100:1209-18. 2002..The frequency and severity of such symptoms and response to hormone therapy in older women have not been well documented... - Depressive symptoms and bone mineral density in older menMary A Whooley
San Francisco Department of Veterans Affairs Medical Center, 4150 Clement Street 111A1, San Francisco, CA 94121, USA
J Geriatr Psychiatry Neurol 17:88-92. 2004..These findings suggest that depressive symptoms are not associated with BMD in community-dwelling, older men... - Older women with diabetes have a higher risk of falls: a prospective studyAnn V Schwartz
Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA
Diabetes Care 25:1749-54. 2002..To determine whether older women with diabetes have an increased risk of falls and whether known risk factors for falls account for any increased risk... - Ethnic variation in bone density in premenopausal and early perimenopausal women: effects of anthropometric and lifestyle factorsJoel S Finkelstein
Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA. org
J Clin Endocrinol Metab 87:3057-67. 2002..Femoral neck BMD is highest in African-Americans and similar in Chinese, Japanese, and Caucasians. These findings may explain why Caucasian women have higher fracture rates than African-Americans and Asians... - Oral daily ibandronate prevents bone loss in early postmenopausal women without osteoporosisMichael R McClung
Oregon Osteoporosis Center, Portland, Oregon 97213, USA
J Bone Miner Res 19:11-8. 2004..1% and 1.8%, respectively; p < or = 0.0001 versus placebo) with 2.5 mg ibandronate after 24 months. Oral ibandronate is a promising option for the prevention of postmenopausal bone loss... - Prediction of clinical non-spine fractures in older black and white men and women with volumetric BMD of the spine and areal BMD of the hip: the Health, Aging, and Body Composition Study*Dawn C Mackey
San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, CA 94107, USA
J Bone Miner Res 22:1862-8. 2007..4 yr), vertebral TrvBMD from QCT predicted non-spine fracture in black and white women and black men, but it was not a stronger predictor than total hip aBMD from DXA. Hip aBMD predicted non-spine fracture in black men... - Cystatin-C, renal function, and incidence of hip fracture in postmenopausal womenAndrea Z LaCroix
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
J Am Geriatr Soc 56:1434-41. 2008..To evaluate the association between chronic kidney disease and incident hip fracture using serum cystatin-C as a biomarker of renal function calculated without reference to muscle mass... - Mammographic density in a multiethnic cohortLaurel A Habel
Division of Research, Kaiser Permanente, Oakland, CA 94612, USA
Menopause 14:891-9. 2007..To compare mammographic density among premenopausal and early perimenopausal women from four racial/ethnic groups and to examine density and acculturation among Japanese and Chinese women... - Binocular visual-field loss increases the risk of future falls in older white womenAnne L Coleman
Jules Stein Eye Institute, Los Angeles, CA 90095, USA
J Am Geriatr Soc 55:357-64. 2007..To examine the relationship between binocular visual field loss and the risk of incident frequent falls in older white women... - Women who maintain optimal cognitive function into old ageDeborah E Barnes
Department of Psychiatry, University of California at San Francisco, Scan Francisco, California, USA
J Am Geriatr Soc 55:259-64. 2007..To determine whether older women who maintain optimal cognitive function into old age differ from those who experience minor cognitive decline typically associated with normal aging... - Renal function and risk of hip and vertebral fractures in older womenKristine E Ensrud
Center for Chronic Disease Outcomes Research, VA Medical Center, Minneapolis, MN 55417, USA
Arch Intern Med 167:133-9. 2007..An increased rate of hip fractures has been reported in patients with end-stage renal disease, but the effect of less severe renal dysfunction on fracture risk is uncertain... - Effects of continuing or stopping alendronate after 5 years of treatment: the Fracture Intervention Trial Long-term Extension (FLEX): a randomized trialDennis M Black
San Francisco Coordinating Center, Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94107, USA
JAMA 296:2927-38. 2006..The optimal duration of treatment of women with postmenopausal osteoporosis is uncertain... - Patterns and correlates of muscle strength loss in older womenKimberly Y Z Forrest
Department of Health and Safety, Slippery Rock University of Pennsylvania, Slippery Rock, PA 16057, USA
Gerontology 53:140-7. 2007..The aging process is associated with progressive declines in muscle strength, resulting in functional disability and reduced quality of life...
Research Grants
- 3 of 4: Study of Osteoporotic Fractures (SOF)-Pittsburgh Clinical CenterJane Cauley; Fiscal Year: 2010..The SOF Coordinating Center was funded for 5 years;SOF clinical centers for 3 years. In order to meet these aims, two years of support is requested for the SOF clinical centers. ..
- Estradiol, Cytokines & Bone Turnover--Effects on FractureJane Cauley; Fiscal Year: 2007..Improved understanding of the biological mechanisms for these associations could lead to the development and testing of preventive intervention. ..
- Outcomes of Sleep Disorders in Older Men - PittsburghJane Cauley; Fiscal Year: 2007..We will also supplement the bank of MrOS specimens to allow for testing of future hypotheses concerning the role of sleep in the development of age-related diseases and conditions. ..
- TRAINING IN THE EPIDEMIOLOGY OF AGINGJane Cauley; Fiscal Year: 2007....
- Hip Strength Across the Menopausal TransitionJane Cauley; Fiscal Year: 2007..Our long-term objective is to substantially improve our understanding of the impact of aging and menopause on measures of hip size, structure, and strength in a well-characterized multiethnic cohort of mid-life women. ..
- Osteoporotic Fractures in Men - Renewal: PittsburghJane Cauley; Fiscal Year: 2007....
- STUDY OF OSTEOPOROTIC FRACTURESJane Cauley; Fiscal Year: 2007..If our hypotheses are born out, this may lead to trials and recommendations about lifestyle, Vitamin D supplementation, or medication, to promote high levels of function late in life. ..
- Hip Strength Across the Menopausal TransitionJane Cauley; Fiscal Year: 2010..Our long-term objective is to substantially improve our understanding of the impact of aging and menopause on measures of hip size, structure, and strength in a well-characterized multiethnic cohort of mid-life women. ..
- Hip Strength Across the Menopausal TransitionJane Cauley; Fiscal Year: 2009..Our long-term objective is to substantially improve our understanding of the impact of aging and menopause on measures of hip size, structure, and strength in a well-characterized multiethnic cohort of mid-life women. ..
- 3 of 4: Study of Osteoporotic Fractures (SOF)-Pittsburgh Clinical CenterJane Cauley; Fiscal Year: 2009..The SOF Coordinating Center was funded for 5 years; SOF clinical centers for 3 years. In order to meet these aims, two years of support is requested for the SOF clinical centers. ..
- STUDY OF OSTEOPOROTIC FRACTURESJane Cauley; Fiscal Year: 2005....
- RISK FACTORS FOR HIP AND COLLES' FRACTURESJane Cauley; Fiscal Year: 1991..The results of our study will guide future research and rationalize clinical and public health efforts to prevent these fractures...
- OSTEOPOROTIC FRACTURESJane Cauley; Fiscal Year: 2001..We propose using our archived DNA specimens and existing data about hip and vertebral fractures, breast cancer, bone mass, serum sex hormones and lipoproteins to determine whether these ER variations have biological importance. ..
- FRACTURES IN OLDER WOMENJane Cauley; Fiscal Year: 1993..Continued study of this unique cohort is likely to produce important advances in understanding and preventing fractures in older women...