Jane A Cauley

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint The Women's Health Initiative: Hormone Therapy and Calcium/Vitamin D supplementation trials
    Jane A Cauley
    Graduate School of Public Health, Department of Epidemiology, University of Pittsburgh, 130 DeSoto St, Crabtree A510, Pittsburgh, PA, 15261, USA
    Curr Osteoporos Rep 11:171-8. 2013
  2. pmc Public health impact of osteoporosis
    Jane A Cauley
    DRPH, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261
    J Gerontol A Biol Sci Med Sci 68:1243-51. 2013
  3. pmc Objective measures of physical activity, fractures and falls: the osteoporotic fractures in men study
    Jane A Cauley
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Am Geriatr Soc 61:1080-8. 2013
  4. pmc Bone resorption and fracture across the menopausal transition: the Study of Women's Health Across the Nation
    Jane A Cauley
    Department of Epidemiology, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Menopause 19:1200-7. 2012
  5. pmc Race/ethnic differences in bone mineral densities in older men
    H S Nam
    Department of Preventive Medicine, Research Institute for Medical Sciences, Chungnam National University College of Medicine, Daejeon, South Korea
    Osteoporos Int 21:2115-23. 2010
  6. pmc Postmenopausal hormones and sleep quality in the elderly: a population based study
    Gregory J Tranah
    CPMC Research Institute, San Francisco, CA, USA
    BMC Womens Health 10:15. 2010
  7. pmc Indicators of "healthy aging" in older women (65-69 years of age). A data-mining approach based on prediction of long-term survival
    William R Swindell
    Department of Pathology, University of Michigan, School of Medicine, Ann Arbor, MI 48109 2200, USA
    BMC Geriatr 10:55. 2010
  8. ncbi request reprint Risk factors for breast cancer in older women: the relative contribution of bone mineral density and other established risk factors
    Jane A Cauley
    Department of Epidemiology, University of Pittsburgh, Crabtree Hall A524, Pittsburgh, PA 15261, USA
    Breast Cancer Res Treat 102:181-8. 2007
  9. ncbi request reprint Osteoporosis in men: prevalence and investigation
    Jane A Cauley
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    Clin Cornerstone 8:S20-5. 2006
  10. ncbi request reprint Inflammatory markers and incident fracture risk in older men and women: the Health Aging and Body Composition Study
    Jane A Cauley
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Bone Miner Res 22:1088-95. 2007

Collaborators

Detail Information

Publications141 found, 100 shown here

  1. ncbi request reprint The Women's Health Initiative: Hormone Therapy and Calcium/Vitamin D supplementation trials
    Jane A Cauley
    Graduate School of Public Health, Department of Epidemiology, University of Pittsburgh, 130 DeSoto St, Crabtree A510, Pittsburgh, PA, 15261, USA
    Curr Osteoporos Rep 11:171-8. 2013
    ..Overall, the common practice of taking calcium and vitamin D supplementation with possible benefits on hip and positive evidence on bone mineral density and few risks is reasonable. ..
  2. pmc Public health impact of osteoporosis
    Jane A Cauley
    DRPH, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261
    J Gerontol A Biol Sci Med Sci 68:1243-51. 2013
    ..To describe the public health impact of osteoporosis including the magnitude of the problem and important consequences of osteoporotic fractures...
  3. pmc Objective measures of physical activity, fractures and falls: the osteoporotic fractures in men study
    Jane A Cauley
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Am Geriatr Soc 61:1080-8. 2013
    ..To determine the association between objectively measured physical activity (PA), fractures, and falls...
  4. pmc Bone resorption and fracture across the menopausal transition: the Study of Women's Health Across the Nation
    Jane A Cauley
    Department of Epidemiology, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Menopause 19:1200-7. 2012
    ..Bone turnover markers (BTMs) predict fracture in older women, whereas data on younger women are lacking. To test the hypothesis that BTMs measured before and after menopause predict fracture risk, we performed a cohort study of 2,305 women...
  5. pmc Race/ethnic differences in bone mineral densities in older men
    H S Nam
    Department of Preventive Medicine, Research Institute for Medical Sciences, Chungnam National University College of Medicine, Daejeon, South Korea
    Osteoporos Int 21:2115-23. 2010
    ..Additional adjustment for body size greatly attenuated or reversed the differences between US Caucasian men vs Asian men. It illustrates the role of body size on the difference between these groups...
  6. pmc Postmenopausal hormones and sleep quality in the elderly: a population based study
    Gregory J Tranah
    CPMC Research Institute, San Francisco, CA, USA
    BMC Womens Health 10:15. 2010
    ..Using data from the multicenter Study of Osteoporotic Fractures (SOF), we tested the relationship between HT and sleep-wake estimated from actigraphy...
  7. pmc Indicators of "healthy aging" in older women (65-69 years of age). A data-mining approach based on prediction of long-term survival
    William R Swindell
    Department of Pathology, University of Michigan, School of Medicine, Ann Arbor, MI 48109 2200, USA
    BMC Geriatr 10:55. 2010
    ..The aims of this study were to identify predictors of long-term survival in older women and to develop a multivariable model based upon longitudinal data from the Study of Osteoporotic Fractures (SOF)...
  8. ncbi request reprint Risk factors for breast cancer in older women: the relative contribution of bone mineral density and other established risk factors
    Jane A Cauley
    Department of Epidemiology, University of Pittsburgh, Crabtree Hall A524, Pittsburgh, PA 15261, USA
    Breast Cancer Res Treat 102:181-8. 2007
    ..To determine the contribution of bone mineral density (BMD) to breast cancer risk relative to other established breast cancer risk factors in postmenopausal women with osteoporosis...
  9. ncbi request reprint Osteoporosis in men: prevalence and investigation
    Jane A Cauley
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    Clin Cornerstone 8:S20-5. 2006
    ..Routine analyses of blood and biochemistry should be carried out in any older male patient with newly diagnosed osteoporosis. Dual x-ray energy absorptiometry should be performed on every new patient with newly diagnosed osteoporosis...
  10. ncbi request reprint Inflammatory markers and incident fracture risk in older men and women: the Health Aging and Body Composition Study
    Jane A Cauley
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Bone Miner Res 22:1088-95. 2007
    ..We tested this hypothesis in relationship to fractures in 2985 men and women enrolled in the Health ABC study. Results showed that subjects with the greatest number of inflammatory markers have the highest risk of fracture...
  11. pmc Sex steroid hormones in older men: longitudinal associations with 4.5-year change in hip bone mineral density--the osteoporotic fractures in men study
    Jane A Cauley
    University of Pittsburgh, Department of Epidemiology, 130 DeSoto Street, Crabtree A524, Pittsburgh, Pennsylvania 15261, USA
    J Clin Endocrinol Metab 95:4314-23. 2010
    ..There is limited information on the association between sex hormones and bone loss in older men...
  12. pmc Correlates of trabecular and cortical volumetric bone mineral density at the femoral neck and lumbar spine: the osteoporotic fractures in men study (MrOS)
    Jane A Cauley
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Bone Miner Res 25:1958-71. 2010
    ..There was no relationship between sex hormones and femoral neck trabecular vBMD. Our conclusion is that correlates of trabecular vBMD and cortical vBMD appear to differ in older men...
  13. doi request reprint Once-yearly zoledronic acid and days of disability, bed rest, and back pain: randomized, controlled HORIZON Pivotal Fracture Trial
    Jane A Cauley
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Bone Miner Res 26:984-92. 2011
    ....
  14. pmc Serum 25-hydroxyvitamin D and clinical fracture risk in a multiethnic cohort of women: the Women's Health Initiative (WHI)
    Jane A Cauley
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Bone Miner Res 26:2378-88. 2011
    ..Our results suggest divergent associations between 25(OH)D and fracture by race/ethnicity. The optimal level of 25(OH)D for skeletal health may differ in white and black women...
  15. pmc Successful skeletal aging: a marker of low fracture risk and longevity. The Study of Osteoporotic Fractures (SOF)
    Jane A Cauley
    University of Pittsburgh, Department of Epidemiology, Pittsburgh, Pennsylvania 15261, USA
    J Bone Miner Res 24:134-43. 2009
    ..These women experienced a lower risk of fractures, disability, and mortality, suggesting that this phenotype may be a marker of successful aging...
  16. pmc Serum 25-hydroxyvitamin D concentrations and risk for hip fractures
    Jane A Cauley
    University of Pittsburgh, Department of Epidemiology, 130 DeSoto Street, Crabtree A524, Pittsburgh, PA 15261, USA
    Ann Intern Med 149:242-50. 2008
    ..The relationship between serum 25-hydroxyvitamin D [25(OH) vitamin D] concentration and hip fractures is unclear...
  17. ncbi request reprint Clinical risk factors for fractures in multi-ethnic women: the Women's Health Initiative
    Jane A Cauley
    Department of Epidemiology, University of Pittsburgh, Graduate School of Public Health, Pittsburgh, Pennsylvania, USA
    J Bone Miner Res 22:1816-26. 2007
    ..However, irrespective of their ethnicity, women with multiple risk factors have a high risk of fracture. Targeting these high-risk women for screening and intervention could reduce fractures...
  18. pmc Serum 25-hydroxyvitamin D and the risk of hip and nonspine fractures in older men
    Jane A Cauley
    University of Pittsburgh, Department of Epidemiology, Pittsburgh, Pennsylvania 15261, USA
    J Bone Miner Res 25:545-53. 2010
    ..065 for trend). Low serum 25(OH)D concentrations are associated with a higher risk of hip fracture in older men. Measurement of 25(OH)D may be useful in identifying men at high risk of hip fracture...
  19. doi request reprint Long-term risk of incident vertebral fractures
    Jane A Cauley
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    JAMA 298:2761-7. 2007
    ..Women with low bone mineral density (BMD) and prevalent vertebral fractures have a greater risk of incident vertebral fractures over the short-term, but their absolute risk of vertebral fracture over the long-term is uncertain...
  20. pmc Baseline serum estradiol and fracture reduction during treatment with hormone therapy: the Women's Health Initiative randomized trial
    J A Cauley
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Osteoporos Int 21:167-77. 2010
    ..The purpose of the study was to test the hypothesis that the reduction in fractures with hormone therapy (HT) is greater in women with lower estradiol levels...
  21. pmc Prevalent vertebral fractures in black women and white women
    Jane A Cauley
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Bone Miner Res 23:1458-67. 2008
    ..The prevalence of vertebral fractures is lower in black compared with white women but increases with age, low BMD, and number of risk factors...
  22. pmc Incidence of fractures compared to cardiovascular disease and breast cancer: the Women's Health Initiative Observational Study
    J A Cauley
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Osteoporos Int 19:1717-23. 2008
    ..The projected number of fractures was similar to or exceeded the combined number of cardiovascular events and breast cancers. Osteoporosis prevention efforts should target women of all ethnicities...
  23. pmc Risk factors for severity and type of the hip fracture
    Jane A Cauley
    University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Bone Miner Res 24:943-55. 2009
    ..Little difference was reported in the self-reported circumstances surrounding each type of fracture. In conclusion, the lower the BMD, the greater the likelihood of experiencing a hip fracture that is less displaced and more stable...
  24. ncbi request reprint Estrogen metabolizing polymorphisms and breast cancer risk among older white women
    Francesmary Modugno
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA, USA
    Breast Cancer Res Treat 93:261-70. 2005
    ..To investigate breast cancer risk according to metabolizing genes polymorphisms in older women...
  25. pmc Sex hormone levels and risk of breast cancer with estrogen plus progestin
    Ghada N Farhat
    Affiliations of authors San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, CA GNF, NP, SRC Faculty of Health Sciences, University of Balamand, Beirut, Lebanon GNF Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA RTC Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA JEM Fred Hutchinson Cancer Research Center, Seattle, WA GA, AZL Department of Internal Medicine, University of California San Francisco, San Francisco, CA AH, DG Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA EV Department of Internal Medicine, University of California Davis, Sacramento, CA JSL Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA JAC Department of Internal Medicine, Ohio State University, Columbus, OH RJ Department of Preventive Medicine, Stony Brook University, Stony Brook, NY DL Department of Medicine, Emory University, Atlanta, GA LP Karmanos Cancer Institute, Wayne State University, Detroit, MI MSS
    J Natl Cancer Inst 105:1496-503. 2013
    ..Although high endogenous sex hormone levels and estrogen plus progestin (E+P) therapy are associated with increased breast cancer risk, it is unknown whether pretreatment levels of sex hormones modify E+P effect on breast cancer...
  26. ncbi request reprint Nontraumatic fracture risk with diabetes mellitus and impaired fasting glucose in older white and black adults: the health, aging, and body composition study
    Elsa S Strotmeyer
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Arch Intern Med 165:1612-7. 2005
    ..Diabetes mellitus (DM) and related complications may increase clinical fracture risk in older adults...
  27. pmc Association analysis of WNT10B with bone mass and structure among individuals of African ancestry
    Joseph M Zmuda
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Bone Miner Res 24:437-47. 2009
    ..This analysis implicates the WNT10B locus as a genetic element in the regulation of bone mass and structural geometry...
  28. ncbi request reprint Reduced peripheral nerve function is related to lower hip BMD and calcaneal QUS in older white and black adults: the Health, Aging, and Body Composition Study
    Elsa S Strotmeyer
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Bone Miner Res 21:1803-10. 2006
    ..Poor peripheral nerve function may directly affect bone...
  29. pmc Familial resemblance and shared latent familial variance in recurrent fall risk in older women
    Kimberly A Faulkner
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto St, A 551, Pittsburgh, PA 15261, USA
    J Appl Physiol (1985) 108:1142-7. 2010
    ..A possible familial component to fracture risk may be mediated through a genetic liability to fall recurrently...
  30. ncbi request reprint Longitudinal study of changes in hip bone mineral density in Caucasian and African-American women
    Jane A Cauley
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Am Geriatr Soc 53:183-9. 2005
    ..To determine whether changes in hip bone mineral density (BMD) differ in Caucasian and African American women...
  31. doi request reprint Influence of estrogen plus testosterone supplementation on breast cancer
    Roberta B Ness
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Arch Intern Med 169:41-6. 2009
    ..We sought to examine the relationship between the use of estrogen plus testosterone (E + T) therapy (esterified estradiol plus methyltestosterone) and the occurrence of breast cancer...
  32. pmc Calcium plus vitamin D supplementation and health outcomes five years after active intervention ended: the Women's Health Initiative
    Jane A Cauley
    1 University of Pittsburgh, Pittsburgh, Pennsylvania
    J Womens Health (Larchmt) 22:915-29. 2013
    ..0 years of active intervention. We now report outcomes 4.9 years after the intervention stopped and cumulative findings...
  33. pmc Natural history and correlates of hip BMD loss with aging in men of African ancestry: the Tobago Bone Health Study
    Yahtyng Sheu
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Bone Miner Res 24:1290-8. 2009
    ..Additional studies are needed to better define the natural history and factors underlying bone loss with aging in men of African ancestry...
  34. ncbi request reprint Factors associated with the lumbar spine and proximal femur bone mineral density in older men
    Jane A Cauley
    Department of Epidemiology, University of Pittsburgh, 130 DeSoto Street, Crabtree Hall A524, Pittsburgh, PA 15261, USA
    Osteoporos Int 16:1525-37. 2005
    ..Identification of these correlates could improve methods to identify men at risk for fracture and improve our understanding of fracture etiology...
  35. doi request reprint Baseline mammographic breast density and the risk of invasive breast cancer in postmenopausal women participating in the NSABP study of tamoxifen and raloxifene (STAR)
    Reena S Cecchini
    NSABP Biostatistical Center, One Sterling Plaza, Pittsburgh, PA 15213, USA
    Cancer Prev Res (Phila) 5:1321-9. 2012
    ....
  36. ncbi request reprint Middle-aged premenopausal women with type 1 diabetes have lower bone mineral density and calcaneal quantitative ultrasound than nondiabetic women
    Elsa S Strotmeyer
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 North Bellefield Ave, Room 519, Pittsburgh, PA 15213, USA
    Diabetes Care 29:306-11. 2006
    ..To determine whether middle-aged premenopausal women with type 1 diabetes had more self-reported fractures and lower bone mineral density (BMD) compared with nondiabetic women...
  37. pmc Bioactive androgens and glucuronidated androgen metabolites are associated with subcutaneous and ectopic skeletal muscle adiposity among older black men
    Iva Miljkovic
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Metabolism 60:1178-85. 2011
    ..Longitudinal studies are needed to further evaluate the relationship between androgens and androgen metabolites with changes in skeletal muscle fat distribution with aging and the incidence of T2DM...
  38. pmc Poor sleep is associated with poorer physical performance and greater functional limitations in older women
    Suzanne E Goldman
    Department of Epidemiology, University ofPittsburgh, Pittsburgh, PA, USA
    Sleep 30:1317-24. 2007
    ..This study examined the association between disturbed sleep and poorer daytime function in older women...
  39. ncbi request reprint Multitasking: association between poorer performance and a history of recurrent falls
    Kimberly A Faulkner
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Am Geriatr Soc 55:570-6. 2007
    ..To examine the association between poorer performance on concurrent walking and reaction time and recurrent falls...
  40. pmc Functional characterization of genetic variation in the Frizzled 1 (FZD1) promoter and association with bone phenotypes: more to the LRP5 story?
    Laura M Yerges
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Bone Miner Res 24:87-96. 2009
    ..This study indicates that a cis-regulatory polymorphism in the FZD1 promoter region may have a functional role in determining bone structural geometry...
  41. pmc Correlates of trabecular and cortical volumetric bone mineral density of the radius and tibia in older men: the Osteoporotic Fractures in Men Study
    Kamil E Barbour
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Bone Miner Res 25:1017-28. 2010
    ..An ascertainment of potential risk factors associated with trabecular and cortical vBMD may lead to better understanding and preventive efforts for osteoporosis in men...
  42. pmc Candidate gene analysis of femoral neck trabecular and cortical volumetric bone mineral density in older men
    Laura M Yerges
    Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Bone Miner Res 25:330-8. 2010
    ..These findings identify novel genetic variants for cortical and trabecular vBMD and raise the possibility that some genetic loci may be unique for each bone compartment...
  43. ncbi request reprint Race and sex differences in age-related hearing loss: the Health, Aging and Body Composition Study
    Elizabeth P Helzner
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Am Geriatr Soc 53:2119-27. 2005
    ..To determine the prevalence of and risk factors for hearing loss in a sample of 2,052 older adults (aged 73-84; 46.9% male, 37.3% black) enrolled in the Health, Aging and Body Composition (Health ABC) Study...
  44. pmc The association of bone mineral density with prostate cancer risk in the Osteoporotic Fractures in Men (MrOS) Study
    Ghada N Farhat
    University of Pittsburgh, Department of Epidemiology and Division of Cancer Prevention and Population Science, University of Pittsburgh Medical Center, Cancer Pavilion, Suite 4C, 5150 Centre Avenue, Pittsburgh, PA 15232, USA
    Cancer Epidemiol Biomarkers Prev 18:148-54. 2009
    ..However, no associations were observed with low-grade disease. Our results provide support for an inverse association between BMD and PCa risk. Possible pathophyisological mechanisms linking BMD and PCa should be elucidated...
  45. ncbi request reprint Ethnic differences in the frequency and circumstances of falling in older community-dwelling women
    Kimberly A Faulkner
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Am Geriatr Soc 53:1774-9. 2005
    ..To examine ethnic differences in fall rates and fall circumstances in older community-dwelling Caucasian and African-American women...
  46. pmc Bone strength measured by peripheral quantitative computed tomography and the risk of nonvertebral fractures: the osteoporotic fractures in men (MrOS) study
    Yahtyng Sheu
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Bone Miner Res 26:63-71. 2011
    ..73 to 0.80). Peripheral bone strength measures are associated with fracture risk and may improve our ability to identify older men at high risk of fracture...
  47. ncbi request reprint Association of the VDR translation start site polymorphism and fracture risk in older women
    Susan P Moffett
    Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Bone Miner Res 22:730-6. 2007
    ..The high frequency of this variant confers a population attributable risk that is similar to several established risk factors for fracture...
  48. pmc Inflammation and thrombosis biomarkers and incident frailty in postmenopausal women
    Alexander P Reiner
    Women s Health Initiative Clinical Coordinating Center, Fred Hutchinson Cancer Research Center, Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195, USA
    Am J Med 122:947-54. 2009
    ....
  49. ncbi request reprint Magnesium intake, bone mineral density, and fractures: results from the Women's Health Initiative Observational Study
    Tonya S Orchard
    Department of Human Nutrition, College of Education and Human Ecology TSO and the Division of Endocrinology, Diabetes, and Metabolism, College of Medicine NA and RDJ, The Ohio State University, Columbus, OH TSO the Fred Hutchinson Cancer Research Center, Seattle, WA JCL and AZL the Nationwide Children s Hospital, Columbus, OH SB T the Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA JAC the Epidemiology and Biostatistics Division, University of Arizona, Tucson, AZ ZC and the Departments of Social and Preventive Medicine and Gynecology Obstetrics, University at Buffalo, Buffalo, NY JW W
    Am J Clin Nutr 99:926-33. 2014
    ..Magnesium is a necessary component of bone, but its relation to osteoporotic fractures is unclear...
  50. pmc Abdominal myosteatosis is independently associated with hyperinsulinemia and insulin resistance among older men without diabetes
    Iva Miljkovic
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Obesity (Silver Spring) 21:2118-25. 2013
    ..It remains unclear if myosteatosis is associated to glucose and insulin homeostasis independent of total and central adiposity...
  51. ncbi request reprint Body mass index and mortality among older breast cancer survivors in the Study of Osteoporotic Fractures
    Katherine W Reeves
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 516A Parran Hall, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Cancer Epidemiol Biomarkers Prev 16:1468-73. 2007
    ..This study investigated the association between BMI and mortality after breast cancer diagnosis in a cohort of older Caucasian women enrolled in the Study of Osteoporotic Fractures...
  52. ncbi request reprint Association of the G-174C variant in the interleukin-6 promoter region with bone loss and fracture risk in older women
    Susan P Moffett
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Bone Miner Res 19:1612-8. 2004
    ..Variation at the IL-6 locus may contribute to the genetic susceptibility to bone fragility...
  53. ncbi request reprint Racial/ethnic differences in bone mineral density among older women
    Hae Sung Nam
    Department of Preventive Medicine and Public Health, Research Institute for Medical Sciences, Chungnam National University School of Medicine, Daejeon, South Korea
    J Bone Miner Metab 31:190-8. 2013
    ..These findings show substantial racial/ethnic differences in BMD even within African or Asian origin individuals, and highlight the contributing role of body weight and estrogen use to the geographic and racial/ethnic variation in BMD...
  54. pmc Greater adipose tissue infiltration in skeletal muscle among older men of African ancestry
    Iva Miljkovic
    Department of Epidemiology, Center for Aging and Population Health, University of Pittsburgh, 130 North Bellefield Avenue, Room 542, Pittsburgh, PA 15213, USA
    J Clin Endocrinol Metab 94:2735-42. 2009
    ..Skeletal muscle fat has been identified as an important depot that increases with aging and may contribute to the development of diabetes...
  55. pmc Changes in bone resorption across the menopause transition: effects of reproductive hormones, body size, and ethnicity
    MaryFran R Sowers
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Clin Endocrinol Metab 98:2854-63. 2013
    ..Our objective was to characterize changes in bone resorption in relation to the final menstrual period (FMP), reproductive hormones, body mass index (BMI), and ethnicity...
  56. ncbi request reprint Bone mineral density and the risk of incident nonspinal fractures in black and white women
    Jane A Cauley
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    JAMA 293:2102-8. 2005
    ..Black women have a lower rate of fracture than white women, but whether bone mineral density (BMD) predicts fracture risk as well in black women as it does in white women is not established...
  57. ncbi request reprint Diabetes is associated independently of body composition with BMD and bone volume in older white and black men and women: The Health, Aging, and Body Composition Study
    Elsa S Strotmeyer
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Bone Miner Res 19:1084-91. 2004
    ..Diabetes predicted higher hip, whole body, and volumetric spine BMD, and lower spine bone volume, independent of body composition and fasting insulin...
  58. pmc Low prevalence of vitamin D deficiency in elderly Afro-Caribbean men
    Iva Miljkovic
    Department of Epidemiology, Graduate School of Public Health, Pittsburgh, University of Pittsburgh, PA 15213, USA
    Ethn Dis 21:79-84. 2011
    ..Longitudinal studies are needed to delineate the possible effects of high vitamin D levels in this population on major diseases hypothesized to be associated with vitamin D deficiency...
  59. ncbi request reprint Association of estrogen receptor alpha polymorphisms with breast cancer risk in older Caucasian women
    Francesmary Modugno
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Int J Cancer 116:984-91. 2005
    ..60 vs. 1.12 for nulliparous vs. parous women; interaction p = 0.03). ESR1 polymorphisms in combination with lifestyle factors may be associated with breast cancer risk in older Caucasian women...
  60. ncbi request reprint Lipid-lowering drug use and breast cancer in older women: a prospective study
    Jane A Cauley
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Womens Health (Larchmt) 12:749-56. 2003
    ..To test the hypothesis that use of lipid-lowering drugs reduces the risk of breast cancer in older women...
  61. ncbi request reprint Effect of raloxifene on sexual function in older postmenopausal women with osteoporosis
    Francesmary Modugno
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Obstet Gynecol 101:353-61. 2003
    ..To assess the effect of raloxifene compared with placebo on sexual function in older postmenopausal women undergoing therapy for the treatment of osteoporosis...
  62. ncbi request reprint Effects of estrogen plus progestin on risk of fracture and bone mineral density: the Women's Health Initiative randomized trial
    Jane A Cauley
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    JAMA 290:1729-38. 2003
    ..In the Women's Health Initiative trial of estrogen-plus-progestin therapy, women assigned to active treatment had fewer fractures...
  63. pmc Correlates of trabecular and cortical volumetric BMD in men of African ancestry
    Yahtyng Sheu
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsuburgh, Pennsylvania 15261, USA
    J Bone Miner Res 24:1960-8. 2009
    ..Longitudinal studies are needed to gain a better understanding of the mechanisms underlying these differential associations that may show new insight into the etiology of trabecular and cortical bone loss in men...
  64. doi request reprint Association of cumulative lead and neurocognitive function in an occupational cohort
    Naila Khalil
    Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Neuropsychology 23:10-9. 2009
    ..Finally, there was no association with bone lead level and recency of exposure, suggesting that cumulative body burden is most likely responsible for the progressive cognitive decrement evidenced with vulnerability because of aging...
  65. pmc Caregiving, metabolic syndrome indicators, and 1-year decline in walking speed: results of Caregiver-SOF
    Lisa Fredman
    Department of Epidemiology, Boston University School of Public Health 715 Albany Street, Boston, MA 02118, USA
    J Gerontol A Biol Sci Med Sci 65:565-72. 2010
    ..Chronic stress may lead to health decline through metabolic syndrome. Thus, persons in stressful caregiving situations who also have more indicators of metabolic syndrome may experience more decline than other caregivers or noncaregivers...
  66. ncbi request reprint High bone density is associated with prostate cancer in older Afro-Caribbean men: Tobago prostate survey
    Clareann H Bunker
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Cancer Causes Control 17:1083-9. 2006
    ..To test the hypothesis that bone mineral density (BMD), a possible surrogate of lifetime exposure to hormone/growth factor/vitamin D/calcium exposure, is higher in prostate cancer cases than controls...
  67. ncbi request reprint Hearing sensitivity and the risk of incident falls and fracture in older women: the study of osteoporotic fractures
    Elizabeth L Purchase-Helzner
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Ann Epidemiol 14:311-8. 2004
    ..We further hypothesized that decreased bone mineral density would be associated with hearing loss...
  68. pmc Calciotropic hormones and the risk of hip and nonspine fractures in older adults: the Health ABC Study
    Kamil E Barbour
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Bone Miner Res 27:1177-85. 2012
    ..We found limited evidence to support an association between calciotropic hormones and hip and nonspine fractures in older men and women...
  69. pmc Association of blood lead concentrations with mortality in older women: a prospective cohort study
    Naila Khalil
    University of Pittsburgh, Department of Epidemiology, Pittsburgh, PA, USA
    Environ Health 8:15. 2009
    ..We aimed to determine the association between blood lead, all cause and cause specific mortality in elderly, community residing women...
  70. pmc Correlates of bone mineral density among postmenopausal women of African Caribbean ancestry: Tobago women's health study
    Deanna D Hill
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, Pennsylvania 15261, USA
    Bone 43:156-61. 2008
    ..This may reflect low European admixture. Correlates of BMD among Caribbean women of West African ancestry were similar to those reported for U.S. Black and White women...
  71. pmc Relationship of blood lead levels to incident nonspine fractures and falls in older women: the study of osteoporotic fractures
    Naila Khalil
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Bone Miner Res 23:1417-25. 2008
    ..07, 2.45; p trend = 0.014) compared with women with lowest lead level. Blood lead levels are associated with an increased risk of falls and fractures, extending the negative health consequences of lead to include osteoporotic fractures...
  72. pmc Caregiving, mortality, and mobility decline: the Health, Aging, and Body Composition (Health ABC) Study
    Lisa Fredman
    Department of Epidemiology, Boston University School of Public Health, Boston, MA 02118, USA
    Arch Intern Med 168:2154-62. 2008
    ..We hypothesized that caregivers may be more physically active than noncaregivers, which may protect them from health decline...
  73. doi request reprint Official Positions for FRAX® clinical regarding international differences from Joint Official Positions Development Conference of the International Society for Clinical Densitometry and International Osteoporosis Foundation on FRAX®
    Jane A Cauley
    Department of Epidemiology, University of Pittsburgh, PA, USA
    J Clin Densitom 14:240-62. 2011
    ..The statements approved by the panel of experts are discussed in the current paper...
  74. pmc Adipokines and the risk of fracture in older adults
    Kamil E Barbour
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Bone Miner Res 26:1568-76. 2011
    ..More research is needed to understand the physiologic basis underlying these sex differences...
  75. ncbi request reprint Kidney function predicts the rate of bone loss in older individuals: the Cardiovascular Health Study
    Linda F Fried
    VA Pittsburgh Healthcare System, Pittsburgh, PA 15240, USA
    J Gerontol A Biol Sci Med Sci 61:743-8. 2006
    ....
  76. pmc High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men
    Laura M Yerges
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Bone Miner Res 24:2039-49. 2009
    ....
  77. ncbi request reprint Hearing sensitivity and bone mineral density in older adults: the Health, Aging and Body Composition Study
    Elizabeth P Helzner
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA
    Osteoporos Int 16:1675-82. 2005
    ..These results suggest that axial and appendicular bone parameters may be modestly associated with hearing loss in older men, but not in women...
  78. ncbi request reprint Bone mineral density and prevalent vertebral fractures in men and women
    Jane A Cauley
    Department of Epidemiology, University of Pittsburgh, 130 DeSoto Street, Crabtree Hall A524, Pittsburgh, PA 15261, USA
    Osteoporos Int 15:32-7. 2004
    ..Measures of bone mass that partially correct for gender differences in bone size may yield universal estimates of fracture risk. Prospective studies are needed to confirm this observation...
  79. ncbi request reprint Association of lipoprotein(a), insulin resistance, and reproductive hormones in a multiethnic cohort of pre- and perimenopausal women (The SWAN Study)
    MaryFran Sowers
    Department of Epidemiology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Am J Cardiol 92:533-7. 2003
    ..Lp(a) was very modestly associated (r = -0.04) with insulin resistance after adjusting for ethnicity and BMI, and this association was not modified by reproductive hormones, including androgens...
  80. ncbi request reprint Nuclear receptor coactivator-3 alleles are associated with serum bioavailable testosterone, insulin-like growth factor-1, and vertebral bone mass in men
    Yah Tyng Sheu
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Clin Endocrinol Metab 91:307-12. 2006
    ..Nuclear receptor coactivator-3 (NCOA3) is a member of the steroid receptor coactivator family that interacts with nuclear hormone receptors to enhance their transcriptional activation function and may play a role in somatic growth...
  81. ncbi request reprint Foot and ankle fractures in elderly white women. Incidence and risk factors
    Carl T Hasselman
    University of Pittsburgh, Pennsylvania, USA
    J Bone Joint Surg Am 85:820-4. 2003
    ..This study was designed to determine the incidence of and risk factors for foot and ankle fractures in a cohort of 9704 elderly, nonblack women enrolled in the multicenter Study of Osteoporotic Fractures...
  82. ncbi request reprint Vitamin D receptor and aromatase gene interaction and bone mass in older African-American women
    Joseph M Zmuda
    Departments of Epidemiology and Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Metabolism 52:521-3. 2003
    ..05 for interaction). We conclude that VDR and CYP19 gene polymorphisms may jointly influence bone mass and the rate of bone loss in older African-American women...
  83. pmc Longitudinal physical activity changes in older men in the Osteoporotic Fractures in Men Study
    Carol A Janney
    Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Am Geriatr Soc 58:1128-33. 2010
    ..To describe the change in physical activity (total, leisure, household, occupational) in men over a mean 5-year follow-up period and to identify sociodemographic and health factors associated with change in physical activity...
  84. ncbi request reprint Vitamin D receptor genotype is associated with fat-free mass and sarcopenia in elderly men
    Stephen M Roth
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, PA, USA
    J Gerontol A Biol Sci Med Sci 59:10-5. 2004
    ..19-3.85; p =.03) compared to men with one or more f alleles. The VDR translation start site (FokI) polymorphism is significantly associated with FFM and sarcopenia in this cohort of older Caucasian men...
  85. ncbi request reprint Is social integration associated with the risk of falling in older community-dwelling women?
    Kimberly A Faulkner
    Department of Epidemiology, University of Pittsburgh, Pennsylvania 15261, USA
    J Gerontol A Biol Sci Med Sci 58:M954-9. 2003
    ..Social integration may lead to social support and influence that may in turn protect older community-dwelling adults from falls...
  86. ncbi request reprint Peroxisome proliferator-activated receptor-gamma polymorphism, body mass and prostate cancer risk: evidence for gene-environment interaction
    Joseph M Zmuda
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Oncology 70:185-9. 2006
    ..Peroxisome proliferator-activated receptor (PPAR)-gamma has been implicated in prostate cancer. In the present case-control study, we tested if a common Pro12Ala polymorphism in PPAR-gamma is associated with the risk of prostate cancer...
  87. ncbi request reprint Estrogen metabolites and the risk of breast cancer in older women
    Jane A Cauley
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Epidemiology 14:740-4. 2003
    ..The objective of this study was to test the hypothesis that serum concentrations of 2-hydroxyestrone (2-OHE1) and 16alpha-hydroxyestrone (16alpha-OHE1), as well as their ratio, predict the risk of breast cancer in older women...
  88. doi request reprint FRAX® International Task Force of the 2010 Joint International Society for Clinical Densitometry & International Osteoporosis Foundation Position Development Conference
    Jane A Cauley
    Department of Epidemiology, University of Pittsburgh, PA, USA
    J Clin Densitom 14:237-9. 2011
    ..This synthesis was presented to the expert panel and constitutes the data on which the subsequent Official Positions are predicated. A summary of the International Task Force composition and charge is presented here...
  89. ncbi request reprint Volumetric BMD and vascular calcification in middle-aged women: the Study of Women's Health Across the Nation
    Ghada N Farhat
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    J Bone Miner Res 21:1839-46. 2006
    ..Lower vBMD was related to high AC, but not to CAC, independent of age and shared risk factors between osteoporosis and cardiovascular disease...
  90. ncbi request reprint Physical activity and decreased risk of clinical gallstone disease among post-menopausal women
    Kristi L Storti
    Department of Epidemiology, 505 Parran Hall, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Prev Med 41:772-7. 2005
    ..Physical activity may play a role in preventing gallstone disease...
  91. ncbi request reprint Diabetes mellitus, bone mineral density, and fracture risk
    Elsa S Strotmeyer
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Curr Opin Endocrinol Diabetes Obes 14:429-35. 2007
    ..To review recent research on type 1 and 2 diabetes mellitus, bone mineral density, and fractures and to identify high-priority research areas...
  92. pmc Defining ethnic and racial differences in osteoporosis and fragility fractures
    Jane A Cauley
    Department of Epidemiology, University of Pittsburgh, 130 DeSoto Street, Crabtree A543, Pittsburgh, PA 15261, USA
    Clin Orthop Relat Res 469:1891-9. 2011
    ..Osteoporotic fractures are a major public health issue. The literature suggests there are variations in occurrence of fractures by ethnicity and race...
  93. pmc Leukocyte Telomere Length Is Not Associated With BMD, Osteoporosis, or Fracture in Older Adults: Results From the Health, Aging and Body Composition Study
    Jason L Sanders
    Medical Scientist Training Program, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Bone Miner Res 24:1531-6. 2009
    ..TL is not associated with BMD, osteoporosis, or fracture in older men or women in this sample...
  94. ncbi request reprint Physical activity and risk of revision total knee arthroplasty in individuals with knee osteoarthritis: a matched case-control study
    Dina L Jones
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Rheumatol 31:1384-90. 2004
    ..To determine if physical activity was a risk factor for revision arthroplasty after primary total knee arthroplasty (TKA) due to osteoarthritis (OA) within the previous 15 years...
  95. ncbi request reprint Reciprocal influence of concurrent walking and cognitive testing on performance in older adults
    Kimberly A Faulkner
    University of Pittsburgh, 130 DeSoto Street, Parran 509, Pittsburgh, PA 15261, USA
    Gait Posture 24:182-9. 2006
    ..062). Findings suggest that walking requires significant cognitive resources among older adults and slower-walking adults and weaker adults may require higher cognitive loading while walking...
  96. pmc The effect of androgen deprivation therapy on periodontal disease in men with prostate cancer
    Pouran Famili
    Department of Periodontics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Urol 177:921-4. 2007
    ..We tested the hypothesis that men undergoing androgen deprivation therapy as treatment for prostate cancer are at greater risk for periodontitis and tooth loss...
  97. ncbi request reprint Breast cancer risk factors and mammographic breast density in women over age 70
    Francesmary Modugno
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Breast Cancer Res Treat 97:157-66. 2006
    ..Breast density is a strong risk factor for breast cancer, but little is known about factors associated with breast density in women over 70...
  98. pmc Duration of lactation and risk factors for maternal cardiovascular disease
    Eleanor Bimla Schwarz
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Obstet Gynecol 113:974-82. 2009
    ..To examine dose-response relationships between the cumulative number of months women lactated and postmenopausal risk factors for cardiovascular disease...
  99. ncbi request reprint Depressive symptoms and bone mineral density in older men
    Mary A Whooley
    San Francisco Department of Veterans Affairs Medical Center, 4150 Clement Street 111A1, San Francisco, CA 94121, USA
    J Geriatr Psychiatry Neurol 17:88-92. 2004
    ..These findings suggest that depressive symptoms are not associated with BMD in community-dwelling, older men...
  100. ncbi request reprint Risk-benefit profile for raloxifene: 4-year data From the Multiple Outcomes of Raloxifene Evaluation (MORE) randomized trial
    Elizabeth Barrett-Connor
    Division of Epidemiology, Department of Family and Preventive Medicine, University of California at San Diego, La Jolla, California 92093 0607, USA
    J Bone Miner Res 19:1270-5. 2004
    ..39% and 1.83% in the raloxifene and placebo groups, respectively (HR, 0.75; 95% CI, 0.62-0.92), compatible with a favorable risk-benefit profile for raloxifene for treating postmenopausal osteoporosis...
  101. ncbi request reprint Raloxifene reduces risk of vertebral fractures [corrected] in postmenopausal women regardless of prior hormone therapy
    Olaf Johnell
    Department of Orthopedics, Universitetssjukhuset MAS, SE 20502 Malmo, Sweden
    J Fam Pract 53:789-96. 2004
    ..We examined whether past use of hormone therapy influences the effects of raloxifene on the risk of new vertebral fracture, cardiovascular events, or breast cancer...