W A Catterall

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Synergistic GABA-Enhancing Therapy against Seizures in a Mouse Model of Dravet Syndrome
    John C Oakley
    Box 357280, 1959 NE Pacific St, Seattle, WA 98195 7280
    J Pharmacol Exp Ther 345:215-24. 2013
  2. pmc Voltage-gated sodium channels at 60: structure, function and pathophysiology
    William A Catterall
    Department of Pharmacology, University of Washington, Seattle, WA 98195 7280, USA
    J Physiol 590:2577-89. 2012
  3. pmc Overview of the voltage-gated sodium channel family
    Frank H Yu
    Department of Pharmacology, University of Washington, Seattle, WA 98195 7280, USA
    Genome Biol 4:207. 2003
  4. pmc Inherited neuronal ion channelopathies: new windows on complex neurological diseases
    William A Catterall
    Department of Pharmacology, University of Washington, Seattle, Washington 98195 7280, USA
    J Neurosci 28:11768-77. 2008
  5. pmc Ion channel voltage sensors: structure, function, and pathophysiology
    William A Catterall
    Department of Pharmacology, University of Washington, Seattle, WA 98195 7280, USA
    Neuron 67:915-28. 2010
  6. ncbi request reprint Helical motion of an S4 voltage sensor revealed by gating pore currents
    William A Catterall
    Department of Pharmacology, University of Washington, Seattle, USA
    Channels (Austin) 4:75-7. 2010
  7. ncbi request reprint Regulation of sodium and calcium channels by signaling complexes
    William A Catterall
    Department of Pharmacology, University of Washington, Seattle, Washington 98195 7280, USA
    J Recept Signal Transduct Res 26:577-98. 2006
  8. ncbi request reprint Structure and regulation of voltage-gated Ca2+ channels
    W A Catterall
    Department of Pharmacology, Box 357280, University of Washington, Seattle, Washington 98195 7280, USA
    Annu Rev Cell Dev Biol 16:521-55. 2000
  9. pmc Signaling complexes of voltage-gated sodium and calcium channels
    William A Catterall
    Department of Pharmacology, Box 357280, University of Washington, Seattle, WA 98195 7280, United States
    Neurosci Lett 486:107-16. 2010
  10. pmc NaV1.1 channels and epilepsy
    William A Catterall
    University of Washington, Department of Pharmacology, SJ 30, Seattle, WA 98195 7280, USA
    J Physiol 588:1849-59. 2010

Research Grants

  1. Molecular Properties of Voltage-Sensitive Calcium Channels
    William A Catterall; Fiscal Year: 2010
  2. VOLTAGE SENSITIVE SODIUM CHANNELS IN BRAIN
    William Catterall; Fiscal Year: 2004
  3. MOLECULAR PROPERTIES OF VOLTAGE SENSITIVE CA++ CHANNELS
    William Catterall; Fiscal Year: 2003
  4. CELL BIOLOGY OF THE NEURONAL SODIUM CHANNEL
    William Catterall; Fiscal Year: 2006
  5. CELL BIOLOGY OF THE NEURONAL SODIUM CHANNEL
    William A Catterall; Fiscal Year: 2010
  6. Regulation of Cardiac Calcium Channels by an Autoinhibitory Signaling Complex
    William A Catterall; Fiscal Year: 2010
  7. VOLTAGE SENSITIVE SODIUM CHANNELS IN BRAIN
    William A Catterall; Fiscal Year: 2010
  8. Receptor Sites and Antagonists for Paralytic Neurotoxins
    William Catterall; Fiscal Year: 2007
  9. TRAINING IN MOLECULAR NEUROBIOLOGY
    William Catterall; Fiscal Year: 2007
  10. MOLECULAR PROPERTIES OF VOLTAGE SENSITIVE CA++ CHANNELS
    William Catterall; Fiscal Year: 2007

Detail Information

Publications110 found, 100 shown here

  1. pmc Synergistic GABA-Enhancing Therapy against Seizures in a Mouse Model of Dravet Syndrome
    John C Oakley
    Box 357280, 1959 NE Pacific St, Seattle, WA 98195 7280
    J Pharmacol Exp Ther 345:215-24. 2013
    ..The synergistic actions of clonazepam and tiagabine gave enhanced seizure protection and reduced toxicity, suggesting that combination therapy may be well tolerated and effective for seizures in DS...
  2. pmc Voltage-gated sodium channels at 60: structure, function and pathophysiology
    William A Catterall
    Department of Pharmacology, University of Washington, Seattle, WA 98195 7280, USA
    J Physiol 590:2577-89. 2012
    ..A perspective for the future envisions new advances in understanding the structural basis for sodium channel function, the role of sodium channels in disease and the opportunity for discovery of novel therapeutics...
  3. pmc Overview of the voltage-gated sodium channel family
    Frank H Yu
    Department of Pharmacology, University of Washington, Seattle, WA 98195 7280, USA
    Genome Biol 4:207. 2003
    ..The different sodium channels have remarkably similar functional properties, but small changes in sodium-channel function are biologically relevant, as underscored by mutations that cause several human diseases of hyperexcitability...
  4. pmc Inherited neuronal ion channelopathies: new windows on complex neurological diseases
    William A Catterall
    Department of Pharmacology, University of Washington, Seattle, Washington 98195 7280, USA
    J Neurosci 28:11768-77. 2008
    ..Overall, these experiments indicate that imbalance in the activity of excitatory and inhibitory neurons is an important underlying cause of these diseases...
  5. pmc Ion channel voltage sensors: structure, function, and pathophysiology
    William A Catterall
    Department of Pharmacology, University of Washington, Seattle, WA 98195 7280, USA
    Neuron 67:915-28. 2010
    ..The emerging structural model for voltage sensor function opens the way to development of a new generation of ion-channel drugs that act on voltage sensors rather than blocking the pore...
  6. ncbi request reprint Helical motion of an S4 voltage sensor revealed by gating pore currents
    William A Catterall
    Department of Pharmacology, University of Washington, Seattle, USA
    Channels (Austin) 4:75-7. 2010
    ..Their results provide strong support for a sliding helix or helical screw mechanism of gating charge movement...
  7. ncbi request reprint Regulation of sodium and calcium channels by signaling complexes
    William A Catterall
    Department of Pharmacology, University of Washington, Seattle, Washington 98195 7280, USA
    J Recept Signal Transduct Res 26:577-98. 2006
    ..These localized signaling complexes are essential for normal function and regulation of electrical excitability, synaptic transmission, and excitation-contraction coupling...
  8. ncbi request reprint Structure and regulation of voltage-gated Ca2+ channels
    W A Catterall
    Department of Pharmacology, Box 357280, University of Washington, Seattle, Washington 98195 7280, USA
    Annu Rev Cell Dev Biol 16:521-55. 2000
    ....
  9. pmc Signaling complexes of voltage-gated sodium and calcium channels
    William A Catterall
    Department of Pharmacology, Box 357280, University of Washington, Seattle, WA 98195 7280, United States
    Neurosci Lett 486:107-16. 2010
    ..These localized signaling complexes are essential for normal function and regulation of electrical excitability, synaptic transmission, and excitation-contraction coupling...
  10. pmc NaV1.1 channels and epilepsy
    William A Catterall
    University of Washington, Department of Pharmacology, SJ 30, Seattle, WA 98195 7280, USA
    J Physiol 588:1849-59. 2010
    ..1 channels, in which mild impairment predisposes to febrile seizures, intermediate impairment leads to GEFS+ epilepsy, and severe or complete loss of function leads to the intractable seizures and comorbidities of SMEI...
  11. doi request reprint Calcium channel regulation and presynaptic plasticity
    William A Catterall
    Department of Pharmacology, University of Washington, Seattle, WA 98195 7280, USA
    Neuron 59:882-901. 2008
    ..We propose that presynaptic Ca(2+) channels serve as the regulatory node in a dynamic, multilayered signaling network that exerts short-term control of neurotransmission in response to synaptic activity...
  12. ncbi request reprint International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels
    William A Catterall
    Department of Pharmacology, University of Washington, Mailstop 357280, Seattle, WA 98195 7280, USA
    Pharmacol Rev 57:411-25. 2005
    ..This article presents the molecular relationships and physiological functions of these calcium channel proteins and provides comprehensive information on their molecular, genetic, physiological, and pharmacological properties...
  13. ncbi request reprint Voltage-gated ion channels and gating modifier toxins
    William A Catterall
    Department of Pharmacology, University of Washington, Seattle, WA 98195 7280, USA
    Toxicon 49:124-41. 2007
    ..The voltage-sensor trapping mechanism may be a common mode of action for polypeptide gating modifier toxins acting on all of the voltage-gated ion channels...
  14. ncbi request reprint International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels
    William A Catterall
    Department of Pharmacology, University of Washington, Mailstop 357280, Seattle, WA 98195 7280
    Pharmacol Rev 57:397-409. 2005
    ..This article presents the molecular relationships and physiological roles of these sodium channel proteins and provides comprehensive information on their molecular, genetic, physiological, and pharmacological properties...
  15. ncbi request reprint International Union of Pharmacology. XL. Compendium of voltage-gated ion channels: calcium channels
    William A Catterall
    Department of Pharmacology, University of Washington School of Medicine, Box 357280, Seattle, WA 98195 7280, USA
    Pharmacol Rev 55:579-81. 2003
    ..The complete Compendium, including data tables for each member of the calcium channel family can be found at http://www.iuphar-db.org/iuphar-ic/...
  16. ncbi request reprint International Union of Pharmacology. XXXIX. Compendium of voltage-gated ion channels: sodium channels
    William A Catterall
    Department of Pharmacology, Mailstop 357280, University of Washington, Seattle, WA 98195 7280, USA
    Pharmacol Rev 55:575-8. 2003
    ..The complete Compendium, including data tables for each member of the sodium channel family can be found at <http://www.iuphar-db.org/iuphar-ic/>...
  17. ncbi request reprint Molecular determinants of voltage-dependent gating and binding of pore-blocking drugs in transmembrane segment IIIS6 of the Na(+) channel alpha subunit
    V Yarov-Yarovoy
    Department of Pharmacology, University of Washington, Seattle, Washington 98195 7280, USA
    J Biol Chem 276:20-7. 2001
    ....
  18. ncbi request reprint Differential interactions of lamotrigine and related drugs with transmembrane segment IVS6 of voltage-gated sodium channels
    G Liu
    Department of Pharmacology, Mailstop 357280, University of Washington, Seattle, WA 98195 7280, USA
    Neuropharmacology 44:413-22. 2003
    ..The amino acid residues interacting with these pore-blocking drugs define a surface of IVS6 that is exposed to the pore and may rotate during gating...
  19. ncbi request reprint Differential phosphorylation of two size forms of the neuronal class C L-type calcium channel alpha 1 subunit
    J W Hell
    Department of Pharmacology, University of Washington, Seattle 98195
    J Biol Chem 268:19451-7. 1993
    ....
  20. ncbi request reprint Cyclic AMP-dependent phosphorylation of two size forms of alpha 1 subunits of L-type calcium channels in rat skeletal muscle cells
    Y Lai
    Department of Pharmacology, School of Medicine, University of Washington, Seattle 98195
    J Biol Chem 265:20839-48. 1990
    ....
  21. ncbi request reprint A sodium channel signaling complex: modulation by associated receptor protein tyrosine phosphatase beta
    C F Ratcliffe
    Department of Pharmacology, Mailstop 357280, University of Washington, Seattle, Washington 98195 7280, USA
    Nat Neurosci 3:437-44. 2000
    ..Our results define a sodium channel signaling complex containing RPTPbeta, which acts to regulate sodium channel modulation by tyrosine phosphorylation...
  22. pmc Sodium channel beta1 and beta3 subunits associate with neurofascin through their extracellular immunoglobulin-like domain
    C F Ratcliffe
    Department of Pharmacology, University of Washington, Seattle, WA 98195, USA
    J Cell Biol 154:427-34. 2001
    ..This association of beta1 subunit extracellular domains with neurofascin in developing axons may facilitate recruitment and concentration of sodium channel complexes at nodes of Ranvier...
  23. ncbi request reprint Site of covalent labeling by a photoreactive batrachotoxin derivative near transmembrane segment IS6 of the sodium channel alpha subunit
    V L Trainer
    Department of Pharmacology, University of Washington, Seattle 98185, USA
    J Biol Chem 271:11261-7. 1996
    ..These results implicate the S6 transmembrane region of domain I of the Na+ channel alpha subunit as an important component of the batrachotoxin receptor site...
  24. ncbi request reprint Molecular determinants of state-dependent block of Na+ channels by local anesthetics
    D S Ragsdale
    Department of Pharmacology, University of Washington, Seattle 98195
    Science 265:1724-8. 1994
    ..The results define the location of the local anesthetic receptor site in the pore of the Na+ channel and identify molecular determinants of the state-dependent binding of local anesthetics...
  25. ncbi request reprint Differential modulation of sodium channel gating and persistent sodium currents by the beta1, beta2, and beta3 subunits
    Y Qu
    Department of Pharmacology, University of Washington, Seattle 98195 7280, USA
    Mol Cell Neurosci 18:570-80. 2001
    ..Because persistent sodium currents are thought to amplify summation of synaptic inputs, expression of this subunit would increase the excitability of specific groups of neurons to all of their inputs...
  26. ncbi request reprint Structure and function of the beta 2 subunit of brain sodium channels, a transmembrane glycoprotein with a CAM motif
    L L Isom
    Department of Pharmacology, University of Washington Seattle 98195 7280, USA
    Cell 83:433-42. 1995
    ..They may be important regulators of sodium channel expression and localization in neurons...
  27. ncbi request reprint Neurotoxin binding and allosteric modulation at receptor sites 2 and 5 on purified and reconstituted rat brain sodium channels
    V L Trainer
    Department of Pharmacology, University of Washington, Seattle 98195
    J Biol Chem 268:17114-9. 1993
    ....
  28. pmc Isoform-specific interaction of the alpha1A subunits of brain Ca2+ channels with the presynaptic proteins syntaxin and SNAP-25
    J Rettig
    Department of Pharmacology, University of Washington, Seattle 98195 7280, USA
    Proc Natl Acad Sci U S A 93:7363-8. 1996
    ..Our results provide a molecular basis for a physical link between Ca2+ influx into nerve terminals and subsequent exocytosis of neurotransmitters at synapses that have presynaptic Ca2+ channels containing alpha1A subunits...
  29. ncbi request reprint Distinct effects of mutations in transmembrane segment IVS6 on block of L-type calcium channels by structurally similar phenylalkylamines
    B D Johnson
    Department of Pharmacology, University of Washington School of Medicine, Seattle 98195 7280, USA
    Mol Pharmacol 50:1388-400. 1996
    ..The different effects of the YAI mutations on the actions of (-)-D888, verapamil, and D600 indicate that these residues interact differently with these closely related drugs...
  30. ncbi request reprint Structure and chromosomal localization of the beta2 subunit of the human brain sodium channel
    J Eubanks
    Graduate Program in Neurobiology and Behavior, University of Washington, Seattle 98195, USA
    Neuroreport 8:2775-9. 1997
    ..The similarity of beta2 to cell adhesion molecules, including myelin protein p0, and its chromosomal location at 11q23 suggest a potential role in these demyelinating diseases...
  31. ncbi request reprint Control of neuronal excitability by phosphorylation and dephosphorylation of sodium channels
    T Scheuer
    Department of Pharmacology, Mailstop 357280, University of Washington, Seattle, WA 98195 7280, USA
    Biochem Soc Trans 34:1299-302. 2006
    ..Analogous molecular complexes between sodium channels, kinases and other signalling molecules are expected to be necessary for specific and localized transmitter-mediated modulation of sodium channels by other protein kinases...
  32. ncbi request reprint Ion permeation through a voltage- sensitive gating pore in brain sodium channels having voltage sensor mutations
    Stanislav Sokolov
    Department of Pharmacology, University of Washington, Seattle, WA 98195, USA
    Neuron 47:183-9. 2005
    ..Paired substitutions of glutamine allow cation movement through the constriction when appropriately positioned by the gating movements of the S4 segment...
  33. pmc Neutralization of gating charges in domain II of the sodium channel alpha subunit enhances voltage-sensor trapping by a beta-scorpion toxin
    S Cestele
    Department of Pharmacology, University of Washington School of Medicine, Seattle, WA 98195 7280, USA
    J Gen Physiol 118:291-302. 2001
    ..Evidently, neutralization of R850 and R853 removes kinetic barriers to binding of the IIS4 segment by Css IV, and thereby enhances toxin-induced channel activation...
  34. pmc Type II regulatory subunits are not required for the anchoring-dependent modulation of Ca2+ channel activity by cAMP-dependent protein kinase
    K A Burton
    Department of Pharmacology, University of Washington School of Medicine, Box 357750, Seattle, WA 98195 7750, USA
    Proc Natl Acad Sci U S A 94:11067-72. 1997
    ..The potentiation of the L-type Ca2+ channel in RIIalpha knockout mouse skeletal muscle suggests that, despite a lower affinity for AKAP binding, RIalpha is capable of physiologically relevant anchoring interactions...
  35. ncbi request reprint Identification of the sites of selective phosphorylation and dephosphorylation of the rat brain Na+ channel alpha subunit by cAMP-dependent protein kinase and phosphoprotein phosphatases
    B J Murphy
    Department of Pharmacology, University of Washington, Seattle 98195
    J Biol Chem 268:27355-62. 1993
    ....
  36. ncbi request reprint Specific binding of the novel Na+ channel blocker PD85,639 to the alpha subunit of rat brain Na+ channels
    W Thomsen
    Department of Pharmacology, University of Washington, Seattle 98195
    Mol Pharmacol 43:955-64. 1993
    ..PD85,639 may be a useful molecular probe of this important drug receptor site on the Na+ channel...
  37. pmc Interaction of batrachotoxin with the local anesthetic receptor site in transmembrane segment IVS6 of the voltage-gated sodium channel
    N J Linford
    Department of Pharmacology, Box 357280, University of Washington, Seattle, WA 98195 7280, USA
    Proc Natl Acad Sci U S A 95:13947-52. 1998
    ..Evidently, BTX conforms to a domain-interface allosteric model of ligand binding and action, as previously proposed for calcium agonist and antagonist drugs acting on L-type calcium channels...
  38. ncbi request reprint Primary structure and functional expression of the beta 1 subunit of the rat brain sodium channel
    L L Isom
    Department of Pharmacology, University of Washington, Seattle 98195
    Science 256:839-42. 1992
    ..These results indicate that the beta 1 subunit is crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the rat brain sodium channel...
  39. pmc Interaction of voltage-gated sodium channels with the extracellular matrix molecules tenascin-C and tenascin-R
    J Srinivasan
    Departments of Pharmacology and Neurological Surgery, University of Washington, Seattle, WA 98195 7280, USA
    Proc Natl Acad Sci U S A 95:15753-7. 1998
    ....
  40. pmc Modulation of CaV1.2 channels by Mg2+ acting at an EF-hand motif in the COOH-terminal domain
    Sylvain Brunet
    Department of Pharmacology, University of Washington, Seattle, WA 98195, USA
    J Gen Physiol 126:311-23. 2005
    ..2 channels, and reveal a potentially important role of Mg(i) binding to the COOH-terminal EF-hand in regulating Ca(2+) influx in physiological and pathophysiological states...
  41. pmc Increased expression of the cardiac L-type calcium channel in estrogen receptor-deficient mice
    B D Johnson
    Department of Pharmacology, University of Washington, Seattle, Washington 98195 7280, USA
    J Gen Physiol 110:135-40. 1997
    ....
  42. pmc Control of gating mode by a single amino acid residue in transmembrane segment IS3 of the N-type Ca2+ channel
    H Zhong
    Department of Pharmacology, University of Washington, Seattle, WA 98195-7280, USA
    Proc Natl Acad Sci U S A 98:4705-9. 2001
    ..2a by a voltage sensor-trapping mechanism. G protein betagamma subunits may produce reluctant channels by a similar molecular mechanism...
  43. pmc Role of the C-terminal domain in inactivation of brain and cardiac sodium channels
    M Mantegazza
    Department of Pharmacology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 98:15348-53. 2001
    ..Thus, the C terminus has a strong influence on kinetics and voltage dependence of inactivation in brain Na(v)1.2 and cardiac Na(v)1.5 channels and is primarily responsible for their differing rates of channel inactivation...
  44. ncbi request reprint Subunits of purified calcium channels. Alpha 2 and delta are encoded by the same gene
    K S De Jongh
    Department of Pharmacology, University of Washington, Seattle 98195
    J Biol Chem 265:14738-41. 1990
    ..Thus, the delta subunits are encoded by the same gene as the alpha 2 subunit and are integral components of the skeletal muscle calcium channel...
  45. ncbi request reprint Neuromodulation of Na+ channel slow inactivation via cAMP-dependent protein kinase and protein kinase C
    Yuan Chen
    Department of Pharmacology, University of Washington, Seattle, Washington 98195, USA
    Neuron 49:409-20. 2006
    ..Modulation of slow inactivation by neurotransmitters acting through G protein-coupled receptors, PKA, and PKC is a flexible mechanism of cellular plasticity controlling the firing behavior of central neurons...
  46. ncbi request reprint Molecular mechanism of convergent regulation of brain Na(+) channels by protein kinase C and protein kinase A anchored to AKAP-15
    Angela R Cantrell
    Department of Pharmacology, University of Washington, Seattle 98195 7280, USA
    Mol Cell Neurosci 21:63-80. 2002
    ..This convergent regulation provides a novel mechanism by which information from multiple signaling pathways may be integrated at the cellular level in the hippocampus and throughout the central nervous system...
  47. ncbi request reprint Molecular determinants for modulation of persistent sodium current by G-protein betagamma subunits
    Massimo Mantegazza
    Department of Pharmacology, University of Washington School of Medicine, Seattle, Washington 98195 7280, USA
    J Neurosci 25:3341-9. 2005
    ....
  48. ncbi request reprint Inhibition of sodium channel gating by trapping the domain II voltage sensor with protoxin II
    Stanislav Sokolov
    University of Washington School of Medicine Department of Pharmacology, Box 357280, Seattle, WA 98195 7280, USA
    Mol Pharmacol 73:1020-8. 2008
    ....
  49. ncbi request reprint Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini
    J W Hell
    Department of Pharmacology, University of Washington, Seattle 98195
    J Biol Chem 269:7390-6. 1994
    ..Specific phosphorylation of the long form of the class B alpha 1 subunit by CaM kinase II may differentially regulate the function of N-type calcium channels containing different size forms of their alpha 1 subunits in vivo...
  50. ncbi request reprint Identification of a 15-kDa cAMP-dependent protein kinase-anchoring protein associated with skeletal muscle L-type calcium channels
    P C Gray
    Department of Pharmacology, University of Washington, Seattle, Washington 98195 7280, USA
    J Biol Chem 272:6297-302. 1997
    ..Together, these findings demonstrate a physical link between PKA and the calcium channel and suggest that AKAP-15 may mediate their interaction...
  51. pmc Allosteric modulation of Ca2+ channels by G proteins, voltage-dependent facilitation, protein kinase C, and Ca(v)beta subunits
    S Herlitze
    Department of Pharmacology, University of Washington, Seattle, WA 98195-7280, USA
    Proc Natl Acad Sci U S A 98:4699-704. 2001
    ..Such regulation will modulate transmission at synapses that use N-type and P/Q-type Ca(2+) channels to initiate neurotransmitter release...
  52. ncbi request reprint Differential regulation of CaV2.1 channels by calcium-binding protein 1 and visinin-like protein-2 requires N-terminal myristoylation
    Alexandra P Few
    Department of Pharmacology, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 25:7071-80. 2005
    ..Differential, myristoylation-dependent regulation of presynaptic Ca2+ channels by nCaBPs may provide a flexible mechanism for diverse forms of short-term synaptic plasticity...
  53. ncbi request reprint Mechanism of SNARE protein binding and regulation of Cav2 channels by phosphorylation of the synaptic protein interaction site
    Charles T Yokoyama
    Department of Pharmacology, University of Washington, Seattle, WA 98195, USA
    Mol Cell Neurosci 28:1-17. 2005
    ..Our results support a bipartite model for the synprint site in which each SNARE-binding microdomain is controlled by a separate PKC and CaMKII phosphorylation site that regulates channel modulation by SNARE proteins...
  54. ncbi request reprint Axonal L-type Ca2+ channels and anoxic injury in rat CNS white matter
    A M Brown
    Department of Neurology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    J Neurophysiol 85:900-11. 2001
    ..Double labeling with anti-neurofilament antibodies or anti-glial fibrillary acidic protein antibodies localized L-type Ca2+ channels to axons and astrocytes...
  55. ncbi request reprint Upregulation of L-type Ca2+ channels in reactive astrocytes after brain injury, hypomyelination, and ischemia
    R E Westenbroek
    Department of Pharmacology, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 18:2321-34. 1998
    ....
  56. ncbi request reprint Photoaffinity labeling of the receptor site for alpha-scorpion toxins on purified and reconstituted sodium channels by a new toxin derivative
    F J Tejedor
    Department of Pharmacology, University of Washington, Seattle 98195
    Cell Mol Neurobiol 10:257-65. 1990
    ..4. MAB-LqTx will be valuable in further defining the structure-activity relationships at the alpha-scorpion toxin receptor site...
  57. pmc Cooperative regulation of Ca(v)1.2 channels by intracellular Mg(2+), the proximal C-terminal EF-hand, and the distal C-terminal domain
    Sylvain Brunet
    Department of Pharmacology, University of Washington, Seattle, WA 98195, USA
    J Gen Physiol 134:81-94. 2009
    ..2 channels by Mg(i), the proximal C-terminal EF-hand, and the DCT, and suggest that conformational changes that regulate VDI are propagated from the DCT through the proximal C-terminal EF-hand to the channel-gating mechanism...
  58. pmc Depolarization-activated gating pore current conducted by mutant sodium channels in potassium-sensitive normokalemic periodic paralysis
    Stanislav Sokolov
    Department of Pharmacology, University of Washington, Seattle, WA 98195 7280, USA
    Proc Natl Acad Sci U S A 105:19980-5. 2008
    ....
  59. ncbi request reprint Modulation of CaV2.1 channels by the neuronal calcium-binding protein visinin-like protein-2
    Nathan J Lautermilch
    Department of Pharmacology, University of Washington, Seattle, Washington 98195 7280, USA
    J Neurosci 25:7062-70. 2005
    ..Differential regulation of CaV2.1 channels by CaM, VILIP-2, CaBP1, and other neurospecific Ca2+-binding proteins is a potentially important determinant of Ca2+ entry in neurotransmission...
  60. ncbi request reprint Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy
    Frank H Yu
    Department of Pharmacology, University of Washington, Seattle, Washington 98195 7280, USA
    Nat Neurosci 9:1142-9. 2006
    ..Our results indicate that reduced sodium currents in GABAergic inhibitory interneurons in Scn1a+/- heterozygotes may cause the hyperexcitability that leads to epilepsy in patients with SMEI...
  61. ncbi request reprint Role of amino acid residues in transmembrane segments IS6 and IIS6 of the Na+ channel alpha subunit in voltage-dependent gating and drug block
    Vladimir Yarov-Yarovoy
    Department of Pharmacology, University of Washington, Seattle, Washington 98195 7280, USA
    J Biol Chem 277:35393-401. 2002
    ..These results suggest that the local anesthetic receptor site is formed primarily by residues in segments IIIS6 and IVS6 with the contribution of a single amino acid in segment IS6...
  62. ncbi request reprint Mice lacking sodium channel beta1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture
    Chunling Chen
    Department of Pharmacology, The University of Michigan, Ann Arbor, Michigan 48109 0632, USA
    J Neurosci 24:4030-42. 2004
    ....
  63. ncbi request reprint Distinct subcellular localization of different sodium channel alpha and beta subunits in single ventricular myocytes from mouse heart
    Sebastian K G Maier
    Department of Pharmacology, University of Washington, Seattle, WA 98195 7280, USA
    Circulation 109:1421-7. 2004
    ..Voltage-gated sodium channels composed of pore-forming alpha and auxiliary beta subunits are responsible for the rising phase of the action potential in cardiac muscle, but their localizations have not yet been clearly defined...
  64. ncbi request reprint Ca(v)1.3 channels produce persistent calcium sparklets, but Ca(v)1.2 channels are responsible for sparklets in mouse arterial smooth muscle
    Manuel F Navedo
    Department of Physiology and Biophysics, University of Washington, Box 357290, Seattle, WA 98195, USA
    Am J Physiol Heart Circ Physiol 293:H1359-70. 2007
    ..We conclude that although Ca(v)1.3 channels can produce Ca(2+) sparklets, Ca(v)1.2 channels underlie I(Ca), Ca(2+) sparklets, and hence dihydropyridine-sensitive Ca(2+) influx in mouse arterial myocytes...
  65. ncbi request reprint Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2
    Frank H Yu
    Department of Pharmacology, University of Washington, Seattle, Washington 98195 7280, USA
    J Neurosci 23:7577-85. 2003
    ..This novel, disulfide-linked beta subunit is likely to affect both protein-protein interactions and physiological function of multiple sodium channel alpha subunits...
  66. pmc Modulation of CaV2.1 channels by Ca2+/calmodulin-dependent protein kinase II bound to the C-terminal domain
    Xin Jiang
    Department of Pharmacology, University of Washington, Mailstop 357280, Seattle, WA 98195 7280, USA
    Proc Natl Acad Sci U S A 105:341-6. 2008
    ..This regulatory mechanism would be important in presynaptic nerve terminals, where Ca(V)2.1 channels initiate synaptic transmission and CaMKII has noncatalytic effects on presynaptic plasticity...
  67. pmc An unexpected role for brain-type sodium channels in coupling of cell surface depolarization to contraction in the heart
    Sebastian K G Maier
    Department of Pharmacology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 99:4073-8. 2002
    ....
  68. pmc Autoinhibitory control of the CaV1.2 channel by its proteolytically processed distal C-terminal domain
    Joanne T Hulme
    Department of Pharmacology, Mailstop 357280, University of Washington, Seattle, 98195 7280, USA
    J Physiol 576:87-102. 2006
    ..2 channel function...
  69. ncbi request reprint Gating pore current in an inherited ion channelopathy
    Stanislav Sokolov
    Department of Pharmacology, University of Washington, Seattle, Washington 98195 7280, USA
    Nature 446:76-8. 2007
    ..A survey of other ion channelopathies reveals numerous examples of mutations that would be expected to cause gating pore current, raising the possibility of a broader impact of gating pore current in ion channelopathies...
  70. pmc Structure and function of the voltage sensor of sodium channels probed by a beta-scorpion toxin
    Sandrine Cestele
    Department of Pharmacology, University of Washington, Seattle, 98195 7280, USA
    J Biol Chem 281:21332-44. 2006
    ....
  71. pmc Differential modulation of Ca(v)2.1 channels by calmodulin and Ca2+-binding protein 1
    Amy Lee
    Department of Pharmacology, University of Washington School of Medicine, Seattle, Washington 98195 7280, USA
    Nat Neurosci 5:210-7. 2002
    ..Our results identify an interaction between Ca2+ channels and CaBP1 that may regulate Ca2+-dependent forms of synaptic plasticity by inhibiting Ca2+ influx into neurons...
  72. pmc Sequential formation of ion pairs during activation of a sodium channel voltage sensor
    Paul G DeCaen
    Department of Pharmacology, University of Washington, Seattle, WA 98195 7280, USA
    Proc Natl Acad Sci U S A 106:22498-503. 2009
    ..Our results directly demonstrate sequential ion pair formation that is an essential feature of the sliding helix model of voltage sensor function but is not compatible with the other widely discussed gating models...
  73. ncbi request reprint Sites and molecular mechanisms of modulation of Na(v)1.2 channels by Fyn tyrosine kinase
    Daniel Beacham
    Department of Pharmacology, University of Washington, Seattle, Washington 98195 7280, USA
    J Neurosci 27:11543-51. 2007
    ..2 channels are expressed in brain neurons...
  74. ncbi request reprint Distribution of high-voltage-activated calcium channels in cultured gamma-aminobutyric acidergic neurons from mouse cerebral cortex
    Daniel B Timmermann
    Department of Pharmacology, University of Washington, Seattle, WA 98195, USA
    J Neurosci Res 67:48-61. 2002
    ..The complementary localization patterns observed for two different isoforms of the Ca(v)2.1 subunits provide direct evidence for alternative splicing as a means of generating functional diversity among neuronal calcium channels...
  75. ncbi request reprint A gating hinge in Na+ channels; a molecular switch for electrical signaling
    Yong Zhao
    Department of Pharmacology, Box 357280, University of Washington, Seattle, WA 98105, USA
    Neuron 41:859-65. 2004
    ..Our results fit a model in which concerted bending at glycine 219 in the S6 segments of NaChBac serves as a gating hinge. This gating motion may be conserved in most members of this large ion channel protein family...
  76. pmc Reversed voltage-dependent gating of a bacterial sodium channel with proline substitutions in the S6 transmembrane segment
    Yong Zhao
    Department of Pharmacology, Mail Stop 357280, University of Washington, Seattle, WA 98195 7280, USA
    Proc Natl Acad Sci U S A 101:17873-8. 2004
    ..Native hyperpolarization-activated gating of hyperpolarization- and cyclic nucleotide-gated (HCN) channels in animals and KAT channels in plants may involve bending at analogous S6 amino acid residues...
  77. ncbi request reprint Specific modulation of Na+ channels in hippocampal neurons by protein kinase C epsilon
    Yuan Chen
    Department of Pharmacology, University of Washington, Seattle, Washington 98195 7280, USA
    J Neurosci 25:507-13. 2005
    ..Overall, our data from four experimental approaches indicate that anchored PKCepsilon is the isozyme responsible for PKC-mediated reduction of peak Na+ currents in mouse hippocampal neurons...
  78. pmc Sympathetic stimulation of adult cardiomyocytes requires association of AKAP5 with a subpopulation of L-type calcium channels
    C Blake Nichols
    Department of Pharmacology, University of Washington, Seattle, WA 98195, USA
    Circ Res 107:747-56. 2010
    ..We hypothesized that scaffolding of cAMP signaling complexes by AKAP5 is required for efficient sympathetic stimulation of calcium transients...
  79. ncbi request reprint Specific phosphorylation of a COOH-terminal site on the full-length form of the alpha 1 subunit of the skeletal muscle calcium channel by cAMP-dependent protein kinase
    E I Rotman
    Department of Pharmacology, University of Washington, Seattle 98105
    J Biol Chem 267:16100-5. 1992
    ..Phosphorylation of serine 1854 may play a pivotal role in the regulation of calcium channel function by cA-PK...
  80. ncbi request reprint Elevated expression of type II Na+ channels in hypomyelinated axons of shiverer mouse brain
    R E Westenbroek
    Department of Pharmacology, University of Washington, Seattle 98195
    J Neurosci 12:2259-67. 1992
    ..The selective increase in the number of type II channels in hypomyelinated fiber tracts may contribute to the hyperexcitable phenotype of the shiverer mouse...
  81. ncbi request reprint Functional role of a C-terminal Gbetagamma-binding domain of Ca(v)2.2 channels
    Bin Li
    Department of Pharmacology, University of Washington, Box 357280, Seattle, WA 98195 7280, USA
    Mol Pharmacol 66:761-9. 2004
    ..C-terminal binding of Gbetagamma may influence the physiological responsiveness of Ca(2+) channels to low-level G protein activation...
  82. pmc Beta-adrenergic-regulated phosphorylation of the skeletal muscle Ca(V)1.1 channel in the fight-or-flight response
    Michelle A Emrick
    Department of Pharmacology, University of Washington, Seattle, WA 98195 7280, USA
    Proc Natl Acad Sci U S A 107:18712-7. 2010
    ....
  83. pmc Ion permeation and block of the gating pore in the voltage sensor of NaV1.4 channels with hypokalemic periodic paralysis mutations
    Stanislav Sokolov
    Department of Pharmacology, University of Washington, Seattle, WA 98195, USA
    J Gen Physiol 136:225-36. 2010
    ..4 gating pores, define voltage-dependent and voltage-independent block by divalent and trivalent cations, respectively, and provide initial support for the concept that guanidine-based gating pore blockers could be therapeutically useful...
  84. pmc Dopamine modulation of neuronal Na(+) channels requires binding of A kinase-anchoring protein 15 and PKA by a modified leucine zipper motif
    W Preston Few
    Department of Pharmacology, University of Washington, Seattle, WA 98195 7280, USA
    Proc Natl Acad Sci U S A 104:5187-92. 2007
    ..Our results define the molecular mechanism by which G protein-coupled signaling pathways can rapidly and efficiently modulate neuronal excitability through local protein phosphorylation of Na(+) channels by specifically anchored PKA...
  85. ncbi request reprint Molecular mechanisms of gating and drug block of sodium channels
    William A Catterall
    Department of Pharmacology, University of Washington, Seattle 98195 7280, USA
    Novartis Found Symp 241:206-18; discussion 218-32. 2002
    ..The emerging knowledge of the molecular mechanisms of Na+ channel gating and drug block may allow development of novel therapeutics for epilepsy, cardiac arrhythmia and persistent pain syndromes...
  86. ncbi request reprint Overview of molecular relationships in the voltage-gated ion channel superfamily
    Frank H Yu
    Department of Pharmacology, Campus Box 357280, University of Washington, Seattle, WA 98195 7280, USA
    Pharmacol Rev 57:387-95. 2005
  87. pmc Functional properties and differential neuromodulation of Na(v)1.6 channels
    Yuan Chen
    Department of Pharmacology, Mailstop 357280, University of Washington, Seattle, WA 98195, USA
    Mol Cell Neurosci 38:607-15. 2008
    ..The unique properties of Na(V)1.6 channels, together with the resurgent currents that they conduct in neurons, make these channels well-suited to provide the driving force for sustained repetitive firing, a crucial property of neurons...
  88. ncbi request reprint A novel leucine zipper targets AKAP15 and cyclic AMP-dependent protein kinase to the C terminus of the skeletal muscle Ca2+ channel and modulates its function
    Joanne T Hulme
    Department of Pharmacology, University of Washington, Seattle, Washington 98195 7280, USA
    J Biol Chem 277:4079-87. 2002
    ..Our results reveal a novel mechanism whereby anchoring of PKA to Ca(2+) channels via LZ interactions ensures rapid and efficient phosphorylation of Ca(2+) channels in response to local signals such as cAMP and depolarization...
  89. pmc Disulfide locking a sodium channel voltage sensor reveals ion pair formation during activation
    Paul G DeCaen
    Department of Pharmacology, University of Washington, Seattle, WA 98195 7280, USA
    Proc Natl Acad Sci U S A 105:15142-7. 2008
    ..Our results demonstrate voltage-dependent formation of an ion pair during activation of the voltage sensor in real time and suggest that this interaction catalyzes S4 movement and channel activation...
  90. ncbi request reprint Regulation of cardiac ion channels by signaling complexes: role of modified leucine zipper motifs
    Joanne T Hulme
    Department of Pharmacology, University of Washington, Box 357280, Seattle, WA 98195 7280, USA
    J Mol Cell Cardiol 37:625-31. 2004
    ..This review will summarize the recent advances made on the regulation of cardiac ion channels by these macromolecular signaling complexes in the normal and diseased heart...
  91. pmc Beta-adrenergic regulation requires direct anchoring of PKA to cardiac CaV1.2 channels via a leucine zipper interaction with A kinase-anchoring protein 15
    Joanne T Hulme
    Department of Pharmacology, University of Washington, Seattle, WA 98195 7280, USA
    Proc Natl Acad Sci U S A 100:13093-8. 2003
    ....
  92. pmc Phosphorylation of serine 1928 in the distal C-terminal domain of cardiac CaV1.2 channels during beta1-adrenergic regulation
    Joanne T Hulme
    Department of Pharmacology, University of Washington, Mailstop 357280, Seattle, WA 98195 7280, USA
    Proc Natl Acad Sci U S A 103:16574-9. 2006
    ..Our results correlate phosphorylation of S1928 with beta1-adrenergic functional up-regulation of cardiac calcium channels in the presence of BAPTA in intact ventricular myocytes...
  93. pmc Molecular determinants of Ca(2+)/calmodulin-dependent regulation of Ca(v)2.1 channels
    Amy Lee
    Department of Pharmacology, University of Washington School of Medicine, Seattle, WA 98195 7280, USA
    Proc Natl Acad Sci U S A 100:16059-64. 2003
    ..This multifaceted mechanism allows positive regulation of Cav2.1 in response to local Ca2+ increases (CDF) and negative regulation during more global Ca2+ increases (CDI)...
  94. pmc Sites of proteolytic processing and noncovalent association of the distal C-terminal domain of CaV1.1 channels in skeletal muscle
    Joanne T Hulme
    Department of Pharmacology, University of Washington, Mailstop 357280, Seattle, WA 98195 7280, USA
    Proc Natl Acad Sci U S A 102:5274-9. 2005
    ..1 channels in skeletal muscle cells...
  95. pmc Convergent regulation of skeletal muscle Ca2+ channels by dystrophin, the actin cytoskeleton, and cAMP-dependent protein kinase
    Barry D Johnson
    Department of Pharmacology, University of Washington, Box 357280, Seattle, WA 98195 7280, USA
    Proc Natl Acad Sci U S A 102:4191-6. 2005
    ....
  96. ncbi request reprint Regulation of Na(v)1.2 channels by brain-derived neurotrophic factor, TrkB, and associated Fyn kinase
    Misol Ahn
    Department of Pharmacology, University of Washington, Seattle, Washington 98195 7280, USA
    J Neurosci 27:11533-42. 2007
    ..These results indicate that Fyn kinase is associated with sodium channels in brain neurons and can modulate Na(V)1.2 channels by tyrosine phosphorylation after activation of TrkB/p75 signaling by BDNF...
  97. ncbi request reprint The VGL-chanome: a protein superfamily specialized for electrical signaling and ionic homeostasis
    Frank H Yu
    Department of Pharmacology, Mailstop 357280, University of Washington, Seattle, WA 98195 7280, USA
    Sci STKE 2004:re15. 2004
    ..This article identifies all of the members of this protein superfamily in the human genome, reviews the molecular and evolutionary relations among these ion channels, and describes their functional roles in cell physiology...
  98. ncbi request reprint Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancy
    Franck Kalume
    Department of Pharmacology, University of Washington, Seattle, Washington 98195 7280, USA
    J Neurosci 27:11065-74. 2007
    ..Loss of these channels in Purkinje neurons of mutant mice and SMEI patients may be sufficient to cause their ataxia and related functional deficits...
  99. pmc An unexpected requirement for brain-type sodium channels for control of heart rate in the mouse sinoatrial node
    Sebastian K G Maier
    Department of Pharmacology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 100:3507-12. 2003
    ..Our results demonstrate an important contribution of TTX-sensitive brain-type Na(+) channels to SA nodal automaticity in mouse heart and suggest that they may also contribute to SA nodal function and dysfunction in human heart...
  100. ncbi request reprint Transmitter modulation of slow, activity-dependent alterations in sodium channel availability endows neurons with a novel form of cellular plasticity
    David B Carr
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Neuron 39:793-806. 2003
    ..This process is strictly associated with neuronal activity and develops over seconds, endowing neurons with a novel form of cellular plasticity shaping synaptic integration, dendritic electrogenesis, and repetitive discharge...
  101. ncbi request reprint Bidirectional modulation of transmitter release by calcium channel/syntaxin interactions in vivo
    Ryan K Keith
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 27:265-9. 2007
    ..As such, these two effects of syntaxin on calcium channels modulate transmitter release in a bidirectional manner...

Research Grants66

  1. Molecular Properties of Voltage-Sensitive Calcium Channels
    William A Catterall; Fiscal Year: 2010
    ....
  2. VOLTAGE SENSITIVE SODIUM CHANNELS IN BRAIN
    William Catterall; Fiscal Year: 2004
    ..These proposed studies will give new insight into the molecular mechanisms of sodium channel gating and its modification by second messenger-activated protein phosphorylation and by drugs and neurotoxins. ..
  3. MOLECULAR PROPERTIES OF VOLTAGE SENSITIVE CA++ CHANNELS
    William Catterall; Fiscal Year: 2003
    ..abstract_text> ..
  4. CELL BIOLOGY OF THE NEURONAL SODIUM CHANNEL
    William Catterall; Fiscal Year: 2006
    ..Our results will add substantially to understanding of the cell biology of the Na channel and the functional significance of Na channel signaling complexes. ..
  5. CELL BIOLOGY OF THE NEURONAL SODIUM CHANNEL
    William A Catterall; Fiscal Year: 2010
    ..This project will use a mouse genetic model of this disease to determine how this gene defect causes epilepsy and to test new drug combinations for control of this intractable epilepsy syndrome. ..
  6. Regulation of Cardiac Calcium Channels by an Autoinhibitory Signaling Complex
    William A Catterall; Fiscal Year: 2010
    ..This information will provide the essential basic science background for translational research aimed at preventing and treating cardiovascular disease. ..
  7. VOLTAGE SENSITIVE SODIUM CHANNELS IN BRAIN
    William A Catterall; Fiscal Year: 2010
    ..This basic science information will be essential to understand and treat periodic paralysis, epilepsy, chronic pain, and cardiac arrhythmia. ..
  8. Receptor Sites and Antagonists for Paralytic Neurotoxins
    William Catterall; Fiscal Year: 2007
    ....
  9. TRAINING IN MOLECULAR NEUROBIOLOGY
    William Catterall; Fiscal Year: 2007
    ..The training program will integrate the substantial expertise of this group of faculty in a coordinated pre-doctoral and post-doctoral training effort. ..
  10. MOLECULAR PROPERTIES OF VOLTAGE SENSITIVE CA++ CHANNELS
    William Catterall; Fiscal Year: 2007
    ..These studies will give important new insight into the mechanism and regulation of synaptic transmission and will further define the function of Cav2.1 channels and their regulation in synaptic plasticity. ..
  11. VOLTAGE SENSITIVE SODIUM CHANNELS IN BRAIN
    William Catterall; Fiscal Year: 2007
    ..These proposed studies will give new insight into the molecular mechanisms of sodium channel gating and its modification by second messenger-activated protein phosphorylation. ..
  12. VOLTAGE-SENSITIVE SODIUM CHANNELS IN BRAIN
    William Catterall; Fiscal Year: 1991
    ..These studies will provide essential information to understanding the molecular basis of electrical excitability...
  13. CELL BIOLOGY OF THE NEURONAL SODIUM CHANNEL
    William Catterall; Fiscal Year: 1993
    ..Together, these experiments will provide important new information on the mechanisms used by central neurons to control the localization, cell surface density, and functional activity of sodium channels...
  14. VOLTAGE-SENSITIVE SODIUM CHANNELS IN BRAIN
    William Catterall; Fiscal Year: 1980
    ..These experiments will greatly enhance knoledge of the basic molecular mechanisms responsible for electrical excitability...
  15. VOLTAGE-SENSITIVE SODIUM CHANNELS IN BRAIN
    William Catterall; Fiscal Year: 1993
    ....
  16. CELL BIOLOGY OF THE NEURONAL SODIUM CHANNEL
    William Catterall; Fiscal Year: 1992
    ..The results will define the functional roles of these proteins in the development and maintenance of normal electrical excitability in central neurons...