Research Topics
| Corey CasperSummaryAffiliation: University of Washington Country: USA Publications
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Detail Information
Publications
Condom use and the prevention of genital herpes acquisitionCorey Casper
Department of Medicine, University of Washington, Seattle 98122, USA
Herpes 9:10-4. 2002....
Valganciclovir for suppression of human herpesvirus-8 replication: a randomized, double-blind, placebo-controlled, crossover trialCorey Casper
Department of Medicine, University of Washington, Washington, USA
J Infect Dis 198:23-30. 2008..In vitro and observational studies suggest that ganciclovir inhibits HHV-8 replication, but no randomized clinical trials have been conducted...- Frequent and asymptomatic oropharyngeal shedding of human herpesvirus 8 among immunocompetent menCorey Casper
Department of Medicine, University of Washington, Seattle, WA, USA
J Infect Dis 195:30-6. 2007..Little is known about the clinical and virologic manifestations of human herpesvirus (HHV)-8 infection in immunocompetent persons in the absence of malignancy... - The use of antiviral drugs in the prevention and treatment of Kaposi sarcoma, multicentric Castleman disease and primary effusion lymphomaC Casper
University of Washington Virology Research Clinic, 600 Broadway, Suite 400, Seattle, WA 98122, USA
Curr Top Microbiol Immunol 312:289-307. 2007..A growing body of basic science, preclinical, and observational data suggests that antiviral medications may play an important role in the prevention and treatment of KSHV-associated disease... - Human herpesvirus 8 infection among adolescents in the REACH cohortCorey Casper
Departments of Medicine, Laboratory Medicine, and Epidemiology, University of Washington, Seattle, USA
Arch Pediatr Adolesc Med 160:937-42. 2006..We examined the prevalence and predictors of HHV-8 infection among adolescents with or at high risk for acquiring HIV infection... - Defining a role for antiviral drugs in the treatment of persons with HHV-8 infectionC Casper
The Department of Medicine, University of Washington, and The Program in Infectious Disease, Fred Hutchinson Cancer Research Center, Seattle, WA 98122, USA
Herpes 13:42-7. 2006..This review discusses current evidence for the efficacy of antivirals against HHV-8 and proposes novel uses for such medications in HHV-8 treatment... - HIV serodiscordant sex partners and the prevalence of human herpesvirus 8 infection among HIV negative men who have sex with men: baseline data from the EXPLORE StudyC Casper
Department of Medicine, The University of Washington, Seattle, WA, USA
Sex Transm Infect 82:229-35. 2006..We sought to determine whether oral or anogenital contact with HIV discordant, or unknown serostatus sexual partners is associated with HHV-8 seroprevalence among HIV negative MSM... - The aetiology and management of Castleman disease at 50 years: translating pathophysiology to patient careCorey Casper
Department of Medicine, Division of Infectious Disease, University of Washington School of Medicine, and The Program in Infectious Disease, Fred Hutchinson Cancer Research Center, Seattle, WA 98122, USA
Br J Haematol 129:3-17. 2005..Finally, the natural history of CD and the myriad of therapeutic options are reviewed in the context of a unified model of CD pathophysiology, and continued areas of uncertainty are discussed... - HIV infection and human herpesvirus-8 oral shedding among men who have sex with menCorey Casper
Department of Medicine, The University of Washington, Seattle 98122, USA
J Acquir Immune Defic Syndr 35:233-8. 2004..8, 95% CI 1.0-22.8, P = 0.05), or with detectable oral leukocyte esterase (odds ratio 5.0, 95% CI 2.0-12.5, P < 0.01). CD4 count, antiretroviral therapy, and oral inflammation may influence HHV-8 oropharyngeal shedding... - Remission of HHV-8 and HIV-associated multicentric Castleman disease with ganciclovir treatmentCorey Casper
Department of Medicine, University of Washington School of Medicine, Seattle, USA
Blood 103:1632-4. 2004..These data provide in vivo evidence for the utility of antiviral agents against HHV-8 in the management of MCD... - Assessment of a combined testing strategy for detection of antibodies to human herpesvirus 8 (HHV-8) in persons with Kaposi's sarcoma, persons with asymptomatic HHV-8 infection, and persons at low risk for HHV-8 infectionCorey Casper
Department of Medicine, Virology Research Clinic, University of Washington School of Medicine, Box 359928, Seattle, WA 98195, USA
J Clin Microbiol 40:3822-5. 2002..15 to 0.35) where there was considerable overlap between HHV-8-infected and uninfected individuals. The sensitivity of the testing strategy was 88%, with a specificity of 97%... - Correlates of prevalent and incident Kaposi's sarcoma-associated herpesvirus infection in men who have sex with menCorey Casper
Department of Medicine, University of Washington, Seattle, WA 98195, USA
J Infect Dis 185:990-3. 2002..Reporting > or =1 HIV-positive partner (OR, 5.9; 95% CI, 1.8-19.3), amyl nitrite use (OR, 7.0; 95% CI, 2.1-23.0), and lymphadenopathy in the past 6 months (OR, 7.7; 95% CI, 1.9-31.0) correlated with KSHV seroconversion... - Treatment with valacyclovir, famciclovir, or antiretrovirals reduces human herpesvirus-8 replication in HIV-1 seropositive menAshok Cattamanchi
Department of Medicine, University of Washington, Seattle, Washington, USA
J Med Virol 83:1696-703. 2011..In contrast, HAART was a potent inhibitor of HHV-8 replication. Studies of whether antiviral therapy in combination with ART will prevent HHV-8-associated disease appear warranted... - Persistent genital herpes simplex virus-2 shedding years following the first clinical episodeWarren Phipps
Department of Medicine, University of Washington, Seattle, Washington, USA
J Infect Dis 203:180-7. 2011..Rates of genital shedding initially decrease over time after infection, but data on long-term viral shedding are lacking... - Gender differences in clinical presentation and outcomes of epidemic Kaposi sarcoma in UgandaWarren Phipps
Department of Medicine, University of Washington, Seattle, Washington, United States of America
PLoS ONE 5:e13936. 2010..To identify gender-related differences in KS presentation and outcomes, we evaluated the clinical manifestations and response in men and women with AIDS-associated KS in Uganda... - Clinical presentation and outcome of epidemic Kaposi sarcoma in Ugandan childrenSoren Gantt
Seattle Children s Hospital, Seattle, WA, USA
Pediatr Blood Cancer 54:670-4. 2010..Kaposi sarcoma (KS) is one of the most common pediatric cancers in sub-Saharan Africa. Few data are available about the clinical presentation or response to treatment of children with epidemic (HIV-associated) KS... - Persistent Kaposi sarcoma in the era of highly active antiretroviral therapy: characterizing the predictors of clinical responseHuong Q Nguyen
Department of Epidemiology, University of Washington, Seattle, Washington, USA
AIDS 22:937-45. 2008..To evaluate the role of highly active antiretroviral therapy and chemotherapy on tumor response among persons with AIDS-related Kaposi sarcoma and identify factors associated with response in a clinic setting... - Reduced levels of neutralizing antibodies to Kaposi sarcoma-associated herpesvirus in persons with a history of Kaposi sarcomaLouise E Kimball
Department of Pathobiology, University of Washington, and Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, 98109, USA
J Infect Dis 189:2016-22. 2004..The data from the present study suggest that NAb may play a role in the control of KSHV infection and the prevention of progression of KSHV infection to KS... - The HIV protease inhibitor nelfinavir inhibits Kaposi's sarcoma-associated herpesvirus replication in vitroSoren Gantt
Department of Pediatrics, University of Washington, Seattle, Washington, USA
Antimicrob Agents Chemother 55:2696-703. 2011..Nelfinavir may provide unique benefits for the prevention or treatment of HIV-associated KS and potentially other human herpesviruses by direct inhibition of replication... - Clinical correlates of herpes simplex virus viremia among hospitalized adultsWilliam R Berrington
Department of Medicine, University of Washington, Seattle, Washington, USA
Clin Infect Dis 49:1295-301. 2009..Quantification of herpes simplex virus (HSV) DNA in the peripheral blood is often used to evaluate patients suspected of having disseminated HSV infection. Few studies have examined the clinical correlates of HSV viremia among adults... - Correlates of human herpesvirus-8 seropositivity among U.S. military members recently infected with human immunodeficiency virusNancy F Crum
Department of Medicine, Infectious Diseases Division, Naval Medical Center San Diego, San Diego, California 92134 1005, USA
Sex Transm Dis 30:713-8. 2003..Human herpesvirus 8 (HHV-8), the cause of Kaposi's sarcoma, is common among HIV-infected persons. The exact route of transmission of HHV-8 in various populations is still debated... - New approaches to the treatment of human herpesvirus 8-associated diseaseCorey Casper
Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, and the Department of Medicine, University of Washington, Seattle, Washington 98109, USA
Rev Med Virol 18:321-9. 2008..Finally, novel approaches to treatment and prevention are described, including antiviral agents, targeted molecular therapy and a combination of these modalities... - Predictors of survival after a diagnosis of non-Hodgkin lymphoma in a resource-limited setting: a retrospective study on the impact of HIV infection and its treatmentMoses H Bateganya
Department of Global Health, University of Washington, Seattle, WA 98104, USA
J Acquir Immune Defic Syndr 56:312-9. 2011..We examined factors associated with survival among patients with newly diagnosed non-Hodgkin lymphoma (NHL) in Uganda... - Impact of HIV infection and Kaposi sarcoma on human herpesvirus-8 mucosal replication and dissemination in UgandaChristine Johnston
Department of Medicine, University of Washington, Seattle, Washington, United States of America
PLoS ONE 4:e4222. 2009..Human herpesvirus-8 (HHV-8) replication is important both in transmission of HHV-8 and progression to KS. We characterized the sites and frequency of HHV-8 detection in Ugandans with and without HIV and KS... - HIV-specific CD8+ T cells from HIV+ individuals receiving HAART can be expanded ex vivo to augment systemic and mucosal immunity in vivoAude G Chapuis
Program in Immunology, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
Blood 117:5391-402. 2011.... 
The increasing burden of HIV-associated malignancies in resource-limited regionsCorey Casper
Vaccine and Infectious Disease, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Annu Rev Med 62:157-70. 2011..The pathogenesis of HIV-associated cancers is considered in relation to potential strategies for their prevention and treatment...- Gamma delta+ T cells involvement in viral immune control of chronic human herpesvirus 8 infectionSerge Barcy
Department of Laboratory Medicine, University of Washington, Seattle, WA 98109, USA
J Immunol 180:3417-25. 2008..These data indicate that gammadelta T cells play a role in both innate and adaptive T cell responses against HHV-8 in immunocompetent individuals... - A case report of dengue virus infection and acalculous cholecystitis in a pregnant returning travelerWilliam R Berrington
Department of Medicine, Division of Allergy and Infectious Disease, University of Washington, Seattle, WA 98195, USA
Travel Med Infect Dis 5:251-3. 2007..Travel during pregnancy to dengue-endemic areas poses a risk to both mother and fetus. Pregnancies complicated by dengue infection require close monitoring for potential maternal and fetal complications... - Cutaneous T-cell lymphoma in sub-Saharan AfricaMatthew Ulrickson
Clinical Research Division, Fred Hutchinson Cancer Research Center, and Department of Medicine, University of Washington, Seattle, Washington, USA
J Natl Compr Canc Netw 11:275-80. 2013..Areas for future investigation that can improve the care of patients in this region are identified... - Paradoxical immune reconstitution inflammatory syndrome in HIV-infected patients treated with combination antiretroviral therapy after AIDS-defining opportunistic infectionChad J Achenbach
Department of Medicine, Feinberg School of Medicine, Division of Infectious Diseases and Center for Global Health, Northwestern University, Chicago, Illinois 60611, USA
Clin Infect Dis 54:424-33. 2012..The incidence of immune reconstitution inflammatory syndrome (IRIS) when antiretroviral therapy (ART) is initiated after an AIDS-defining opportunistic infection (OI) is uncertain and understudied for the most common OIs... - How I treat influenza in patients with hematologic malignanciesCorey Casper
Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Blood 115:1331-42. 2010..We also summarize infection control and vaccination strategies for patients, family members, and caregivers... - Human herpesvirus 8-associated neoplasms: the roles of viral replication and antiviral treatmentSoren Gantt
Department of Pediatrics, University of Washington, Seattle Children s Hospital, Seattle, WA 98101, USA
Curr Opin Infect Dis 24:295-301. 2011..In this review, we highlight the importance of human herpesvirus 8 (HHV-8) lytic replication and the potential for antiviral therapies to prevent or treat HHV-8-related neoplasms... - The contribution of malglycemia to mortality among allogeneic hematopoietic cell transplant recipientsMarilyn J Hammer
Department of Biobehavioral Nursing and Health Systems, University of Washington, Seattle, Washington, USA
Biol Blood Marrow Transplant 15:344-51. 2009..The applicability of these findings to other situations and whether correcting malglycemia in HCT can lead to reductions in mortality remain to be determined... - HIV/AIDS: epidemiology, pathophysiology, and treatment of Kaposi sarcoma-associated herpesvirus disease: Kaposi sarcoma, primary effusion lymphoma, and multicentric Castleman diseaseRyan J Sullivan
Division of Hematology and Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Clin Infect Dis 47:1209-15. 2008..The scope of this review is to present contemporary knowledge about the epidemiology, virology, and immunology of Kaposi sarcoma-associated herpesvirus and to highlight several key oncogene products that may be targets for chemotherapy...