Research Topics
| Sherwood CasjensSummaryAffiliation: University of Utah Country: USA Publications
Research Grants
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Detail Information
Publications
Genome stability of Lyme disease spirochetes: comparative genomics of Borrelia burgdorferi plasmidsSherwood R Casjens
Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
PLoS ONE 7:e33280. 2012..In spite of these rearrangements and differences in plasmid contents, the overall gene complement of the different isolates has remained relatively constant...- The protein interaction map of bacteriophage lambdaSeesandra V Rajagopala
J Craig Venter Institute, Rockville, MD 20850, USA
BMC Microbiol 11:213. 2011..We have manually curated the lambda literature and compiled a total of 33 interactions that have been found among lambda proteins. We set out to find out how many protein-protein interactions remain to be found in this phage... 
Analysis of the lambdoid prophage element e14 in the E. coli K-12 genomePreeti Mehta
Bioinformatics Centre, School of Biotechnology, Madurai Kamaraj University, Madurai 625021, India
BMC Microbiol 4:4. 2004..coli K-12 genome. This prophage encodes important functional genes such as lit (T4 exclusion), mcrA (modified cytosine restriction activity) and pin (recombinase)...- Genomic analysis of bacteriophage epsilon 34 of Salmonella enterica serovar Anatum (15+)Robert Villafane
Ponce School of Medicine, Department of Microbiology, Ponce, Puerto Rico 00732, USA
BMC Microbiol 8:227. 2008.... 
Comparative genomics and evolution of the tailed-bacteriophagesSherwood R Casjens
Division of Cell Biology and Immunology, Department of Pathology, University of Utah Medical School, Salt Lake City, UT 84132, USA
Curr Opin Microbiol 8:451-8. 2005..Recent molecular studies of phages other than these model system phages have made it clear that much remains to be learnt about the variety of lifestyle strategies utilized by the tailed-phage...- Diversity among the tailed-bacteriophages that infect the EnterobacteriaceaeSherwood R Casjens
Department of Pathology, Room 5200K EEJMRB, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
Res Microbiol 159:340-8. 2008..More recent horizontal exchange of phage tail fiber and early proteins between the categories occurs, but is probably not extremely rapid... - The generalized transducing Salmonella bacteriophage ES18: complete genome sequence and DNA packaging strategySherwood R Casjens
Department of Pathology, University of Utah Medical School, Salt Lake City, UT 84132, USA
J Bacteriol 187:1091-104. 2005..Bioinformatic analysis of large terminase subunits shows that the different functional classes of phage-encoded terminases can usually be predicted from their amino acid sequence... - Whole genome sequence of an unusual Borrelia burgdorferi sensu lato isolateSherwood R Casjens
Department of Pathology, Room 2200 EEJMRB, 15 North Medical Drive East, University of Utah Medical School, Salt Lake City, UT 84112, USA
J Bacteriol 193:1489-90. 2011..We suggest that this isolate should be named "Borrelia finlandensis.".. 
The DNA-packaging nanomotor of tailed bacteriophagesSherwood R Casjens
Division of Microbiology and Immunology, Pathology Department, University of Utah School of Medicine, 15 North Medical Drive East, Salt Lake City, Utah 84112, USA
Nat Rev Microbiol 9:647-57. 2011....- The chromosome of Shigella flexneri bacteriophage Sf6: complete nucleotide sequence, genetic mosaicism, and DNA packagingSherwood Casjens
Department of Pathology, University of Utah Medical School, Salt Lake City, UT 84132, USA
J Mol Biol 339:379-94. 2004..This is unlike previously characterized phage packaging mechanisms... - The pKO2 linear plasmid prophage of Klebsiella oxytocaSherwood R Casjens
Department of Pathology, University of Utah Medical School, Salt Lake City, Utah 84132, USA
J Bacteriol 186:1818-32. 2004..We show that these divergently transcribed genes are regulated by LexA protein binding to a single target site that overlaps both promoters... - Whole-genome sequences of two Borrelia afzelii and two Borrelia garinii Lyme disease agent isolatesSherwood R Casjens
Department of Pathology, Division of Microbiology and Immunology, University of Utah Medical School, Salt Lake City, Utah 84112, USA
J Bacteriol 193:6995-6. 2011..We report here the whole-genome sequences of four isolates from two of the Borrelia species that cause human Lyme disease, B. afzelii isolates ACA-1 and PKo and B. garinii isolates PBr and Far04... - Prophages and bacterial genomics: what have we learned so far?Sherwood Casjens
Department of Pathology, University of Utah Medical School, Salt Lake City, UT 84132 2501, USA
Mol Microbiol 49:277-300. 2003..In addition, many genes in defective prophages remain functional, so a significant portion of the temperate bacteriophage gene pool resides in prophages... - Linear chromosome-generating system of Agrobacterium tumefaciens C58: protelomerase generates and protects hairpin endsWai Mun Huang
Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, Utah 84112, USA
J Biol Chem 287:25551-63. 2012..The biochemical analyses of the protelomerase reactions further revealed that the tip of the hairpin telomere may be unusually polymorphically capable of accommodating any nucleotide... - The DNA site utilized by bacteriophage P22 for initiation of DNA packagingHongyu Wu
Department of Pathology, University of Utah Medical Center, Salt Lake City 84132, USA
Mol Microbiol 45:1631-46. 2002..It is an asymmetric site that spans 22 basepairs and is located near the centre of P22 gene 3... - Telomere exchange between linear replicons of Borrelia burgdorferiWai Mun Huang
Department of Pathology, University of Utah Medical School, Salt Lake City, Utah 84132, USA
J Bacteriol 186:4134-41. 2004..The unusual nonhomologous nature of this rearrangement suggests that, barring horizontal transfer, it can be used as a unique genetic marker for this lineage of B. burgdorferi chromosomes... - Evolution of mosaically related tailed bacteriophage genomes seen through the lens of phage P22 virion assemblySherwood R Casjens
Pathology Department, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
Virology 411:393-415. 2011..The relatively large sample size and the fact that phage P22 virion structure and assembly are exceptionally well understood make the conclusions especially informative and convincing... - Protelomerase uses a topoisomerase IB/Y-recombinase type mechanism to generate DNA hairpin endsWai Mun Huang
Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT 84132 2501, USA
J Mol Biol 337:77-92. 2004..Comparative studies using the related target sites of different protelomerases suggest that these proteins may require both sequence-specific and structure (possibly cruciform)-specific recognition for activity... - Determining DNA packaging strategy by analysis of the termini of the chromosomes in tailed-bacteriophage virionsSherwood R Casjens
Division of Cell Biology and Immunology, Department of Pathology, University of Utah Medical School, Salt Lake City, UT, USA
Methods Mol Biol 502:91-111. 2009..This chapter discusses these methods... - Molecular genetics of bacteriophage P22 scaffolding protein's functional domainsPeter R Weigele
Department of Pathology, University of Utah School of Medicine, 50 North 1900 East, Salt Lake City, UT 84132, USA
J Mol Biol 348:831-44. 2005..Finally, scaffolding protein amino acids 280 through 294 constitute its minimal coat protein binding site... - Nucleotide sequence of the head assembly gene cluster of bacteriophage L and decoration protein characterizationEddie B Gilcrease
Division of Cell Biology and Immunology, Department of Pathology, University of Utah Medical School, Salt Lake City, UT 84132, USA
J Bacteriol 187:2050-7. 2005.... - Genetic exchange and plasmid transfers in Borrelia burgdorferi sensu stricto revealed by three-way genome comparisons and multilocus sequence typingWei Gang Qiu
Department of Biological Sciences, Hunter College of the City University of New York, 695 Park Avenue, New York, NY 10021, USA
Proc Natl Acad Sci U S A 101:14150-5. 2004..Frequent recombination implies a potential for rapid adaptive evolution and a possible polygenic basis of B. burgdorferi pathogenicity... - Corrected sequence of the bacteriophage p22 genomeMarisa L Pedulla
Pittsburgh Bacteriophage Institute Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
J Bacteriol 185:1475-7. 2003..DNA sequencing technology is now good enough that genomes of important model systems like P22 can be sequenced with essentially 100% accuracy with minimal investment of time and resources... - Bidirectional replication from an internal ori site of the linear N15 plasmid prophageNikolai V Ravin
Centre Bioengineering, Russian Academy of Sciences, Prosp 60 let Oktiabria, Building 7 1, Moscow, 117312, Russia
Nucleic Acids Res 31:6552-60. 2003.... - The structure of an infectious P22 virion shows the signal for headful DNA packagingGabriel C Lander
Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Science 312:1791-5. 2006..We propose that the tight dsDNA spooling activates the switch that signals the headful chromosome packing density to the particle exterior... - Assembly architecture and DNA binding of the bacteriophage P22 terminase small subunitDaniel Nemecek
School of Biological Sciences, University of Missouri Kansas City, Kansas City, MO 64110 2499, USA
J Mol Biol 383:494-501. 2008..The results suggest a plausible molecular mechanism for gp3 function in DNA recognition and translocation... - Binding-induced stabilization and assembly of the phage P22 tail accessory factor gp4Adam S Olia
Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, 750, E. Adams Street, Syracuse, NY 13210, USA
J Mol Biol 363:558-76. 2006.... - Highly discriminatory binding of capsid-cementing proteins in bacteriophage LLiang Tang
Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Structure 14:837-45. 2006..Sequence analysis shows striking similarity between the C-terminal portion of phage L Dec protein and five regions in the long tail fiber of a T4-like phage, suggesting functional parallelism between them...
Research Grants
- Comparative Genomics of Lyme Disease SpirochetesSherwood Casjens; Fiscal Year: 2004..burgdorferi population. These findings will impact the study of the molecular pathogenesis of Lyme disease in many ways. ..
- DNA packaging and delivery by dsDNA virusesSherwood Casjens; Fiscal Year: 2007..The aims of the project will be pursued through a combination of genetic, biochemical, biophysical and structural analysis strategies. ..
- DNA packaging and delivery by dsDNA virusesSherwood Casjens; Fiscal Year: 2009..The roles of these proteins, which form the motor that packages DNA and releases DNA during injection, are studied by genetic, biochemical and structural analysis ..
- DNA packaging and delivery by dsDNA virusesSherwood R Casjens; Fiscal Year: 2010..The roles of these proteins, which form the motor that packages DNA and releases DNA during injection, are studied by genetic, biochemical and structural analysis ..
- DNA packaging and delivery by dsDNA virusesSherwood R Casjens; Fiscal Year: 2010..The roles of these proteins, which form the motor that packages DNA and releases DNA during injection, are studied by genetic, biochemical and structural analysis ..