JOHN CASIDA

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Golden age of insecticide research: past, present, or future?
    J E Casida
    Department of Environmental Science, Policy and Management, University of California, Berkeley 94720 3112, USA
    Annu Rev Entomol 43:1-16. 1998
  2. ncbi request reprint Serine hydrolase targets of organophosphorus toxicants
    John E Casida
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
    Chem Biol Interact 157:277-83. 2005
  3. ncbi request reprint Organophosphate toxicology: safety aspects of nonacetylcholinesterase secondary targets
    John E Casida
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    Chem Res Toxicol 17:983-98. 2004
  4. doi request reprint Pest toxicology: the primary mechanisms of pesticide action
    John E Casida
    Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    Chem Res Toxicol 22:609-19. 2009
  5. pmc Organophosphate-sensitive lipases modulate brain lysophospholipids, ether lipids and endocannabinoids
    John E Casida
    Environmental Chemistry and Toxicology Laboratory Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
    Chem Biol Interact 175:355-64. 2008
  6. ncbi request reprint Insect nicotinic acetylcholine receptors: neonicotinoid binding site specificity is usually but not always conserved with varied substituents and species
    Hideo Honda
    Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    J Agric Food Chem 54:3365-71. 2006
  7. pmc Atypical nicotinic agonist bound conformations conferring subtype selectivity
    Motohiro Tomizawa
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
    Proc Natl Acad Sci U S A 105:1728-32. 2008
  8. ncbi request reprint Defining nicotinic agonist binding surfaces through photoaffinity labeling
    Motohiro Tomizawa
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    Biochemistry 46:8798-806. 2007
  9. pmc Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels
    Daniel K Nomura
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, 115 Wellman Hall, University of California, Berkeley, CA 94720 3112, USA
    Bioorg Med Chem Lett 18:5875-8. 2008
  10. doi request reprint Potency and selectivity of trifluoroacetylimino and pyrazinoylimino nicotinic insecticides and their fit at a unique binding site niche
    Motohiro Tomizawa
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy, and Management, University of California, Berkeley, California 94720 3112, USA
    J Med Chem 51:4213-8. 2008

Research Grants

  1. ORGANOPHOSPHORUS INSECTICIDE TOXICOLOGY
    JOHN CASIDA; Fiscal Year: 2002
  2. CHOLINERGIC INSECTICIDE TOXICOLOGY
    JOHN CASIDA; Fiscal Year: 2002
  3. Organophosphorus Pesticide Toxicology
    JOHN CASIDA; Fiscal Year: 2006
  4. GABAERGIC INSECTICIDE TOXICOLOGY
    JOHN CASIDA; Fiscal Year: 2002
  5. CHOLINERGIC INSECTICIDE TOXICOLOGY
    JOHN CASIDA; Fiscal Year: 2006

Collaborators

Detail Information

Publications72

  1. ncbi request reprint Golden age of insecticide research: past, present, or future?
    J E Casida
    Department of Environmental Science, Policy and Management, University of California, Berkeley 94720 3112, USA
    Annu Rev Entomol 43:1-16. 1998
    ..Insecticide research, having passed through several Golden Ages, is now in a renaissance of integrating chemicals and biologicals for sustainable pest control with human safety...
  2. ncbi request reprint Serine hydrolase targets of organophosphorus toxicants
    John E Casida
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
    Chem Biol Interact 157:277-83. 2005
    ..e. it is not clear if they play a role in OP toxicology...
  3. ncbi request reprint Organophosphate toxicology: safety aspects of nonacetylcholinesterase secondary targets
    John E Casida
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    Chem Res Toxicol 17:983-98. 2004
  4. doi request reprint Pest toxicology: the primary mechanisms of pesticide action
    John E Casida
    Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    Chem Res Toxicol 22:609-19. 2009
    ..Defining and applying the principles of pest toxicology are critical to food production and human health...
  5. pmc Organophosphate-sensitive lipases modulate brain lysophospholipids, ether lipids and endocannabinoids
    John E Casida
    Environmental Chemistry and Toxicology Laboratory Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
    Chem Biol Interact 175:355-64. 2008
    ..Only the first steps have been taken to achieve appropriate selective action for OP therapeutic agents...
  6. ncbi request reprint Insect nicotinic acetylcholine receptors: neonicotinoid binding site specificity is usually but not always conserved with varied substituents and species
    Hideo Honda
    Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    J Agric Food Chem 54:3365-71. 2006
    ..The TFM moiety of DIN may bind in a different orientation compared to the CPM group of IMI and ACE...
  7. pmc Atypical nicotinic agonist bound conformations conferring subtype selectivity
    Motohiro Tomizawa
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
    Proc Natl Acad Sci U S A 105:1728-32. 2008
    ..Accordingly, the subtype selectivity is based on two disparate bound conformations of nicotinic agonists, thereby establishing an atypical concept for neonicotinoid versus nicotinoid selectivity between insect and vertebrate nAChRs...
  8. ncbi request reprint Defining nicotinic agonist binding surfaces through photoaffinity labeling
    Motohiro Tomizawa
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    Biochemistry 46:8798-806. 2007
    ..These findings enabled us to use AChBP as a structural surrogate to define the nAChR agonist site...
  9. pmc Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels
    Daniel K Nomura
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, 115 Wellman Hall, University of California, Berkeley, CA 94720 3112, USA
    Bioorg Med Chem Lett 18:5875-8. 2008
    ..Apparent direct OP inhibition of CB1 agonist binding may be due instead to metabolic stabilization of 2-AG in brain membranes as the actual inhibitor...
  10. doi request reprint Potency and selectivity of trifluoroacetylimino and pyrazinoylimino nicotinic insecticides and their fit at a unique binding site niche
    Motohiro Tomizawa
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy, and Management, University of California, Berkeley, California 94720 3112, USA
    J Med Chem 51:4213-8. 2008
    ....
  11. pmc Activation of the endocannabinoid system by organophosphorus nerve agents
    Daniel K Nomura
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, 114 Wellman Hall, Berkeley, California 94720 3112, USA
    Nat Chem Biol 4:373-8. 2008
    ..Arachidonic acid levels are decreased by the organophosphorus agents in amounts equivalent to elevations in 2-AG, which indicates that endocannabinoid and eicosanoid signaling pathways may be coordinately regulated in the brain...
  12. ncbi request reprint Specificity of ethephon as a butyrylcholinesterase inhibitor and phosphorylating agent
    J Eric Haux
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    Chem Res Toxicol 15:1527-33. 2002
    ..More than a dozen other esterases examined are 10-100-fold less sensitive than BChE to ethephon. Thus, BChE inhibition continues to be the most sensitive marker of ethephon exposure...
  13. ncbi request reprint Structural features of azidopyridinyl neonicotinoid probes conferring high affinity and selectivity for mammalian alpha4beta2 and Drosophila nicotinic receptors
    Nanjing Zhang
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
    J Med Chem 45:2832-40. 2002
    ..Preferred compounds are N-(5-azido-6-chloropyridin-3-ylmethyl) with 2-iminothiazoline for alpha4beta2 (K(i) = 0.47 nM) and with 2-nitroiminothiazoline or 2-nitromethyleneimidazolidine for Drosophila (K(i) = 0.72-3.9 nM)...
  14. ncbi request reprint Unique and common metabolites of thiamethoxam, clothianidin, and dinotefuran in mice
    Kevin A Ford
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    Chem Res Toxicol 19:1549-56. 2006
    ..The diversity of biodegradable sites and multiple pathways insures against parent compound accumulation but provides intermediates reported to be active as nicotinic agonists and inducible nitric oxide synthase inhibitors...
  15. pmc Mapping the elusive neonicotinoid binding site
    Motohiro Tomizawa
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy, and Management, University of California, Berkeley, CA 94720 3112, USA
    Proc Natl Acad Sci U S A 104:9075-80. 2007
    ..These structural models based on AChBP directly map the elusive neonicotinoid binding site and further describe the molecular determinants of agonists on nicotinic receptors...
  16. doi request reprint S-Arachidonoyl-2-thioglycerol synthesis and use for fluorimetric and colorimetric assays of monoacylglycerol lipase
    John E Casida
    Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720, USA
    Bioorg Med Chem 18:1942-7. 2010
    ..Inhibitor structure-activity relationships observed here for hMAGL and 2-ATG correlate well (r(2)=0.93, n=9) with earlier findings for mouse brain MAG hydrolase with non-thiol substrates...
  17. pmc Dual roles of brain serine hydrolase KIAA1363 in ether lipid metabolism and organophosphate detoxification
    Daniel K Nomura
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, 115 Wellman Hall, University of California, Berkeley, CA 94720 3112, USA
    Toxicol Appl Pharmacol 228:42-8. 2008
    ..This study establishes the relevance of KIAA1363 in ether lipid metabolism and OP detoxification...
  18. pmc Nicotinic agonist binding site mapped by methionine- and tyrosine-scanning coupled with azidochloropyridinyl photoaffinity labeling
    Motohiro Tomizawa
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    J Med Chem 52:3735-41. 2009
    ..Methionine and tyrosine are the only residues found derivatized, and their reactivity exquisitely depends on the direction of the azido moiety and its apposition to the reactive amino acid side chains...
  19. ncbi request reprint Selective inhibitors of fatty acid amide hydrolase relative to neuropathy target esterase and acetylcholinesterase: toxicological implications
    Gary B Quistad
    Environmental Chemistry and Toxicology Laboratory, University of California, Berkeley, California 94720 3112, USA
    Toxicol Appl Pharmacol 179:57-63. 2002
    ..Thus, FAAH inhibition in mouse brain does not appear to be a primary target for organophosphorus pesticide-induced neurotoxic action (cholinergic or intermediate syndrome or delayed neurotoxicity)...
  20. ncbi request reprint Substrate specificity of rabbit aldehyde oxidase for nitroguanidine and nitromethylene neonicotinoid insecticides
    Ryan A Dick
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    Chem Res Toxicol 19:38-43. 2006
    ..These in vitro observations show large structural differences in the rates of AOX-catalyzed reduction and help to interpret the extensive studies on in vivo metabolism of neonicotinoid insecticides...
  21. ncbi request reprint Selective toxicity of neonicotinoids attributable to specificity of insect and mammalian nicotinic receptors
    Motohiro Tomizawa
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    Annu Rev Entomol 48:339-64. 2003
    ....
  22. doi request reprint Michael Elliott's billion dollar crystals and other discoveries in insecticide chemistry
    John E Casida
    Environmental Chemistry and Toxicology Laboratory, University of California, Berkeley, CA 94720 3112, USA
    Pest Manag Sci 66:1163-70. 2010
    ..This review considers Michael's seminal discoveries in insecticide chemistry, with emphasis on his Berkeley years...
  23. doi request reprint Molecular recognition of neonicotinoid insecticides: the determinants of life or death
    Motohiro Tomizawa
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    Acc Chem Res 42:260-9. 2009
    ..Therefore, the unique binding conformations of nicotinic agonists in these insect and vertebrate receptor homologues define the basis for molecular recognition of neonicotinoid insecticides as the determinants of life or death...
  24. ncbi request reprint Major intermediates in organophosphate synthesis (PCl3, POCl3, PSCl3, and their diethyl esters) are anticholinesterase agents directly or on activation
    Yoffi Segall
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    Chem Res Toxicol 16:350-6. 2003
    ..In contrast, the toxicity to mice of phosphofluorides [FP(O)Cl(2), F(Cl)P(O)OH, and F(2)P(O)OH; studied as model compounds for comparison] may be due to liberating fluoride ion...
  25. ncbi request reprint Neonicotinoid insecticide toxicology: mechanisms of selective action
    Motohiro Tomizawa
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    Annu Rev Pharmacol Toxicol 45:247-68. 2005
    ..The low affinity of neonicotinoids for vertebrate relative to insect nicotinic receptors is a major factor in their favorable toxicological profile...
  26. pmc Enzymes and inhibitors in neonicotinoid insecticide metabolism
    Xueyan Shi
    Department of Environmental Science, Environmental Chemistry and Toxicology Laboratory, University of California, Berkeley, California 94720 3112, USA
    J Agric Food Chem 57:4861-6. 2009
    ..Two organophosphorus CYP450 inhibitors partially block IMI, thiacloprid, and CLO metabolism in vivo in mice, elevating brain and liver levels of the parent compounds while reducing amounts of the hydroxylated metabolites...
  27. ncbi request reprint Platelet-activating factor acetylhydrolase: selective inhibition by potent n-alkyl methylphosphonofluoridates
    Gary B Quistad
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
    Toxicol Appl Pharmacol 205:149-56. 2005
    ..These studies with a mouse model indicate that PAF-AH is not a major secondary target of OP pesticide poisoning. The optimized PAF-AH inhibitors may facilitate investigations on other aspects of PAF metabolism and action...
  28. ncbi request reprint Monoacylglycerol lipase inhibition by organophosphorus compounds leads to elevation of brain 2-arachidonoylglycerol and the associated hypomotility in mice
    Gary B Quistad
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, 115 Wellman Hall, Berkeley, CA 94720 3112, USA
    Toxicol Appl Pharmacol 211:78-83. 2006
    ..It therefore appears that OP-induced MAG lipase inhibition leads to elevated 2-AG and the associated hypomotility...
  29. ncbi request reprint Pharmacological profiles of recombinant and native insect nicotinic acetylcholine receptors
    Motohiro Tomizawa
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, 94720 3112, USA
    Insect Biochem Mol Biol 35:1347-55. 2005
    ..These findings are consistent with the agonist binding site being located at the nAChR subunit interface and indicate that both alpha and beta subunits influence the pharmacological properties of insect nAChRs...
  30. ncbi request reprint Chloropyridinyl neonicotinoid insecticides: diverse molecular substituents contribute to facile metabolism in mice
    Kevin A Ford
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, 94720 3112, USA
    Chem Res Toxicol 19:944-51. 2006
  31. ncbi request reprint Blood acylpeptide hydrolase activity is a sensitive marker for exposure to some organophosphate toxicants
    Gary B Quistad
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    Toxicol Sci 86:291-9. 2005
    ..Blood APH activity is therefore a sensitive marker for exposure to some but not all OP pesticides and chemical warfare agents...
  32. pmc Serine hydrolase KIAA1363: toxicological and structural features with emphasis on organophosphate interactions
    Daniel K Nomura
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, 115 Wellman Hall, University of California, Berkeley, California 94720 3112, USA
    Chem Res Toxicol 19:1142-50. 2006
    ..The structural modeling of KIAA1363 helps us understand OP structure-activity relationships and the toxicological relevance of this detoxifying enzyme...
  33. ncbi request reprint 6'-Methylpyrido[3,4-b]norhomotropane: synthesis and outstanding potency in relation to the alpha4beta2 nicotinic receptor pharmacophore model
    David B Kanne
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
    Bioorg Med Chem Lett 15:877-81. 2005
    ..In this pharmacophore model, the 6'-methyl substituent may be equivalent to the acetyl methyl of acetylcholine...
  34. ncbi request reprint Desnitro-imidacloprid activates the extracellular signal-regulated kinase cascade via the nicotinic receptor and intracellular calcium mobilization in N1E-115 cells
    Motohiro Tomizawa
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy, and Management, University of California, Berkeley 94720 3112, USA
    Toxicol Appl Pharmacol 184:180-6. 2002
    ..It is further suggested that intracellular Ca(2+) activates a sequential pathway from PKC to ERK...
  35. doi request reprint Comparative metabolism and pharmacokinetics of seven neonicotinoid insecticides in spinach
    Kevin A Ford
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    J Agric Food Chem 56:10168-75. 2008
    ..The findings highlight both metabolites common to several neonicotinoids and those that are compound specific...
  36. pmc Neonicotinoid insecticides induce salicylate-associated plant defense responses
    Kevin A Ford
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 107:17527-32. 2010
    ..Thus, via different mechanisms, these chloropyridinyl- and chlorothiazolyl-neonicotinoids induce SA responses associated with enhanced stress tolerance...
  37. pmc Lysophosphatidylcholine hydrolases of human erythrocytes, lymphocytes, and brain: sensitive targets of conserved specificity for organophosphorus delayed neurotoxicants
    Sarah C Vose
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, 115 Wellman Hall, University of California, Berkeley, CA 94720 3112, USA
    Toxicol Appl Pharmacol 224:98-104. 2007
    ..The relative contributions of NTE and LysoPLAs to LysoPC hydrolysis and clearance from erythrocytes, lymphocytes, and brain remain to be defined...
  38. ncbi request reprint 5-Azidoepibatidine: an exceptionally potent photoaffinity ligand for neuronal alpha 4 beta 2 and alpha 7 nicotinic acetylcholine receptors
    Nanjing Zhang
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
    Bioorg Med Chem Lett 13:525-7. 2003
    ..027 nM for alpha 4 beta 2 and 9.7 nM for alpha 7) and excellent photoreactivity...
  39. ncbi request reprint Imidacloprid insecticide metabolism: human cytochrome P450 isozymes differ in selectivity for imidazolidine oxidation versus nitroimine reduction
    Daniel A Schulz-Jander
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
    Toxicol Lett 132:65-70. 2002
    ..These observations establish site specificity in IMI metabolism by CYP450 isozymes and that a single enzyme (CYP3A4) both oxidizes and reduces IMI at the imidazolidine and nitroimine moieties, respectively...
  40. ncbi request reprint Glutathione S-transferase conjugation of organophosphorus pesticides yields S-phospho-, S-aryl-, and S-alkylglutathione derivatives
    Kazutoshi Fujioka
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
    Chem Res Toxicol 20:1211-7. 2007
    ..Nine other OP pesticides gave only O-dealkylation in the GST/GSH system. GST-catalyzed metabolism joins P450s and hydrolases as important contributors to OP detoxification...
  41. ncbi request reprint Each lipase has a unique sensitivity profile for organophosphorus inhibitors
    Gary B Quistad
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    Toxicol Sci 91:166-72. 2006
    ..In general, each lipase (like each serine hydrolase) has a different spectrum of OP sensitivity, and individual OPs have unique ranking of potency for inhibition of serine hydrolases...
  42. pmc Structural model for gamma-aminobutyric acid receptor noncompetitive antagonist binding: widely diverse structures fit the same site
    Ligong Chen
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy, and Management, College of Chemistry, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 103:5185-90. 2006
    ..Thus, widely diverse NCA structures fit the same GABA receptor beta subunit site with important implications for insecticide cross-resistance and selective toxicity between insects and mammals...
  43. ncbi request reprint Neonicotinoid nitroguanidine insecticide metabolites: synthesis and nicotinic receptor potency of guanidines, aminoguanidines, and their derivatives
    David B Kanne
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    Chem Res Toxicol 18:1479-84. 2005
    ..In sharp contrast, potency at the vertebrate alpha4beta2 nicotinic receptor is generally increased on conversion from the nitroguanidine to aminoguanidine and particularly guanidine derivatives...
  44. ncbi request reprint The neonicotinoid electronegative pharmacophore plays the crucial role in the high affinity and selectivity for the Drosophila nicotinic receptor: an anomaly for the nicotinoid cation--pi interaction model
    Motohiro Tomizawa
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    Biochemistry 42:7819-27. 2003
    ....
  45. ncbi request reprint GABA receptor antagonists and insecticides: common structural features of 4-alkyl-1-phenylpyrazoles and 4-alkyl-1-phenyltrioxabicyclooctanes
    Robert E Sammelson
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
    Bioorg Med Chem 12:3345-55. 2004
    ....
  46. ncbi request reprint Drosophila nicotinic receptors: evidence for imidacloprid insecticide and alpha-bungarotoxin binding to distinct sites
    Nanjing Zhang
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, 114 Wellman Hall, Berkeley, CA 94720 3112, USA
    Neurosci Lett 371:56-9. 2004
    ..This study, therefore, provides direct evidence for distinct IMI- and alpha-BGT-sensitive sites or subtypes in Drosophila brain...
  47. pmc Evidence that mouse brain neuropathy target esterase is a lysophospholipase
    Gary B Quistad
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy, and Management, University of California, Berkeley, CA 94720 3112, USA
    Proc Natl Acad Sci U S A 100:7983-7. 2003
    ..This mouse model has some features in common with OP-induced delayed neuropathy in hens and people but differs in the neuropathological signs and apparently the requirement for NTE aging...
  48. ncbi request reprint Cartap hydrolysis relative to its action at the insect nicotinic channel
    Seog Jong Lee
    Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    J Agric Food Chem 52:95-8. 2004
    ..1 but quickly forms the dithiol and some NTX at pH 7.4. The relationship between potency and hydrolysis products at various pH ranges suggests that cartap dithiol is the most plausible blocking agent...
  49. ncbi request reprint Cannabinoid CB1 receptor as a target for chlorpyrifos oxon and other organophosphorus pesticides
    Gary B Quistad
    Department of Environmental Science, Policy and Management, Environmental Chemistry and Toxicology Laboratory, University of California, Berkeley, CA 94720 3112, USA
    Toxicol Lett 135:89-93. 2002
    ..3H-ethyl]Chlorpyrifos oxon may be suitable for radiolabeling and characterization of this proposed nucleophilic site...
  50. ncbi request reprint Novel irreversible butyrylcholinesterase inhibitors: 2-chloro-1-(substituted-phenyl)ethylphosphonic acids
    Nanjing Zhang
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
    Bioorg Med Chem 10:1281-90. 2002
    ..These observations suggest dissociation of chloride as the first and rate-limiting step both in the hydrolysis and by analogy in phosphorylation of BChE by bound at the active site...
  51. ncbi request reprint Neonicotinoid insecticides: reduction and cleavage of imidacloprid nitroimine substituent by liver microsomal and cytosolic enzymes
    Daniel A Schulz-Jander
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    Chem Res Toxicol 15:1158-65. 2002
    ..Other neonicotinoids with nitroimine, nitrosoimine, and nitromethylene substituents are probably also metabolized by "neonicotinoid nitro reductase(s)" since they serve as competitive substrates for [(3)H]IMI metabolism...
  52. ncbi request reprint Neo-nicotinoid metabolic activation and inactivation established with coupled nicotinic receptor-CYP3A4 and -aldehyde oxidase systems
    Hideo Honda
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
    Toxicol Lett 161:108-14. 2006
    ....
  53. ncbi request reprint Insecticides in Chinese medicinal plants: survey leading to jacaranone, a neurotoxicant and glutathione-reactive quinol
    Hanhong Xu
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
    J Agric Food Chem 51:2544-7. 2003
    ....
  54. ncbi request reprint Unique insecticide specificity of human homomeric rho 1 GABA(C) receptor
    Gurpreet S Ratra
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
    Toxicol Lett 129:47-53. 2002
    ..The inhibitor sensitivity and specificity of this rho 1 GABA(C) receptor differ greatly from those of human homomeric beta 3 and native GABA(A) receptors...
  55. ncbi request reprint Toxicological and structural features of organophosphorus and organosulfur cannabinoid CB1 receptor ligands
    Yoffi Segall
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    Toxicol Sci 76:131-7. 2003
    ..On the other hand, the most potent CB1 inhibitors examined here are also NTE-LysoPLA inhibitors and cause delayed toxicity in mice...
  56. ncbi request reprint Phenylpyrazole insecticide photochemistry, metabolism, and GABAergic action: ethiprole compared with fipronil
    Pierluigi Caboni
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    J Agric Food Chem 51:7055-61. 2003
    ..On an overall basis, the ethiprole series is very similar in potency to the fipronil series...
  57. ncbi request reprint Nereistoxin and cartap neurotoxicity attributable to direct block of the insect nicotinic receptor/channel
    Seog Jong Lee
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
    J Agric Food Chem 51:2646-52. 2003
    ..Surprisingly, cartap is not just a pro-NTX but instead directly induces inhibitory neurotoxicity by blocking the nAChR/channel, whereas NTX may have dual NCB and agonist targets...
  58. ncbi request reprint Cloning, expression, and catalytic triad of recombinant arylformamidase
    Michael K Pabarcus
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
    Protein Expr Purif 44:39-44. 2005
    ..The single mutants (S162A, D247A, and H279A) lost essentially all (>99%) activity. The predicted catalytic triad of S162, D247, and H279 is therefore confirmed by site-directed mutagenesis...
  59. ncbi request reprint Rotenone, deguelin, their metabolites, and the rat model of Parkinson's disease
    Pierluigi Caboni
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    Chem Res Toxicol 17:1540-8. 2004
    ..These toxicological features must be considered in using rotenone, deguelin, and their analogues as pesticides, candidate radioimaging and cancer chemopreventive agents, and models of PD...
  60. ncbi request reprint Alpha-nitro ketone as an electrophile and nucleophile: synthesis of 3-substituted 2-nitromethylenetetrahydrothiophene and -tetrahydrofuran as drosophila nicotinic receptor probes
    Nanjing Zhang
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    J Org Chem 69:876-81. 2004
    ..These compounds, together with the corresponding 2-nitromethylenepyrrolidine (1), were used to probe the Drosophila neonicotinoid-nicotinic acetylcholine receptor interaction...
  61. ncbi request reprint Identification of aldehyde oxidase as the neonicotinoid nitroreductase
    Ryan A Dick
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    Chem Res Toxicol 18:317-23. 2005
    ..In contrast, dog, cat, and chicken liver cytosols do not reduce IMI at appreciable rates. AOX, as a neonicotinoid nitroreductase, may limit the persistence of IMI, and possibly other neonicotinoids, in mammals...
  62. ncbi request reprint Synthesis of a tritium-labeled, fipronil-based, highly potent, photoaffinity probe for the GABA receptor
    Robert E Sammelson
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    J Org Chem 68:8075-9. 2003
    ..The last step involved reduction of the diiodofiprole with tritium, Pd/C, and triethylamine in ethyl acetate and afforded [(3)H]TDF with a specific activity of 15 Ci/mmol and 99% radiopurity...
  63. ncbi request reprint Kynurenine formamidase: determination of primary structure and modeling-based prediction of tertiary structure and catalytic triad
    Michael K Pabarcus
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
    Biochim Biophys Acta 1596:201-11. 2002
    ..A three-dimensional model based on the structures of homologous carboxylesterase EST2 and brefeldin A esterase implicates Ser162, Asp247 and His279 as the active site triad...
  64. pmc Atomic interactions of neonicotinoid agonists with AChBP: molecular recognition of the distinctive electronegative pharmacophore
    Todd T Talley
    Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, CA 99093 0657, USA
    Proc Natl Acad Sci U S A 105:7606-11. 2008
    ..This template defines the association of interacting amino acids and their energetic contributions to the distinctive interactions of neonicotinoids...
  65. ncbi request reprint Loss of neuropathy target esterase in mice links organophosphate exposure to hyperactivity
    Christopher J Winrow
    The Salk Institute for Biological Studies, The Laboratory of Genetics, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Genet 33:477-85. 2003
    ....
  66. ncbi request reprint Melatonin reduces phosphine-induced lipid and DNA oxidation in vitro and in vivo in rat brain
    Ching Hung Hsu
    Department of Public Health, School of Medicine, Taipei Medical University, Taipei, Taiwan
    J Pineal Res 32:53-8. 2002
    ..It is concluded that melatonin, probably because of its free radical scavenging ability, confers marked protection against PH(3)-induced oxidative toxicity in brain...
  67. ncbi request reprint Effect of arylformamidase (kynurenine formamidase) gene inactivation in mice on enzymatic activity, kynurenine pathway metabolites and phenotype
    Vasily N Dobrovolsky
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, 3900 NCTR Rd, HFT 120, Jefferson, AR 72079, USA
    Biochim Biophys Acta 1724:163-72. 2005
    ..On this basis, the most significant function of the kynurenine pathway and Afmid in mice may be in eliminating toxic metabolites and to a lesser extent in providing intermediates for other processes...
  68. pmc A brain detoxifying enzyme for organophosphorus nerve poisons
    Daniel K Nomura
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
    Proc Natl Acad Sci U S A 102:6195-200. 2005
    ..KIAA1363 therefore is the principal enzyme for metabolizing low levels of CPO in brain and may play a more general role in detoxification of OP nerve poisons...
  69. ncbi request reprint Nitroso-imidacloprid irreversibly inhibits rabbit aldehyde oxidase
    Ryan A Dick
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley 94720 3112, USA
    Chem Res Toxicol 20:1942-6. 2007
    ..These findings demonstrate that IMI-NO is metabolically activated by rabbit AOX to form both an irreversible inhibitor and a reactive intermediate that is capable of covalently binding to protein...
  70. ncbi request reprint Insect muscarinic acetylcholine receptor: pharmacological and toxicological profiles of antagonists and agonists
    Hideo Honda
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    J Agric Food Chem 55:2276-81. 2007
    ..The insect mAChR warrants continuing study in lead generation to discover novel insecticides...
  71. ncbi request reprint Lysophospholipase inhibition by organophosphorus toxicants
    Gary B Quistad
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
    Toxicol Appl Pharmacol 196:319-26. 2004
    ....
  72. doi request reprint Liquid chromatography-tandem mass spectrometric ion-switching determination of chlorantraniliprole and flubendiamide in fruits and vegetables
    Pierluigi Caboni
    Department of Toxicology, University of Cagliari, Via Ospedale 72, 09124 Cagliari, Italy
    J Agric Food Chem 56:7696-9. 2008
    ....

Research Grants22

  1. ORGANOPHOSPHORUS INSECTICIDE TOXICOLOGY
    JOHN CASIDA; Fiscal Year: 2002
    ..This research is necessary to ensure the safe use of phosphorus-containing insecticides. ..
  2. CHOLINERGIC INSECTICIDE TOXICOLOGY
    JOHN CASIDA; Fiscal Year: 2002
    ..The goal will be to define the binding site as to subtype, subunit, peptide sequence and ultimately amino acid derivatized. These multiple approaches will establish mechanisms for nicotinoid selective toxicity in mammals and insects. ..
  3. Organophosphorus Pesticide Toxicology
    JOHN CASIDA; Fiscal Year: 2006
    ..Knowledge gained on OP pesticide toxicology is also applicable to OP nerve gases as chemical warfare and terrorism agents. ..
  4. GABAERGIC INSECTICIDE TOXICOLOGY
    JOHN CASIDA; Fiscal Year: 2002
    ....
  5. CHOLINERGIC INSECTICIDE TOXICOLOGY
    JOHN CASIDA; Fiscal Year: 2006
    ....