Manuel F Casanova

Summary

Affiliation: University of Louisville
Country: USA

Publications

  1. pmc Autism as a sequence: from heterochronic germinal cell divisions to abnormalities of cell migration and cortical dysplasias
    Manuel F Casanova
    Department of Psychiatry, University of Louisville, 500 South Preston Street, Building A, Room 217, Louisville, KY 40202, United States Electronic address
    Med Hypotheses 83:32-8. 2014
  2. pmc Laws of conservation as related to brain growth, aging, and evolution: symmetry of the minicolumn
    Manuel F Casanova
    Department of Psychiatry and Behavioral Sciences, University of Louisville Louisville, KY, USA
    Front Neuroanat 5:66. 2011
  3. ncbi request reprint Schizophrenia seen as a deficit in the modulation of cortical minicolumns by monoaminergic systems
    Manuel F Casanova
    Department of Psychiatry, Neurology, and Anatomy, Medical College of Georgia, USA
    Int Rev Psychiatry 19:361-72. 2007
  4. pmc The minicolumnopathy of autism: A link between migraine and gastrointestinal symptoms
    Manuel F Casanova
    Department of Psychiatry and Behavioral Sciences, 500 South Preston Street, Building 55A, Room 217, Louisville, KY 40292, United States
    Med Hypotheses 70:73-80. 2008
  5. ncbi request reprint A comparison study of the vertical bias of pyramidal cells in the hippocampus and neocortex
    Manuel F Casanova
    Department of Psychiatry, University of Louisville, Louisville, KY 40292, USA
    Dev Neurosci 29:193-200. 2007
  6. ncbi request reprint A temporal continuity to the vertical organization of the human neocortex
    Manuel F Casanova
    Department of Psychiatry and Behavioral Sciences, University of Louisville, Louisville, KY 40292, USA
    Cereb Cortex 17:130-7. 2007
  7. ncbi request reprint [Schizophrenia as a neurological condition caused by a failure in the lateralisation of the brain: macro and microscopic observations]
    M F Casanova
    University of Louisville, Department of Psychiatry, Louisville, KY 40202, USA
    Rev Neurol 49:136-42. 2009
  8. ncbi request reprint Magnetic resonance imaging study of brain asymmetries in dyslexic patients
    Manuel F Casanova
    Department of Psychiatry and Behavioral Sciences, University of Louisville, KY 40292, USA
    J Child Neurol 20:842-7. 2005
  9. doi request reprint Neuronal distribution in the neocortex of schizophrenic patients
    Manuel F Casanova
    Department of Psychiatry and Behavioral Sciences, University of Louisville, Louisville, KY 40292, USA
    Psychiatry Res 158:267-77. 2008
  10. ncbi request reprint The neuropathology of autism
    Manuel F Casanova
    Department of Psychiatry and Behavioral Sciences, University of Louisville, Louisville, KY 40292, USA
    Brain Pathol 17:422-33. 2007

Collaborators

Detail Information

Publications68

  1. pmc Autism as a sequence: from heterochronic germinal cell divisions to abnormalities of cell migration and cortical dysplasias
    Manuel F Casanova
    Department of Psychiatry, University of Louisville, 500 South Preston Street, Building A, Room 217, Louisville, KY 40202, United States Electronic address
    Med Hypotheses 83:32-8. 2014
    ..The variety of endogenous and exogenous factors, their timing of action during brain development, and the genetic susceptibility of affected individuals (a Triple Hit hypothesis) may all account for the clinical heterogeneity of ASD...
  2. pmc Laws of conservation as related to brain growth, aging, and evolution: symmetry of the minicolumn
    Manuel F Casanova
    Department of Psychiatry and Behavioral Sciences, University of Louisville Louisville, KY, USA
    Front Neuroanat 5:66. 2011
    ..The putative preservations of parameters related to the symmetry of the minicolumn suggest that the development and final organization of the cortex follows a deterministic process...
  3. ncbi request reprint Schizophrenia seen as a deficit in the modulation of cortical minicolumns by monoaminergic systems
    Manuel F Casanova
    Department of Psychiatry, Neurology, and Anatomy, Medical College of Georgia, USA
    Int Rev Psychiatry 19:361-72. 2007
    ..This ontogenetic deficit propitiates a cascade of neurochemical changes resulting in varying abnormalities relating information processing to behavioural states...
  4. pmc The minicolumnopathy of autism: A link between migraine and gastrointestinal symptoms
    Manuel F Casanova
    Department of Psychiatry and Behavioral Sciences, 500 South Preston Street, Building 55A, Room 217, Louisville, KY 40292, United States
    Med Hypotheses 70:73-80. 2008
    ..Abdominal migraine therefore stands as a falsifiable hypothesis with added importance accrued to potential therapeutic interventions...
  5. ncbi request reprint A comparison study of the vertical bias of pyramidal cells in the hippocampus and neocortex
    Manuel F Casanova
    Department of Psychiatry, University of Louisville, Louisville, KY 40292, USA
    Dev Neurosci 29:193-200. 2007
    ..Pyramidal cell arrays within allocortical areas and the neocortex constitute different modular arrangements. This morphological variability may be the expression of evolutionary differences in cortical development...
  6. ncbi request reprint A temporal continuity to the vertical organization of the human neocortex
    Manuel F Casanova
    Department of Psychiatry and Behavioral Sciences, University of Louisville, Louisville, KY 40292, USA
    Cereb Cortex 17:130-7. 2007
    ..Neuropil development follows a prenatal phase of cubic volumetric growth with a postnatal phase of linear volumetric growth. The data suggest the continuity of columnar structures from early in gestation through postnatal maturation...
  7. ncbi request reprint [Schizophrenia as a neurological condition caused by a failure in the lateralisation of the brain: macro and microscopic observations]
    M F Casanova
    University of Louisville, Department of Psychiatry, Louisville, KY 40202, USA
    Rev Neurol 49:136-42. 2009
    ..Some of its salient symptomatology refers to language abnormalities that resemble an aphasic disorder. Recent studies suggest that brain structures that define language functions may be abnormally lateralized in schizophrenic patients...
  8. ncbi request reprint Magnetic resonance imaging study of brain asymmetries in dyslexic patients
    Manuel F Casanova
    Department of Psychiatry and Behavioral Sciences, University of Louisville, KY 40292, USA
    J Child Neurol 20:842-7. 2005
    ..This stream of temporal analysis is of importance in motor movements. Reading might have evolved as an exaptation to motor movements requiring the sequential analysis of information...
  9. doi request reprint Neuronal distribution in the neocortex of schizophrenic patients
    Manuel F Casanova
    Department of Psychiatry and Behavioral Sciences, University of Louisville, Louisville, KY 40292, USA
    Psychiatry Res 158:267-77. 2008
    ..The findings suggest an alteration in the modulatory systems innervating the cell minicolumn. Furthermore, the lack of variation in core columnarity parameters argues in favor of a defect post-dating the formation of the cell minicolumn...
  10. ncbi request reprint The neuropathology of autism
    Manuel F Casanova
    Department of Psychiatry and Behavioral Sciences, University of Louisville, Louisville, KY 40292, USA
    Brain Pathol 17:422-33. 2007
    ..The significance of future controlled studies should be judged based on their explanatory powers; that is, how well do they relate to brain growth abnormalities and/or provide useful clinicopathological correlates...
  11. ncbi request reprint Comparative minicolumnar morphometry of three distinguished scientists
    Manuel F Casanova
    University of Louisville, Department of Psychiatry and Behavioral Sciences, KY 40292, USA
    Autism 11:557-69. 2007
    ..A minicolumnar phenotype that provides for discrimination and/or focused attention may help explain the savant abilities observed in some autistic people and the intellectually gifted...
  12. ncbi request reprint Encephalization, emergent properties, and psychiatry: a minicolumnar perspective
    Manuel F Casanova
    Department of Psychiatry and Behavioral Sciences, University of Louisville, Louisville, KY 40292, USA
    Neuroscientist 14:101-18. 2008
    ..In addition to reframing the evolution of mind, this perspective provides a conceptual framework for a better understanding of the origin and maladaptive nature of certain psychiatric conditions...
  13. pmc Recursive trace line method for detecting myelinated bundles: a comparison study with pyramidal cell arrays
    Manuel F Casanova
    Department of Psychiatry and Behavioral Sciences, University of Louisville, 500 South Preston Street, Building 55 A, Suite 217, Louisville, KY 40292, United States
    J Neurosci Methods 168:367-72. 2008
    ..The close correspondence of derived values for myelinated axon bundles and pyramidal cell arrays suggests their participation and interaction within the same modular arrangement of the isocortex...
  14. pmc Morphometric variability of minicolumns in the striate cortex of Homo sapiens, Macaca mulatta, and Pan troglodytes
    Manuel F Casanova
    Department of Psychiatry and Behavioral Sciences, University of Louisville, Kentucky 40292, USA
    J Anat 214:226-34. 2009
    ....
  15. pmc Radial cytoarchitecture and patterns of cortical connectivity in autism
    Manuel Casanova
    Department of Psychiatry and Behavioral Sciences, University of Louisville, 500 South Preston Street, Building 55A, Suite 217, Louisville, KY 40292, USA
    Philos Trans R Soc Lond B Biol Sci 364:1433-6. 2009
    ..However, recent post-mortem studies of brains of individuals with autism have shown characteristic differences in the morphometry of radial cell minicolumns, which add credence to the connectivity hypothesis...
  16. doi request reprint Minicolumnar width: Comparison between supragranular and infragranular layers
    Manuel F Casanova
    Department of Psychiatry and Behavioral Sciences, University of Louisville, Louisville, KY 40292, United States
    J Neurosci Methods 184:19-24. 2009
    ..A review of the literature on corticogenesis provides some ideas as to how these laminar differences in minicolumnar core width are engendered...
  17. doi request reprint A topographic study of minicolumnar core width by lamina comparison between autistic subjects and controls: possible minicolumnar disruption due to an anatomical element in-common to multiple laminae
    Manuel F Casanova
    Department of Psychiatry and Behavioral Sciences, University of Louisville, Louisville, KY, USA
    Brain Pathol 20:451-8. 2010
    ..In this article we discuss the possible role of double bouquet and pyramidal cells in the translaminar minicolumnar width narrowing observed in autistic subjects...
  18. doi request reprint Clinicopathological correlates of behavioral and psychological symptoms of dementia
    Manuel F Casanova
    Department of Psychiatry, University of Louisville, KY 40202, USA
    Acta Neuropathol 122:117-35. 2011
    ..g., intellectual achievement and life-long learning), family history, and genetic susceptibility are factors, among others, that influence BPSD...
  19. ncbi request reprint Mean cell spacing abnormalities in the neocortex of patients with schizophrenia
    Manuel F Casanova
    Department of Psychiatry and Behavioral Sciences, University of Louisville, 500 South Preston Street, A Building, Room 217, Louisville, KY 40292, USA
    Psychiatry Res 133:1-12. 2005
    ..The lack of variation in the columnarity index argues in favor of a defect postdating the formation of the cell minicolumn...
  20. ncbi request reprint Reduced brain size and gyrification in the brains of dyslexic patients
    Manuel F Casanova
    Gottfried and Gisela Kolb Endowed Chair of Psychiatry, Department of Psychiatry, University of Louisville, 500 South Preston St, Bldg A, Rm 217, Louisville, KY 40292, USA
    J Child Neurol 19:275-81. 2004
    ..The article also emphasizes the contrast between findings in dyslexia and in autism...
  21. pmc Quantitative analysis of the shape of the corpus callosum in patients with autism and comparison individuals
    Manuel F Casanova
    University of Louisville, Kentucky, USA
    Autism 15:223-38. 2011
    ....
  22. ncbi request reprint Disruption in the inhibitory architecture of the cell minicolumn: implications for autism
    Manuel F Casanova
    Department of Psychiatry, Medical College of Georgia, USA
    Neuroscientist 9:496-507. 2003
    ..The authors conclude that GABAergic interneurons are vital to proper minicolumnar differentiation and signal processing (e.g., filtering capacity of the neocortex), thus providing a putative correlate to autistic symptomatology...
  23. pmc Low-frequency repetitive transcranial magnetic stimulation (rTMS) affects event-related potential measures of novelty processing in autism
    Estate Sokhadze
    Department of Psychiatry and Behavioral Science, University of Louisville School of Medicine, Louisville, KY, 40292, USA
    Appl Psychophysiol Biofeedback 35:147-61. 2010
    ..Overall, our preliminary results show that rTMS may prove to be an important research tool or treatment modality in addressing the stimulus hypersensitivity characteristic of autism spectrum disorders...
  24. doi request reprint Prefrontal neuromodulation using rTMS improves error monitoring and correction function in autism
    Estate M Sokhadze
    Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, KY 40202, USA
    Appl Psychophysiol Biofeedback 37:91-102. 2012
    ..g., rTMS) in children with autism and thus may have important practical implications...
  25. ncbi request reprint Minicolumnar abnormalities in autism
    Manuel F Casanova
    Department of Psychiatry and Behavioral Sciences, University of Louisville, 500 South Preston Street, Louisville, KY 40292, USA
    Acta Neuropathol 112:287-303. 2006
    ..A reduction in both somatic and nucleolar cross sections could reflect a bias towards shorter connecting fibers, which favors local computation at the expense of inter-areal and callosal connectivity...
  26. pmc Reduced gyral window and corpus callosum size in autism: possible macroscopic correlates of a minicolumnopathy
    Manuel F Casanova
    Department of Psychiatry, University of Louisville, Louisville, KY 40292, USA
    J Autism Dev Disord 39:751-64. 2009
    ..The findings may help explain abnormalities in motor skill development, differences in postnatal brain growth, and the regression of acquired functions observed in some autistic patients...
  27. doi request reprint Event-related potential study of novelty processing abnormalities in autism
    Estate Sokhadze
    Department of Psychiatry and Behavioral Science, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Appl Psychophysiol Biofeedback 34:37-51. 2009
    ..We propose the potential application of ERP evaluations in a novelty task as outcome measurements in the biobehavioral treatment (e.g., EEG biofeedback, TMS) of autism...
  28. ncbi request reprint Neuronal density and architecture (Gray Level Index) in the brains of autistic patients
    Manuel F Casanova
    Department of Psychiatry, Medical College of Georgia, Augusta, USA
    J Child Neurol 17:515-21. 2002
    ..4% in controls and 18.7% in autism (P = .724). In autism, an increased number of minicolumns, combined with fewer cells per column (or their greater dispersion), results in no global difference in neuronal density...
  29. doi request reprint Accurate automated detection of autism related corpus callosum abnormalities
    Ayman El-Baz
    Department of Bioengineering, University of Louisville, Louisville, KY, USA
    J Med Syst 35:929-39. 2011
    ..Our experiments revealed significant differences (at the 95% confidence level) between 17 normal and 17 autistic subjects in four anatomical divisions, i.e. splenium, rostrum, genu and body of their CCs...
  30. pmc Increased white matter gyral depth in dyslexia: implications for corticocortical connectivity
    Manuel F Casanova
    Department of Psychiatry and Behavioral Sciences, University of Louisville, Louisville, KY, USA
    J Autism Dev Disord 40:21-9. 2010
    ..The structural findings hereby reported are diametrically opposed to those reported for autism...
  31. doi request reprint Dyslexia diagnostics by 3-D shape analysis of the corpus callosum
    Ahmed Elnakib
    Bioengineering Department, University of Louisville, Louisville, KY 40292, USA
    IEEE Trans Inf Technol Biomed 16:700-8. 2012
    ..Moreover, the initial classification results based on the centerline length and CC thickness suggest that the proposed shape analysis is a promising supplement to the current techniques for diagnosing dyslexia...
  32. ncbi request reprint Preservation of hippocampal pyramidal cells in paraphrenia
    Manuel F Casanova
    Medical College of Georgia, Downtown VA Medical Center 24, 26 Psychiatry Service, Room 3B 121, One Freedom Way, Augusta, GA 30910 6285, USA
    Schizophr Res 62:141-6. 2003
    ..The lack of cell loss not only distinguishes paraphrenia from Alzheimer's disease but offers, in addition, a marked similarity to a condition denoted in the medical literature as senile dementia with tangles...
  33. ncbi request reprint Asperger's syndrome and cortical neuropathology
    Manuel F Casanova
    Department of Psychiatry, Medical College of Georgia, USA
    J Child Neurol 17:142-5. 2002
    ..The minicolumnar changes provide a possible link to receptive field abnormalities and a useful clinicopathologic correlate to Asperger's syndrome...
  34. ncbi request reprint Autism or autisms? Finding the lowest common denominator
    Emily L Williams
    Department of Anatomical Sciences and Neurobiology, University of Louisville, Louisville, Kentucky 40202, USA
    Bol Asoc Med P R 102:17-24. 2010
    ..e., the minicolumn) and then examining which pathways are vulnerable to involved genetic and environmental factors, we may gain a greater understanding of the pathophysiologic mechanisms underlying Autism Spectrum Conditions...
  35. ncbi request reprint Autism diagnostics by 3D texture analysis of cerebral white matter gyrifications
    Ayman El-Baz
    Bioengineering Department, University of Louisville, Louisville, KY, USA
    Med Image Comput Comput Assist Interv 10:882-90. 2007
    ..Initial experimental results suggest that the proposed 3D texture analysis is a promising supplement to the current techniques for diagnosing autism...
  36. ncbi request reprint Shape distortion of the hippocampus: a possible explanation of the pyramidal cell disarray reported in schizophrenia
    Manuel F Casanova
    Medical College of Georgia, Downtown VA Medical Center, One Freedom Way, 26 Psychiatry Service, 3B 121, Augusta, GA 30904 6285, USA
    Schizophr Res 55:19-24. 2002
    ..0183). The findings were attributed to a bias accrued to referencing measurements in schizophrenics to the distorted circumventricular surface of the temporal horn...
  37. doi request reprint Autism and dyslexia: a spectrum of cognitive styles as defined by minicolumnar morphometry
    Emily L Williams
    Department of Psychiatry and Behavioral Sciences, University of Louisville, 401 E Chestnut St, Suite 610, Louisville, KY 40202, USA
    Med Hypotheses 74:59-62. 2010
    ..We propose that the cognitive styles present in autism and developmental dyslexia typify the extremes of a minicolumnar spectrum in humans...
  38. ncbi request reprint Hippocampal pathology in two mentally ill paraphiliacs
    Manuel F Casanova
    Medical College of Georgia, 3B 121, Downtown VA Medical Center 24, Augusta, GA 30910, USA
    Psychiatry Res 115:79-89. 2002
    ..The accompanying astrocytosis indicates a reactive, ongoing process. The findings suggest new therapeutic interventions in the treatment of paraphilia...
  39. ncbi request reprint Minicolumnar pathology in dyslexia
    Manuel F Casanova
    Department of Psychiatry and Neurology, Medical College of Georgia, Augusta, USA
    Ann Neurol 52:108-10. 2002
    ..We report minicolumnar abnormalities in the brain of a dyslexic patient. The corresponding developmental disturbance (ie, large minicolumns) could account for the perceptual errors observed in dyslexia...
  40. ncbi request reprint Minicolumnar pathology in autism
    Manuel F Casanova
    Medical College of Georgia, Augusta, GA 30910, USA
    Neurology 58:428-32. 2002
    ..To determine whether differences exist in the configuration of minicolumns between the brains of autistic and control patients...
  41. doi request reprint The pathology of paraphrenia
    Manuel F Casanova
    Department of Psychiatry, University of Louisville, 500 South Preston Street, Building A, Room 217, Louisville, KY 40292, USA
    Curr Psychiatry Rep 12:196-201. 2010
    ..Risk factors, including organic lesions, may precipitate an earlier onset of symptomatology in patients exhibiting this pathology. Many of the symptoms in paraphrenia can be explained by involvement of the entorhinal cortex...
  42. ncbi request reprint Reduced temporal lobe volume in early onset conduct disorder
    Markus J P Kruesi
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, P O Box 250861, Charleston, SC 29425, USA
    Psychiatry Res 132:1-11. 2004
    ..Further investigation of both the temporal and frontal localizations of the pathophysiology of early onset conduct disorder is warranted in larger samples...
  43. ncbi request reprint The minicolumn hypothesis in neuroscience
    Daniel P Buxhoeveden
    Department of Psychiatry, Medical College of Georgia, Augusta, GA, USA
    Brain 125:935-51. 2002
    ....
  44. ncbi request reprint The importance of using equimolar DNA for transfection analysis of the 5' flanking promoter regions of genes
    Ratnam S Seelan
    Department of Psychiatry and Behavioral Sciences, Health Sciences Center, University of Louisville, Louisville, KY 40202, USA
    Anal Biochem 349:306-8. 2006
  45. pmc Identification of myo-inositol-3-phosphate synthase isoforms: characterization, expression, and putative role of a 16-kDa gamma(c) isoform
    Ratnam S Seelan
    Department of Psychiatry, University of Louisville, Louisville, Kentucky 40202, USA
    J Biol Chem 284:9443-57. 2009
    ..Our findings have important ramifications for understanding the mood stabilization process and suggest that inositol biosynthesis is a highly regulated and dynamic process...
  46. doi request reprint Deciphering the lithium transcriptome: microarray profiling of lithium-modulated gene expression in human neuronal cells
    R S Seelan
    Department of Psychiatry and Behavioral Sciences, University of Louisville, 501 East Broadway, Louisville, KY 40202, USA
    Neuroscience 151:1184-97. 2008
    ..The list of highly regulated genes, besides encoding putative targets for antimanic agents, should prove useful in defining novel pathways, or to better understand the mechanisms, underlying the mood stabilization process...
  47. doi request reprint The role of the entorhinal cortex in paraphrenia
    Manuel F Casanova
    Department of Psychiatry, University of Louisville, 500 South Preston Street, Building A, Room 217, Louisville, KY 40292, USA
    Curr Psychiatry Rep 12:202-7. 2010
    ..The results will help explain why hallucinations in paraphrenia are usually limited to the patient's surroundings...
  48. ncbi request reprint Shape modeling of the corpus callosum
    Ahmed Farag
    Department of Electrical and Computer Engineering, University of Louisville, USA
    Conf Proc IEEE Eng Med Biol Soc 2010:4288-91. 2010
    ....
  49. ncbi request reprint Regulatory mechanisms of cortical laminar development
    Manuel F Casanova
    University of Louisville, Department of Psychiatry, 500 S Preston St, Bldg 55A Ste 210, Louisville, KY 40292, USA
    Brain Res Rev 51:72-84. 2006
    ....
  50. ncbi request reprint Intracortical circuitry: one of psychiatry's missing assumptions
    Manuel F Casanova
    Medical College of Georgia, Department of Psychiatry, 1515 Pope St, Augusta, 30910, USA
    Eur Arch Psychiatry Clin Neurosci 254:148-51. 2004
    ..An appreciation of the modular framework of the brain provides a better insight as to how minicolumns contribute to the larger scope of information processing in the normal and pathological state...
  51. ncbi request reprint Effects of low frequency repetitive transcranial magnetic stimulation (rTMS) on gamma frequency oscillations and event-related potentials during processing of illusory figures in autism
    Estate M Sokhadze
    Cognitive Neuroscience Laboratory, Department of Psychiatry and Behavioral Science, University of Louisville School of Medicine, Louisville, KY 40292, USA
    J Autism Dev Disord 39:619-34. 2009
    ..Outcome measures based on event-related potentials (ERP), induced gamma activity, and behavioral measures showed significant post-TMS improvement. The results suggest that rTMS offers a potential therapeutic intervention for autism...
  52. ncbi request reprint Clinical and macroscopic correlates of minicolumnar pathology in autism
    Manuel F Casanova
    Department of Psychiatry, Medical College of Georgia, Augusta, USA
    J Child Neurol 17:692-5. 2002
    ..This article relates different aspects of the cell minicolumn and larger-scale neuronal assemblies to potential research techniques and their application to clinical practice...
  53. ncbi request reprint The minicolumn and evolution of the brain
    Daniel P Buxhoeveden
    Medical College of Georgia, Augusta, GA, USA
    Brain Behav Evol 60:125-51. 2002
    ..However, recent advances in methodology enable standardized, quantified comparisons of minicolumn morphology...
  54. ncbi request reprint Changes in gray-/white-matter ratios in the parahippocampal gyri of late-onset schizophrenia patients
    Manuel F Casanova
    Department of Psychiatry, Medical College of Georgia, Anatomy and Cell Biology, Medical College of Georgia, Augusta, GA 30904 6285, USA
    Am J Geriatr Psychiatry 11:605-9. 2003
    ..The present article is an attempt at finding a macroscopic correlate to the described pathology...
  55. ncbi request reprint Modular concepts of brain organization and the neuropathology of psychiatric conditions
    Manuel F Casanova
    Medical College of Georgia, Augusta, GA, USA
    Psychiatry Res 118:101-2. 2003
  56. ncbi request reprint Neuropathological and genetic findings in autism: the significance of a putative minicolumnopathy
    Manuel F Casanova
    Department of Psychiatry and Behavioral Sciences University of Louisville, 500 South Preston Street, Louisville, KY, USA
    Neuroscientist 12:435-41. 2006
    ..This article summarizes possible links between minicolumns and other topics-cortical modularity, age of onset, gliosis, and genetics-relevant to the pathophysiology of autism...
  57. ncbi request reprint Mineralization of the basal ganglia: implications for neuropsychiatry, pathology and neuroimaging
    Manuel F Casanova
    Department of Psychiatry, Medical College of Georgia, Augusta, GA 30912, USA
    Psychiatry Res 121:59-87. 2003
    ..The authors suggest that these metabolic abnormalities may link basal ganglia mineralization to psychotic symptomatology...
  58. ncbi request reprint Disentangling the pathology of schizophrenia and paraphrenia
    Manuel F Casanova
    Department of Psychiatry and Neurology, Medical College of Georgia, Downtown VA Medical Center, 1 Freedom Way, 26 Psychiatry Service, 3B 121, Augusta, GA 30910, USA
    Acta Neuropathol 103:313-20. 2002
    ....
  59. ncbi request reprint Mammalian inositol 3-phosphate synthase: its role in the biosynthesis of brain inositol and its clinical use as a psychoactive agent
    Latha K Parthasarathy
    Molecular Neuroscience Laboratory, Autism Research Unit, Mental Health, Behavioral Science and Research Services, VA Medical Center 151, Louisville, Kentucky 40206, USA
    Subcell Biochem 39:293-314. 2006
  60. ncbi request reprint Senile plaques exert no mass lesion effect on surrounding neurons
    M F Casanova
    Department of Psychiatry and Neurology, Medical College of Georgia, USA
    J Neurosci Methods 110:125-33. 2001
    ..Contrary to earlier reports, our results noted no evidence of pyramidal cell disarray in schizophrenic patients. Our results suggest that SP's incorporate, rather than displace, their surrounding neuropil...
  61. ncbi request reprint Morphological differences between minicolumns in human and nonhuman primate cortex
    D P Buxhoeveden
    Department of Psychiatry, Medical College of Georgia, Augusta, Georgia 30904, USA
    Am J Phys Anthropol 115:361-71. 2001
    ..Because the minicolumn is a basic anatomical and functional unit of the cortex, this strong evidence showed reorganization in this area of the human brain. The relationship between the minicolumn and cortical volume is also discussed...
  62. ncbi request reprint Lateralization of minicolumns in human planum temporale is absent in nonhuman primate cortex
    D P Buxhoeveden
    Medical College of Georgia, Downtown VA Medical Center, Psychiatry Service, Augusta, GA 30904, USA
    Brain Behav Evol 57:349-58. 2001
    ..Only human brain tissue revealed robust asymmetry in two aspects of minicolumn morphology: wider columns and more neuropil space on the left side. This asymmetry was absent in chimpanzee and rhesus monkey brains...
  63. ncbi request reprint Rett syndrome as a minicolumnopathy
    M F Casanova
    Medical College of Georgia, Augusta, GA, USA
    Clin Neuropathol 22:163-8. 2003
    ..Patients with Rett syndrome are often misdiagnosed as autistic. Recent reports of minicolumnar abnormalities in the brains of autistic and Asperger's syndrome prompted us to search for similar pathology in Rett syndrome...
  64. ncbi request reprint Minicolumn thinning in temporal lobe association cortex but not primary auditory cortex in normal human ageing
    Steven A Chance
    Department of Neuropathology, Radcliffe Infirmary, Woodstock Road, OX2 6HE, Oxford, UK
    Acta Neuropathol 111:459-64. 2006
    ..Since old age is the greatest risk factor for dementia, the transition to dementia may involve an extension of normal ageing processes...
  65. ncbi request reprint White matter volume increase and minicolumns in autism
    Manuel F Casanova
    Ann Neurol 56:453; author reply 454. 2004
  66. ncbi request reprint Accelerated maturation in brains of patients with Down syndrome
    Daniel Buxhoeveden
    J Intellect Disabil Res 48:704-5. 2004

Research Grants16

  1. Normal Human and Schizophrenic Brain
    Manuel Casanova; Fiscal Year: 2001
    ..Another possible outcome is that the number of minicolumns in the temporal lobe may differ without a concomitant change in the structural reorganization. ..
  2. Building a Selective Inhibitory Control Tone in Autism: An rTMS Study
    Manuel F Casanova; Fiscal Year: 2010
    ..The proposal represents a new development in combining TMS with functional outcome measures (cognitive ERP, EEG), using TMS as a theory-guided psychiatric therapy in autism. ..
  3. Gross morphological correlates to the minicolumnopathy of autism
    Manuel Casanova; Fiscal Year: 2009
    ..The intent is to develop markers of the condition that can be detected while the patient is alive. Another innovative aspect of the proposal is an attempt to validate current diagnostic screening techniques against autopsy findings. ..
  4. Building a Selective Inhibitory Control Tone in Autism: An rTMS Study
    Manuel Casanova; Fiscal Year: 2009
    ..The proposal represents a new development in combining TMS with functional outcome measures (cognitive ERP, EEG), using TMS as a theory-guided psychiatric therapy in autism. ..
  5. Modular Abnormalities of Brain Organization in Autism
    Manuel Casanova; Fiscal Year: 2007
    ..Treatment modalities, especially neuropharmaceutical agents, will prove more specific as their targets are better understood. ..
  6. Modular Abnormalities of Brain Organization in Autism
    Manuel Casanova; Fiscal Year: 2006
    ..Treatment modalities, especially neuropharmaceutical agents, will prove more specific as their targets are better understood. ..
  7. Normal Human and Schizophrenic Brain
    Manuel Casanova; Fiscal Year: 2004
    ..Another possible outcome is that the number of minicolumns in the temporal lobe may differ without a concomitant change in the structural reorganization. ..
  8. Modular Abnormalities of Brain Organization in Autism
    Manuel Casanova; Fiscal Year: 2005
    ..Treatment modalities, especially neuropharmaceutical agents, will prove more specific as their targets are better understood. ..
  9. Reduced Interneuronal Space in Schizophrenic Brains
    Manuel Casanova; Fiscal Year: 2004
    ..If our preliminary findings are corroborated, the smaller than normal minicolumns will demonstrate a reorganization of brain circuitry most probably defined during development. ..
  10. Modular Abnormalities of Brain Organization in Autism
    Manuel Casanova; Fiscal Year: 2004
    ..Treatment modalities, especially neuropharmaceutical agents, will prove more specific as their targets are better understood. ..
  11. Reduced Interneuronal Space in Schizophrenic Brains
    Manuel Casanova; Fiscal Year: 2005
    ..If our preliminary findings are corroborated, the smaller than normal minicolumns will demonstrate a reorganization of brain circuitry most probably defined during development. ..
  12. Normal Human and Schizophrenic Brain
    Manuel Casanova; Fiscal Year: 2003
    ..Another possible outcome is that the number of minicolumns in the temporal lobe may differ without a concomitant change in the structural reorganization. ..
  13. Reduced Interneuronal Space in Schizophrenic Brains
    Manuel Casanova; Fiscal Year: 2003
    ..If our preliminary findings are corroborated, the smaller than normal minicolumns will demonstrate a reorganization of brain circuitry most probably defined during development. ..
  14. Normal Human and Schizophrenic Brain
    Manuel Casanova; Fiscal Year: 2002
    ..Another possible outcome is that the number of minicolumns in the temporal lobe may differ without a concomitant change in the structural reorganization. ..
  15. Reduced Interneuronal Space in Schizophrenic Brains
    Manuel Casanova; Fiscal Year: 2002
    ..If our preliminary findings are corroborated, the smaller than normal minicolumns will demonstrate a reorganization of brain circuitry most probably defined during development. ..
  16. Gross morphological correlates to the minicolumnopathy of autism
    Manuel F Casanova; Fiscal Year: 2010
    ..The intent is to develop markers of the condition that can be detected while the patient is alive. Another innovative aspect of the proposal is an attempt to validate current diagnostic screening techniques against autopsy findings. ..