Affiliation: University of Virginia
Thomas K, Owen K, Conger K, Llewellyn R, Bouton A, Casanova J. Non-redundant functions of FAK and Pyk2 in intestinal epithelial repair. Sci Rep. 2019;9:4497 pubmed publisher
..Normal colonic phenotype and function are restored upon treatment of the double knockout mice with antibiotics, implicating commensal bacteria or bacterial products in the etiology of the spontaneous colitis exhibited by these mice. ..
Owen K, Casanova J. Salmonella Manipulates Autophagy to "Serve and Protect". Cell Host Microbe. 2015;18:517-9 pubmed publisher
..In this issue of Cell Host & Microbe, Kreibich etÂ al. (2015) demonstrate a role for the autophagic machinery in the repair of damaged Salmonella-containing vacuoles (SCVs). ..
Owen K, Anderson C, Casanova J. Salmonella Suppresses the TRIF-Dependent Type I Interferon Response in Macrophages. MBio. 2016;7:e02051-15 pubmed publisher
..Together, these findings identify a novel virulence strategy whereby Salmonella bacteria prevent cell autonomous elimination via autophagy and suppress the activation of innate immune responses. ..
Casanova J. Regulation of Arf activation: the Sec7 family of guanine nucleotide exchange factors. Traffic. 2007;8:1476-85 pubmed
..Here we review recent progress in our understanding of the structure, localization and biology of the different classes of Arf GEFs. ..
D Souza R, Semus R, Billings E, Meyer C, Conger K, Casanova J. Rab4 orchestrates a small GTPase cascade for recruitment of adaptor proteins to early endosomes. Curr Biol. 2014;24:1187-98 pubmed publisher
..Together these findings indicate that Arl1 links Rab4-dependent formation of endosomal sorting domains with downstream assembly of adaptor protein complexes that constitute the endosomal sorting machinery. ..
Billings E, Lee C, Owen K, D Souza R, Ravichandran K, Casanova J. The adhesion GPCR BAI1 mediates macrophage ROS production and microbicidal activity against Gram-negative bacteria. Sci Signal. 2016;9:ra14 pubmed publisher
..Together, these findings suggest that BAI1 mediates the clearance of Gram-negative bacteria by stimulating both phagocytosis and NADPH oxidase activation, thereby coupling bacterial detection to the cellular microbicidal machinery. ..