Research Topics
| R CasaburiSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Exercise training decreases ventilatory requirements and exercise-induced hyperinflation at submaximal intensities in patients with COPDJanos Porszasz
Division of Respiratory and Critical Care Physiology and Medicine, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Rehabilitation Clinical Trials Center, Torrance, CA 90502, USA
Chest 128:2025-34. 2005..We hypothesized that endurance exercise training would reduce the degree of hyperinflation for a given level of exercise and thereby improve submaximal exercise endurance...- COPD therapeutics: picking the low-hanging fruitRichard Casaburi
COPD 3:1-2. 2006 
Influence of lightweight ambulatory oxygen on oxygen use and activity patterns of COPD patients receiving long-term oxygen therapyRichard Casaburi
Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California, USA
COPD 9:3-11. 2012..Future efforts might focus on strategies to encourage oxygen use and enhance activity in this patient group. This trial is registered at ClinicalTrials.gov (NCT003257540)...- Factors determining constant work rate exercise tolerance in COPD and their role in dictating the minimal clinically important difference in response to interventionsRichard Casaburi
Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California, USA
COPD 2:131-6. 2005..There is clearly insufficient information to reliably determine a minimal clinically important difference for this test. A lower bound of 1.75 minutes is suggested... - Effects of testosterone and resistance training in men with chronic obstructive pulmonary diseaseRichard Casaburi
Division of Respiratory and Critical Care Physiology and Medicine, Los Angeles Biomedical Research Institute, Building RB2, 1124 West Carson Street, Torrance, CA 90502, USA
Am J Respir Crit Care Med 170:870-8. 2004..Further studies are required to determine long-term benefits of adding testosterone supplementation and resistance training to rehabilitative programs for carefully screened men with COPD and low testosterone levels... - Activity monitoring in assessing activities of daily livingRichard Casaburi
Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California, USA
COPD 4:251-5. 2007..When applied to chronic obstructive pulmonary disease patients, accelerometric monitors have demonstrated low levels of activity; those using long-term oxygen and those having exacerbations are particularly inactive... - A brief history of pulmonary rehabilitationRichard Casaburi
Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor, University of California at Los Angeles Medical Center, Torrance, California 90502, USA
Respir Care 53:1185-9. 2008..The current decade has yielded studies that exploited those insights to design interventions that boost the effectiveness of rehabilitative exercise... - Improvement in exercise tolerance with the combination of tiotropium and pulmonary rehabilitation in patients with COPDRichard Casaburi
Division of Respiratory and Critical Care Physiology and Medicine, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 W Carson St, Building RB 2, Torrance, CA 90502, USA
Chest 127:809-17. 2005..We hypothesized that ventilatory mechanics improvements from tiotropium would permit enhanced ability to train muscles of ambulation and therefore augment exercise tolerance benefits of PR... - Reduction of hyperinflation by pharmacologic and other interventionsRichard Casaburi
Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor University of California at Los Angeles Medical Center, Torrance, California 90502, USA
Proc Am Thorac Soc 3:185-9. 2006..With a firm understanding of the physiologic basis of exercise limitation, we can focus on defining new and better strategies to improve exercise tolerance... - Activity promotion: a paradigm shift for chronic obstructive pulmonary disease therapeuticsRichard Casaburi
Rehabilitation Clinical Trial Center, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
Proc Am Thorac Soc 8:334-7. 2011..In particular, pulmonary rehabilitation seems ripe for augmentation with scientifically based strategies for activity promotion... - Skeletal muscle dysfunction in chronic obstructive pulmonary diseaseR Casaburi
Division of Respiratory and Critical Care Physiology, Harbor UCLA Research and Education Institute, Torrance, CA 90502, USA
Med Sci Sports Exerc 33:S662-70. 2001..Though short-term administration of testosterone in moderate doses seems to be well tolerated in both men and women, further studies are required before safety and effectiveness can be established for routine use in COPD patients... - The spirometric efficacy of once-daily dosing with tiotropium in stable COPD: a 13-week multicenter trial. The US Tiotropium Study GroupR Casaburi
Harbor UCLA Research and Education Institute Dr Casaburi, Torrance, CA 90509, USA
Chest 118:1294-302. 2000..To compare the bronchodilator efficacy and safety of tiotropium and placebo... - Skeletal muscle function in COPDR Casaburi
Division of Respiratory and Critical Care Physiology and Medicine, Harbor UCLA Medical Center, Torrance, CA 90509, USA
Chest 117:267S-71S. 2000..Further research will be necessary to refine these concepts... - A long-term evaluation of once-daily inhaled tiotropium in chronic obstructive pulmonary diseaseR Casaburi
Harbor-UCLA Research and Education Institute, Torrance, CA 90502, USA
Eur Respir J 19:217-24. 2002..This suggests that tiotropium will make an important contribution to chronic obstructive pulmonary disease therapy... - Dose-response effect of oxygen on hyperinflation and exercise endurance in nonhypoxaemic COPD patientsA Somfay
Rehabilitation Clinical Trials Center, Harbor-UCLA Research and Education Institute, Torrance, CA 90502, USA
Eur Respir J 18:77-84. 2001..This effect is maximized at an inspired oxygen fraction of 0.5... 
Methodology for using long-term accelerometry monitoring to describe daily activity patterns in COPDAriel Hecht
Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
COPD 6:121-9. 2009..This trial is registered at ClinicalTrials.gov (NCT00325754)...- Physiological responses to linear treadmill and cycle ergometer exercise in COPDD Hsia
Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA, USA
Eur Respir J 34:605-15. 2009..However, cycle ergometry elicits less desaturation than does ambulation, making the linear treadmill protocol advantageous when evaluating COPD patients... - Improvement in self-reported exercise participation with the combination of tiotropium and rehabilitative exercise training in COPD patientsSteven Kesten
Boehringer Ingelheim GmbH, Ingelheim, Germany 2Harbor UCLA Medical Center, Torrance, CA, USA
Int J Chron Obstruct Pulmon Dis 3:127-36. 2008..Improvements in ventilatory mechanics with tiotropium increases exercise tolerance during pulmonary rehabilitation. We wondered whether tiotropium also increased physical activities outside of pulmonary rehabilitation... - Testosterone dose-response relationships in healthy young menS Bhasin
Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
Am J Physiol Endocrinol Metab 281:E1172-81. 2001..However, different androgen-dependent processes have different testosterone dose-response relationships... - Older men are as responsive as young men to the anabolic effects of graded doses of testosterone on the skeletal muscleShalender Bhasin
Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, University of California, Los Angeles, CA 90059, USA
J Clin Endocrinol Metab 90:678-88. 2005..The best trade-off was achieved with a testosterone dose (125 mg) that was associated with high normal testosterone levels, low frequency of adverse events, and significant gains in fat-free mass and muscle strength... - Benefits of supplemental oxygen in exercise training in nonhypoxemic chronic obstructive pulmonary disease patientsMargareta Emtner
Rehabilitation Clinical Trials Center, Harbor-UCLA Research and Education Institute, Torrance, CA 90502, USA
Am J Respir Crit Care Med 168:1034-42. 2003..001). We conclude that supplemental oxygen provided during high-intensity training yields higher training intensity and evidence of gains in exercise tolerance in laboratory testing... - Breath-by-breath quantification of progressive airflow limitation during exercise in COPD: a new methodShuyi Ma
Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
Respir Med 104:389-96. 2010.... - Lung function improvements with once-daily tiotropium in chronic obstructive pulmonary diseaseRichard Casaburi
Division of Respiratory and Critical Care Physiology and Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California 90502, USA
Am J Med 117:33S-40S. 2004.... - Influence of work rate on ventilatory and gas exchange kineticsR Casaburi
Division of Respiratory and Critical Care Physiology and Medicine, Harbor UCLA Medical Center, Torrance 90509
J Appl Physiol 67:547-55. 1989..These findings provide guidance for interpretation of ventilatory and gas exchange kinetics... - A treadmill ramp protocol using simultaneous changes in speed and gradeJanos Porszasz
Rehabilitation Clinical Trials Center, Harbor UCLA Research and Education Institute, Torrance, CA 90502, USA
Med Sci Sports Exerc 35:1596-603. 2003.... - Effect of exercise on mRNA levels for growth factors in skeletal muscle of hemodialysis patientsJoel D Kopple
Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA, USA
J Ren Nutr 16:312-24. 2006..This study tested the hypothesis that in MHD patients endurance exercise training (EET) increases mRNA levels for insulin-like growth factors and reduces myostatin mRNA... - Exercise in maintenance hemodialysis patients induces transcriptional changes in genes favoring anabolic muscleJoel D Kopple
Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Los Angeles, California, USA
J Am Soc Nephrol 18:2975-86. 2007 - Skeletal muscle mRNA for IGF-IEa, IGF-II, and IGF-I receptor is decreased in sedentary chronic hemodialysis patientsHuiyuan Wang
Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90509, USA
Kidney Int 68:352-61. 2005..We therefore investigated whether sedentary maintenance hemodialysis patients have decreased skeletal muscle mRNA levels and muscle and serum protein concentrations of certain growth factors... - Endurance exercise training during haemodialysis improves strength, power, fatigability and physical performance in maintenance haemodialysis patientsThomas W Storer
Division of Health Sciences, El Camino College, 16007 Crenshaw Blvd, Torrance, CA 90506, USA
Nephrol Dial Transplant 20:1429-37. 2005..Because many MHD patients are profoundly deconditioned and exhibit significant muscle weakness, endurance training may also improve muscle strength and physical performance in these patients. This study assessed this possibility... - Effect of hyperoxia on gas exchange and lactate kinetics following exercise onset in nonhypoxemic COPD patientsAttila Somfay
Rehabilitation Clinical Trials Center, Harbor UCLA Research and Education Institute, Torrance, CA 90502, USA
Chest 121:393-400. 2002..We determined whether oxygen supplementation during exercise makes the dynamic VO(2) response faster and reduces transient lactate increase... - The effects of volatile salivary acids and bases on exhaled breath condensate pHRichard M Effros
Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 West Carson Street, Torrance, CA 90502 2064, USA
Am J Respir Crit Care Med 173:386-92. 2006..Recent studies have reported acidification of exhaled breath condensate (EBC) in inflammatory lung diseases. This phenomenon, designated "acidopnea," has been attributed to airway inflammation... - Epithelial lining fluid solute concentrations in chronic obstructive lung disease patients and normal subjectsRichard M Effros
Los Angeles Biomedical Research Institute at Harbor University of California Los Angeles Medical Center, Torrance, 90505, USA
J Appl Physiol 99:1286-92. 2005..Dilutional and salivary markers are essential for interpretation of EBC studies... - Utility of exhaled breath condensates in chronic obstructive pulmonary disease: a critical reviewRichard M Effros
Department of Medicine, Harbor UCLA Medical Center, Torrance, California, USA
Curr Opin Pulm Med 11:135-9. 2005..Evaluation of the utility of exhaled breath condensates in chronic obstructive pulmonary disease... - Supervised high intensity continuous and interval training vs. self-paced training in COPDJanos Varga
Department of Pulmonology, Szeged University, Deszk, Hungary
Respir Med 101:2297-304. 2007..Controversy exists regarding whether different modalities of supervised exercise training (continuous (C) or interval (I)) or self-paced (S) programs are equally beneficial... - Is exercise important in chronic obstructive pulmonary disease?Barry Make
Division of Pulmonary Sciences and Critical Care Medicine, National Jewish Medical and Research Center, University of Colorado School of Medicine, Denver, Colorado, USA
COPD 4:185-9. 2007..These concepts were explored in a conference sponsored by Boehringer Ingelheim Pharmaceuticals, Inc. and Pfizer Inc and reviewed in the articles generated from the symposium in this issue of COPD... - Limitation to exercise tolerance in chronic obstructive pulmonary disease: look to the muscles of ambulationRichard Casaburi
Am J Respir Crit Care Med 168:409-10. 2003 - Boosting the effectiveness of rehabilitative exercise trainingRichard Casaburi
Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA
Am J Respir Crit Care Med 177:805-6. 2008 - Skeletal muscle adaptations to testosterone and resistance training in men with COPDMichael I Lewis
Division of Pulmonary and Critical Care Medicine, The Burns and Allen Research Institute at Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
J Appl Physiol 103:1299-310. 2007..Our data suggest that the combined interventions produced an enhanced local anabolic milieu driven in large part by the muscle IGF system, despite potentially negative biochemical influences present in COPD patients... - Pathophysiology of dyspnea in chronic obstructive pulmonary disease: a roundtableDenis E O'Donnell
Department of Medicine, Queen s University, 102 Stuart Street, Kingston, ON, K7L 2V6 Canada
Proc Am Thorac Soc 4:145-68. 2007..Self-management strategies address the affective aspect of dyspnea and are essential to successful treatment... - Testosterone-induced increase in muscle size in healthy young men is associated with muscle fiber hypertrophyIndrani Sinha-Hikim
Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, California 90059, USA
Am J Physiol Endocrinol Metab 283:E154-64. 2002..We conclude that the testosterone induced increase in muscle volume is due to muscle fiber hypertrophy... - Getting serious about strength trainingRichard Casaburi
J Cardiopulm Rehabil 26:338-40. 2006 - Pulmonary rehabilitation in chronic obstructive pulmonary diseaseThierry Troosters
Respiratory Rehabilitation and Respiratory Division, UZ Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium
Am J Respir Crit Care Med 172:19-38. 2005 - Pulmonary rehabilitation for COPDJane Reardon
Department of Medicine, Hartford Hospital, 80 Seymour Street, Hartford, CT 06102, USA
Respir Med 99:S19-27. 2005..Although progress has been made, many questions remain as to the best means of delivering rehabilitation, particularly with respect to the optimum programme of physical training and patient self-management education... - Megestrol acetate stimulates weight gain and ventilation in underweight COPD patientsJeffrey Weisberg
Nova Southeastern University College of Osteopathic Medicine, Fort Lauderdale, FL, USA
Chest 121:1070-8. 2002.... - Testosterone dose-dependently increases maximal voluntary strength and leg power, but does not affect fatigability or specific tensionThomas W Storer
Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
J Clin Endocrinol Metab 88:1478-85. 2003.... - Mitochondrial disorders and exertional intolerance: controversy continuesJames E Hansen
Am J Respir Crit Care Med 166:118; author reply 119-20. 2002 - Pulmonary Rehabilitation: Joint ACCP/AACVPR Evidence-Based Clinical Practice GuidelinesAndrew L Ries
University of California, San Diego, Department of Pulmonary and Critical Care Medicine, UCSD Medical Center, 200 West Arbor Dr, San Diego, CA 92103 8377, USA
Chest 131:4S-42S. 2007.... - Interpreting results from clinical trials: understanding minimal clinically important differences in COPD outcomesBarry Make
COPD 2:1-5. 2005 - Dose-dependent effects of testosterone on sexual function, mood, and visuospatial cognition in older menPeter B Gray
Charles Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, California 90059, USA
J Clin Endocrinol Metab 90:3838-46. 2005..When considered together with previous data from young men, these data indicate that testosterone dose-response relationships for sexual function and visuospatial cognition differ in older and young men... - Assessing the dose of supplemental oxygen: let us compare methodologiesRichard Casaburi
Respir Care 50:594-5. 2005
Research Grants
- Strategies to Improve COPD ManagementRichard Casaburi; Fiscal Year: 2007..These studies should have immediate impact on treatment strategies for large poor-prognosis subgroups of COPD patients. ..