R Casaburi

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Exercise training decreases ventilatory requirements and exercise-induced hyperinflation at submaximal intensities in patients with COPD
    Janos Porszasz
    Division of Respiratory and Critical Care Physiology and Medicine, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Rehabilitation Clinical Trials Center, Torrance, CA 90502, USA
    Chest 128:2025-34. 2005
  2. ncbi request reprint Factors determining constant work rate exercise tolerance in COPD and their role in dictating the minimal clinically important difference in response to interventions
    Richard Casaburi
    Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California, USA
    COPD 2:131-6. 2005
  3. ncbi request reprint COPD therapeutics: picking the low-hanging fruit
    Richard Casaburi
    COPD 3:1-2. 2006
  4. doi request reprint Sinusoidal high-intensity exercise does not elicit ventilatory limitation in chronic obstructive pulmonary disease
    Janos Porszasz
    Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 West Carson Street, Torrance, CA 90502, USA
    Exp Physiol 98:1102-14. 2013
  5. doi request reprint Influence of lightweight ambulatory oxygen on oxygen use and activity patterns of COPD patients receiving long-term oxygen therapy
    Richard Casaburi
    Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California, USA
    COPD 9:3-11. 2012
  6. ncbi request reprint Improvement in exercise tolerance with the combination of tiotropium and pulmonary rehabilitation in patients with COPD
    Richard Casaburi
    Division of Respiratory and Critical Care Physiology and Medicine, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 W Carson St, Building RB 2, Torrance, CA 90502, USA
    Chest 127:809-17. 2005
  7. ncbi request reprint Effects of testosterone and resistance training in men with chronic obstructive pulmonary disease
    Richard Casaburi
    Division of Respiratory and Critical Care Physiology and Medicine, Los Angeles Biomedical Research Institute, Building RB2, 1124 West Carson Street, Torrance, CA 90502, USA
    Am J Respir Crit Care Med 170:870-8. 2004
  8. ncbi request reprint Activity monitoring in assessing activities of daily living
    Richard Casaburi
    Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California, USA
    COPD 4:251-5. 2007
  9. ncbi request reprint Reduction of hyperinflation by pharmacologic and other interventions
    Richard Casaburi
    Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor University of California at Los Angeles Medical Center, Torrance, California 90502, USA
    Proc Am Thorac Soc 3:185-9. 2006
  10. doi request reprint Activity promotion: a paradigm shift for chronic obstructive pulmonary disease therapeutics
    Richard Casaburi
    Rehabilitation Clinical Trial Center, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Proc Am Thorac Soc 8:334-7. 2011

Research Grants

  1. Strategies to Improve COPD Management
    Richard Casaburi; Fiscal Year: 2007

Detail Information

Publications51

  1. ncbi request reprint Exercise training decreases ventilatory requirements and exercise-induced hyperinflation at submaximal intensities in patients with COPD
    Janos Porszasz
    Division of Respiratory and Critical Care Physiology and Medicine, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Rehabilitation Clinical Trials Center, Torrance, CA 90502, USA
    Chest 128:2025-34. 2005
    ..We hypothesized that endurance exercise training would reduce the degree of hyperinflation for a given level of exercise and thereby improve submaximal exercise endurance...
  2. ncbi request reprint Factors determining constant work rate exercise tolerance in COPD and their role in dictating the minimal clinically important difference in response to interventions
    Richard Casaburi
    Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California, USA
    COPD 2:131-6. 2005
    ..There is clearly insufficient information to reliably determine a minimal clinically important difference for this test. A lower bound of 1.75 minutes is suggested...
  3. ncbi request reprint COPD therapeutics: picking the low-hanging fruit
    Richard Casaburi
    COPD 3:1-2. 2006
  4. doi request reprint Sinusoidal high-intensity exercise does not elicit ventilatory limitation in chronic obstructive pulmonary disease
    Janos Porszasz
    Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 West Carson Street, Torrance, CA 90502, USA
    Exp Physiol 98:1102-14. 2013
    ..This high-intensity exercise strategy might be suitable for programmes of rehabilitative exercise training in COPD...
  5. doi request reprint Influence of lightweight ambulatory oxygen on oxygen use and activity patterns of COPD patients receiving long-term oxygen therapy
    Richard Casaburi
    Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California, USA
    COPD 9:3-11. 2012
    ..Future efforts might focus on strategies to encourage oxygen use and enhance activity in this patient group. This trial is registered at ClinicalTrials.gov (NCT003257540)...
  6. ncbi request reprint Improvement in exercise tolerance with the combination of tiotropium and pulmonary rehabilitation in patients with COPD
    Richard Casaburi
    Division of Respiratory and Critical Care Physiology and Medicine, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 W Carson St, Building RB 2, Torrance, CA 90502, USA
    Chest 127:809-17. 2005
    ..We hypothesized that ventilatory mechanics improvements from tiotropium would permit enhanced ability to train muscles of ambulation and therefore augment exercise tolerance benefits of PR...
  7. ncbi request reprint Effects of testosterone and resistance training in men with chronic obstructive pulmonary disease
    Richard Casaburi
    Division of Respiratory and Critical Care Physiology and Medicine, Los Angeles Biomedical Research Institute, Building RB2, 1124 West Carson Street, Torrance, CA 90502, USA
    Am J Respir Crit Care Med 170:870-8. 2004
    ..Further studies are required to determine long-term benefits of adding testosterone supplementation and resistance training to rehabilitative programs for carefully screened men with COPD and low testosterone levels...
  8. ncbi request reprint Activity monitoring in assessing activities of daily living
    Richard Casaburi
    Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California, USA
    COPD 4:251-5. 2007
    ..When applied to chronic obstructive pulmonary disease patients, accelerometric monitors have demonstrated low levels of activity; those using long-term oxygen and those having exacerbations are particularly inactive...
  9. ncbi request reprint Reduction of hyperinflation by pharmacologic and other interventions
    Richard Casaburi
    Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor University of California at Los Angeles Medical Center, Torrance, California 90502, USA
    Proc Am Thorac Soc 3:185-9. 2006
    ..With a firm understanding of the physiologic basis of exercise limitation, we can focus on defining new and better strategies to improve exercise tolerance...
  10. doi request reprint Activity promotion: a paradigm shift for chronic obstructive pulmonary disease therapeutics
    Richard Casaburi
    Rehabilitation Clinical Trial Center, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Proc Am Thorac Soc 8:334-7. 2011
    ..In particular, pulmonary rehabilitation seems ripe for augmentation with scientifically based strategies for activity promotion...
  11. ncbi request reprint A brief history of pulmonary rehabilitation
    Richard Casaburi
    Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor, University of California at Los Angeles Medical Center, Torrance, California 90502, USA
    Respir Care 53:1185-9. 2008
    ..The current decade has yielded studies that exploited those insights to design interventions that boost the effectiveness of rehabilitative exercise...
  12. ncbi request reprint Skeletal muscle function in COPD
    R Casaburi
    Division of Respiratory and Critical Care Physiology and Medicine, Harbor UCLA Medical Center, Torrance, CA 90509, USA
    Chest 117:267S-71S. 2000
    ..Further research will be necessary to refine these concepts...
  13. ncbi request reprint The spirometric efficacy of once-daily dosing with tiotropium in stable COPD: a 13-week multicenter trial. The US Tiotropium Study Group
    R Casaburi
    Harbor UCLA Research and Education Institute Dr Casaburi, Torrance, CA 90509, USA
    Chest 118:1294-302. 2000
    ..To compare the bronchodilator efficacy and safety of tiotropium and placebo...
  14. ncbi request reprint Skeletal muscle dysfunction in chronic obstructive pulmonary disease
    R Casaburi
    Division of Respiratory and Critical Care Physiology, Harbor UCLA Research and Education Institute, Torrance, CA 90502, USA
    Med Sci Sports Exerc 33:S662-70. 2001
    ..Though short-term administration of testosterone in moderate doses seems to be well tolerated in both men and women, further studies are required before safety and effectiveness can be established for routine use in COPD patients...
  15. ncbi request reprint A long-term evaluation of once-daily inhaled tiotropium in chronic obstructive pulmonary disease
    R Casaburi
    Harbor UCLA Research and Education Institute, Torrance, CA 90502, USA
    Eur Respir J 19:217-24. 2002
    ..This suggests that tiotropium will make an important contribution to chronic obstructive pulmonary disease therapy...
  16. ncbi request reprint Dose-response effect of oxygen on hyperinflation and exercise endurance in nonhypoxaemic COPD patients
    A Somfay
    Rehabilitation Clinical Trials Center, Harbor-UCLA Research and Education Institute, Torrance, CA 90502, USA
    Eur Respir J 18:77-84. 2001
    ..This effect is maximized at an inspired oxygen fraction of 0.5...
  17. pmc Methodology for using long-term accelerometry monitoring to describe daily activity patterns in COPD
    Ariel Hecht
    Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
    COPD 6:121-9. 2009
    ..This trial is registered at ClinicalTrials.gov (NCT00325754)...
  18. doi request reprint Physiological responses to linear treadmill and cycle ergometer exercise in COPD
    D Hsia
    Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA, USA
    Eur Respir J 34:605-15. 2009
    ..However, cycle ergometry elicits less desaturation than does ambulation, making the linear treadmill protocol advantageous when evaluating COPD patients...
  19. pmc Improvement in self-reported exercise participation with the combination of tiotropium and rehabilitative exercise training in COPD patients
    Steven Kesten
    Boehringer Ingelheim GmbH, Ingelheim, Germany 2Harbor UCLA Medical Center, Torrance, CA, USA
    Int J Chron Obstruct Pulmon Dis 3:127-36. 2008
    ..Improvements in ventilatory mechanics with tiotropium increases exercise tolerance during pulmonary rehabilitation. We wondered whether tiotropium also increased physical activities outside of pulmonary rehabilitation...
  20. ncbi request reprint Testosterone dose-response relationships in healthy young men
    S Bhasin
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    Am J Physiol Endocrinol Metab 281:E1172-81. 2001
    ..However, different androgen-dependent processes have different testosterone dose-response relationships...
  21. ncbi request reprint Older men are as responsive as young men to the anabolic effects of graded doses of testosterone on the skeletal muscle
    Shalender Bhasin
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, University of California, Los Angeles, CA 90059, USA
    J Clin Endocrinol Metab 90:678-88. 2005
    ..The best trade-off was achieved with a testosterone dose (125 mg) that was associated with high normal testosterone levels, low frequency of adverse events, and significant gains in fat-free mass and muscle strength...
  22. ncbi request reprint Benefits of supplemental oxygen in exercise training in nonhypoxemic chronic obstructive pulmonary disease patients
    Margareta Emtner
    Rehabilitation Clinical Trials Center, Harbor UCLA Research and Education Institute, Torrance, CA 90502, USA
    Am J Respir Crit Care Med 168:1034-42. 2003
    ..001). We conclude that supplemental oxygen provided during high-intensity training yields higher training intensity and evidence of gains in exercise tolerance in laboratory testing...
  23. doi request reprint Breath-by-breath quantification of progressive airflow limitation during exercise in COPD: a new method
    Shuyi Ma
    Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Respir Med 104:389-96. 2010
    ....
  24. ncbi request reprint Lung function improvements with once-daily tiotropium in chronic obstructive pulmonary disease
    Richard Casaburi
    Division of Respiratory and Critical Care Physiology and Medicine, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
    Am J Med 117:33S-40S. 2004
    ....
  25. ncbi request reprint Influence of work rate on ventilatory and gas exchange kinetics
    R Casaburi
    Division of Respiratory and Critical Care Physiology and Medicine, Harbor UCLA Medical Center, Torrance 90509
    J Appl Physiol 67:547-55. 1989
    ..These findings provide guidance for interpretation of ventilatory and gas exchange kinetics...
  26. ncbi request reprint Effect of exercise on mRNA levels for growth factors in skeletal muscle of hemodialysis patients
    Joel D Kopple
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA, USA
    J Ren Nutr 16:312-24. 2006
    ..This study tested the hypothesis that in MHD patients endurance exercise training (EET) increases mRNA levels for insulin-like growth factors and reduces myostatin mRNA...
  27. ncbi request reprint A treadmill ramp protocol using simultaneous changes in speed and grade
    Janos Porszasz
    Rehabilitation Clinical Trials Center, Harbor UCLA Research and Education Institute, Torrance, CA 90502, USA
    Med Sci Sports Exerc 35:1596-603. 2003
    ....
  28. ncbi request reprint Endurance exercise training during haemodialysis improves strength, power, fatigability and physical performance in maintenance haemodialysis patients
    Thomas W Storer
    Division of Health Sciences, El Camino College, 16007 Crenshaw Blvd, Torrance, CA 90506, USA
    Nephrol Dial Transplant 20:1429-37. 2005
    ..Because many MHD patients are profoundly deconditioned and exhibit significant muscle weakness, endurance training may also improve muscle strength and physical performance in these patients. This study assessed this possibility...
  29. ncbi request reprint Exercise in maintenance hemodialysis patients induces transcriptional changes in genes favoring anabolic muscle
    Joel D Kopple
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Los Angeles, California, USA
    J Am Soc Nephrol 18:2975-86. 2007
  30. ncbi request reprint Skeletal muscle mRNA for IGF-IEa, IGF-II, and IGF-I receptor is decreased in sedentary chronic hemodialysis patients
    Huiyuan Wang
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90509, USA
    Kidney Int 68:352-61. 2005
    ..We therefore investigated whether sedentary maintenance hemodialysis patients have decreased skeletal muscle mRNA levels and muscle and serum protein concentrations of certain growth factors...
  31. ncbi request reprint Epithelial lining fluid solute concentrations in chronic obstructive lung disease patients and normal subjects
    Richard M Effros
    Los Angeles Biomedical Research Institute at Harbor University of California Los Angeles Medical Center, Torrance, 90505, USA
    J Appl Physiol 99:1286-92. 2005
    ..Dilutional and salivary markers are essential for interpretation of EBC studies...
  32. ncbi request reprint Effect of hyperoxia on gas exchange and lactate kinetics following exercise onset in nonhypoxemic COPD patients
    Attila Somfay
    Rehabilitation Clinical Trials Center, Harbor UCLA Research and Education Institute, Torrance, CA 90502, USA
    Chest 121:393-400. 2002
    ..We determined whether oxygen supplementation during exercise makes the dynamic VO(2) response faster and reduces transient lactate increase...
  33. pmc The effects of volatile salivary acids and bases on exhaled breath condensate pH
    Richard M Effros
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 West Carson Street, Torrance, CA 90502 2064, USA
    Am J Respir Crit Care Med 173:386-92. 2006
    ..Recent studies have reported acidification of exhaled breath condensate (EBC) in inflammatory lung diseases. This phenomenon, designated "acidopnea," has been attributed to airway inflammation...
  34. ncbi request reprint Utility of exhaled breath condensates in chronic obstructive pulmonary disease: a critical review
    Richard M Effros
    Department of Medicine, Harbor UCLA Medical Center, Torrance, California, USA
    Curr Opin Pulm Med 11:135-9. 2005
    ..Evaluation of the utility of exhaled breath condensates in chronic obstructive pulmonary disease...
  35. ncbi request reprint Testosterone dose-dependently increases maximal voluntary strength and leg power, but does not affect fatigability or specific tension
    Thomas W Storer
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    J Clin Endocrinol Metab 88:1478-85. 2003
    ....
  36. ncbi request reprint Limitation to exercise tolerance in chronic obstructive pulmonary disease: look to the muscles of ambulation
    Richard Casaburi
    Am J Respir Crit Care Med 168:409-10. 2003
  37. doi request reprint Boosting the effectiveness of rehabilitative exercise training
    Richard Casaburi
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA
    Am J Respir Crit Care Med 177:805-6. 2008
  38. ncbi request reprint Testosterone-induced increase in muscle size in healthy young men is associated with muscle fiber hypertrophy
    Indrani Sinha-Hikim
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    Am J Physiol Endocrinol Metab 283:E154-64. 2002
    ..We conclude that the testosterone induced increase in muscle volume is due to muscle fiber hypertrophy...
  39. ncbi request reprint Megestrol acetate stimulates weight gain and ventilation in underweight COPD patients
    Jeffrey Weisberg
    Nova Southeastern University College of Osteopathic Medicine, Fort Lauderdale, FL, USA
    Chest 121:1070-8. 2002
    ....
  40. ncbi request reprint Is exercise important in chronic obstructive pulmonary disease?
    Barry Make
    Division of Pulmonary Sciences and Critical Care Medicine, National Jewish Medical and Research Center, University of Colorado School of Medicine, Denver, Colorado, USA
    COPD 4:185-9. 2007
    ..These concepts were explored in a conference sponsored by Boehringer Ingelheim Pharmaceuticals, Inc. and Pfizer Inc and reviewed in the articles generated from the symposium in this issue of COPD...
  41. ncbi request reprint Skeletal muscle adaptations to testosterone and resistance training in men with COPD
    Michael I Lewis
    Division of Pulmonary and Critical Care Medicine, The Burns and Allen Research Institute at Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    J Appl Physiol 103:1299-310. 2007
    ..Our data suggest that the combined interventions produced an enhanced local anabolic milieu driven in large part by the muscle IGF system, despite potentially negative biochemical influences present in COPD patients...
  42. ncbi request reprint Pulmonary rehabilitation for COPD
    Jane Reardon
    Department of Medicine, Hartford Hospital, 80 Seymour Street, Hartford, CT 06102, USA
    Respir Med 99:S19-27. 2005
    ..Although progress has been made, many questions remain as to the best means of delivering rehabilitation, particularly with respect to the optimum programme of physical training and patient self-management education...
  43. ncbi request reprint Getting serious about strength training
    Richard Casaburi
    J Cardiopulm Rehabil 26:338-40. 2006
  44. ncbi request reprint Pulmonary rehabilitation in chronic obstructive pulmonary disease
    Thierry Troosters
    Respiratory Rehabilitation and Respiratory Division, UZ Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Am J Respir Crit Care Med 172:19-38. 2005
  45. ncbi request reprint Pathophysiology of dyspnea in chronic obstructive pulmonary disease: a roundtable
    Denis E O'Donnell
    Department of Medicine, Queen s University, 102 Stuart Street, Kingston, ON, K7L 2V6 Canada
    Proc Am Thorac Soc 4:145-68. 2007
    ..Self-management strategies address the affective aspect of dyspnea and are essential to successful treatment...
  46. ncbi request reprint Supervised high intensity continuous and interval training vs. self-paced training in COPD
    Janos Varga
    Department of Pulmonology, Szeged University, Deszk, Hungary
    Respir Med 101:2297-304. 2007
    ..Controversy exists regarding whether different modalities of supervised exercise training (continuous (C) or interval (I)) or self-paced (S) programs are equally beneficial...
  47. ncbi request reprint Interpreting results from clinical trials: understanding minimal clinically important differences in COPD outcomes
    Barry Make
    COPD 2:1-5. 2005
  48. ncbi request reprint Dose-dependent effects of testosterone on sexual function, mood, and visuospatial cognition in older men
    Peter B Gray
    Charles Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, California 90059, USA
    J Clin Endocrinol Metab 90:3838-46. 2005
    ..The relationships between testosterone dose and its effects on sexual function, mood, and visuospatial cognition are poorly understood...
  49. ncbi request reprint Mitochondrial disorders and exertional intolerance: controversy continues
    James E Hansen
    Am J Respir Crit Care Med 166:118; author reply 119-20. 2002
  50. ncbi request reprint Pulmonary Rehabilitation: Joint ACCP/AACVPR Evidence-Based Clinical Practice Guidelines
    Andrew L Ries
    University of California, San Diego, Department of Pulmonary and Critical Care Medicine, UCSD Medical Center, 200 West Arbor Dr, San Diego, CA 92103 8377, USA
    Chest 131:4S-42S. 2007
    ....
  51. ncbi request reprint Assessing the dose of supplemental oxygen: let us compare methodologies
    Richard Casaburi
    Respir Care 50:594-5. 2005

Research Grants2

  1. Strategies to Improve COPD Management
    Richard Casaburi; Fiscal Year: 2007
    ..These studies should have immediate impact on treatment strategies for large poor-prognosis subgroups of COPD patients. ..