M J Carvan

Summary

Affiliation: University of Wisconsin-Milwaukee
Country: USA

Publications

  1. ncbi Use of reporter genes and vertebrate DNA motifs in transgenic zebrafish as sentinels for assessing aquatic pollution
    Daniel W Nebert
    Environ Health Perspect 110:A15. 2002
  2. ncbi Accumulation, tissue distribution, and maternal transfer of dietary 2,3,7,8,-tetrachlorodibenzo-p-dioxin: impacts on reproductive success of zebrafish
    Tisha King Heiden
    Marine and Freshwater Biomedical Sciences Center, University of Wisconsin-Milwaukee Great Lakes WATER Institute, 53204, USA
    Toxicol Sci 87:497-507. 2005
  3. ncbi Inhibition of follicular development, vitellogenesis, and serum 17beta-estradiol concentrations in zebrafish following chronic, sublethal dietary exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin
    Tisha King Heiden
    Marine and Freshwater Biomedical Sciences Center, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53204, USA
    Toxicol Sci 90:490-9. 2006
  4. ncbi Gene expression changes related to endocrine function and decline in reproduction in fathead minnow (Pimephales promelas) after dietary methylmercury exposure
    Rebecca Klaper
    Great Lakes WATER Institute, University of Wisconsin Milwaukee, Milwaukee, Wisconsin, USA
    Environ Health Perspect 114:1337-43. 2006
  5. ncbi Activation of transcription factors in zebrafish cell cultures by environmental pollutants
    M J Carvan
    Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0056, USA
    Arch Biochem Biophys 376:320-7. 2000
  6. ncbi Oxidative stress in zebrafish cells: potential utility of transgenic zebrafish as a deployable sentinel for site hazard ranking
    M J Carvan
    Great Lakes WATER Institute and NIEHS Marine and Freshwater Biomedical Sciences Center, University of Wisconsin Milwaukee, 53204, USA
    Sci Total Environ 274:183-96. 2001
  7. ncbi Fish models in toxicology
    Michael J Carvan
    Great Lakes Wisconsin Aquaculture Technology and Environmental Research (WATER) Institute, University of Wisconsin-Milwaukee, 600 E. Greenfield Avenue, Milwaukee, WI 53204, USA
    Zebrafish 4:9-20. 2007
  8. ncbi Selenomethionine reduces visual deficits due to developmental methylmercury exposures
    Daniel N Weber
    Marine and Freshwater Biomedical Sciences Center, University of Wisconsin Milwaukee, 600 E Greenfield Ave, Milwaukee, WI 53204, United States
    Physiol Behav 93:250-60. 2008
  9. ncbi "Gene-swap knock-in" cassette in mice to study allelic differences in human genes
    D W Nebert
    Center for Environmental Genetics and Department of Environmental Health, University of Cincinnati Medical Center, Ohio 45267 0056, USA
    Ann N Y Acad Sci 919:148-70. 2000
  10. ncbi Detection of mercury in aquatic environments using EPRE reporter zebrafish
    Brandon W Kusik
    Department of Biological Sciences, University of Wisconsin Milwaukee, Milwaukee, WI 53204, USA
    Mar Biotechnol (NY) 10:750-7. 2008

Research Grants

  1. FETAL ALCOHOL SYNDROME: GENETIC STUDIES IN ZEBRAFISH
    MICHAEL CARVAN; Fiscal Year: 2002

Collaborators

Detail Information

Publications18

  1. ncbi Use of reporter genes and vertebrate DNA motifs in transgenic zebrafish as sentinels for assessing aquatic pollution
    Daniel W Nebert
    Environ Health Perspect 110:A15. 2002
  2. ncbi Accumulation, tissue distribution, and maternal transfer of dietary 2,3,7,8,-tetrachlorodibenzo-p-dioxin: impacts on reproductive success of zebrafish
    Tisha King Heiden
    Marine and Freshwater Biomedical Sciences Center, University of Wisconsin-Milwaukee Great Lakes WATER Institute, 53204, USA
    Toxicol Sci 87:497-507. 2005
    ..This study provides the necessary framework to utilize the zebrafish model system for further investigations into the molecular mechanisms by which TCDD exerts its reproductive toxic responses...
  3. ncbi Inhibition of follicular development, vitellogenesis, and serum 17beta-estradiol concentrations in zebrafish following chronic, sublethal dietary exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin
    Tisha King Heiden
    Marine and Freshwater Biomedical Sciences Center, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53204, USA
    Toxicol Sci 90:490-9. 2006
    ..This suggests that long-term exposure to very low concentrations of TCDD could greatly affect fecundity and reproductive success in fishes...
  4. ncbi Gene expression changes related to endocrine function and decline in reproduction in fathead minnow (Pimephales promelas) after dietary methylmercury exposure
    Rebecca Klaper
    Great Lakes WATER Institute, University of Wisconsin Milwaukee, Milwaukee, Wisconsin, USA
    Environ Health Perspect 114:1337-43. 2006
    ..Several studies have indicated potential changes in hormone levels as well as declines in vertebrates with increasing dietary MeHg exposure...
  5. ncbi Activation of transcription factors in zebrafish cell cultures by environmental pollutants
    M J Carvan
    Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0056, USA
    Arch Biochem Biophys 376:320-7. 2000
    ....
  6. ncbi Oxidative stress in zebrafish cells: potential utility of transgenic zebrafish as a deployable sentinel for site hazard ranking
    M J Carvan
    Great Lakes WATER Institute and NIEHS Marine and Freshwater Biomedical Sciences Center, University of Wisconsin Milwaukee, 53204, USA
    Sci Total Environ 274:183-96. 2001
    ....
  7. ncbi Fish models in toxicology
    Michael J Carvan
    Great Lakes Wisconsin Aquaculture Technology and Environmental Research (WATER) Institute, University of Wisconsin-Milwaukee, 600 E. Greenfield Avenue, Milwaukee, WI 53204, USA
    Zebrafish 4:9-20. 2007
  8. ncbi Selenomethionine reduces visual deficits due to developmental methylmercury exposures
    Daniel N Weber
    Marine and Freshwater Biomedical Sciences Center, University of Wisconsin Milwaukee, 600 E Greenfield Ave, Milwaukee, WI 53204, United States
    Physiol Behav 93:250-60. 2008
    ..Electrophysiological deficits parallel behavioral patterns in MeHg-treated fish, i.e., initial reactions to the rotating bar were followed by periods of inactivity and then a resumption of responses...
  9. ncbi "Gene-swap knock-in" cassette in mice to study allelic differences in human genes
    D W Nebert
    Center for Environmental Genetics and Department of Environmental Health, University of Cincinnati Medical Center, Ohio 45267 0056, USA
    Ann N Y Acad Sci 919:148-70. 2000
    ..It is anticipated that mouse lines carrying numerous human alleles will become commonplace early in the next millennium...
  10. ncbi Detection of mercury in aquatic environments using EPRE reporter zebrafish
    Brandon W Kusik
    Department of Biological Sciences, University of Wisconsin Milwaukee, Milwaukee, WI 53204, USA
    Mar Biotechnol (NY) 10:750-7. 2008
    ..Furthermore, expression was induced at HgCl(2) concentrations that do not result in obvious morphological defects, making this approach useful for the detection of low levels of oxidative contaminants in aquatic environments...
  11. ncbi Developmental selenomethionine and methylmercury exposures affect zebrafish learning
    Leigh E Smith
    Department of Psychology, University of Wisconsin Milwaukee, Milwaukee, WI 53204, United States
    Neurotoxicol Teratol 32:246-55. 2010
    ..01 microM MeHg. SeMet co-exposure ameliorated but did not prevent changes in telencephalon cell body density. In summary, MeHg affected both learning and brain structure, but SeMet only partially reversed the latter...
  12. ncbi Developmental expression of alcohol dehydrogenase (ADH3) in zebrafish (Danio rerio)
    A K Dasmahapatra
    Great Lakes WATER Institute, University of Wisconsin Milwaukee, Milwaukee, Wisconsin 53204, USA
    Biochem Biophys Res Commun 286:1082-6. 2001
    ..Thus, differential ADH3 expression may be at least partly responsible for temporal variations in the sensitivity of zebrafish embryos to developmental alcohol exposure...
  13. ncbi Ethanol effects on the developing zebrafish: neurobehavior and skeletal morphogenesis
    Michael J Carvan
    Great Lakes WATER Institute, University of Wisconsin Milwaukee, 600 E Greenfield Avenue, Milwaukee, WI 53204, USA
    Neurotoxicol Teratol 26:757-68. 2004
    ..This work provides the foundation for identifying genes and pathways involved in developmental alcohol toxicity in vertebrates, leading to a more complete mechanistic understanding of fetal alcohol disorders in humans...
  14. ncbi Strain-dependent effects of developmental ethanol exposure in zebrafish
    Evyn Loucks
    Great Lakes WATER Institute, University of Wisconsin-Milwaukee, Milwaukee, WI 53204, USA
    Neurotoxicol Teratol 26:745-55. 2004
    ....
  15. ncbi Molecular targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) within the zebrafish ovary: insights into TCDD-induced endocrine disruption and reproductive toxicity
    Tisha C King Heiden
    Department of Biological Sciences, University of Wisconsin Milwaukee, Milwaukee, WI, USA
    Reprod Toxicol 25:47-57. 2008
    ..Data presented here provide further insight into the mechanisms by which TCDD disrupts follicular development and reproduction in fish, and can be used to formulate new hypotheses regarding previously documented ovarian toxicity...
  16. ncbi Fluorescence-based detection of thiols in vitro and in vivo using dithiol probes
    Phani Kumar Pullela
    Chemical Proteomics Facility at Marquette, Department of Chemistry, Marquette University, Milwaukee, WI 53201, USA
    Anal Biochem 352:265-73. 2006
    ..In Escherichia coli, decreased thiol levels were detected in cells deficient in glutathione synthesis. In zebrafish embryos, the DSSA reagent permitted detection of unusually high thiol levels in the zebrafish chorion...
  17. ncbi Views on four key questions about zebrafish research
    Keith C Cheng
    Jake Gittlen Cancer Research Foundation, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    Zebrafish 5:9-24. 2008
  18. ncbi Automated analysis of conserved syntenies for the zebrafish genome
    John Postlethwait
    Institute of Neuroscience, University of Oregon, Eugene, Oregon 97403, USA
    Methods Cell Biol 77:255-71. 2004

Research Grants1

  1. FETAL ALCOHOL SYNDROME: GENETIC STUDIES IN ZEBRAFISH
    MICHAEL CARVAN; Fiscal Year: 2002
    ..abstract_text> ..