Steven Carroll

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. pmc Molecular mechanisms promoting the pathogenesis of Schwann cell neoplasms
    Steven L Carroll
    Division of Neuropathology, Department of Pathology, University of Alabama at Birmingham, 1720 Seventh Avenue South, SC930G3, Birmingham, AL 35294 0017, USA
    Acta Neuropathol 123:321-48. 2012
  2. pmc How does the Schwann cell lineage form tumors in NF1?
    Steven L Carroll
    Division of Neuropathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0017, USA
    Glia 56:1590-605. 2008
  3. pmc A liquid chromatography mass spectrometry assay for determination of PD168393, a specific and irreversible inhibitor of erbB membrane tyrosine kinases, in rat serum
    Jeevan K Prasain
    Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 876:219-24. 2008
  4. pmc Differential activation of c-fos and caspase-3 in hippocampal neuron subpopulations following neonatal hypoxia-ischemia
    Jayne M Ness
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
    J Neurosci Res 86:1115-24. 2008
  5. ncbi request reprint Tumor suppressor mutations and growth factor signaling in the pathogenesis of NF1-associated peripheral nerve sheath tumors: II. The role of dysregulated growth factor signaling
    Steven L Carroll
    Division of Neuropathology, Department of Pathology, University of Alabama School of Medicine, Birmingham, Alabama 35294 0017, USA
    J Neuropathol Exp Neurol 64:1-9. 2005
  6. ncbi request reprint Tumor suppressor mutations and growth factor signaling in the pathogenesis of NF1-associated peripheral nerve sheath tumors. I. The role of tumor suppressor mutations
    Steven L Carroll
    Division of Neuropathology, Department of Pathology, The University of Alabama School of Medicine, Birmingham, Alabama 35294 0017, USA
    J Neuropathol Exp Neurol 63:1115-23. 2004
  7. ncbi request reprint Activation of the neuregulin-1/ErbB signaling pathway promotes the proliferation of neoplastic Schwann cells in human malignant peripheral nerve sheath tumors
    Mark S Stonecypher
    Department of Cell Biology, The University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    Oncogene 24:5589-605. 2005
  8. ncbi request reprint Hypertrophic neuropathies and malignant peripheral nerve sheath tumors in transgenic mice overexpressing glial growth factor beta3 in myelinating Schwann cells
    Richard P H Huijbregts
    Division of Neuropathology, Department of Pathology, The University of Alabama at Birmingham, Birmingham, Alabama 35294 0017, USA
    J Neurosci 23:7269-80. 2003
  9. ncbi request reprint Constitutive activation of the neuregulin-1/ErbB receptor signaling pathway is essential for the proliferation of a neoplastic Schwann cell line
    Paul W Frohnert
    Department of Pathology, Division of Neuropathology, University of Alabama, Birmingham, Alabama 35294, USA
    Glia 43:104-18. 2003
  10. pmc Neuregulin-1 beta and neuregulin-1 alpha differentially affect the migration and invasion of malignant peripheral nerve sheath tumor cells
    Jenell M Eckert
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0017, USA
    Glia 57:1501-20. 2009

Collaborators

  • KEVIN AARON ROTH
  • J M Wyss
  • Robert E Schmidt
  • J M Ness
  • Harald Sontheimer
  • Jeevan Kumar Prasain
  • A Strasser
  • Stephen Barnes
  • Stephanie J Byer
  • Mark S Stonecypher
  • Jenell M Eckert
  • Paul W Frohnert
  • Abhik Ray Chaudhury
  • Kimberly M Gerecke
  • Buffie J Clodfelder-Miller
  • Karina Ricart
  • Rizwan S Akhtar
  • Patricia S Ritch
  • Kenneth B Fallon
  • Richard P H Huijbregts
  • Nicole M Brossier
  • Andrew J Carroll
  • Amy N Turk
  • Kurt R Zinn
  • John C Kappes
  • Ying Geng
  • Richard J Pearson
  • Andreas Villunger
  • Cecelia B Latham
  • Ewa M Michalak
  • Liliana Viera
  • Patricia Cassina
  • Barbara J Klocke
  • ALVARO G ESTEVEZ
  • AndrĂ©s Kamaid
  • William E Grizzle
  • Leo H Hamilton
  • Necat Havlioglu
  • Tammy P H Cheng
  • Marcia N Gordon
  • David G Morgan

Detail Information

Publications19

  1. pmc Molecular mechanisms promoting the pathogenesis of Schwann cell neoplasms
    Steven L Carroll
    Division of Neuropathology, Department of Pathology, University of Alabama at Birmingham, 1720 Seventh Avenue South, SC930G3, Birmingham, AL 35294 0017, USA
    Acta Neuropathol 123:321-48. 2012
    ..However, this improved understanding in turn raises a host of intriguing new questions...
  2. pmc How does the Schwann cell lineage form tumors in NF1?
    Steven L Carroll
    Division of Neuropathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0017, USA
    Glia 56:1590-605. 2008
    ....
  3. pmc A liquid chromatography mass spectrometry assay for determination of PD168393, a specific and irreversible inhibitor of erbB membrane tyrosine kinases, in rat serum
    Jeevan K Prasain
    Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 876:219-24. 2008
    ..The validated method can be used in most or all stages of the screening and optimizing process for future method validation of pharmacokinetic studies...
  4. pmc Differential activation of c-fos and caspase-3 in hippocampal neuron subpopulations following neonatal hypoxia-ischemia
    Jayne M Ness
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
    J Neurosci Res 86:1115-24. 2008
    ..The differential expression of c-Fos in HI-resistant hippocampal subpopulations vs. cleaved caspase-3 in dying neurons suggests a neuroprotective role for c-Fos expression in neonatal HI...
  5. ncbi request reprint Tumor suppressor mutations and growth factor signaling in the pathogenesis of NF1-associated peripheral nerve sheath tumors: II. The role of dysregulated growth factor signaling
    Steven L Carroll
    Division of Neuropathology, Department of Pathology, University of Alabama School of Medicine, Birmingham, Alabama 35294 0017, USA
    J Neuropathol Exp Neurol 64:1-9. 2005
    ....
  6. ncbi request reprint Tumor suppressor mutations and growth factor signaling in the pathogenesis of NF1-associated peripheral nerve sheath tumors. I. The role of tumor suppressor mutations
    Steven L Carroll
    Division of Neuropathology, Department of Pathology, The University of Alabama School of Medicine, Birmingham, Alabama 35294 0017, USA
    J Neuropathol Exp Neurol 63:1115-23. 2004
    ....
  7. ncbi request reprint Activation of the neuregulin-1/ErbB signaling pathway promotes the proliferation of neoplastic Schwann cells in human malignant peripheral nerve sheath tumors
    Mark S Stonecypher
    Department of Cell Biology, The University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    Oncogene 24:5589-605. 2005
    ..These findings suggest that autocrine and/or paracrine NRG-1/erbB signaling promotes neoplastic Schwann cell proliferation and may be an important therapeutic target in neurofibromas and MPNSTs...
  8. ncbi request reprint Hypertrophic neuropathies and malignant peripheral nerve sheath tumors in transgenic mice overexpressing glial growth factor beta3 in myelinating Schwann cells
    Richard P H Huijbregts
    Division of Neuropathology, Department of Pathology, The University of Alabama at Birmingham, Birmingham, Alabama 35294 0017, USA
    J Neurosci 23:7269-80. 2003
    ..Furthermore, overexpression of this NRG-1 isoform frequently induces neoplastic Schwann cell proliferation within PNS ganglia, suggesting that NRG-1 may contribute to human Schwann cell neoplasia...
  9. ncbi request reprint Constitutive activation of the neuregulin-1/ErbB receptor signaling pathway is essential for the proliferation of a neoplastic Schwann cell line
    Paul W Frohnert
    Department of Pathology, Division of Neuropathology, University of Alabama, Birmingham, Alabama 35294, USA
    Glia 43:104-18. 2003
    ..The absence of EGFR expression in JS1 cells suggests that constitutive activation of the NRG-1/erbB signaling pathway is an alternative means of inducing Schwann cell neoplasia...
  10. pmc Neuregulin-1 beta and neuregulin-1 alpha differentially affect the migration and invasion of malignant peripheral nerve sheath tumor cells
    Jenell M Eckert
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0017, USA
    Glia 57:1501-20. 2009
    ..These findings suggest that NRG-1 beta enhances MPNST migration and that NRG-1 beta and NRG-1 alpha differentially modulate this process...
  11. ncbi request reprint Neuregulin-1beta induces neurite extension and arborization in cultured hippocampal neurons
    Kimberly M Gerecke
    Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    Mol Cell Neurosci 27:379-93. 2004
    ..We conclude that NRG-1beta stimulates hippocampal neurite extension and arborization via a signaling pathway that involves erbB membrane tyrosine kinases (erbB2 and/or erbB4), p42/44 ERK, and PKC...
  12. ncbi request reprint BH3-only proapoptotic Bcl-2 family members Noxa and Puma mediate neural precursor cell death
    Rizwan S Akhtar
    Division of Neuropathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0017, USA
    J Neurosci 26:7257-64. 2006
    ..Together, these experiments identify Noxa and Puma as important regulators of genotoxin-induced telencephalic NPC death...
  13. ncbi request reprint Constitutive activation of the neuregulin-1/erbB signaling pathway promotes the proliferation of a human peripheral neuroepithelioma cell line
    Kenneth B Fallon
    Division of Neuropathology, Department of Pathology, The University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    J Neurooncol 66:273-84. 2004
    ....
  14. pmc Tamoxifen inhibits malignant peripheral nerve sheath tumor growth in an estrogen receptor-independent manner
    Stephanie J Byer
    Department of Pathology, University of Alabama at Birmingham, 1720 Seventh Avenue South, SC930G3, Birmingham, AL 35294 0017, USA
    Neuro Oncol 13:28-41. 2011
    ..We conclude that 4-hydroxy-tamoxifen inhibits MPNST cell proliferation and survival via an ER-independent mechanism. The in vivo effectiveness of tamoxifen provides a rationale for clinical trials in cases of MPNSTs...
  15. ncbi request reprint Interactions between beta-neuregulin and neurotrophins in motor neuron apoptosis
    Karina Ricart
    Department of Physiology and Biophysics, The University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Neurochem 97:222-33. 2006
    ....
  16. ncbi request reprint Neuregulin growth factors and their ErbB receptors form a potential signaling network for schwannoma tumorigenesis
    Mark S Stonecypher
    Department of Cell Biology, The University of Alabama at Birmingham, 1720 Seventh Avenue South, Birmingham, AL 35294, USA
    J Neuropathol Exp Neurol 65:162-75. 2006
    ..These observations suggest that autocrine, paracrine, and/or juxtacrine NRG-1/NRG-2 signaling promotes schwannoma pathogenesis and that this signaling pathway may be an important therapeutic target in schwannomas...
  17. ncbi request reprint Lysophosphatidic acid promotes the proliferation of adult Schwann cells isolated from axotomized sciatic nerve
    Paul W Frohnert
    Division of Neuropathology, Department of Pathology, The University of Alabama School of Medicine, Birmingham, Alabama 35294 0017, USA
    J Neuropathol Exp Neurol 62:520-9. 2003
    ....
  18. pmc Neuregulin-1 enhances survival of human astrocytic glioma cells
    Patricia S Ritch
    Department of Neurobiology, Civitan International Research Center, University of Alabama, Birmingham, Alabama 35294, USA
    Glia 51:217-28. 2005
    ..This data suggests that glioma cells may use autocrine or paracrine neuregulin-1/erbB receptor signaling to enhance cell survival under conditions where growth would otherwise be limited...
  19. ncbi request reprint Neuregulin-1 and erbB4 immunoreactivity is associated with neuritic plaques in Alzheimer disease brain and in a transgenic model of Alzheimer disease
    Abhik Ray Chaudhury
    Department of Pathology, The University of Alabama at Birmingham, Birmingham, Alabama 35294 0017, USA
    J Neuropathol Exp Neurol 62:42-54. 2003
    ....

Research Grants12

  1. Novel Treatment of NF-1 Associated Malignant Peripheral Nerve Sheath Tumors
    Steven L Carroll; Fiscal Year: 2010
    ..Inappropriate stimulation by growth factors is thought to cooperate with mutations of tumor suppressor genes such as NF1 and p53 to promote MPNST tumorigenesis. ..
  2. Role of Neuregulin-1 in Schwann Cell Neoplasia
    Steven Carroll; Fiscal Year: 2007
    ..These studies will provide important insights into the mechanisms promoting MPNST formation and establish the NRG-1/erbB signaling pathway as a novel therapeutic target in MPNSTs. ..
  3. NEUREGULINS AND THE PATHOLOGY OF NERVE INJURY
    Steven Carroll; Fiscal Year: 2002
    ....
  4. Novel Treatment of NF-1 Associated Malignant Peripheral Nerve Sheath Tumors
    Steven L Carroll; Fiscal Year: 2011
    ..Inappropriate stimulation by growth factors is thought to cooperate with mutations of tumor suppressor genes such as NF1 and p53 to promote MPNST tumorigenesis. ..