Research Topics
Genomes and Genes | Sean B CarrollSummaryAffiliation: University of Wisconsin Country: USA Publications
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Publications
Evo-devo and an expanding evolutionary synthesis: a genetic theory of morphological evolutionSean B Carroll
Howard Hughes Medical Institute, Laboratory of Molecular Biology, University of Wisconsin Madison, Madison, WI 53706, USA
Cell 134:25-36. 2008....
Evolution at two levels: on genes and formSean B Carroll
Howard Hughes Medical Institute, Laboratory of Molecular Biology, University of Wisconsin, Madison, Wisconsin, USA
PLoS Biol 3:e245. 2005
Regulation of body pigmentation by the Abdominal-B Hox protein and its gain and loss in Drosophila evolutionSangyun Jeong
Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, 1525 Linden Drive, Madison, WI 53706, USA
Cell 125:1387-99. 2006..These results demonstrate how Hox regulation of traits and target genes is gained and lost at the species level and have general implications for the evolution of body form at higher taxonomic levels...- The regulation and evolution of a genetic switch controlling sexually dimorphic traits in DrosophilaThomas M Williams
Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, 1525 Linden Drive, Madison, WI 53706, USA
Cell 134:610-23. 2008..These findings reveal how new dimorphic characters can emerge from genetic networks regulating pre-existing dimorphic traits... - Chance caught on the wing: cis-regulatory evolution and the origin of pigment patterns in DrosophilaNicolas Gompel
Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, 1525 Linden Drive, Madison, Wisconsin 53706, USA
Nature 433:481-7. 2005.... - Evolution of the tan locus contributed to pigment loss in Drosophila santomea: a response to Matute et alMark Rebeiz
Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, 1525 Linden Drive, Madison, WI 53706, USA
Cell 139:1189-96. 2009..s claims. We discuss how the choice of parental species and other factors affect the ability to identify loci responsible for species divergence, and we affirm that all of our previously reported results and conclusions stand... - Repeated morphological evolution through cis-regulatory changes in a pleiotropic geneNicolas Gompel
University of Wisconsin and Howard Hughes Medical Institute, Bock Laboratories, 1525 Linden Drive, Madison, Wisconsin 53706, USA
Nature 440:1050-3. 2006..These results demonstrate how the functional diversification of the modular CREs of pleiotropic genes contributes to evolutionary novelty and the independent evolution of morphological similarities... - The evolution of gene regulation underlies a morphological difference between two Drosophila sister speciesSangyun Jeong
Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, 1525 Linden Drive, Madison, WI 53706, USA
Cell 132:783-93. 2008..We submit that there is sufficient empirical evidence to support the general prediction that functional evolutionary changes at pleiotropic loci will most often involve mutations in their discrete, modular cis-regulatory elements... - Stepwise modification of a modular enhancer underlies adaptation in a Drosophila populationMark Rebeiz
Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, Madison, WI 53706, USA
Science 326:1663-7. 2009..We underscore how enhancers are distinct macromolecular entities, subject to fundamentally different, and generally more relaxed, functional constraints relative to protein sequences... - Hox repression of a target gene: extradenticle-independent, additive action through multiple monomer binding sitesRon Galant
Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, 1525 Linden Drive, Madison, Wisconsin 53706, USA
Development 129:3115-26. 2002.... - Direct regulation of knot gene expression by Ultrabithorax and the evolution of cis-regulatory elements in DrosophilaBradley M Hersh
University of Wisconsin Madison, Howard Hughes Medical Institute, 1525 Linden Drive, Madison, WI 53706, USA
Development 132:1567-77. 2005..The span of regulatory sequences upon which selection acts may, in general, be more expansive and less modular than functional studies of these elements have previously indicated... - Collaboration between Smads and a Hox protein in target gene repressionChristopher M Walsh
Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, 1525 Linden Drive, Madison, WI 53706, USA
Development 134:3585-92. 2007..These results support an emerging view of Hox proteins acting in collaboration with a much more diverse set of transcription factors than has generally been appreciated... - Evolution of yellow gene regulation and pigmentation in DrosophilaPatricia J Wittkopp
Howard Hughes Medical Institute, Laboratory of Molecular Biology, University of Wisconsin, Madison, WI 53706, USA
Curr Biol 12:1547-56. 2002..Here, we compare the regulation of the yellow gene, which is required for melanization, among distantly related Drosophila species with different pigment patterns and determine the phenotypic effects of divergent Yellow expression... - The UBX-regulated network in the haltere imaginal disc of D. melanogasterBradley M Hersh
Howard Hughes Medical Institute and University of Wisconsin Madison, 1525 Linden Drive, Madison, WI 53703, USA
Dev Biol 302:717-27. 2007..The evolution of haltere morphology involved changes in UBX-regulated target genes, both positive and negative, throughout the wing genetic regulatory network... - Pleiotropic functions of a conserved insect-specific Hox peptide motifChris Todd Hittinger
Howard Hughes Medical Institute, University of Wisconsin Madison, Madison, WI 53706, USA
Development 132:5261-70. 2005.... - Rapid evolution of sex pheromone-producing enzyme expression in DrosophilaTroy R Shirangi
Howard Hughes Medical Institute, University of Wisconsin, Madison, United States of America
PLoS Biol 7:e1000168. 2009.... - Genetic mechanisms and constraints governing the evolution of correlated traits in drosophilid fliesNicolas Gompel
Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, 1525 Linden Drive, Madison, Wisconsin 53706, USA
Nature 424:931-5. 2003.... - Generation of a novel wing colour pattern by the Wingless morphogenThomas Werner
Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, 1525 Linden Drive, Madison, Wisconsin 53706, USA
Nature 464:1143-8. 2010..This example of a complex design developing and evolving by the layering of new patterns on pre-patterns is likely to be a general theme in other animals... - Gene duplication and the adaptive evolution of a classic genetic switchChris Todd Hittinger
Howard Hughes Medical Institute, Laboratory of Genetics, University of Wisconsin Madison, 1525 Linden Drive, Madison, Wisconsin 53706, USA
Nature 449:677-81. 2007.... - The evolution of abdominal reduction and the recent origin of distinct Abdominal-B transcript classes in DipteraJohn H Yoder
Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, Madison, 53706, USA
Evol Dev 8:241-51. 2006..We conclude that regulatory modifications to developmental programs downstream of or parallel to Abd-B are responsible for the evolutionary reduction of the higher dipteran postabdomen... - Regulating evolutionSean B Carroll
University of Wisconsin Madison, USA
Sci Am 298:60-7. 2008..If humans want to understand what distinguishes animals, including ourselves, from one another, we have to look beyond genes... - More genes or more taxa? The relative contribution of gene number and taxon number to phylogenetic accuracyAntonis Rokas
Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin Madison, USA
Mol Biol Evol 22:1337-44. 2005..We conclude that, for typical data sets, the number of genes utilized may be a more important determinant of phylogenetic accuracy than taxon number... - Drosophila pigmentation evolution: divergent genotypes underlying convergent phenotypesPatricia J Wittkopp
Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, 1525 Linden Drive, Madison, WI 53706, USA
Proc Natl Acad Sci U S A 100:1808-13. 2003..These findings bear upon understanding classic models of melanism and mimicry... - Emerging principles of regulatory evolutionNicolas Gompel
Howard Hughes Medical Institute and University of Wisconsin, Bock Laboratories, 1525 Linden Drive, Madison, WI 53706, USA
Proc Natl Acad Sci U S A 104:8605-12. 2007.... - Evolutionary origin of a novel gene expression pattern through co-option of the latent activities of existing regulatory sequencesMark Rebeiz
Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, Madison, WI 53706, USA
Proc Natl Acad Sci U S A 108:10036-43. 2011..We suggest that the novel optic lobe enhancer evolved by exploiting the cryptic activity of extant regulatory sequences, and this may reflect a general mechanism whereby new enhancers evolve... - Evolution of key cell signaling and adhesion protein families predates animal originsNicole King
Howard Hughes Medical Institute (HHMI, University of Wisconsin, 1525 Linden Drive, Madison, WI 53706, USA
Science 301:361-3. 2003..The expression in choanoflagellates of proteins involved in cell interactions in Metazoa demonstrates that these proteins evolved before the origin of animals and were later co-opted for development... - Reciprocal functions of the Drosophila yellow and ebony proteins in the development and evolution of pigment patternsPatricia J Wittkopp
Howard Hughes Medical Institute, Laboratory of Molecular Biology, University of Wisconsin, 1525 Linden Drive, Madison, WI 53706, USA
Development 129:1849-58. 2002..These findings provide a developmental and genetic framework for understanding the evolution of melanin patterns... - Evolution of an insect-specific GROUCHO-interaction motif in the ENGRAILED selector proteinChris Todd Hittinger
Laboratory of Genetics, Howard Hughes Medical Institute, University of Wisconsin Madison, Madison, WI 53706 1534, USA
Evol Dev 10:537-45. 2008..The acquisition and conservation of this auxiliary peptide motif shows how the number and activity of short peptide motifs can evolve in transcription factors while existing regulatory functions are maintained... - Quantitative trait loci responsible for variation in sexually dimorphic traits in Drosophila melanogasterArtyom Kopp
Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, Madison, Wisconsin 53706, USA
Genetics 163:771-87. 2003.... - Genome-scale approaches to resolving incongruence in molecular phylogeniesAntonis Rokas
Howard Hughes Medical Institute, Laboratory of Molecular Biology, R. M. Bock Laboratories, University of Wisconsin-Madison, 1525 Linden Drive, Madison, Wisconsin 53706, USA
Nature 425:798-804. 2003..These results have important implications for resolving branches of the tree of life... - Genetics and the making of Homo sapiensSean B Carroll
Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, 1525 Linden Drive, Madison, Wisconsin 53706, USA
Nature 422:849-57. 2003..Comparative genomics, population genetics, gene-expression analyses and medical genetics have begun to make complementary inroads into the complex genetic architecture of human evolution... - Animal evolution and the molecular signature of radiations compressed in timeAntonis Rokas
Howard Hughes Medical Institute, Laboratory of Molecular Biology, R. M. Bock Labs, University of Wisconsin-Madison, 1525 Linden Drive, Madison, WI 53706, USA
Science 310:1933-8. 2005.... - Parallel inactivation of multiple GAL pathway genes and ecological diversification in yeastsChris Todd Hittinger
Howard Hughes Medical Institute and Laboratories of Genetics and Molecular Biology, University of Wisconsin, 1525 Linden Drive, Madison, WI 53706, USA
Proc Natl Acad Sci U S A 101:14144-9. 2004..Inactivated genes may generally serve as markers of specific functions made dispensable by recent adaptive shifts... - The regulatory content of intergenic DNA shapes genome architectureCraig E Nelson
Howard Hughes Medical Institute, University of Wisconsin Madison, 1525 Linden Drive, Madison, WI 53703, USA
Genome Biol 5:R25. 2004..In particular, it has been impossible to estimate the global impact, if any, of regulatory elements on genome architecture... - Pharmacologic approaches to butterfly wing patterning: sulfated polysaccharides mimic or antagonize cold shock and alter the interpretation of gradients of positional informationMichael S Serfas
Howard Hughes Medical Institute, University of Wisconsin-Madison, 1525 Linden Drive, Madison WI 53706, USA
Dev Biol 287:416-24. 2005..We suggest that the primary effect of polysaccharide treatments is to alter the interpretation of gradients of positional information along the proximodistal axis of the pupal wing... - Stephen Jay Gould (1941-2002): a wonderful lifeSean B Carroll
Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin at Madison, 1525 Linden Drive, Madison, WI 53706, USA
Dev Cell 3:21-3. 2002 - Conflicting phylogenetic signals at the base of the metazoan treeAntonis Rokas
Howard Hughes Medical Institute, University of Wisconsin-Madison, 1525 Linden Drive, Madison, WI 53706-1596, USA
Evol Dev 5:346-59. 2003..These factors raise concerns about the ability to resolve the phylogenetic history of animals with molecular sequences. A consensus view of animal evolution may require investigations of genome-scale characters... - Evolution of a transcriptional repression domain in an insect Hox proteinRon Galant
Howard Hughes Medical Institute, University of Wisconsin, Madison 53706, USA
Nature 415:910-3. 2002..The evolution of this domain may have facilitated the greater morphological diversification of posterior thoracic and anterior abdominal segments characteristic of modern insects... - Bushes in the tree of lifeAntonis Rokas
PLoS Biol 4:e352. 2006 - Evolution in black and white: genetic control of pigment patterns in DrosophilaPatricia J Wittkopp
Molecular Biology and Genetics, 227 Biotechnology Building, Cornell University, Ithaca, NY 14853, USA
Trends Genet 19:495-504. 2003 - Molecular mechanisms of selector gene function and evolutionRichard S Mann
Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
Curr Opin Genet Dev 12:592-600. 2002..Elucidation of the architecture of selector-regulated target gene enhancers and gene networks, and comparative studies of selector protein function are providing important insights into the evolution of development and morphology... - Frequent and widespread parallel evolution of protein sequencesAntonis Rokas
Department of Biological Sciences, Vanderbilt University, USA
Mol Biol Evol 25:1943-53. 2008.... - Gene co-option in physiological and morphological evolutionJohn R True
Department of Ecology and Evolution, State University of New York at Stony Brook, 11794 5245, USA
Annu Rev Cell Dev Biol 18:53-80. 2002.... - Monkey see, monkey doSean B Carroll
Nat Genet 38:740-1. 2006