S Carroll

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. ncbi request reprint Endless forms: the evolution of gene regulation and morphological diversity
    S B Carroll
    Howard Hughes Medical Institute, University of Wisconsin, R M Bock Laboratories, Madison 53706, USA
    Cell 101:577-80. 2000
  2. ncbi request reprint Genetics and the making of Homo sapiens
    Sean B Carroll
    Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, 1525 Linden Drive, Madison, Wisconsin 53706, USA
    Nature 422:849-57. 2003
  3. ncbi request reprint Chance and necessity: the evolution of morphological complexity and diversity
    S B Carroll
    Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin Madison, 53706 1596, USA
    Nature 409:1102-9. 2001
  4. pmc Ultrabithorax regulates genes at several levels of the wing-patterning hierarchy to shape the development of the Drosophila haltere
    S D Weatherbee
    Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, Madison, Wisconsin 53706, USA
    Genes Dev 12:1474-82. 1998
  5. ncbi request reprint From pattern to gene, from gene to pattern
    S B Carroll
    Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, Madison 53706, USA
    Int J Dev Biol 42:305-9. 1998
  6. pmc The Vestigial and Scalloped proteins act together to directly regulate wing-specific gene expression in Drosophila
    G Halder
    Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, Madison, Wisconsin 53706 USA
    Genes Dev 12:3900-9. 1998
  7. ncbi request reprint Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic
    J Kim
    Howard Hughes Medical Institute, University of Wisconsin, Madison 53706, USA
    Nature 388:304-8. 1997
  8. ncbi request reprint The development of crustacean limbs and the evolution of arthropods
    G Panganiban
    Laboratory of Molecular Biology, University of Wisconsin, Madison 53706, USA
    Science 270:1363-6. 1995
  9. ncbi request reprint Conservation of wingless patterning functions in the short-germ embryos of Tribolium castaneum
    L M Nagy
    Howard Hughes Medical Institute, Laboratory of Molecular Biology, University of Wisconsin, Madison 53706
    Nature 367:460-3. 1994
  10. ncbi request reprint Morphing: a new graphics tool for animating confocal images
    S Paddock
    Howard Hughes Medical Institute, Laboratory of Molecular Biology, University of Wisconsin, Madison
    Biotechniques 16:448-52. 1994

Collaborators

Detail Information

Publications51

  1. ncbi request reprint Endless forms: the evolution of gene regulation and morphological diversity
    S B Carroll
    Howard Hughes Medical Institute, University of Wisconsin, R M Bock Laboratories, Madison 53706, USA
    Cell 101:577-80. 2000
  2. ncbi request reprint Genetics and the making of Homo sapiens
    Sean B Carroll
    Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, 1525 Linden Drive, Madison, Wisconsin 53706, USA
    Nature 422:849-57. 2003
    ..Comparative genomics, population genetics, gene-expression analyses and medical genetics have begun to make complementary inroads into the complex genetic architecture of human evolution...
  3. ncbi request reprint Chance and necessity: the evolution of morphological complexity and diversity
    S B Carroll
    Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin Madison, 53706 1596, USA
    Nature 409:1102-9. 2001
    ..Although simple filamentous and spherical forms may evolve wherever cellular life exists, the evolution of motile, modular mega-organisms might not be a universal pattern...
  4. pmc Ultrabithorax regulates genes at several levels of the wing-patterning hierarchy to shape the development of the Drosophila haltere
    S D Weatherbee
    Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, Madison, Wisconsin 53706, USA
    Genes Dev 12:1474-82. 1998
    ..Our results suggest that Ubx, and Hox genes in general, independently and selectively regulate genes that act at many levels of regulatory hierarchies to shape the differential development of serially homologous structures...
  5. ncbi request reprint From pattern to gene, from gene to pattern
    S B Carroll
    Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, Madison 53706, USA
    Int J Dev Biol 42:305-9. 1998
    ....
  6. pmc The Vestigial and Scalloped proteins act together to directly regulate wing-specific gene expression in Drosophila
    G Halder
    Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, Madison, Wisconsin 53706 USA
    Genes Dev 12:3900-9. 1998
    ..Combinatorial regulation by selector proteins and signal transducers is likely to be a general feature of the tissue-specific control of gene expression during organogenesis...
  7. ncbi request reprint Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic
    J Kim
    Howard Hughes Medical Institute, University of Wisconsin, Madison 53706, USA
    Nature 388:304-8. 1997
    ..Mad also binds to Dpp-response elements in other genes. These results suggest that Dpp signalling regulates gene expression by activating Mad binding to target gene enhancers...
  8. ncbi request reprint The development of crustacean limbs and the evolution of arthropods
    G Panganiban
    Laboratory of Molecular Biology, University of Wisconsin, Madison 53706, USA
    Science 270:1363-6. 1995
    ..However, differences between crustacean and insect body plans were found to correlate with differences in the deployment of particular homeotic genes and in the ways that these genes regulate limb development...
  9. ncbi request reprint Conservation of wingless patterning functions in the short-germ embryos of Tribolium castaneum
    L M Nagy
    Howard Hughes Medical Institute, Laboratory of Molecular Biology, University of Wisconsin, Madison 53706
    Nature 367:460-3. 1994
    ....
  10. ncbi request reprint Morphing: a new graphics tool for animating confocal images
    S Paddock
    Howard Hughes Medical Institute, Laboratory of Molecular Biology, University of Wisconsin, Madison
    Biotechniques 16:448-52. 1994
    ..It is anticipated that morphing can be applied not only to the display and analysis of developing systems but also to the elucidation of evolutionary relationships between species and to comparative anatomy...
  11. ncbi request reprint Regulation of body pigmentation by the Abdominal-B Hox protein and its gain and loss in Drosophila evolution
    Sangyun Jeong
    Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, 1525 Linden Drive, Madison, WI 53706, USA
    Cell 125:1387-99. 2006
    ..These results demonstrate how Hox regulation of traits and target genes is gained and lost at the species level and have general implications for the evolution of body form at higher taxonomic levels...
  12. pmc The regulatory content of intergenic DNA shapes genome architecture
    Craig E Nelson
    Howard Hughes Medical Institute, University of Wisconsin Madison, 1525 Linden Drive, Madison, WI 53703, USA
    Genome Biol 5:R25. 2004
    ..In particular, it has been impossible to estimate the global impact, if any, of regulatory elements on genome architecture...
  13. pmc Evolution at two levels: on genes and form
    Sean B Carroll
    Howard Hughes Medical Institute, Laboratory of Molecular Biology, University of Wisconsin, Madison, Wisconsin, USA
    PLoS Biol 3:e245. 2005
  14. doi request reprint Evo-devo and an expanding evolutionary synthesis: a genetic theory of morphological evolution
    Sean B Carroll
    Howard Hughes Medical Institute, Laboratory of Molecular Biology, University of Wisconsin Madison, Madison, WI 53706, USA
    Cell 134:25-36. 2008
    ....
  15. pmc The regulation and evolution of a genetic switch controlling sexually dimorphic traits in Drosophila
    Thomas M Williams
    Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, 1525 Linden Drive, Madison, WI 53706, USA
    Cell 134:610-23. 2008
    ..These findings reveal how new dimorphic characters can emerge from genetic networks regulating pre-existing dimorphic traits...
  16. ncbi request reprint Chance caught on the wing: cis-regulatory evolution and the origin of pigment patterns in Drosophila
    Nicolas Gompel
    Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, 1525 Linden Drive, Madison, Wisconsin 53706, USA
    Nature 433:481-7. 2005
    ....
  17. ncbi request reprint Evolution of yellow gene regulation and pigmentation in Drosophila
    Patricia J Wittkopp
    Howard Hughes Medical Institute, Laboratory of Molecular Biology, University of Wisconsin, Madison, WI 53706, USA
    Curr Biol 12:1547-56. 2002
    ..Here, we compare the regulation of the yellow gene, which is required for melanization, among distantly related Drosophila species with different pigment patterns and determine the phenotypic effects of divergent Yellow expression...
  18. ncbi request reprint Hox repression of a target gene: extradenticle-independent, additive action through multiple monomer binding sites
    Ron Galant
    Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, 1525 Linden Drive, Madison, Wisconsin 53706, USA
    Development 129:3115-26. 2002
    ....
  19. ncbi request reprint Pleiotropic functions of a conserved insect-specific Hox peptide motif
    Chris Todd Hittinger
    Howard Hughes Medical Institute, University of Wisconsin Madison, Madison, WI 53706, USA
    Development 132:5261-70. 2005
    ....
  20. ncbi request reprint Repeated morphological evolution through cis-regulatory changes in a pleiotropic gene
    Benjamin Prud'homme
    University of Wisconsin and Howard Hughes Medical Institute, Bock Laboratories, 1525 Linden Drive, Madison, Wisconsin 53706, USA
    Nature 440:1050-3. 2006
    ..These results demonstrate how the functional diversification of the modular CREs of pleiotropic genes contributes to evolutionary novelty and the independent evolution of morphological similarities...
  21. ncbi request reprint Collaboration between Smads and a Hox protein in target gene repression
    Christopher M Walsh
    Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, 1525 Linden Drive, Madison, WI 53706, USA
    Development 134:3585-92. 2007
    ..These results support an emerging view of Hox proteins acting in collaboration with a much more diverse set of transcription factors than has generally been appreciated...
  22. ncbi request reprint Regulating evolution
    Sean B Carroll
    University of Wisconsin Madison, USA
    Sci Am 298:60-7. 2008
    ..If humans want to understand what distinguishes animals, including ourselves, from one another, we have to look beyond genes...
  23. pmc Stepwise modification of a modular enhancer underlies adaptation in a Drosophila population
    Mark Rebeiz
    Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, Madison, WI 53706, USA
    Science 326:1663-7. 2009
    ..We underscore how enhancers are distinct macromolecular entities, subject to fundamentally different, and generally more relaxed, functional constraints relative to protein sequences...
  24. ncbi request reprint The evolution of abdominal reduction and the recent origin of distinct Abdominal-B transcript classes in Diptera
    John H Yoder
    Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, Madison, 53706, USA
    Evol Dev 8:241-51. 2006
    ..We conclude that regulatory modifications to developmental programs downstream of or parallel to Abd-B are responsible for the evolutionary reduction of the higher dipteran postabdomen...
  25. doi request reprint The evolution of gene regulation underlies a morphological difference between two Drosophila sister species
    Sangyun Jeong
    Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, 1525 Linden Drive, Madison, WI 53706, USA
    Cell 132:783-93. 2008
    ..We submit that there is sufficient empirical evidence to support the general prediction that functional evolutionary changes at pleiotropic loci will most often involve mutations in their discrete, modular cis-regulatory elements...
  26. pmc Evolution of an insect-specific GROUCHO-interaction motif in the ENGRAILED selector protein
    Chris Todd Hittinger
    Laboratory of Genetics, Howard Hughes Medical Institute, University of Wisconsin Madison, Madison, WI 53706 1534, USA
    Evol Dev 10:537-45. 2008
    ..The acquisition and conservation of this auxiliary peptide motif shows how the number and activity of short peptide motifs can evolve in transcription factors while existing regulatory functions are maintained...
  27. doi request reprint Evolution of the tan locus contributed to pigment loss in Drosophila santomea: a response to Matute et al
    Mark Rebeiz
    Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, 1525 Linden Drive, Madison, WI 53706, USA
    Cell 139:1189-96. 2009
    ..s claims. We discuss how the choice of parental species and other factors affect the ability to identify loci responsible for species divergence, and we affirm that all of our previously reported results and conclusions stand...
  28. pmc Rapid evolution of sex pheromone-producing enzyme expression in Drosophila
    Troy R Shirangi
    Howard Hughes Medical Institute, University of Wisconsin, Madison, United States of America
    PLoS Biol 7:e1000168. 2009
    ....
  29. ncbi request reprint Gene duplication and the adaptive evolution of a classic genetic switch
    Chris Todd Hittinger
    Howard Hughes Medical Institute, Laboratory of Genetics, University of Wisconsin Madison, 1525 Linden Drive, Madison, Wisconsin 53706, USA
    Nature 449:677-81. 2007
    ....
  30. pmc Emerging principles of regulatory evolution
    Nicolas Gompel
    Howard Hughes Medical Institute and University of Wisconsin, Bock Laboratories, 1525 Linden Drive, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 104:8605-12. 2007
    ....
  31. pmc Drosophila pigmentation evolution: divergent genotypes underlying convergent phenotypes
    Patricia J Wittkopp
    Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, 1525 Linden Drive, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 100:1808-13. 2003
    ..These findings bear upon understanding classic models of melanism and mimicry...
  32. ncbi request reprint Evolution of key cell signaling and adhesion protein families predates animal origins
    Nicole King
    Howard Hughes Medical Institute HHMI, University of Wisconsin, 1525 Linden Drive, Madison, WI 53706, USA
    Science 301:361-3. 2003
    ..The expression in choanoflagellates of proteins involved in cell interactions in Metazoa demonstrates that these proteins evolved before the origin of animals and were later co-opted for development...
  33. ncbi request reprint Evolution of a transcriptional repression domain in an insect Hox protein
    Ron Galant
    Howard Hughes Medical Institute, University of Wisconsin, Madison 53706, USA
    Nature 415:910-3. 2002
    ..The evolution of this domain may have facilitated the greater morphological diversification of posterior thoracic and anterior abdominal segments characteristic of modern insects...
  34. pmc The UBX-regulated network in the haltere imaginal disc of D. melanogaster
    Bradley M Hersh
    Howard Hughes Medical Institute and University of Wisconsin Madison, 1525 Linden Drive, Madison, WI 53703, USA
    Dev Biol 302:717-27. 2007
    ..The evolution of haltere morphology involved changes in UBX-regulated target genes, both positive and negative, throughout the wing genetic regulatory network...
  35. ncbi request reprint Reciprocal functions of the Drosophila yellow and ebony proteins in the development and evolution of pigment patterns
    Patricia J Wittkopp
    Howard Hughes Medical Institute, Laboratory of Molecular Biology, University of Wisconsin, 1525 Linden Drive, Madison, WI 53706, USA
    Development 129:1849-58. 2002
    ..These findings provide a developmental and genetic framework for understanding the evolution of melanin patterns...
  36. ncbi request reprint Genetic mechanisms and constraints governing the evolution of correlated traits in drosophilid flies
    Nicolas Gompel
    Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, 1525 Linden Drive, Madison, Wisconsin 53706, USA
    Nature 424:931-5. 2003
    ....
  37. pmc Parallel inactivation of multiple GAL pathway genes and ecological diversification in yeasts
    Chris Todd Hittinger
    Howard Hughes Medical Institute and Laboratories of Genetics and Molecular Biology, University of Wisconsin, 1525 Linden Drive, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 101:14144-9. 2004
    ..Inactivated genes may generally serve as markers of specific functions made dispensable by recent adaptive shifts...
  38. pmc Quantitative trait loci responsible for variation in sexually dimorphic traits in Drosophila melanogaster
    Artyom Kopp
    Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, Madison, Wisconsin 53706, USA
    Genetics 163:771-87. 2003
    ....
  39. ncbi request reprint Stephen Jay Gould (1941-2002): a wonderful life
    Sean B Carroll
    Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin at Madison, 1525 Linden Drive, Madison, WI 53706, USA
    Dev Cell 3:21-3. 2002
  40. ncbi request reprint Genome-scale approaches to resolving incongruence in molecular phylogenies
    Antonis Rokas
    Howard Hughes Medical Institute, Laboratory of Molecular Biology, R M Bock Laboratories, University of Wisconsin Madison, 1525 Linden Drive, Madison, Wisconsin 53706, USA
    Nature 425:798-804. 2003
    ..These results have important implications for resolving branches of the tree of life...
  41. ncbi request reprint More genes or more taxa? The relative contribution of gene number and taxon number to phylogenetic accuracy
    Antonis Rokas
    Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin Madison, USA
    Mol Biol Evol 22:1337-44. 2005
    ..We conclude that, for typical data sets, the number of genes utilized may be a more important determinant of phylogenetic accuracy than taxon number...
  42. ncbi request reprint Direct regulation of knot gene expression by Ultrabithorax and the evolution of cis-regulatory elements in Drosophila
    Bradley M Hersh
    University of Wisconsin Madison, Howard Hughes Medical Institute, 1525 Linden Drive, Madison, WI 53706, USA
    Development 132:1567-77. 2005
    ..The span of regulatory sequences upon which selection acts may, in general, be more expansive and less modular than functional studies of these elements have previously indicated...
  43. ncbi request reprint Animal evolution and the molecular signature of radiations compressed in time
    Antonis Rokas
    Howard Hughes Medical Institute, Laboratory of Molecular Biology, R M Bock Labs, University of Wisconsin Madison, 1525 Linden Drive, Madison, WI 53706, USA
    Science 310:1933-8. 2005
    ....
  44. ncbi request reprint Conflicting phylogenetic signals at the base of the metazoan tree
    Antonis Rokas
    Howard Hughes Medical Institute, University of Wisconsin Madison, 1525 Linden Drive, Madison, WI 53706 1596, USA
    Evol Dev 5:346-59. 2003
    ..These factors raise concerns about the ability to resolve the phylogenetic history of animals with molecular sequences. A consensus view of animal evolution may require investigations of genome-scale characters...
  45. pmc Bushes in the tree of life
    Antonis Rokas
    PLoS Biol 4:e352. 2006
  46. ncbi request reprint Molecular mechanisms of selector gene function and evolution
    Richard S Mann
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Curr Opin Genet Dev 12:592-600. 2002
    ..Elucidation of the architecture of selector-regulated target gene enhancers and gene networks, and comparative studies of selector protein function are providing important insights into the evolution of development and morphology...
  47. ncbi request reprint Gene co-option in physiological and morphological evolution
    John R True
    Department of Ecology and Evolution, State University of New York at Stony Brook, 11794 5245, USA
    Annu Rev Cell Dev Biol 18:53-80. 2002
    ....
  48. ncbi request reprint Evolution in black and white: genetic control of pigment patterns in Drosophila
    Patricia J Wittkopp
    Molecular Biology and Genetics, 227 Biotechnology Building, Cornell University, Ithaca, NY 14853, USA
    Trends Genet 19:495-504. 2003
  49. ncbi request reprint Pharmacologic approaches to butterfly wing patterning: sulfated polysaccharides mimic or antagonize cold shock and alter the interpretation of gradients of positional information
    Michael S Serfas
    Howard Hughes Medical Institute, University of Wisconsin Madison, 1525 Linden Drive, Madison WI 53706, USA
    Dev Biol 287:416-24. 2005
    ..We suggest that the primary effect of polysaccharide treatments is to alter the interpretation of gradients of positional information along the proximodistal axis of the pupal wing...
  50. ncbi request reprint Monkey see, monkey do
    Benjamin Prud'homme
    Nat Genet 38:740-1. 2006
  51. doi request reprint Frequent and widespread parallel evolution of protein sequences
    Antonis Rokas
    Department of Biological Sciences, Vanderbilt University, USA
    Mol Biol Evol 25:1943-53. 2008
    ....