M E Carroll

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi request reprint Caffeine dependence in teenagers
    Gail A Bernstein
    Division of Child and Adolescent Psychiatry, University of Minnesota Medical School, F256 2B West, 2450 Riverside Avenue, Minneapolis, MN 55454, USA
    Drug Alcohol Depend 66:1-6. 2002
  2. pmc Increased impulsive choice for saccharin during PCP withdrawal in female monkeys: influence of menstrual cycle phase
    Marilyn E Carroll
    Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN 55455, USA
    Psychopharmacology (Berl) 227:413-24. 2013
  3. pmc Effects of cocaine hydrolase on cocaine self-administration under a PR schedule and during extended access (escalation) in rats
    Marilyn E Carroll
    Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN 55455, USA
    Psychopharmacology (Berl) 213:817-29. 2011
  4. ncbi request reprint Intravenous cocaine and heroin self-administration in rats selectively bred for differential saccharin intake: phenotype and sex differences
    Marilyn E Carroll
    Department of Psychiatry, University of Minnesota, Medical School, Box 392 Mayo, Minneapolis 55455, USA
    Psychopharmacology (Berl) 161:304-13. 2002
  5. ncbi request reprint Changing drug choice through conditioned reinforcement: comment on Alessi, Roll, Reilly, and Johanson (2002)
    Marilyn E Carroll
    Department of Psychiatry, University of Minnesota, Minneapolis 55455, USA
    Exp Clin Psychopharmacol 10:87-9; discussion 101-3. 2002
  6. ncbi request reprint Regulation of intravenous cocaine self-administration in rats selectively bred for high (HiS) and low (LoS) saccharin intake
    Marilyn E Carroll
    Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN, 55455, USA
    Psychopharmacology (Berl) 190:331-41. 2007
  7. ncbi request reprint Sex and estrogen influence drug abuse
    Marilyn E Carroll
    Department of Psychiatry, Mayo Box 392, University of Minnesota, Minneapolis, MN 55455, USA
    Trends Pharmacol Sci 25:273-9. 2004
  8. ncbi request reprint Sex differences in the escalation of oral phencyclidine (PCP) self-administration under FR and PR schedules in rhesus monkeys
    Marilyn E Carroll
    Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN 55455, USA
    Psychopharmacology (Berl) 180:414-26. 2005
  9. pmc Higher locomotor response to cocaine in female (vs. male) rats selectively bred for high (HiS) and low (LoS) saccharin intake
    Marilyn E Carroll
    Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN 55455, United States
    Pharmacol Biochem Behav 88:94-104. 2007
  10. doi request reprint Selective breeding for differential saccharin intake as an animal model of drug abuse
    Marilyn E Carroll
    Department of Psychiatry, University of Minnesota, Minneapolis, MN 55455, USA
    Behav Pharmacol 19:435-60. 2008

Detail Information

Publications68

  1. ncbi request reprint Caffeine dependence in teenagers
    Gail A Bernstein
    Division of Child and Adolescent Psychiatry, University of Minnesota Medical School, F256 2B West, 2450 Riverside Avenue, Minneapolis, MN 55454, USA
    Drug Alcohol Depend 66:1-6. 2002
    ..There was no significant difference in the amount of caffeine consumed daily by caffeine dependent versus non-dependent teenagers. These findings are important due to the vast number of adolescents who drink caffeinated beverages...
  2. pmc Increased impulsive choice for saccharin during PCP withdrawal in female monkeys: influence of menstrual cycle phase
    Marilyn E Carroll
    Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN 55455, USA
    Psychopharmacology (Berl) 227:413-24. 2013
    ....
  3. pmc Effects of cocaine hydrolase on cocaine self-administration under a PR schedule and during extended access (escalation) in rats
    Marilyn E Carroll
    Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN 55455, USA
    Psychopharmacology (Berl) 213:817-29. 2011
    ..In the present study, rats were treated with Albu-CocH while self-administering cocaine under a progressive ratio (PR) schedule during 2-h sessions and under a fixed-ratio 1 (FR 1) schedule during 6-h sessions...
  4. ncbi request reprint Intravenous cocaine and heroin self-administration in rats selectively bred for differential saccharin intake: phenotype and sex differences
    Marilyn E Carroll
    Department of Psychiatry, University of Minnesota, Medical School, Box 392 Mayo, Minneapolis 55455, USA
    Psychopharmacology (Berl) 161:304-13. 2002
    ..The HiS phenotype may be a predictor of abuse of other drugs via other routes of administration...
  5. ncbi request reprint Changing drug choice through conditioned reinforcement: comment on Alessi, Roll, Reilly, and Johanson (2002)
    Marilyn E Carroll
    Department of Psychiatry, University of Minnesota, Minneapolis 55455, USA
    Exp Clin Psychopharmacol 10:87-9; discussion 101-3. 2002
    ..Parallels from the animal and human literatures are discussed, as are potential future studies and applications of this approach for preventing and reducing drug abuse in humans...
  6. ncbi request reprint Regulation of intravenous cocaine self-administration in rats selectively bred for high (HiS) and low (LoS) saccharin intake
    Marilyn E Carroll
    Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN, 55455, USA
    Psychopharmacology (Berl) 190:331-41. 2007
    ..v.) cocaine self-administration more rapidly than their low saccharin (LoS)-consuming counterparts. The present experiment was designed to determine whether HiS and LoS rats differed in other aspects of drug abuse...
  7. ncbi request reprint Sex and estrogen influence drug abuse
    Marilyn E Carroll
    Department of Psychiatry, Mayo Box 392, University of Minnesota, Minneapolis, MN 55455, USA
    Trends Pharmacol Sci 25:273-9. 2004
    ..In all phases of drug abuse, females seem to be more sensitive to the rewarding effects of drugs than males, and estrogen is a major factor that underlies these sex differences...
  8. ncbi request reprint Sex differences in the escalation of oral phencyclidine (PCP) self-administration under FR and PR schedules in rhesus monkeys
    Marilyn E Carroll
    Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN 55455, USA
    Psychopharmacology (Berl) 180:414-26. 2005
    ..Studies with male rats indicate that long access (LgA) vs short access (ShA) to i.v. cocaine and heroin self-administration leads to an escalation of drug intake and a subsequent upward shift of the dose-response function...
  9. pmc Higher locomotor response to cocaine in female (vs. male) rats selectively bred for high (HiS) and low (LoS) saccharin intake
    Marilyn E Carroll
    Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN 55455, United States
    Pharmacol Biochem Behav 88:94-104. 2007
    ....
  10. doi request reprint Selective breeding for differential saccharin intake as an animal model of drug abuse
    Marilyn E Carroll
    Department of Psychiatry, University of Minnesota, Minneapolis, MN 55455, USA
    Behav Pharmacol 19:435-60. 2008
    ....
  11. doi request reprint Modeling risk factors for nicotine and other drug abuse in the preclinical laboratory
    Marilyn E Carroll
    University of Minnesota, Department of Psychiatry, Minneapolis, MN 55455, USA
    Drug Alcohol Depend 104:S70-8. 2009
    ..The models offer valuable information that has been transferred to effective prevention and treatment strategies for smoking and other drug abuse in humans...
  12. doi request reprint Impulsivity as a behavioral measure of withdrawal of orally delivered PCP and nondrug rewards in male and female monkeys
    Marilyn E Carroll
    Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN 55455, USA
    Psychopharmacology (Berl) 207:85-98. 2009
    ..Withdrawal of phencyclidine (PCP), ethanol (ETOH), and other drugs reduces operant responding maintained by food...
  13. ncbi request reprint Ketoconazole suppresses food restriction-induced increases in heroin self-administration in rats: sex differences
    M E Carroll
    Department of Psychiatry, University of Minnesota Medical School, Minneapolis 55455, USA
    Exp Clin Psychopharmacol 9:307-16. 2001
    ..Corticosterone reversed the effect of ketoconazole in a group of 8 females, suggesting an interaction between feeding conditions, sex, and the stress response in rats...
  14. doi request reprint Sex differences and ovarian hormones in animal models of drug dependence
    Marilyn E Carroll
    Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN 55455, USA
    Horm Behav 58:44-56. 2010
    ..Overall, sex and hormonal status along with other biological risk factors account for a continuum of addiction-prone and -resistant animal models that are valuable for studying drug abuse prevention and treatment strategies...
  15. ncbi request reprint Quantification of reinforcing effectiveness: comment on Meisch (2000)
    M E Carroll
    Department of Psychiatry, University of Minnesota, Twin Cities Campus, Minneapolis 55455, USA
    Exp Clin Psychopharmacol 8:352-4; discussion 362-5. 2000
    ..Further work will determine how these and other measures of reinforcing effectiveness agree...
  16. ncbi request reprint Effects of estrogen and progesterone on the escalation of cocaine self-administration in female rats during extended access
    Erin B Larson
    Department of Psychiatry, University of Texas Southwestern Medical Center, Texas, USA
    Exp Clin Psychopharmacol 15:461-71. 2007
    ..Estrogen promoted and progesterone inhibited escalation of cocaine self-administration, illustrating the importance of female gonadal hormones in drug-seeking behavior...
  17. ncbi request reprint Effects of bremazocine on self-administration of smoked cocaine base and orally delivered ethanol, phencyclidine, saccharin, and food in rhesus monkeys: a behavioral economic analysis
    Kelly P Cosgrove
    Department of Psychiatry, University of Minnesota, Minneapolis, MN 55455, USA
    J Pharmacol Exp Ther 301:993-1002. 2002
    ..These results extend the findings that kappa-agonists reduce the self-administration of drug and nondrug reinforcers to smoked cocaine base and oral ethanol, PCP, and saccharin in rhesus monkeys...
  18. ncbi request reprint Reinstatement of cocaine self-administration in rats: sex differences
    W J Lynch
    Department of Psychiatry, Box 392 Mayo, University of Minnesota, Minneapolis, MN 55455, USA
    Psychopharmacology (Berl) 148:196-200. 2000
    ..However, the results obtained with humans are equivocal, and few studies have compared male and female animals on reinstatement responding...
  19. ncbi request reprint Effects of ketoconazole on the acquisition of intravenous cocaine self-administration under different feeding conditions in rats
    U C Campbell
    Department of Psychiatry, University of Minnesota Medical School, UMHC, Box 392, Minneapolis, MN 55455, USA
    Psychopharmacology (Berl) 154:311-8. 2001
    ..CONCLUSIONS: These results extended previous findings of the suppressant effects of ketoconazole on cocaine-reinforced responding in rats to the acquisition of cocaine self-administration using food restriction as a stressor...
  20. ncbi request reprint Effects of a non-drug reinforcer, saccharin, on oral self-administration of phencyclidine in male and female rhesus monkeys
    Kelly P Cosgrove
    Department of Psychology, University of Minnesota, Minneapolis, MN 55455, USA
    Psychopharmacology (Berl) 170:9-16. 2003
    ....
  21. ncbi request reprint Regulation of intravenously self-administered nicotine in rats
    W J Lynch
    Department of Psychiatry, University of Minnesota, Minneapolis 55455, USA
    Exp Clin Psychopharmacol 7:198-207. 1999
    ..This procedure suggests that there are differences in regulation among self-administered drugs and that it may serve as a useful baseline for studying differences in vulnerability to drug abuse and potential treatment strategies...
  22. ncbi request reprint A novel paradigm to investigate regulation of drug intake in rats self-administering cocaine or heroin intravenously
    W J Lynch
    Department of Psychiatry, University of Minnesota, Minneapolis 55455, USA
    Exp Clin Psychopharmacol 6:22-31. 1998
    ..These findings indicate that subjects regulated their drug intake by adjusting IDI throughout drug self-administration sessions...
  23. ncbi request reprint Reductions in ethanol, phencyclidine, and food-maintained behavior by naltrexone pretreatment in monkeys is enhanced by open economic conditions
    M E Carroll
    Department of Psychiatry, University of Minnesota, Minneapolis 55455, USA
    Psychopharmacology (Berl) 148:412-22. 2000
    ....
  24. ncbi request reprint Sex differences in the acquisition of intravenously self-administered cocaine and heroin in rats
    W J Lynch
    Department of Psychiatry, University of Minnesota, Minneapolis 55455, USA
    Psychopharmacology (Berl) 144:77-82. 1999
    ..Despite numerous reports that male and female animals differ in behavioral responses to drugs, few studies have investigated sex differences in drug-reinforced behavior...
  25. pmc Effects of altering reinforcer magnitude and reinforcement schedule on phencyclidine (PCP) self-administration in monkeys using an adjusting delay task
    Jennifer L Newman
    Department of Psychiatry, Harvard Medical School, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Pharmacol Biochem Behav 90:778-86. 2008
    ..In Experiment 2, the cost of reinforcers was manipulated by increasing the fixed ratio (FR) requirement for each choice. Increasing the FR led to increased MAD values and decreased PCP self-administration...
  26. ncbi request reprint The economic context of drug and non-drug reinforcers affects acquisition and maintenance of drug-reinforced behavior and withdrawal effects
    M E Carroll
    Department of Psychiatry, University of Minnesota, Minneapolis 55455
    Drug Alcohol Depend 33:201-10. 1993
    ..Animal models of acquisition and withdrawal were examined to identify behavioral economic conditions under which acquisition may be prevented or withdrawal effects (and potential for relapse) may be alleviated...
  27. ncbi request reprint Effects of amphetamine, butorphanol, and morphine pretreatment on the maintenance and reinstatement of cocaine-reinforced responding
    W J Lynch
    Department of Psychiatry, University of Minnesota, Minneapolis 55455, USA
    Exp Clin Psychopharmacol 6:255-63. 1998
    ..These findings indicate that (a) pretreatment drugs with similar stimulus properties potentiate reinstatement of responding and (b) pretreatment drugs can differentially affect maintenance and reinstatement of responding...
  28. ncbi request reprint Effects of baclofen on maintenance and reinstatement of intravenous cocaine self-administration in rats
    U C Campbell
    Department of Psychiatry, University of Minnesota Medical School, Minneapolis 55455 0392, USA
    Psychopharmacology (Berl) 143:209-14. 1999
    ..Recent studies suggest that the GABA(B) receptor agonist, baclofen, may be a useful pharmacotherapy for cocaine abuse...
  29. ncbi request reprint Oral self-administration of N-allylnormetazocine (SKF-10,047) stereoisomers in rhesus monkeys: substitution during phencyclidine self-administration and withdrawal
    M E Carroll
    Psychiatry Department, University of Minnesota, Minneapolis 55455
    Pharmacol Biochem Behav 30:493-500. 1988
    ..Water was then substituted for PCP for four days and PCP, (+)-, (-)- or (+/-)-NANM were reinstated in subsequent replications of the experiment.(ABSTRACT TRUNCATED AT 250 WORDS)..
  30. ncbi request reprint PCP and hallucinogens
    M E Carroll
    Psychiatry Department, University of Minnesota, Medical School, Minneapolis 55455
    Adv Alcohol Subst Abuse 9:167-90. 1990
    ..A fourth determinant is the dependence potential that exists with these drugs, measured by tolerance development and the extent to which behavioral and physiological disturbances occur when drug use is terminated...
  31. pmc Reduction of extinction and reinstatement of cocaine seeking by wheel running in female rats
    Natalie E Zlebnik
    Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN 55455, USA
    Psychopharmacology (Berl) 209:113-25. 2010
    ..WE and WR were retested later to examine the effect of one session of wheel access on cocaine-primed reinstatement...
  32. ncbi request reprint Wheel-running attenuates intravenous cocaine self-administration in rats: sex differences
    Kelly P Cosgrove
    Department of Psychiatry, University of Minnesota, Mayo Box 392, Minneapolis 55455, USA
    Pharmacol Biochem Behav 73:663-71. 2002
    ..These results indicate that wheel-running activity had a greater suppressant effect on cocaine self-administration in females than in males, and in females, wheel-running and cocaine self-administration are substitutable as reinforcers...
  33. doi request reprint The role of impulsive behavior in drug abuse
    Jennifer L Perry
    Minneapolis Medical Research Foundation, S 3, 860, 914 South 8th Street, Minneapolis, MN 55404, USA
    Psychopharmacology (Berl) 200:1-26. 2008
    ..Impulsivity is a multifaceted construct that has recently been recognized as a factor contributing to enhanced vulnerability to drug abuse...
  34. doi request reprint Effects of allopregnanolone on the reinstatement of cocaine-seeking behavior in male and female rats
    Justin J Anker
    Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN, 55455, USA
    Psychopharmacology (Berl) 203:63-72. 2009
    ..This effect of PROG may be in part due to its metabolite allopregnanolone (ALLO), which has been shown to decrease the sensitizing effects of cocaine and reduce lethality associated with cocaine overdose in mice...
  35. doi request reprint Impulsivity on a Go/No-go task for intravenous cocaine or food in male and female rats selectively bred for high and low saccharin intake
    Justin J Anker
    Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Behav Pharmacol 19:615-29. 2008
    ..The results indicate that HiS rats and females are more prone than LoS rats and males to impulsive drug-seeking behavior...
  36. pmc Differential effects of allopregnanolone on the escalation of cocaine self-administration and sucrose intake in female rats
    Justin J Anker
    Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN 55455, USA
    Psychopharmacology (Berl) 212:419-29. 2010
    ..Evidence suggests that the progesterone metabolite allopregnanolone (ALLO) decreases cocaine seeking in animal models of relapse...
  37. ncbi request reprint Sex differences in the vulnerability to drug abuse: a review of preclinical studies
    Megan E Roth
    Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Neurosci Biobehav Rev 28:533-46. 2004
    ..The animal literature on sex differences in drug abuse treatment effectiveness is also discussed...
  38. ncbi request reprint Effects of progesterone on the reinstatement of cocaine-seeking behavior in female rats
    Justin J Anker
    Department of Psychiatry, Division of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA
    Exp Clin Psychopharmacol 15:472-80. 2007
    ..The suppression of cocaine-induced reinstatement following P treatment suggests a role for P in the prevention of relapse to cocaine self-administration in female cocaine users...
  39. doi request reprint Impulsive choice as a predictor of acquisition of IV cocaine self- administration and reinstatement of cocaine-seeking behavior in male and female rats
    Jennifer L Perry
    Division of Pharmacology and Toxicology, Minneapolis Medical Research Foundation, Minneapolis, MN 55404, USA
    Exp Clin Psychopharmacol 16:165-77. 2008
    ..Thus, individual differences in impulsive choice were associated with differences in cocaine-seeking behavior. Impulsive choice and sex may be additive vulnerability factors in certain phases of drug abuse...
  40. pmc The role of progestins in the behavioral effects of cocaine and other drugs of abuse: human and animal research
    Justin J Anker
    Department of Psychiatry, University of Minnesota, Minneapolis, MN 55455, USA
    Neurosci Biobehav Rev 35:315-33. 2010
    ..The findings discussed here highlight the complexity of progestin-drug interactions, and they suggest a possible use for these agents in understanding the etiology of and developing treatments for drug abuse...
  41. doi request reprint Performance under a Go/No-go task in rats selected for high and low impulsivity with a delay-discounting procedure
    Justin J Anker
    Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Behav Pharmacol 20:406-14. 2009
    ..These results indicate that the effects of cocaine on measures of impulsivity may be determined by a preexisting level of impulsive behavior...
  42. pmc Impulsivity predicts the escalation of cocaine self-administration in rats
    Justin J Anker
    Department of Psychiatry, University of Minnesota, Minneapolis, MN 55455, USA
    Pharmacol Biochem Behav 93:343-8. 2009
    ..This study suggests that individual differences in impulsivity predict escalation of cocaine self-administration in female rats, which may have implications in the prediction of binge-like patterns of cocaine intake in women...
  43. pmc Reinstatement of cocaine seeking induced by drugs, cues, and stress in adolescent and adult rats
    Justin J Anker
    Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN 55455, USA
    Psychopharmacology (Berl) 208:211-22. 2010
    ..However, little is known of how vulnerability factors such as adolescence are related to conditions that induce relapse, triggered by the drug itself, drug-associated cues, or stress...
  44. pmc Operant responding for sucrose by rats bred for high or low saccharin consumption
    Blake A Gosnell
    Department of Food Science and Nutrition, University of Minnesota, 1334 Eckles Ave, St Paul, MN 55108, USA
    Physiol Behav 99:529-33. 2010
    ..These studies provide further characterization of the HiS and LoS rat lines by demonstrating that motivation to consume sucrose is greater in HiS than in LoS rats...
  45. pmc Sex differences in the effects of allopregnanolone on yohimbine-induced reinstatement of cocaine seeking in rats
    Justin J Anker
    University of Minnesota, Department of Psychiatry, MMC 392, 420 Delaware St SE, Minneapolis, MN 55455, USA
    Drug Alcohol Depend 107:264-7. 2010
    ..These results suggest that females may be more sensitive than males to stress-induced reinstatement of cocaine-seeking behavior, and the progesterone metabolite, allopregnanolone, offers protection against this vulnerability...
  46. pmc Social stimuli enhance phencyclidine (PCP) self-administration in rhesus monkeys
    Jennifer L Newman
    Department of Psychiatry, University of Minnesota Medical School, MMC 392, Minneapolis, MN 55455, United States
    Pharmacol Biochem Behav 87:280-8. 2007
    ..The results suggest that social stimulation among monkeys in adjoining cages leads to enhanced reinforcing strength of PCP...
  47. ncbi request reprint Sex differences in the escalation of intravenous cocaine intake following long- or short-access to cocaine self-administration
    Megan E Roth
    Department of Psychiatry, University of Minnesota, Minneapolis, MN 55455, USA
    Pharmacol Biochem Behav 78:199-207. 2004
    ..These results suggest that female rats are more sensitive than male rats to factors that contribute to the escalation of cocaine intake (e.g., extended access conditions)...
  48. ncbi request reprint Sex differences in the acquisition of IV methamphetamine self-administration and subsequent maintenance under a progressive ratio schedule in rats
    Megan E Roth
    Department of Psychiatry, University of Minnesota Medical School, Mayo Box 392, Minneapolis, MN 55455 0392, USA
    Psychopharmacology (Berl) 172:443-9. 2004
    ..Previous work indicates that female rats initiate cocaine use sooner than male rats and reach significantly higher break points (BPs) for a single injection of cocaine under a progressive ratio (PR) schedule compared to male rats...
  49. ncbi request reprint Differential effects of bremazocine on oral phencyclidine (PCP) self-administration in male and female rhesus monkeys
    Kelly P Cosgrove
    Department of Psychiatry, University of Minnesota, Minneapolis, MN 55455, USA
    Exp Clin Psychopharmacol 12:111-7. 2004
    ....
  50. ncbi request reprint Influence of estrogen in the acquisition of intravenously self-administered heroin in female rats
    Megan E Roth
    Department of Psychiatry, University of Minnesota, Mayo Mail Code 392, Minneapolis, MN 55455, USA
    Pharmacol Biochem Behav 72:313-8. 2002
    ..These results indicate that OVX+EB rats initiate heroin use sooner than OVX+VEH rats and consume greater amounts of heroin during the last 5 days of acquisition compared to OVX+VEH female rats...
  51. ncbi request reprint Escalation of intravenous cocaine self-administration, progressive-ratio performance, and reinstatement in rats selectively bred for high (HiS) and low (LoS) saccharin intake
    Andrew D Morgan
    Department of Psychiatry, University of Minnesota Medical School, MMC 392, Minneapolis, MN 55455, USA
    Psychopharmacology (Berl) 178:41-51. 2005
    ..Rats selectively bred for high saccharin (HiS) intake consume more alcohol and acquire intravenous (IV) cocaine self-administration more rapidly than their low saccharin (LoS) consuming counterparts...
  52. ncbi request reprint Impulsivity (delay discounting) as a predictor of acquisition of IV cocaine self-administration in female rats
    Jennifer L Perry
    Department of Psychiatry, University of Minnesota Medical School, MMC 392, Minneapolis, MN 55455, USA
    Psychopharmacology (Berl) 178:193-201. 2005
    ..However, it is not clear whether impulsivity precedes drug abuse or drug abuse influences impulsivity...
  53. ncbi request reprint Effect of short- vs. long-term estrogen on reinstatement of cocaine-seeking behavior in female rats
    Erin B Larson
    Graduate Program in Neuroscience, University of Minnesota, MMC 392 Minneapolis, MN 55455, USA
    Pharmacol Biochem Behav 82:98-108. 2005
    ....
  54. ncbi request reprint Wheel running as a predictor of cocaine self-administration and reinstatement in female rats
    Erin B Larson
    Graduate Program in Neuroscience, University of Minnesota, MMC 392, Minneapolis, MN 55455, United States
    Pharmacol Biochem Behav 82:590-600. 2005
    ..These results suggest that a propensity for wheel running is associated with increased vulnerability for cocaine self-administration and reinstatement and that HiR rats are more motivated than LoR rats to seek cocaine...
  55. ncbi request reprint Sex differences in physical dependence on orally self-administered phencyclidine (PCP) in rhesus monkeys (Macaca mulatta)
    Jennifer L Perry
    Department of Psychiatry, University of Minnesota, MN 55455, USA
    Exp Clin Psychopharmacol 14:68-78. 2006
    ..This study is the 1st to use nonhuman primates to document sex differences in withdrawal severity as measured by a quantifiable baseline...
  56. ncbi request reprint Effects of agmatine on the escalation of intravenous cocaine and fentanyl self-administration in rats
    Andrew D Morgan
    Department of Psychiatry, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Pharmacol Biochem Behav 72:873-80. 2002
    ..These data indicate that agmatine attenuates the escalation of fentanyl self-administration if administered before the escalation begins and may mediate neuroadaptive events related to chronic opioid self-administration...
  57. pmc Effects of menstrual cycle phase on the reinforcing effects of phencyclidine (PCP) in rhesus monkeys
    Jennifer L Newman
    Department of Psychiatry, University of Minnesota Medical School, MMC 392, Minneapolis, MN 55455, USA
    Pharmacol Biochem Behav 85:584-91. 2006
    ..The results from this study suggest that PCP's reinforcing effects in female monkeys differ as a function of menstrual cycle phase...
  58. ncbi request reprint Estrogen receptor beta, but not alpha, mediates estrogen's effect on cocaine-induced reinstatement of extinguished cocaine-seeking behavior in ovariectomized female rats
    Erin B Larson
    Department of Psychiatry, Graduate Program in Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA
    Neuropsychopharmacology 32:1334-45. 2007
    ....
  59. ncbi request reprint Reinforcing effects of smoked methamphetamine in rhesus monkeys
    Jennifer L Newman
    Department of Psychiatry, University of Minnesota Medical School, MMC 392, Minneapolis, MN 55455, USA
    Psychopharmacology (Berl) 188:193-200. 2006
    ..A nonhuman primate model for examining the reinforcing effects of smoked METH would be valuable for testing potential interventions for treating METH abuse disorders...
  60. ncbi request reprint Escalation of i.v. cocaine self-administration and reinstatement of cocaine-seeking behavior in rats bred for high and low saccharin intake
    Jennifer L Perry
    Department of Psychiatry, University of Minnesota Medical School, MMC 392, Minneapolis, MN 55455, USA
    Psychopharmacology (Berl) 186:235-45. 2006
    ..v.) cocaine self-administration more rapidly, and show more dysregulated patterns of cocaine self-administration than their low saccharin-consuming (LoS) counterparts...
  61. ncbi request reprint Effects of dopamine receptor antagonists (D1 and D2) on the demand for smoked cocaine base in rhesus monkeys
    U C Campbell
    Department of Psychiatry, University of Minnesota Medical School, Minneapolis 55455 0392, USA
    Psychopharmacology (Berl) 144:381-8. 1999
    ..Previous studies suggest that dopamine antagonists may reduce the reinforcing effects of cocaine. However, the effects of these antagonists on the demand for smoked cocaine base have not been quantified...
  62. ncbi request reprint Deconstructing relative reinforcing efficacy and situating the measures of pharmacological reinforcement with behavioral economics: a theoretical proposal
    W K Bickel
    University of Vermont, Department of Psychiatry, Human Behavioral Pharmacology Laboratory, 38 Fletcher Place, Ira Allen School, Burlington, VT 05401 1419, USA
    Psychopharmacology (Berl) 153:44-56. 2000
    ..However, a variety of studies suggest that relative reinforcing efficacy may be heterogeneous...
  63. ncbi request reprint Decreased cocaine self-administration in Kir3 potassium channel subunit knockout mice
    Andrew D Morgan
    Department of Psychiatry, University of Minnesota, Minneapolis, MN, USA
    Neuropsychopharmacology 28:932-8. 2003
    ..2/3.3 double knockout mice self-administered cocaine at levels significantly higher than either single knockout alone. These findings suggest that Kir3 channels play significant and complex roles in the reinforcing effect of cocaine...
  64. ncbi request reprint Biological basis of sex differences in drug abuse: preclinical and clinical studies
    Wendy J Lynch
    Department of Psychiatry, Yale University, New Haven, CT 06508, USA
    Psychopharmacology (Berl) 164:121-37. 2002
    ..Future research is necessary to provide information on how to design more effective drug abuse treatment programs and resources that are sex specific...
  65. ncbi request reprint Regulation of drug intake
    W J Lynch
    Department of Psychology, University of Minnesota, USA
    Exp Clin Psychopharmacol 9:131-43. 2001
    ....
  66. ncbi request reprint Sex differences in the effects of baclofen on the acquisition of intravenous cocaine self-administration in rats
    Una C Campbell
    Merck Research Laboratories, San Diego, 505 Coast Boulevard South, Suite 300, La Jolla, CA 92037, USA
    Drug Alcohol Depend 66:61-9. 2002
    ....
  67. ncbi request reprint Acquisition of i.v. cocaine self-administration in adolescent and adult male rats selectively bred for high and low saccharin intake
    Jennifer L Perry
    University of Kentucky, BBSRB, Room 248F, 741 S Limestone, Lexington, KY 40536 0509, United States
    Physiol Behav 91:126-33. 2007
    ..These results suggest that during adolescence, compared with adulthood, rats have both an increased avidity for sweets and vulnerability to initiate drug abuse...
  68. ncbi request reprint Impulsivity (delay discounting) for food and cocaine in male and female rats selectively bred for high and low saccharin intake
    Jennifer L Perry
    Department of Psychology, University of Kentucky, Lexington, KY 40536 0509, USA
    Pharmacol Biochem Behav 86:822-37. 2007
    ..Understanding the relationship between impulsivity and other predictors of drug abuse (e.g., sex, saccharin intake) is important in developing prevention and treatment strategies...

Research Grants56

  1. Adolescence, Impulsivity, and Drug Abuse: Sex/Hormones
    Marilyn E Carroll; Fiscal Year: 2010
    ..The study of impulsivity in drug-seeking behavior will increase our understanding of the etiology, prevention, and treatment of drug abuse. ..
  2. Animal Models for the Prevention and Treatment of Drug Abuse
    Marilyn Carroll; Fiscal Year: 2007
    ....
  3. Vulnerability to Drug Abuse: Experimental Interventions
    Marilyn Carroll; Fiscal Year: 2005
    ....
  4. Adolescence, Impulsivity, and Drug Abuse: Sex/Hormones
    Marilyn Carroll; Fiscal Year: 2007
    ..The study of impulsivity in drug-seeking behavior will increase our understanding of the etiology, prevention, and treatment of drug abuse. ..
  5. Primate Model of Drug Abuse: Intervention Strategies
    Marilyn Carroll; Fiscal Year: 2007
    ..The proposed work will further our understanding of addiction-prone vulnerability factors and treatment for drug abuse. ..
  6. Vulnerability to Drug Abuse and Treatment Efficacy: Animal Models
    Marilyn E Carroll; Fiscal Year: 2010
    ..The proposed research will show how enhanced drug-seeking behavior in vulnerable phenotypes can be reduced at the most critical, vulnerable phases of drug abuse through behavioral and pharmacological interventions. ..
  7. Primate Model of Drug Abuse: Intervention Strategies
    Marilyn E Carroll; Fiscal Year: 2010
    ..The proposed work will further our understanding of addiction-prone vulnerability factors and treatment for drug abuse. ..
  8. Adolescence, Impulsivity, and Drug Abuse: Sex/Hormones
    Marilyn Carroll; Fiscal Year: 2009
    ..The study of impulsivity in drug-seeking behavior will increase our understanding of the etiology, prevention, and treatment of drug abuse. ..
  9. Vulnerability to Drug Abuse and Treatment Efficacy: Animal Models
    Marilyn Carroll; Fiscal Year: 2009
    ..The proposed research will show how enhanced drug-seeking behavior in vulnerable phenotypes can be reduced at the most critical, vulnerable phases of drug abuse through behavioral and pharmacological interventions. ..
  10. Vulnerability to Drug Abuse and Treatment Efficacy: Animal Models
    Marilyn Carroll; Fiscal Year: 2007
    ..The proposed research will show how enhanced drug-seeking behavior in vulnerable phenotypes can be reduced at the most critical, vulnerable phases of drug abuse through behavioral and pharmacological interventions. ..
  11. A PRIMATE MODEL OF DRUG ABUSE: INTERVENTION STRATEGIES
    Marilyn Carroll; Fiscal Year: 2006
    ..It is hoped that this information will lead to earlier and more effective prevention and treatment of drug abuse. ..
  12. PRIMATE MODEL OF DRUG ABUSE--INTERVENTION STRATEGIES
    Marilyn Carroll; Fiscal Year: 2000
    ..The results will yield guidelines for evaluating reinforcing effects of drugs and provide information about factors that contribute to prevention and optimal treatment of drug abuse. ..
  13. PHENCYCLIDINE--A BEHAVIORAL PROFILE
    Marilyn Carroll; Fiscal Year: 1990
    ..Related experiments will evaluate the effectiveness of brief stimuli associated with alternative reinforcers on PCP-reinforced behavior. A final study will assess the physiological effects of long-term phencyclidine use...
  14. A PRIMATE MODEL OF DRUG ABUSE: INTERVENTION STRATEGIES
    Marilyn Carroll; Fiscal Year: 1993
    ..g., maintenance, withdrawal and relapse). The health related consequence of this research is that it will provide animal models of prevention and reduction of drug abuse...
  15. PHENCYCLIDINE: A BEHAVIORAL PROFILE
    Marilyn Carroll; Fiscal Year: 1980
    ..These measures will also be made after abrupt termination of PCP accesss...
  16. ENVIRONMENTAL AND PHARMACOLOGICAL CONTROL OF DRUG ABUSE
    Marilyn Carroll; Fiscal Year: 1990
    ....