Jones A, Kainz D, Khan F, Lee C, Carrithers M. Human macrophage SCN5A activates an innate immune signaling pathway for antiviral host defense. J Biol Chem. 2014;289:35326-40 pubmed publisher
..It is postulated that SCN5A is a novel pathogen sensor and that this pathway represents a channel activation-dependent mechanism of transcriptional regulation. ..
Carrithers M. Update on disease-modifying treatments for multiple sclerosis. Clin Ther. 2014;36:1938-45 pubmed publisher
..An evidence-based approach can be used for the selection of disease-modifying treatments based on disease phenotype and severity, adverse events, and perceived efficacy. ..
Carrithers M, Chatterjee G, Carrithers L, Offoha R, Iheagwara U, Rahner C, et al. Regulation of podosome formation in macrophages by a splice variant of the sodium channel SCN8A. J Biol Chem. 2009;284:8114-26 pubmed publisher
..6 participates in the control of podosome and invadopodia formation and suggest that intracellular sodium release mediated by NaV1.6 may regulate cellular invasion of macrophages and melanoma cells. ..
Carrithers L, Hulseberg P, Sandor M, Carrithers M. The human macrophage sodium channel NaV1.5 regulates mycobacteria processing through organelle polarization and localized calcium oscillations. FEMS Immunol Med Microbiol. 2011;63:319-27 pubmed publisher
..5 and mitochondrial-dependent calcium signaling regulate mycobacteria phagocytosis and phagosome maturation in human macrophages through spatial-temporal coordination of calcium signaling within a unique subcellular region. ..