Robert Carraway

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. doi request reprint Enhanced vascular permeability is hypothesized to promote inflammation-induced carcinogenesis and tumor development via extravasation of large molecular proteins into the tissue
    Robert E Carraway
    Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, MA, United States
    Med Hypotheses 78:738-43. 2012
  2. doi request reprint Zinc pyrithione induces ERK- and PKC-dependent necrosis distinct from TPEN-induced apoptosis in prostate cancer cells
    Robert E Carraway
    Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Biochim Biophys Acta 1823:544-57. 2012
  3. doi request reprint Protein kinase C inhibitors alter neurotensin receptor binding and function in prostate cancer PC3 cells
    Robert E Carraway
    Department of Cellular and Molecular Physiology, University of Massachusetts Medical School, 55 Lake Avenue North Worcester, MA, 01655, United States
    Regul Pept 147:96-109. 2008
  4. ncbi request reprint Neurotensin receptor binding and neurotensin-induced growth signaling in prostate cancer PC3 cells are sensitive to metabolic stress
    Robert E Carraway
    Department of Physiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Regul Pept 141:140-53. 2007
  5. ncbi request reprint Involvement of neurotensin in cancer growth: evidence, mechanisms and development of diagnostic tools
    Robert E Carraway
    Department of Physiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Peptides 27:2445-60. 2006
  6. ncbi request reprint Regulation of neurotensin receptor function by the arachidonic acid-lipoxygenase pathway in prostate cancer PC3 cells
    Robert E Carraway
    Department of Physiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Prostaglandins Leukot Essent Fatty Acids 74:93-107. 2006
  7. ncbi request reprint Ca2+ channel blockers enhance neurotensin (NT) binding and inhibit NT-induced inositol phosphate formation in prostate cancer PC3 cells
    Robert E Carraway
    Department of Physiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    J Pharmacol Exp Ther 307:640-50. 2003
  8. ncbi request reprint Polyphenolic antioxidants mimic the effects of 1,4-dihydropyridines on neurotensin receptor function in PC3 cells
    Robert E Carraway
    Department of Physiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    J Pharmacol Exp Ther 309:92-101. 2004
  9. ncbi request reprint Involvement of MAP-kinase, PI3-kinase and EGF-receptor in the stimulatory effect of Neurotensin on DNA synthesis in PC3 cells
    Sazzad Hassan
    Department of Cellular and Molecular Physiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester 01655 0127, USA
    Regul Pept 120:155-66. 2004
  10. ncbi request reprint Involvement of arachidonic acid metabolism and EGF receptor in neurotensin-induced prostate cancer PC3 cell growth
    Sazzad Hassan
    Department of Cellular and Molecular Physiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655 0127, USA
    Regul Pept 133:105-14. 2006

Collaborators

  • David E Cochrane
  • P R Dobner
  • Sazzad Hassan
  • Richard C Scarpa
  • Kimberly A Petrie
  • Xianyong Gui
  • Roy Dekel
  • Michael Bubser
  • Dennis Schmidt
  • Jim Fadel
  • Ariel Y Deutch
  • Colleen Green
  • Ronnie Fass

Detail Information

Publications15

  1. doi request reprint Enhanced vascular permeability is hypothesized to promote inflammation-induced carcinogenesis and tumor development via extravasation of large molecular proteins into the tissue
    Robert E Carraway
    Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, MA, United States
    Med Hypotheses 78:738-43. 2012
    ..It is tempting to speculate that differences in tumor growth/metastasis and patient outcome are at least partly due to the degree of permeability of the tumor vasculature...
  2. doi request reprint Zinc pyrithione induces ERK- and PKC-dependent necrosis distinct from TPEN-induced apoptosis in prostate cancer cells
    Robert E Carraway
    Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Biochim Biophys Acta 1823:544-57. 2012
    ..The enhanced sensitivity of PCa cells to ZP and the apparent ability of ZP and TPEN to kill quiescent and rapidly dividing cells in a p53-independent manner suggest that ZP/TPEN might be used to develop adjunct treatments for PCa...
  3. doi request reprint Protein kinase C inhibitors alter neurotensin receptor binding and function in prostate cancer PC3 cells
    Robert E Carraway
    Department of Cellular and Molecular Physiology, University of Massachusetts Medical School, 55 Lake Avenue North Worcester, MA, 01655, United States
    Regul Pept 147:96-109. 2008
    ..Since NT can activate PKC upon binding to its receptor, it is possible that NT receptor is also subject to homologous regulation by PKC...
  4. ncbi request reprint Neurotensin receptor binding and neurotensin-induced growth signaling in prostate cancer PC3 cells are sensitive to metabolic stress
    Robert E Carraway
    Department of Physiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Regul Pept 141:140-53. 2007
    ..In a broader context, these findings are compatible with the idea that one means by which cells might coordinate mitogenic signaling to metabolic status could involve changes in growth factor receptor function...
  5. ncbi request reprint Involvement of neurotensin in cancer growth: evidence, mechanisms and development of diagnostic tools
    Robert E Carraway
    Department of Physiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Peptides 27:2445-60. 2006
    ..These exciting advances encourage us to pursue further research and stimulate us to consider novel ideas regarding the multiple inputs to cancer growth that neurotensin might influence...
  6. ncbi request reprint Regulation of neurotensin receptor function by the arachidonic acid-lipoxygenase pathway in prostate cancer PC3 cells
    Robert E Carraway
    Department of Physiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Prostaglandins Leukot Essent Fatty Acids 74:93-107. 2006
    ..These findings suggest that NTR1 is regulated by specific feedback mechanism(s) involving lipid peroxidation and/or LOX-dependent processes...
  7. ncbi request reprint Ca2+ channel blockers enhance neurotensin (NT) binding and inhibit NT-induced inositol phosphate formation in prostate cancer PC3 cells
    Robert E Carraway
    Department of Physiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    J Pharmacol Exp Ther 307:640-50. 2003
    ....
  8. ncbi request reprint Polyphenolic antioxidants mimic the effects of 1,4-dihydropyridines on neurotensin receptor function in PC3 cells
    Robert E Carraway
    Department of Physiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    J Pharmacol Exp Ther 309:92-101. 2004
    ..In conclusion, DHPs indirectly alter NTR1 function in live cells by a mechanism that depends on the drug's ability to donate hydrogen but does not simply involve sulfhydryl reduction...
  9. ncbi request reprint Involvement of MAP-kinase, PI3-kinase and EGF-receptor in the stimulatory effect of Neurotensin on DNA synthesis in PC3 cells
    Sazzad Hassan
    Department of Cellular and Molecular Physiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester 01655 0127, USA
    Regul Pept 120:155-66. 2004
    ..We conclude that NT stimulated mitogenesis in PC3 cells by a PKC-dependent ligand-mediated transactivation of EGFR, which led to stimulation of the Raf-MEK-ERK pathway in a PI3 kinase-dependent manner...
  10. ncbi request reprint Involvement of arachidonic acid metabolism and EGF receptor in neurotensin-induced prostate cancer PC3 cell growth
    Sazzad Hassan
    Department of Cellular and Molecular Physiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655 0127, USA
    Regul Pept 133:105-14. 2006
    ..NT also upregulates cPLA2 and 5-LOX protein expression. Thus, the growth effects of NT and EGF involve a feed-forward system that requires cooperative interactions of the 5-LOX, ERK and AKT pathways...
  11. ncbi request reprint Involvement of mast cells in basal and neurotensin-induced intestinal absorption of taurocholate in rats
    Xianyong Gui
    Dept of Physiology, Univ of Massachusetts Medical School, Worcester, MA 01655 0127, USA
    Am J Physiol Gastrointest Liver Physiol 287:G408-16. 2004
    ..These results argue that basal and NT-stimulated TC uptake in rat jejunum are similarly dependent on mast cells, are largely mediated by release of mast cell mediators, and are subject to regulation by NO...
  12. ncbi request reprint The effect of neurotensin on insulin-induced proliferation of human fibroblasts
    Richard C Scarpa
    Department of Biology, Tufts University, Medford, MA 02155, USA
    Peptides 25:1159-69. 2004
    ..These results show that neurotensin can enhance insulin-dependent proliferation of human fibroblasts and suggest a possible role for neurotensin in tissue growth and repair...
  13. ncbi request reprint Neurotensin activates GABAergic interneurons in the prefrontal cortex
    Kimberly A Petrie
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
    J Neurosci 25:1629-36. 2005
    ..These findings suggest that neurotensin plays an important role in regulating prefrontal cortical interneurons and that it may be useful to consider neurotensin agonists as an adjunct in the treatment of schizophrenia...
  14. ncbi request reprint The relationship between the esophageal tissue content of neurotensin and the presence or absence of esophageal inflammation
    Roy Dekel
    The Neuro Enteric Clinical Research Group, Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System and University of Arizona Health Science Center, Tucson, Arizona 85723, USA
    Dig Dis Sci 49:42-7. 2004
    ..We suggest that the lower tissue content detected in patients with erosive esophagitis may represent a local protective mechanism against gastroesophageal reflux...
  15. ncbi request reprint Insulin-like growth factor (IGF) induced proliferation of human lung fibroblasts is enhanced by neurotensin
    Richard C Scarpa
    Department of Biology, Tufts University, 117 Barnum Hall, Medford, MA 02155, USA
    Peptides 26:2201-10. 2005
    ..These results suggest that interactions between NT and the IGFs may contribute to the regulation of fibroblasts in for example, inflamed or injured tissues...