Todd Carpenter

Summary

Affiliation: University of Colorado School of Medicine
Location: Aurora, USA
Summary:
pediatric intensive care physician
research interests in lung injury, pulmonary edema formation, altitude-related illness

Publications

  1. pmc EphA2 receptor mediates increased vascular permeability in lung injury due to viral infection and hypoxia
    Melissa A Cercone
    Developmental Lung Biology Laboratory, Box B 131, Department of Pediatrics, University of Colorado School of Medicine, 12700 East 19th Ave, Aurora, CO 80045, USA
    Am J Physiol Lung Cell Mol Physiol 297:L856-63. 2009
  2. pmc Endothelial EphA receptor stimulation increases lung vascular permeability
    Jacqueline Larson
    Developmental Lung Biology Laboratory, Box B 131, Univ of Colorado School of Medicine, 4200 East 9th Ave, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 295:L431-9. 2008
  3. ncbi Hypoxia upregulates lung microvascular neurokinin-1 receptor expression
    Eric D Zee
    Department of Pediatrics, Univ of Colorado School of Medicine, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 291:L102-10. 2006
  4. ncbi Endothelin-mediated increases in lung VEGF content promote vascular leak in young rats exposed to viral infection and hypoxia
    Todd C Carpenter
    Developmental Lung Biology Laboratory, Box B 131, University of Colorado School of Medicine, 4200 E 9th Avenue, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 289:L1075-82. 2005
  5. ncbi Predisposition of infants with chronic lung disease to respiratory syncytial virus-induced respiratory failure: a vascular hypothesis
    Todd C Carpenter
    Developmental Lung Biology Laboratory, University of Colorado Health Sciences Center, Denver, 80602, USA
    Pediatr Infect Dis J 23:S33-40. 2004
  6. ncbi Hypoxia decreases lung neprilysin expression and increases pulmonary vascular leak
    T C Carpenter
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Lung Cell Mol Physiol 281:L941-8. 2001
  7. ncbi Endothelin receptor blockade decreases lung water in young rats exposed to viral infection and hypoxia
    T C Carpenter
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Lung Cell Mol Physiol 279:L547-54. 2000
  8. pmc Eph-A2 promotes permeability and inflammatory responses to bleomycin-induced lung injury
    Todd C Carpenter
    Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Colorado School of Medicine, Aurora, 80045, USA
    Am J Respir Cell Mol Biol 46:40-7. 2012

Collaborators

  • Kurt R Stenmark
  • Stacey Schomberg
  • Melissa A Cercone
  • William Schroeder
  • Jacqueline Larson
  • Eric D Zee

Detail Information

Publications11

  1. pmc EphA2 receptor mediates increased vascular permeability in lung injury due to viral infection and hypoxia
    Melissa A Cercone
    Developmental Lung Biology Laboratory, Box B 131, Department of Pediatrics, University of Colorado School of Medicine, 12700 East 19th Ave, Aurora, CO 80045, USA
    Am J Physiol Lung Cell Mol Physiol 297:L856-63. 2009
    ..EphA2 may be a previously unrecognized contributor to the pathophysiology of lung injury...
  2. pmc Endothelial EphA receptor stimulation increases lung vascular permeability
    Jacqueline Larson
    Developmental Lung Biology Laboratory, Box B 131, Univ of Colorado School of Medicine, 4200 East 9th Ave, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 295:L431-9. 2008
    ..These observations describe a novel role for ephrin-a1 and EphA receptors in the regulation of vascular permeability in the lung...
  3. ncbi Hypoxia upregulates lung microvascular neurokinin-1 receptor expression
    Eric D Zee
    Department of Pediatrics, Univ of Colorado School of Medicine, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 291:L102-10. 2006
    ..We speculate that this effect may contribute to the formation of pulmonary edema in the setting of regional or environmental hypoxia...
  4. ncbi Endothelin-mediated increases in lung VEGF content promote vascular leak in young rats exposed to viral infection and hypoxia
    Todd C Carpenter
    Developmental Lung Biology Laboratory, Box B 131, University of Colorado School of Medicine, 4200 E 9th Avenue, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 289:L1075-82. 2005
    ..These findings suggest that ET-driven increases in lung VEGF content can contribute to the formation of pulmonary edema...
  5. ncbi Predisposition of infants with chronic lung disease to respiratory syncytial virus-induced respiratory failure: a vascular hypothesis
    Todd C Carpenter
    Developmental Lung Biology Laboratory, University of Colorado Health Sciences Center, Denver, 80602, USA
    Pediatr Infect Dis J 23:S33-40. 2004
    ..e. impaired alveolar and pulmonary vascular development). This article describes potential mechanisms by which RSV infection causes respiratory failure in the infant with BPD...
  6. ncbi Hypoxia decreases lung neprilysin expression and increases pulmonary vascular leak
    T C Carpenter
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Lung Cell Mol Physiol 281:L941-8. 2001
    ..We conclude that in young rats hypoxia decreases lung neprilysin expression, which contributes to increased pulmonary vascular leak via substance P and bradykinin receptors...
  7. ncbi Endothelin receptor blockade decreases lung water in young rats exposed to viral infection and hypoxia
    T C Carpenter
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Lung Cell Mol Physiol 279:L547-54. 2000
    ....
  8. pmc Eph-A2 promotes permeability and inflammatory responses to bleomycin-induced lung injury
    Todd C Carpenter
    Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Colorado School of Medicine, Aurora, 80045, USA
    Am J Respir Cell Mol Biol 46:40-7. 2012
    ..This study demonstrates that the expression of EphA2 increases in the injured lung, and not only contributes to changes in permeability, but also plays a previously unrecognized role in promoting inflammatory responses...