Todd Carpenter

Summary

Affiliation: University of Colorado School of Medicine
Location: Aurora, USA
Summary:
pediatric intensive care physician
research interests in lung injury, pulmonary edema formation, altitude-related illness

Publications

  1. ncbi EphA2 receptor mediates increased vascular permeability in lung injury due to viral infection and hypoxia
    Melissa A Cercone
    Developmental Lung Biology Laboratory, Box B 131, Department of Pediatrics, University of Colorado School of Medicine, 12700 East 19th Ave, Aurora, CO 80045, USA
    Am J Physiol Lung Cell Mol Physiol 297:L856-63. 2009
  2. ncbi Endothelial EphA receptor stimulation increases lung vascular permeability
    Jacqueline Larson
    Developmental Lung Biology Laboratory, Box B 131, Univ of Colorado School of Medicine, 4200 East 9th Ave, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 295:L431-9. 2008
  3. ncbi Hypoxia upregulates lung microvascular neurokinin-1 receptor expression
    Eric D Zee
    Department of Pediatrics, Univ of Colorado School of Medicine, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 291:L102-10. 2006
  4. ncbi Endothelin-mediated increases in lung VEGF content promote vascular leak in young rats exposed to viral infection and hypoxia
    Todd C Carpenter
    Developmental Lung Biology Laboratory, Box B 131, University of Colorado School of Medicine, 4200 E 9th Avenue, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 289:L1075-82. 2005
  5. ncbi Predisposition of infants with chronic lung disease to respiratory syncytial virus-induced respiratory failure: a vascular hypothesis
    Todd C Carpenter
    Developmental Lung Biology Laboratory, University of Colorado Health Sciences Center, Denver, 80602, USA
    Pediatr Infect Dis J 23:S33-40. 2004
  6. ncbi Hypoxia decreases lung neprilysin expression and increases pulmonary vascular leak
    T C Carpenter
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Lung Cell Mol Physiol 281:L941-8. 2001
  7. ncbi Endothelin receptor blockade decreases lung water in young rats exposed to viral infection and hypoxia
    T C Carpenter
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Lung Cell Mol Physiol 279:L547-54. 2000
  8. ncbi Eph-A2 promotes permeability and inflammatory responses to bleomycin-induced lung injury
    Todd C Carpenter
    Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Colorado School of Medicine, Aurora, 80045, USA
    Am J Respir Cell Mol Biol 46:40-7. 2012

Collaborators

  • Kurt R Stenmark
  • Stacey Schomberg
  • Melissa A Cercone
  • William Schroeder
  • Jacqueline Larson
  • Eric D Zee

Detail Information

Publications11

  1. ncbi EphA2 receptor mediates increased vascular permeability in lung injury due to viral infection and hypoxia
    Melissa A Cercone
    Developmental Lung Biology Laboratory, Box B 131, Department of Pediatrics, University of Colorado School of Medicine, 12700 East 19th Ave, Aurora, CO 80045, USA
    Am J Physiol Lung Cell Mol Physiol 297:L856-63. 2009
    ..EphA2 may be a previously unrecognized contributor to the pathophysiology of lung injury...
  2. ncbi Endothelial EphA receptor stimulation increases lung vascular permeability
    Jacqueline Larson
    Developmental Lung Biology Laboratory, Box B 131, Univ of Colorado School of Medicine, 4200 East 9th Ave, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 295:L431-9. 2008
    ..These observations describe a novel role for ephrin-a1 and EphA receptors in the regulation of vascular permeability in the lung...
  3. ncbi Hypoxia upregulates lung microvascular neurokinin-1 receptor expression
    Eric D Zee
    Department of Pediatrics, Univ of Colorado School of Medicine, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 291:L102-10. 2006
    ..We speculate that this effect may contribute to the formation of pulmonary edema in the setting of regional or environmental hypoxia...
  4. ncbi Endothelin-mediated increases in lung VEGF content promote vascular leak in young rats exposed to viral infection and hypoxia
    Todd C Carpenter
    Developmental Lung Biology Laboratory, Box B 131, University of Colorado School of Medicine, 4200 E 9th Avenue, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 289:L1075-82. 2005
    ..These findings suggest that ET-driven increases in lung VEGF content can contribute to the formation of pulmonary edema...
  5. ncbi Predisposition of infants with chronic lung disease to respiratory syncytial virus-induced respiratory failure: a vascular hypothesis
    Todd C Carpenter
    Developmental Lung Biology Laboratory, University of Colorado Health Sciences Center, Denver, 80602, USA
    Pediatr Infect Dis J 23:S33-40. 2004
    ..CONCLUSIONS: Novel therapies for managing RSV-induced respiratory failure in the infant with CLD/BPD must consider factors responsible for the substantial pulmonary vascular component of this illness...
  6. ncbi Hypoxia decreases lung neprilysin expression and increases pulmonary vascular leak
    T C Carpenter
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Lung Cell Mol Physiol 281:L941-8. 2001
    ..We conclude that in young rats hypoxia decreases lung neprilysin expression, which contributes to increased pulmonary vascular leak via substance P and bradykinin receptors...
  7. ncbi Endothelin receptor blockade decreases lung water in young rats exposed to viral infection and hypoxia
    T C Carpenter
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Lung Cell Mol Physiol 279:L547-54. 2000
    ....
  8. ncbi Eph-A2 promotes permeability and inflammatory responses to bleomycin-induced lung injury
    Todd C Carpenter
    Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Colorado School of Medicine, Aurora, 80045, USA
    Am J Respir Cell Mol Biol 46:40-7. 2012
    ..This study demonstrates that the expression of EphA2 increases in the injured lung, and not only contributes to changes in permeability, but also plays a previously unrecognized role in promoting inflammatory responses...