STANLEY CARMICHAEL

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Neural progenitor implantation restores metabolic deficits in the brain following striatal quinolinic acid lesion
    Koppany Visnyei
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Exp Neurol 197:465-74. 2006
  2. pmc Opinion & special articles: a guide from fellowship to faculty: Nietzsche and the academic neurologist
    S Thomas Carmichael
    David Geffen School of Medicine, UCLA, Los Angeles, CA, USA
    Neurology 79:e116-9. 2012
  3. doi request reprint Brain excitability in stroke: the yin and yang of stroke progression
    S Thomas Carmichael
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Arch Neurol 69:161-7. 2012
  4. pmc Targets for neural repair therapies after stroke
    S Thomas Carmichael
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Stroke 41:S124-6. 2010
  5. pmc Translating the frontiers of brain repair to treatments: starting not to break the rules
    S Thomas Carmichael
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Neurobiol Dis 37:237-42. 2010
  6. pmc Genomic profiles of damage and protection in human intracerebral hemorrhage
    S Thomas Carmichael
    Department of Neurology, Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    J Cereb Blood Flow Metab 28:1860-75. 2008
  7. pmc Themes and strategies for studying the biology of stroke recovery in the poststroke epoch
    S Thomas Carmichael
    Department of Neurology, David Geffen School of Medicine at UCLA, Neuroscience Research Building, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Stroke 39:1380-8. 2008
  8. ncbi request reprint New patterns of intracortical projections after focal cortical stroke
    S T Carmichael
    Department of Neurology and Neurological Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Neurobiol Dis 8:910-22. 2001
  9. ncbi request reprint Cellular and molecular mechanisms of neural repair after stroke: making waves
    S Thomas Carmichael
    Department of Neurology, David Geffen School of Medicine at the University of California Los Angeles, 90095, USA
    Ann Neurol 59:735-42. 2006
  10. pmc Rodent models of focal stroke: size, mechanism, and purpose
    S Thomas Carmichael
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    NeuroRx 2:396-409. 2005

Research Grants

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Neural progenitor implantation restores metabolic deficits in the brain following striatal quinolinic acid lesion
    Koppany Visnyei
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Exp Neurol 197:465-74. 2006
    ..These data demonstrate that progenitor cell implantation results in enhanced metabolic function and sparing of neuron number, but that these functions do not necessarily result in the restoration of complex circuitry...
  2. pmc Opinion & special articles: a guide from fellowship to faculty: Nietzsche and the academic neurologist
    S Thomas Carmichael
    David Geffen School of Medicine, UCLA, Los Angeles, CA, USA
    Neurology 79:e116-9. 2012
    ..This article is a practical guide to the milestones and barriers to successful faculty achievement after residency or fellowship training...
  3. doi request reprint Brain excitability in stroke: the yin and yang of stroke progression
    S Thomas Carmichael
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Arch Neurol 69:161-7. 2012
    ..These changes in the excitability of neuronal circuits in peri-infarct cortex after stroke may underlie the process of remapping motor and sensory function after stroke and may identify new therapeutic targets to promote stroke recovery...
  4. pmc Targets for neural repair therapies after stroke
    S Thomas Carmichael
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Stroke 41:S124-6. 2010
    ..This review focuses on some emerging targets for neural repair or recovery in stroke and on their limitations...
  5. pmc Translating the frontiers of brain repair to treatments: starting not to break the rules
    S Thomas Carmichael
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Neurobiol Dis 37:237-42. 2010
    ..These actions may trigger a unique set of "neural repair side effects" that need to be considered in planning clinical trials...
  6. pmc Genomic profiles of damage and protection in human intracerebral hemorrhage
    S Thomas Carmichael
    Department of Neurology, Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    J Cereb Blood Flow Metab 28:1860-75. 2008
    ..These inflammatory and anti-inflammatory networks interact at several key points in neutrophil signaling, apoptotic cell death, and protease responses, and indicate that secondary damage in ICH activates opposing molecular systems...
  7. pmc Themes and strategies for studying the biology of stroke recovery in the poststroke epoch
    S Thomas Carmichael
    Department of Neurology, David Geffen School of Medicine at UCLA, Neuroscience Research Building, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Stroke 39:1380-8. 2008
    ..This review will focus on the emerging principles of neural repair after stroke, and on the overlap between cellular mechanisms of neural repair in stroke and clinical principles of recovery and rehabilitation...
  8. ncbi request reprint New patterns of intracortical projections after focal cortical stroke
    S T Carmichael
    Department of Neurology and Neurological Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Neurobiol Dis 8:910-22. 2001
    ..Thus, after focal cortical stroke, the peri-infarct cortex is structurally abnormal, loses thalamic connections, and develops new horizontal cortical connections by axonal sprouting...
  9. ncbi request reprint Cellular and molecular mechanisms of neural repair after stroke: making waves
    S Thomas Carmichael
    Department of Neurology, David Geffen School of Medicine at the University of California Los Angeles, 90095, USA
    Ann Neurol 59:735-42. 2006
    ..Poststroke neuronal regeneration is characterized by waves of specific cellular and molecular events. Manipulating these waves of regeneration may provide for novel therapies that will improve recovery after stroke...
  10. pmc Rodent models of focal stroke: size, mechanism, and purpose
    S Thomas Carmichael
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    NeuroRx 2:396-409. 2005
    ....
  11. ncbi request reprint Growth-associated gene expression after stroke: evidence for a growth-promoting region in peri-infarct cortex
    S Thomas Carmichael
    Department of Neurology, Geffen School of Medicine at UCLA, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Exp Neurol 193:291-311. 2005
    ..This region may be a growth-promoting zone after stroke...
  12. ncbi request reprint New laboratory start-up in the 21st century
    S Thomas Carmichael
    Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Trends Neurosci 25:287-8. 2002
    ..This review highlights laboratory start-up maxims and their applications to web-based purchasing, cost containment and budgeting...
  13. ncbi request reprint Synchronous neuronal activity is a signal for axonal sprouting after cortical lesions in the adult
    S Thomas Carmichael
    Department of Neurology, University of California Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 22:6062-70. 2002
    ....
  14. ncbi request reprint Evolution of diaschisis in a focal stroke model
    S Thomas Carmichael
    Department of Neurology, David Geffen School of Medicine at University of California at Los Angeles, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Stroke 35:758-63. 2004
    ..The sequential changes in diaschisis over time and the relationship of regions of diaschisis to functional cortical areas and regions of poststroke neuroplasticity have not been determined...
  15. ncbi request reprint Plasticity of cortical projections after stroke
    S Thomas Carmichael
    Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    Neuroscientist 9:64-75. 2003
    ..Thus, stroke induces a process of remapping and reconnection within the adult brain through changes in neuronal activity that may involve a reactivation of developmental programs in areas connected to the infarct...
  16. ncbi request reprint Gene expression changes after focal stroke, traumatic brain and spinal cord injuries
    S Thomas Carmichael
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Curr Opin Neurol 16:699-704. 2003
    ..These studies provide insights into coordinated patterns of gene expression within the injury and the interrelationships of neurodegenerative and neural repair processes after injury...
  17. ncbi request reprint A neurovascular niche for neurogenesis after stroke
    John J Ohab
    Department of Neurology, University of California, Los Angeles, Los Angeles, California 90095 1735, USA
    J Neurosci 26:13007-16. 2006
    ..These experiments define a novel brain environment for neuronal regeneration after stroke and identify molecular mechanisms that are shared between angiogenesis and neurogenesis during functional recovery from brain injury...
  18. doi request reprint Local hemodynamics dictate long-term dendritic plasticity in peri-infarct cortex
    Ricardo Mostany
    Departments of Neurology and Neurobiology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 30:14116-26. 2010
    ..Our data suggest that maintaining tissue perfusion in the area surrounding the infarct could hasten or augment synaptic plasticity and functional recovery after stroke...
  19. doi request reprint A white matter stroke model in the mouse: axonal damage, progenitor responses and MRI correlates
    Elif G Sozmen
    Department of Neurology, David Geffen School of Medicine at UCLA, Neuroscience Research Building, 635 Charles Young Drive South, Los Angeles, CA 90095, United States
    J Neurosci Methods 180:261-72. 2009
    ....
  20. ncbi request reprint Growth-associated gene and protein expression in the region of axonal sprouting in the aged brain after stroke
    Songlin Li
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Neurobiol Dis 23:362-73. 2006
    ..young adult after stroke. The aged brain does not simply have a reduction in growth-associated molecules after stroke, but a completely unique molecular profile of post-stroke axonal sprouting...
  21. ncbi request reprint A critical role of erythropoietin receptor in neurogenesis and post-stroke recovery
    Peter T Tsai
    Department of Molecular and Medical Pharmacology, University of California, Los Angeles, California 90095, USA
    J Neurosci 26:1269-74. 2006
    ..Our results suggest that both EPO and EPOR are essential for early embryonic neural development and that the classical EPOR is important for adult neurogenesis and for migration of regenerating neurons during post-injury recovery...
  22. pmc Reducing excessive GABA-mediated tonic inhibition promotes functional recovery after stroke
    Andrew N Clarkson
    Department of Neurology, The David Geffen School of Medicine at UCLA, 635 Charles Young Drive South, Los Angeles, California 90095, USA
    Nature 468:305-9. 2010
    ..Together, our results identify new pharmacological targets and provide the rationale for a novel strategy to promote recovery after stroke and possibly other brain injuries...
  23. ncbi request reprint Tissue microenvironments within functional cortical subdivisions adjacent to focal stroke
    Diana Katsman
    Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Cereb Blood Flow Metab 23:997-1009. 2003
    ..Adjacent tissue microenvironments are sites of distinct reactive cellular signaling and may serve as a link between the processes of acute cell death and delayed neuronal plasticity after focal stroke...
  24. ncbi request reprint Metabolic correlates of lesion-specific plasticity: an in vivo imaging study
    Halleh M Mir
    Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Brain Res 1002:28-34. 2004
    ....
  25. pmc Pten deletion in adult neural stem/progenitor cells enhances constitutive neurogenesis
    Caroline Gregorian
    Department of Molecular and Medical Pharmacology, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 29:1874-86. 2009
    ....
  26. ncbi request reprint Increased oxidative protein and DNA damage but decreased stress response in the aged brain following experimental stroke
    Songlin Li
    Department of Neurology, David Geffen School of Medicine at UCLA, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Neurobiol Dis 18:432-40. 2005
    ..Stroke in the aged brain is associated with a greater degree of DNA and protein damage and a reduced stress response in intact, surviving tissue that surrounds the infarct...
  27. pmc Laminar and compartmental regulation of dendritic growth in mature cortex
    David K Chow
    Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles, 635 Charles Young Drive, South, Los Angeles, California 90095 1761, USA
    Nat Neurosci 12:116-8. 2009
    ..We found that Pten/mTOR signaling uniquely regulates the growth of layer 2/3 apical dendrites; no effects of gene deletion were observed on basal dendrites of these pyramidal neurons or along layer 5 apical dendrites...
  28. ncbi request reprint The response of the aged brain to stroke: too much, too soon?
    Aurel Popa-Wagner
    Department of Neurology, University of Greifswald, Greifswald, Germany
    Curr Neurovasc Res 4:216-27. 2007
    ..Elucidating the molecular basis of this phenomenon in the aging brain could yield novel approaches to neurorestoration following stroke or head injury in the elderly...

Research Grants15

  1. Mechanisms of Neural Repair in White Matter Stroke
    STANLEY THOMAS CARMICHAEL; Fiscal Year: 2010
    ..However, there have been few studies of the mechanisms of damage and brain repair in this disease. The studies in this grant determine the molecular and cellular mechanisms of repair and recovery in white matter stroke. ..
  2. Mechanisms of Neuronal Regeneration after Stroke in a Novel Neurovascular Niche
    STANLEY THOMAS CARMICHAEL; Fiscal Year: 2010
    ..An understanding of the molecules that promote this neural stem cell response after stroke will help develop novel therapies to promote replacement of brain cells in this disease. ..
  3. Mechanisms of Neuronal Regeneration after Stroke in a Novel Neurovascular Niche
    STANLEY CARMICHAEL; Fiscal Year: 2009
    ..An understanding of the molecules that promote this neural stem cell response after stroke will help develop novel therapies to promote replacement of brain cells in this disease. ..
  4. Mechanisms of Neural Repair in White Matter Stroke
    STANLEY THOMAS CARMICHAEL; Fiscal Year: 2010
    ..However, there have been few studies of the mechanisms of damage and brain repair in this disease. The studies in this grant determine the molecular and cellular mechanisms of repair and recovery in white matter stroke. ..
  5. Mechanisms of Neuronal Regeneration after Stroke in a Novel Neurovascular Niche
    STANLEY CARMICHAEL; Fiscal Year: 2007
    ..An understanding of the molecules that promote this neural stem cell response after stroke will help develop novel therapies to promote replacement of brain cells in this disease. ..
  6. Mechanisms of Axonal Sprouting After Stroke
    STANLEY CARMICHAEL; Fiscal Year: 2007
    ..These experiments will identify neuronal growth programs after stroke, and Iocal inhibitory molecules, and provide an understanding of the mechanisms of regeneration in the adult brain. ..