Susan Carlton

Summary

Affiliation: University of Texas Medical Branch
Country: USA

Publications

  1. pmc Regulation of Wnt signaling by nociceptive input in animal models
    Yuqiang Shi
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Mol Pain 8:47. 2012
  2. pmc Group II/III metabotropic glutamate receptors exert endogenous activity-dependent modulation of TRPV1 receptors on peripheral nociceptors
    Susan M Carlton
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555 1069, USA
    J Neurosci 31:12727-37. 2011
  3. pmc Peripheral and central sensitization in remote spinal cord regions contribute to central neuropathic pain after spinal cord injury
    Susan M Carlton
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555 1069, USA
    Pain 147:265-76. 2009
  4. pmc Group II metabotropic glutamate receptor activation on peripheral nociceptors modulates TRPV1 function
    Susan M Carlton
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1069, USA
    Brain Res 1248:86-95. 2009
  5. ncbi request reprint Colocalization of metabotropic glutamate receptors in rat dorsal root ganglion cells
    Susan M Carlton
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Marine Biomedical Institute, Galveston, Texas 77555 1069, USA
    J Comp Neurol 501:780-9. 2007
  6. ncbi request reprint Somatostatin modulates the transient receptor potential vanilloid 1 (TRPV1) ion channel
    Susan M Carlton
    Department of Anatomy and Neurosciences, Marine Biomedical Institute, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1069, USA
    Pain 110:616-27. 2004
  7. ncbi request reprint Plasticity in alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunits in the rat dorsal horn following deafferentation
    S M Carlton
    Department of Anatomy and Neuroscience, Marine Biomedical Institute, University of Texas Medical Branch, Galveston 77555 1069, USA
    Neurosci Lett 242:21-4. 1998
  8. ncbi request reprint A role for peripheral somatostatin receptors in counter-irritation-induced analgesia
    S M Carlton
    Department of Anatomy and Neurosciences, Marine Biomedical Institute, 301 University Boulevard, University of Texas Medical Branch, Galveston, TX 77555 1069, USA
    Neuroscience 120:499-508. 2003
  9. ncbi request reprint Localization of CaMKIIalpha in rat primary sensory neurons: increase in inflammation
    Susan M Carlton
    Department of Anatomy and Neurosciences, Marine Biomedical Institute, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1069, USA
    Brain Res 947:252-9. 2002
  10. ncbi request reprint Inflammation-induced up-regulation of neurokinin 1 receptors in rat glabrous skin
    Susan M Carlton
    Department of Anatomy and Neurosciences, Marine Biomedical Institute, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1069, USA
    Neurosci Lett 326:29-32. 2002

Research Grants

Collaborators

Detail Information

Publications27

  1. pmc Regulation of Wnt signaling by nociceptive input in animal models
    Yuqiang Shi
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Mol Pain 8:47. 2012
    ..Emerging evidence suggests that Wnt signaling plays a crucial role in regulation of synaptic plasticity. Little is known about the potential function of the Wnt signaling cascades in chronic pain development...
  2. pmc Group II/III metabotropic glutamate receptors exert endogenous activity-dependent modulation of TRPV1 receptors on peripheral nociceptors
    Susan M Carlton
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555 1069, USA
    J Neurosci 31:12727-37. 2011
    ..They are endogenously activated after high-frequency and/or prolonged nociceptor stimulation, acting as built-in negative modulators of TRPV1 and nociceptor function, reducing pain transmission to the CNS...
  3. pmc Peripheral and central sensitization in remote spinal cord regions contribute to central neuropathic pain after spinal cord injury
    Susan M Carlton
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555 1069, USA
    Pain 147:265-76. 2009
    ..We hypothesize that reactive glia in the cervical cord release pro-inflammatory substances which drive chronic CNP. Thus a complex cascade of events spanning many cord segments underlies above-level CNP...
  4. pmc Group II metabotropic glutamate receptor activation on peripheral nociceptors modulates TRPV1 function
    Susan M Carlton
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1069, USA
    Brain Res 1248:86-95. 2009
    ..The data are consistent with group II and TRPV1 receptors being linked intracellularly by the cAMP/PKA pathway. Peripheral group II mGluRs are important targets for drug discovery in controlling TRPV1-induced nociception...
  5. ncbi request reprint Colocalization of metabotropic glutamate receptors in rat dorsal root ganglion cells
    Susan M Carlton
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Marine Biomedical Institute, Galveston, Texas 77555 1069, USA
    J Comp Neurol 501:780-9. 2007
    ..These anatomical data highlight the potential inhibitory role glutamate may play in peripheral sensory transmission...
  6. ncbi request reprint Somatostatin modulates the transient receptor potential vanilloid 1 (TRPV1) ion channel
    Susan M Carlton
    Department of Anatomy and Neurosciences, Marine Biomedical Institute, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1069, USA
    Pain 110:616-27. 2004
    ..These data strongly suggest that SSTRs modulate nociceptors through phasic and tonic regulation of peripheral TRPV1 receptors...
  7. ncbi request reprint Plasticity in alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunits in the rat dorsal horn following deafferentation
    S M Carlton
    Department of Anatomy and Neuroscience, Marine Biomedical Institute, University of Texas Medical Branch, Galveston 77555 1069, USA
    Neurosci Lett 242:21-4. 1998
    ..Glutamate activation of these receptors could initiate or potentiate second messenger cascades that could well contribute to neuronal changes documented in the dorsal horn of deafferented animals...
  8. ncbi request reprint A role for peripheral somatostatin receptors in counter-irritation-induced analgesia
    S M Carlton
    Department of Anatomy and Neurosciences, Marine Biomedical Institute, 301 University Boulevard, University of Texas Medical Branch, Galveston, TX 77555 1069, USA
    Neuroscience 120:499-508. 2003
    ..Identifying a peripheral contribution of SRIF to mechanisms of counter-irritation analgesia offers opportunities for peripheral therapy...
  9. ncbi request reprint Localization of CaMKIIalpha in rat primary sensory neurons: increase in inflammation
    Susan M Carlton
    Department of Anatomy and Neurosciences, Marine Biomedical Institute, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1069, USA
    Brain Res 947:252-9. 2002
    ....
  10. ncbi request reprint Inflammation-induced up-regulation of neurokinin 1 receptors in rat glabrous skin
    Susan M Carlton
    Department of Anatomy and Neurosciences, Marine Biomedical Institute, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1069, USA
    Neurosci Lett 326:29-32. 2002
    ....
  11. ncbi request reprint Stereological analysis of Ca(2+)/calmodulin-dependent protein kinase II alpha -containing dorsal root ganglion neurons in the rat: colocalization with isolectin Griffonia simplicifolia, calcitonin gene-related peptide, or vanilloid receptor 1
    Susan M Carlton
    Department of Anatomy and Neurosciences, Marine Biomedical Institute, University of Texas Medical Branch, Galveston, Texas 77555 1069, USA
    J Comp Neurol 448:102-10. 2002
    ..Thus, this enzyme may play a critical role in the modulation of nociceptor activity and plasticity of primary sensory neurons...
  12. ncbi request reprint Tonic control of peripheral cutaneous nociceptors by somatostatin receptors
    S M Carlton
    Department of Anatomy and Neurosciences, Marine Biomedical Institute, University of Texas Medical Branch, Galveston, Texas 77555 1069, USA
    J Neurosci 21:4042-9. 2001
    ..These findings demonstrate that SRIF receptors maintain a tonic inhibitory control over peripheral nociceptors, and this may contribute to mechanisms that control the excitability of these terminals...
  13. ncbi request reprint Inflammation-induced changes in peripheral glutamate receptor populations
    S M Carlton
    Department of Anatomy and Neurosciences, Marine Biomedical Institute, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX, 77555 1069, USA
    Brain Res 820:63-70. 1999
    ..These data indicate that the number of sensory axons containing ionotropic glutamate receptors increases during inflammation, and this may be a contributing factor to peripheral sensitization in inflammation...
  14. ncbi request reprint Peripheral capsaicin receptors increase in the inflamed rat hindpaw: a possible mechanism for peripheral sensitization
    S M Carlton
    Department of Anatomy and Neurosciences, Marine Biomedical Institute, University of Texas Medical Branch, Galveston, TX 77555 1069, USA
    Neurosci Lett 310:53-6. 2001
    ..The data suggest that an increase in number of unmyelinated sensory axons expressing VR1 may be one mechanism underlying peripheral sensitization of nociceptors in inflammation...
  15. ncbi request reprint Attenuation of formalin-induced nociceptive behaviors following local peripheral injection of gabapentin
    S M Carlton
    Department of Anatomy and Neuroscience, Marine Biomedical Institute, University of Texas Medical Branch, Galveston 77555 1069, USA
    Pain 76:201-7. 1998
    ..Although the mechanism of action of GP has yet to be elucidated, these results indicate that GP has a peripheral site of action and thus may offer a novel therapeutic agent for topical or local treatment of pain of peripheral origin...
  16. ncbi request reprint Localization of metabotropic glutamate receptors 2/3 on primary afferent axons in the rat
    S M Carlton
    Department of Anatomy and Neurosciences, Marine Biomedical Institute, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1069, USA
    Neuroscience 105:957-69. 2001
    ..Since these receptors are concentrated in lamina IIi and also largely co-localized with I-B4, they may have considerable influence on nociceptive processing by what are considered to be non-peptidergic primary afferent neurons...
  17. ncbi request reprint Peripheral excitatory amino acids
    S M Carlton
    Department of Anatomy and Neurosciences, Marine Biomedical Institute, University of Texas Medical Branch, Galveston 77555 1069, USA
    Curr Opin Pharmacol 1:52-6. 2001
    ..These data provide strong motivation to develop new pharmacological agents that will target peripheral GluRs, offering novel approaches to treatment of pain of peripheral origin...
  18. ncbi request reprint Somatostatin receptors on peripheral primary afferent terminals: inhibition of sensitized nociceptors
    S M Carlton
    Department of Anatomy and Neurosciences, Marine Biomedical Institute, University of Texas Medical Branch, Houston, TX 77555 1069, USA
    Pain 90:233-44. 2001
    ..Thus, activation of peripheral SSTRs reduces both inflammatory pain and the activity of sensitized nociceptors, avoids deleterious CNS side effects and may be clinically useful in the treatment of pain of peripheral origin...
  19. pmc Chronic spontaneous activity generated in the somata of primary nociceptors is associated with pain-related behavior after spinal cord injury
    Supinder S Bedi
    Department of Integrative Biology and Pharmacology, University of Texas Medical School at Houston, Houston, Texas 77030, USA
    J Neurosci 30:14870-82. 2010
    ..SCI promotes the entry of primary nociceptors into a chronic hyperexcitable-SA state that may provide a useful therapeutic target in some forms of persistent pain...
  20. ncbi request reprint Differential expression of tetrodotoxin-resistant sodium channels Nav1.8 and Nav1.9 in normal and inflamed rats
    Richard E Coggeshall
    Department of Anatomy and Neurosciences, Marine Biomedical Institute, University of Texas Medical Branch, Galveston, TX 77555 1069, USA
    Neurosci Lett 355:45-8. 2004
    ..The massive increase in Nav1.8 expression in myelinated axons suggests that these may contribute to peripheral sensitization and inflammatory hyperalgesia...
  21. pmc Mechanisms of chronic central neuropathic pain after spinal cord injury
    Claire E Hulsebosch
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1043, USA
    Brain Res Rev 60:202-13. 2009
    ..Targeting regional mechanisms will be of enormous benefit to the SCI population that suffer chronic pain, and will contribute to better treatment strategies for other chronic pain syndromes...
  22. ncbi request reprint Peripheral metabotropic glutamate receptors as drug targets for pain relief
    Volker Neugebauer
    Department of Anatomy and Neurosciences and Marine Biomedical Institute, University of Texas, Medical Branch, Galveston, TX 77555 1069, USA
    Expert Opin Ther Targets 6:349-61. 2002
    ....
  23. ncbi request reprint Control of postganglionic sympathetic efferent fibers by neurokinin 1 receptors in rats
    Richard E Coggeshall
    Department of Anatomy and Neurosciences, Marine Biomedical Institute, University of Texas Medical Branch, Galveston, TX 77555 1069, USA
    Neurosci Lett 353:197-200. 2003
    ..This control is enhanced after inflammation...
  24. ncbi request reprint Pronociceptive role of peripheral and spinal 5-HT7 receptors in the formalin test
    Héctor I Rocha-González
    Departamento de Farmacobiologia, Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional, Calzada de los Tenorios 235, Colonia Granjas Coapa, 14330 Mexico, D F, Mexico
    Pain 117:182-92. 2005
    ..Data suggest that 5-HT7, but not 5-HT1A, receptors play a pronociceptive role in peripheral and spinal sites in the rat formalin test...
  25. ncbi request reprint Pro-nociceptive role of peripheral galanin in inflammatory pain
    Juan Miguel Jimenez-Andrade
    Seccion Externa de Farmacologia, Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional, Mexico, D F Mexico
    Pain 110:10-21. 2004
    ..These results suggest that peripheral GAL has an excitatory role in inflammatory pain, likely mediated by peripheral GalR2 and that GAL can modulate VR1 function...
  26. ncbi request reprint Mechanism by which peripheral galanin increases acute inflammatory pain
    Juan Miguel Jimenez-Andrade
    Seccion Externa de Farmacologia, Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional, Mexico, D F, Mexico
    Brain Res 1056:113-7. 2005
    ..These results suggest that GAL enhances acute inflammatory pain through activation of PKC intracellular pathways...
  27. ncbi request reprint Activation of peripheral galanin receptors: differential effects on nociception
    Juan Miguel Jimenez-Andrade
    Seccion Externa de Farmacologia, Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional, Av IPN 2508 San Pedro Zacatenco 07360, Mexico, DF Mexico
    Pharmacol Biochem Behav 85:273-80. 2006
    ..Thus, the use of these pharmacological tools may help to elucidate the contribution of GalR subtypes in nociceptive processing, identifying potential drug targets for the treatment of peripheral pain...

Research Grants26

  1. NMDA MEDIATED EVENTS IN NEUROPATHIC PAIN
    Susan Carlton; Fiscal Year: 1999
    ..The results will elucidate mechanisms of neuropathic pain and determine whether NMDA antagonists will provide a needed therapeutic tool for a clinical phenomenon historically very difficult to treat. ..
  2. PERIPHERAL SOMATOSTATIN CONTROLS INFLAMMATORY PAIN
    Susan Carlton; Fiscal Year: 2004
    ..Peripheral SST receptors offer novel targets for nociceptor modulation and are likely targets for further development of non-opioid therapies to aid in reducing the pain and long-term deleterious changes that can accompany inflammation. ..
  3. Mechanisms of Peripheral Analgesia: Group II mGluRs
    Susan Carlton; Fiscal Year: 2007
    ..Enhancing activity of peripheral inhibitory Group II mGluRs could provide a non-opioid therapy for pain, avoiding CNS and PNS side effects inherent in opioid treatment. ..
  4. Non-Peptide Somatostatin Agonist Analgesics
    Susan Carlton; Fiscal Year: 2007
    ..We will assess the behavioral, physiological and anatomical outcomes of NISAs treatment, evaluating their potential to yield highly desirable analgesics which could greatly reduce the current reliance on opioid therapies. ..
  5. Peripheral Sensitization Following Spinal Cord Injury
    Susan Carlton; Fiscal Year: 2007
    ..In this proposal we will elucidate mechanisms that heretofore have been unknown contributors to central neuropathic pain. ..
  6. Peripheral Sensitization Following Spinal Cord Injury
    Susan Carlton; Fiscal Year: 2009
    ..In this proposal we will elucidate mechanisms that heretofore have been unknown contributors to central neuropathic pain. ..
  7. Peripheral Sensitization Following Spinal Cord Injury
    Susan Carlton; Fiscal Year: 2009
    ..In this proposal we will elucidate mechanisms that heretofore have been unknown contributors to central neuropathic pain. ..
  8. Group III mGLURs: Mechanisms of Analgesia
    Susan M Carlton; Fiscal Year: 2010
    ....
  9. PERIPHERAL GLUTAMATE RECEPTORS IN INFLAMMATORY PAIN
    Susan Carlton; Fiscal Year: 2003
    ..abstract_text> ..
  10. Peripheral Sensitization Following Spinal Cord Injury
    Susan M Carlton; Fiscal Year: 2010
    ..In this proposal we will elucidate mechanisms that heretofore have been unknown contributors to central neuropathic pain. ..