Cynthia Carlsson

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. pmc Effects of atorvastatin on cerebral blood flow in middle-aged adults at risk for Alzheimer's disease: a pilot study
    Cynthia M Carlsson
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
    Curr Alzheimer Res 9:990-7. 2012
  2. pmc The effect of body mass index on global brain volume in middle-aged adults: a cross sectional study
    Michael A Ward
    Geriatric Research Education and Clinical Center, Wm S Middleton VA Hospital, Madison, WI, USA
    BMC Neurol 5:23. 2005
  3. ncbi request reprint Lessons learned from failed and discontinued clinical trials for the treatment of Alzheimer's disease: future directions
    Cynthia M Carlsson
    Department of Medicine, Section of Geriatrics and Gerontology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
    J Alzheimers Dis 15:327-38. 2008
  4. ncbi request reprint Effects of simvastatin on cerebrospinal fluid biomarkers and cognition in middle-aged adults at risk for Alzheimer's disease
    Cynthia M Carlsson
    Department of Medicine, Section of Geriatrics and Gerontology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
    J Alzheimers Dis 13:187-97. 2008
  5. ncbi request reprint Lowering homocysteine for stroke prevention
    Cynthia M Carlsson
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
    Lancet 369:1841-2. 2007
  6. pmc Increased atherogenic lipoproteins are associated with cognitive impairment: effects of statins and subclinical atherosclerosis
    Cynthia M Carlsson
    Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI53705, USA
    Alzheimer Dis Assoc Disord 23:11-7. 2009
  7. ncbi request reprint Homocysteine lowering with folic acid and vitamin B supplements: effects on cardiovascular disease in older adults
    Cynthia M Carlsson
    Department of Medicine, Section of Geriatrics and Gerontology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53705, USA
    Drugs Aging 23:491-502. 2006
  8. ncbi request reprint Effects of multivitamins and low-dose folic acid supplements on flow-mediated vasodilation and plasma homocysteine levels in older adults
    Cynthia M Carlsson
    Section of Cardiovascular Medicine, University of Wisconsin Medical School, and the Veterans Affairs Geriatrics Research, Education, and Clinical Center GRECC, Madison, Wis 53705, USA
    Am Heart J 148:E11. 2004
  9. doi request reprint Type 2 diabetes mellitus, dyslipidemia, and Alzheimer's disease
    Cynthia M Carlsson
    Department of Medicine, Section of Geriatrics and Gerontology, University of Wisconsin School of Medicine and Public Health, William S Middleton Memorial Veterans Hospital Geriatric Research, Education and Clinical Center GRECC, Wisconsin Alzheimer s Disease Research Center, Madison, WI 53705, USA
    J Alzheimers Dis 20:711-22. 2010
  10. ncbi request reprint Cardiovascular disease and the aging woman: overcoming barriers to lifestyle changes
    Cynthia M Carlsson
    University of Wisconsin Department of Medicine and Center for Women s Health and Women s Health Research, 2500 Overlook Terrace, Madison, WI 53705, USA
    Curr Womens Health Rep 2:366-72. 2002

Detail Information

Publications26

  1. pmc Effects of atorvastatin on cerebral blood flow in middle-aged adults at risk for Alzheimer's disease: a pilot study
    Cynthia M Carlsson
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
    Curr Alzheimer Res 9:990-7. 2012
    ..Statins improve vascular reactivity, but it is unknown if they increase regional cerebral blood flow (CBF) in individuals at risk for AD...
  2. pmc The effect of body mass index on global brain volume in middle-aged adults: a cross sectional study
    Michael A Ward
    Geriatric Research Education and Clinical Center, Wm S Middleton VA Hospital, Madison, WI, USA
    BMC Neurol 5:23. 2005
    ..The purpose of this study was to determine whether body type affects global brain volume, a marker of atrophy, in middle-aged men and women...
  3. ncbi request reprint Lessons learned from failed and discontinued clinical trials for the treatment of Alzheimer's disease: future directions
    Cynthia M Carlsson
    Department of Medicine, Section of Geriatrics and Gerontology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
    J Alzheimers Dis 15:327-38. 2008
    ..While there are few treatments available for AD currently, the potential for discovery over the next decade is promising...
  4. ncbi request reprint Effects of simvastatin on cerebrospinal fluid biomarkers and cognition in middle-aged adults at risk for Alzheimer's disease
    Cynthia M Carlsson
    Department of Medicine, Section of Geriatrics and Gerontology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
    J Alzheimers Dis 13:187-97. 2008
    ..It is unclear if statins modify Abeta metabolism or improve cognition in asymptomatic middle-aged adults at increased risk for AD...
  5. ncbi request reprint Lowering homocysteine for stroke prevention
    Cynthia M Carlsson
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
    Lancet 369:1841-2. 2007
  6. pmc Increased atherogenic lipoproteins are associated with cognitive impairment: effects of statins and subclinical atherosclerosis
    Cynthia M Carlsson
    Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI53705, USA
    Alzheimer Dis Assoc Disord 23:11-7. 2009
    ..Randomized-controlled clinical trials and longitudinal studies are necessary to determine if statins protect against cognitive decline...
  7. ncbi request reprint Homocysteine lowering with folic acid and vitamin B supplements: effects on cardiovascular disease in older adults
    Cynthia M Carlsson
    Department of Medicine, Section of Geriatrics and Gerontology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53705, USA
    Drugs Aging 23:491-502. 2006
    ..Data to date do not support use of homocysteine-lowering therapies in either middle-aged or older adults...
  8. ncbi request reprint Effects of multivitamins and low-dose folic acid supplements on flow-mediated vasodilation and plasma homocysteine levels in older adults
    Cynthia M Carlsson
    Section of Cardiovascular Medicine, University of Wisconsin Medical School, and the Veterans Affairs Geriatrics Research, Education, and Clinical Center GRECC, Madison, Wis 53705, USA
    Am Heart J 148:E11. 2004
    ..The objective of this study was to determine the effects of multivitamins (MV) and folic acid (FA) supplements on flow-mediated vasodilation (FMD) in older adults...
  9. doi request reprint Type 2 diabetes mellitus, dyslipidemia, and Alzheimer's disease
    Cynthia M Carlsson
    Department of Medicine, Section of Geriatrics and Gerontology, University of Wisconsin School of Medicine and Public Health, William S Middleton Memorial Veterans Hospital Geriatric Research, Education and Clinical Center GRECC, Wisconsin Alzheimer s Disease Research Center, Madison, WI 53705, USA
    J Alzheimers Dis 20:711-22. 2010
    ....
  10. ncbi request reprint Cardiovascular disease and the aging woman: overcoming barriers to lifestyle changes
    Cynthia M Carlsson
    University of Wisconsin Department of Medicine and Center for Women s Health and Women s Health Research, 2500 Overlook Terrace, Madison, WI 53705, USA
    Curr Womens Health Rep 2:366-72. 2002
    ..This article addresses age-related changes in cardiovascular risk factors in women, with a focus on lifestyle interventions...
  11. pmc Short-term hormone therapy with transdermal estradiol improves cognition for postmenopausal women with Alzheimer's disease: results of a randomized controlled trial
    Whitney Wharton
    University of Wisconsin, School of Medicine and Public Health, William S Middleton Memorial VA Hospital, 2500 Overlook Terrace, GRECC11G Madison, WI 53705, USA
    J Alzheimers Dis 26:495-505. 2011
    ..Moreover, treatment-related changes in plasma estradiol were positively correlated with improvements in visual memory. Short-term HT that includes the use of estradiol has favorable effects on cognition in women with AD...
  12. pmc Awareness of memory abilities in community-dwelling older adults with suspected dementia and mild cognitive impairment
    Feng Lin
    School of Nursing, Department of Medicine, School of Medicine and Public Health, University of Wisconsin Madison, Madison, WI, USA
    Dement Geriatr Cogn Disord 30:83-92. 2010
    ....
  13. pmc Cognitive benefits of hormone therapy: cardiovascular factors and healthy-user bias
    Whitney Wharton
    School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA
    Maturitas 64:182-7. 2009
    ..The present observational, community-based, case-controlled study examined the 'healthy-user' bias theory by comparing cognitive task performance in two groups of postmenopausal women, who were either HT users or non-users...
  14. pmc Anosognosia in mild cognitive impairment: Relationship to activation of cortical midline structures involved in self-appraisal
    Michele L Ries
    Geriatric Research Education and Clinical Center, William S Middleton VA Hospital, Madison, Wisconsin 53705, USA
    J Int Neuropsychol Soc 13:450-61. 2007
    ..This finding highlights the level of anosognosia in MCI as an important predictor of response to self-appraisal in cortical midline structures, brain regions vulnerable to changes in early AD...
  15. pmc Effect of Alzheimer disease risk on brain function during self-appraisal in healthy middle-aged adults
    Sterling C Johnson
    Geriatric Research Education and Clinical Center, William S Middleton Memorial Veterans Hospital, 2500 Overlook Terrace, Madison, WI 53705, USA
    Arch Gen Psychiatry 64:1163-71. 2007
    ....
  16. pmc Magnetic resonance imaging characterization of brain structure and function in mild cognitive impairment: a review
    Michele L Ries
    William S Middleton Memorial Veterans Hospital Geriatric Research Education and Clinical Center, Madison, Wisconsin 53705, USA
    J Am Geriatr Soc 56:920-34. 2008
    ..Third, we will make recommendations regarding the current clinical use of MRI in identification of MCI. As a conclusion, we will look to the future of neuroimaging as a tool in early AD detection...
  17. doi request reprint Standardized note template improves screening of firearm access and driving among veterans with dementia
    Noelle K Loconte
    Department of Medicine, Section of Hematology Oncology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
    Am J Alzheimers Dis Other Demen 23:313-8. 2008
    ..001). In memory assessment clinic, 31.8% had firearms access and 50% were driving. Many patients continued to drive and have access to firearms. The use of templates for the progress note was effective in increasing the screening rate...
  18. pmc The influence of Alzheimer disease family history and apolipoprotein E epsilon4 on mesial temporal lobe activation
    Sterling C Johnson
    University of Wisconsin Madison, Wisconsin 53705, USA
    J Neurosci 26:6069-76. 2006
    ....
  19. pmc A preliminary study of the safety, feasibility and cognitive efficacy of soy isoflavone supplements in older men and women
    Carey E Gleason
    Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin, Madison, WI 53705, USA
    Age Ageing 38:86-93. 2009
    ..Unfortunately, few studies enrolled adults over the age of 70, and none included older men...
  20. ncbi request reprint Clinical pharmacology and differential cognitive efficacy of estrogen preparations
    Carey E Gleason
    Department of Medicine, University of Wisconsin Medical School, and Geriatric Research, Education and Clinical Center GRECC, William S Middleton Memorial Veterans Hospital, Madison, WI 53705, USA
    Ann N Y Acad Sci 1052:93-115. 2005
    ....
  21. pmc Growing old with epilepsy: the neglected issue of cognitive and brain health in aging and elder persons with chronic epilepsy
    Bruce Hermann
    Department of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Epilepsia 49:731-40. 2008
    ..We suggest that a research agenda be developed to systematically identify and treat known modifiable risk factors in order to protect and promote cognitive and brain health in aging and elder persons with chronic epilepsy...
  22. ncbi request reprint Health-related quality of life and long-term therapy with pravastatin and tocopherol (vitamin E) in older adults
    Cynthia M Carlsson
    University of Wisconsin Medical School, Madison, Wisconsin 53792, USA
    Drugs Aging 19:793-805. 2002
    ..These concerns also may prevent clinicians from enrolling older patients in clinical trials assessing the efficacy of statins as a preventive therapy for Alzheimer's disease...
  23. pmc White matter is altered with parental family history of Alzheimer's disease
    Barbara B Bendlin
    Geriatric Research Educational and Clinical Center, William S Middleton Memorial Veterans Hospital, Madison, WI, USA
    Alzheimers Dement 6:394-403. 2010
    ..We examined the main effects of family history and APOE varepsilon4 on brain integrity, in addition to assessing possible additive effects of these two risk factors...
  24. ncbi request reprint Inaccuracy of lipid measurements with the portable Cholestech L.D.X analyzer in patients with hypercholesterolemia
    James H Stein
    University of Wisconsin Medical School, Madison, WI 53792, USA
    Clin Chem 48:284-90. 2002
    ..This study determined the biases and variability in portable lipid measurements in older patients with hypercholesterolemia and related them to National Cholesterol Education Program Adult Treatment Panel III guidelines...
  25. ncbi request reprint Clinical trials testing the homocysteine hypothesis
    Cynthia M Carlsson
    Ann Intern Med 137:295-6. 2002
  26. ncbi request reprint Cerivastatin and endothelial function in elderly patients with diabetes mellitus
    James H Stein
    Circulation 105:E32-3. 2002

Research Grants5

  1. Effect of Statins on Pathobiology of Alzheimer's Disease
    Cynthia Carlsson; Fiscal Year: 2004
    ..Cognitive testing will also be repeated at the 3-month follow-up. Outcome measures at 9 months will be compared to baseline. Results will be analyzed by apolipoprotein E4 status. ..
  2. Effect of Statins on Pathobiology of Alzheimer's Disease
    Cynthia Carlsson; Fiscal Year: 2007
    ..Cognitive testing will also be repeated at the 3-month follow-up. Outcome measures at 9 months will be compared to baseline. Results will be analyzed by apolipoprotein E4 status. ..
  3. Statin Effects on Beta-Amyloid and Cerebral Perfusion in Adults at Risk for AD
    Cynthia M Carlsson; Fiscal Year: 2010
    ..If statins prevent or delay the onset of AD, they could have a profound impact not only on the physical and emotional health of millions of individual patients at risk for the disease, but also on their families and caregivers. ..