Research Topics
Species | Cynthia CarlssonSummaryAffiliation: University of Wisconsin Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Effects of atorvastatin on cerebral blood flow in middle-aged adults at risk for Alzheimer's disease: a pilot studyCynthia M Carlsson
Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
Curr Alzheimer Res 9:990-7. 2012..Statins improve vascular reactivity, but it is unknown if they increase regional cerebral blood flow (CBF) in individuals at risk for AD...- The effect of body mass index on global brain volume in middle-aged adults: a cross sectional studyMichael A Ward
Geriatric Research Education and Clinical Center, Wm S Middleton VA Hospital, Madison, WI, USA
BMC Neurol 5:23. 2005..The purpose of this study was to determine whether body type affects global brain volume, a marker of atrophy, in middle-aged men and women... 
Lessons learned from failed and discontinued clinical trials for the treatment of Alzheimer's disease: future directionsCynthia M Carlsson
Department of Medicine, Section of Geriatrics and Gerontology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
J Alzheimers Dis 15:327-38. 2008..While there are few treatments available for AD currently, the potential for discovery over the next decade is promising...- Effects of simvastatin on cerebrospinal fluid biomarkers and cognition in middle-aged adults at risk for Alzheimer's diseaseCynthia M Carlsson
Department of Medicine, Section of Geriatrics and Gerontology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
J Alzheimers Dis 13:187-97. 2008..It is unclear if statins modify Abeta metabolism or improve cognition in asymptomatic middle-aged adults at increased risk for AD... - Lowering homocysteine for stroke preventionCynthia M Carlsson
Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
Lancet 369:1841-2. 2007 - Increased atherogenic lipoproteins are associated with cognitive impairment: effects of statins and subclinical atherosclerosisCynthia M Carlsson
Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI53705, USA
Alzheimer Dis Assoc Disord 23:11-7. 2009..Randomized-controlled clinical trials and longitudinal studies are necessary to determine if statins protect against cognitive decline... - Homocysteine lowering with folic acid and vitamin B supplements: effects on cardiovascular disease in older adultsCynthia M Carlsson
Department of Medicine, Section of Geriatrics and Gerontology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53705, USA
Drugs Aging 23:491-502. 2006..Data to date do not support use of homocysteine-lowering therapies in either middle-aged or older adults... - Effects of multivitamins and low-dose folic acid supplements on flow-mediated vasodilation and plasma homocysteine levels in older adultsCynthia M Carlsson
Section of Cardiovascular Medicine, University of Wisconsin Medical School, and the Veterans Affairs Geriatrics Research, Education, and Clinical Center GRECC, Madison, Wis 53705, USA
Am Heart J 148:E11. 2004..The objective of this study was to determine the effects of multivitamins (MV) and folic acid (FA) supplements on flow-mediated vasodilation (FMD) in older adults... 
Type 2 diabetes mellitus, dyslipidemia, and Alzheimer's diseaseCynthia M Carlsson
Department of Medicine, Section of Geriatrics and Gerontology, University of Wisconsin School of Medicine and Public Health, William S Middleton Memorial Veterans Hospital Geriatric Research, Education and Clinical Center GRECC, Wisconsin Alzheimer s Disease Research Center, Madison, WI 53705, USA
J Alzheimers Dis 20:711-22. 2010....- Cardiovascular disease and the aging woman: overcoming barriers to lifestyle changesCynthia M Carlsson
University of Wisconsin Department of Medicine and Center for Women s Health and Women s Health Research, 2500 Overlook Terrace, Madison, WI 53705, USA
Curr Womens Health Rep 2:366-72. 2002..This article addresses age-related changes in cardiovascular risk factors in women, with a focus on lifestyle interventions... - Short-term hormone therapy with transdermal estradiol improves cognition for postmenopausal women with Alzheimer's disease: results of a randomized controlled trialWhitney Wharton
University of Wisconsin, School of Medicine and Public Health, William S Middleton Memorial VA Hospital, 2500 Overlook Terrace, GRECC11G Madison, WI 53705, USA
J Alzheimers Dis 26:495-505. 2011..Moreover, treatment-related changes in plasma estradiol were positively correlated with improvements in visual memory. Short-term HT that includes the use of estradiol has favorable effects on cognition in women with AD... - Awareness of memory abilities in community-dwelling older adults with suspected dementia and mild cognitive impairmentFeng Lin
School of Nursing, Department of Medicine, School of Medicine and Public Health, University of Wisconsin Madison, Madison, WI, USA
Dement Geriatr Cogn Disord 30:83-92. 2010.... - Cognitive benefits of hormone therapy: cardiovascular factors and healthy-user biasWhitney Wharton
School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA
Maturitas 64:182-7. 2009..The present observational, community-based, case-controlled study examined the 'healthy-user' bias theory by comparing cognitive task performance in two groups of postmenopausal women, who were either HT users or non-users... - Anosognosia in mild cognitive impairment: Relationship to activation of cortical midline structures involved in self-appraisalMichele L Ries
Geriatric Research Education and Clinical Center, William S Middleton VA Hospital, Madison, Wisconsin 53705, USA
J Int Neuropsychol Soc 13:450-61. 2007..This finding highlights the level of anosognosia in MCI as an important predictor of response to self-appraisal in cortical midline structures, brain regions vulnerable to changes in early AD... - Effect of Alzheimer disease risk on brain function during self-appraisal in healthy middle-aged adultsSterling C Johnson
Geriatric Research Education and Clinical Center, William S Middleton Memorial Veterans Hospital, 2500 Overlook Terrace, Madison, WI 53705, USA
Arch Gen Psychiatry 64:1163-71. 2007.... - Magnetic resonance imaging characterization of brain structure and function in mild cognitive impairment: a reviewMichele L Ries
William S Middleton Memorial Veterans Hospital Geriatric Research Education and Clinical Center, Madison, Wisconsin 53705, USA
J Am Geriatr Soc 56:920-34. 2008..Third, we will make recommendations regarding the current clinical use of MRI in identification of MCI. As a conclusion, we will look to the future of neuroimaging as a tool in early AD detection... - Standardized note template improves screening of firearm access and driving among veterans with dementiaNoelle K Loconte
Department of Medicine, Section of Hematology Oncology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
Am J Alzheimers Dis Other Demen 23:313-8. 2008..001). In memory assessment clinic, 31.8% had firearms access and 50% were driving. Many patients continued to drive and have access to firearms. The use of templates for the progress note was effective in increasing the screening rate... - The influence of Alzheimer disease family history and apolipoprotein E epsilon4 on mesial temporal lobe activationSterling C Johnson
University of Wisconsin Madison, Wisconsin 53705, USA
J Neurosci 26:6069-76. 2006.... - A preliminary study of the safety, feasibility and cognitive efficacy of soy isoflavone supplements in older men and womenCarey E Gleason
Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin, Madison, WI 53705, USA
Age Ageing 38:86-93. 2009..Unfortunately, few studies enrolled adults over the age of 70, and none included older men... - Clinical pharmacology and differential cognitive efficacy of estrogen preparationsCarey E Gleason
Department of Medicine, University of Wisconsin Medical School, and Geriatric Research, Education and Clinical Center GRECC, William S Middleton Memorial Veterans Hospital, Madison, WI 53705, USA
Ann N Y Acad Sci 1052:93-115. 2005.... - Growing old with epilepsy: the neglected issue of cognitive and brain health in aging and elder persons with chronic epilepsyBruce Hermann
Department of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
Epilepsia 49:731-40. 2008..We suggest that a research agenda be developed to systematically identify and treat known modifiable risk factors in order to protect and promote cognitive and brain health in aging and elder persons with chronic epilepsy... - Health-related quality of life and long-term therapy with pravastatin and tocopherol (vitamin E) in older adultsCynthia M Carlsson
University of Wisconsin Medical School, Madison, Wisconsin 53792, USA
Drugs Aging 19:793-805. 2002.... - White matter is altered with parental family history of Alzheimer's diseaseBarbara B Bendlin
Geriatric Research Educational and Clinical Center, William S Middleton Memorial Veterans Hospital, Madison, WI, USA
Alzheimers Dement 6:394-403. 2010..We examined the main effects of family history and APOE varepsilon4 on brain integrity, in addition to assessing possible additive effects of these two risk factors... - Inaccuracy of lipid measurements with the portable Cholestech L.D.X analyzer in patients with hypercholesterolemiaJames H Stein
University of Wisconsin Medical School, Madison, WI 53792, USA
Clin Chem 48:284-90. 2002..CONCLUSIONS: Lipid values obtained from portable lipid analyzers may be useful for screening, but they should not be used to make clinical decisions regarding the diagnosis and management of dyslipidemia in individual patients... - Clinical trials testing the homocysteine hypothesisCynthia M Carlsson
Ann Intern Med 137:295-6. 2002 - Cerivastatin and endothelial function in elderly patients with diabetes mellitusJames H Stein
Circulation 105:E32-3. 2002
Research Grants
- Effect of Statins on Pathobiology of Alzheimer's DiseaseCynthia Carlsson; Fiscal Year: 2004..Cognitive testing will also be repeated at the 3-month follow-up. Outcome measures at 9 months will be compared to baseline. Results will be analyzed by apolipoprotein E4 status. ..
- Effect of Statins on Pathobiology of Alzheimer's DiseaseCynthia Carlsson; Fiscal Year: 2007..Cognitive testing will also be repeated at the 3-month follow-up. Outcome measures at 9 months will be compared to baseline. Results will be analyzed by apolipoprotein E4 status. ..
- Statin Effects on Beta-Amyloid and Cerebral Perfusion in Adults at Risk for ADCynthia M Carlsson; Fiscal Year: 2010..If statins prevent or delay the onset of AD, they could have a profound impact not only on the physical and emotional health of millions of individual patients at risk for the disease, but also on their families and caregivers. ..