Gregory C Carlson
Affiliation: University of Pennsylvania
- Glutamate receptor dysfunction and drug targets across models of autism spectrum disordersGreg C Carlson
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Pharmacol Biochem Behav 100:850-4. 2012..Further development of preclinical models focusing on glutamate receptors may provide tools to target a clinically important subset of ASD symptoms...
- Dysbindin-1 mutant mice implicate reduced fast-phasic inhibition as a final common disease mechanism in schizophreniaGregory C Carlson
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104 3403, USA
Proc Natl Acad Sci U S A 108:E962-70. 2011..Furthermore, these data implicate reduced fast-phasic inhibition as a common underlying mechanism of schizophrenia-associated intermediate phenotypes...
- Pyramidal cell selective ablation of N-methyl-D-aspartate receptor 1 causes increase in cellular and network excitabilityValerie M Tatard-Leitman
Translational Neuroscience Program, University of Pennsylvania, Philadelphia, Pennsylvania Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania
Biol Psychiatry 77:556-68. 2015..However, this computational model has not been tested experimentally and the molecular mechanisms underlying pyramidal neuron dysfunction in SZ remain unclear...
- High fat diet produces brain insulin resistance, synaptodendritic abnormalities and altered behavior in miceSteven E Arnold
Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, 125 South 31st St, Philadelphia, PA 19104, USA Electronic address
Neurobiol Dis 67:79-87. 2014..These findings indicate that HFD is associated with telencephalic insulin resistance and deleterious effects on synaptic integrity and cognitive behaviors...
- Divergent functional effects of sazetidine-a and varenicline during nicotine withdrawalJill R Turner
Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Neuropsychopharmacology 38:2035-47. 2013..These findings highlight the importance of drug history in understanding the mechanisms through which nicotinic compounds may be aiding smoking cessation in individuals experiencing withdrawal-associated anxiety...
- Temporally dependent changes in cocaine-induced synaptic plasticity in the nucleus accumbens shell are reversed by D1-like dopamine receptor stimulationPavel I Ortinski
Department of Psychiatry, Center for Neurobiology and Behavior, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA
Neuropsychopharmacology 37:1671-82. 2012....
- Prospective MEG biomarkers in ASD: pre-clinical evidence and clinical promise of electrophysiological signaturesRussell G Port
Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Lurie Family Foundations MEG Imaging Center, Department of Radiology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania Neurosciences Graduate Group, University of Pennsylvania, Philadelphia, Pennsylvania
Yale J Biol Med 88:25-36. 2015..g., language impairment), and putative biological underpinnings. ..
- Parvalbumin cell ablation of NMDA-R1 causes increased resting network excitability with associated social and self-care deficitsEddie N Billingslea
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
Neuropsychopharmacology 39:1603-13. 2014..Although previous data suggest that MPEP may be beneficial for core features of autism spectrum disorders, current data suggest that such effects require intact function of NMDAR on PV interneurons. ..
- Akt1 deficiency in schizophrenia and impairment of hippocampal plasticity and functionDarrick T Balu
Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Hippocampus 22:230-40. 2012..Taken together, these results implicate the Akt1 isoform in regulating hippocampal neuroplasticity and cognition and in contributing to the etiology of schizophrenia...